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1. 发明申请

WO1996022270A1 BIOPOLYMERS DERIVED FROM HYDROLYZABLE DIACID FATS 审中-公开
标题翻译：来自可水解脱脂脂肪的生物聚合物
公开(公告)号：WO1996022270A1
公开(公告)日：1996-07-25
申请号：PCT/IB1995000007
申请日：1995-01-18
申请人： YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , DOMB, Abraham, Jacob , NUDELMAN, Raphael
发明人： YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： C07C51/12
CPC分类号： A61K9/2031 , A61K9/204 , C07C59/347 , C07C69/675 , C08G63/48 , C08G67/04
摘要： A monomeric diacid derivative includes at least two fatty acids coupled by a hydrolytically or enzymatically degradable bond. In a biological environment, the bond degrades forming naturally occurring fatty acid products thereby allowing elimination.
摘要翻译：单体二酸衍生物包括通过水解或酶可降解键偶联的至少两种脂肪酸。在生物环境中，该键降解形成天然存在的脂肪酸产物，从而允许消除。

2. 发明申请

WO1995028962A1 INHIBITION OF MYELIN DESTRUCTION BY INTERFERING WITH THE INTERACTION BETWEEN MAC-2 AND MYELIN 审中-公开
标题翻译：通过干扰MAC-2和MYELIN之间的相互作用来抑制MYELIN破坏
公开(公告)号：WO1995028962A1
公开(公告)日：1995-11-02
申请号：PCT/US1995004766
申请日：1995-04-17
申请人： YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
发明人： YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , ROTSHENKER, Shlomo
IPC分类号： A61K39/395
CPC分类号： A61K31/7004 , A61K31/7028 , A61K38/00 , C07K16/18 , C07K2317/77
摘要： A method for inhibiting myelin destruction including the steps of identifying the type of myelin destruction and determining if MAC-2 expression has been induced on the cells involved. Compounds are then administered to act at the MAC-2 site thereby inhibiting interactions between MAC-2 and myelin.
摘要翻译：一种抑制髓鞘破坏的方法，包括鉴定髓鞘破坏的类型和确定是否在所涉及的细胞上诱导MAC-2表达的步骤。然后施用化合物以在MAC-2位点起作用，从而抑制MAC-2和髓磷脂之间的相互作用。

3. 发明申请

WO1996013193A2 NON-INVASIVE DEVICE AND METHOD FOR QUANTITATIVE DETERMINATION OF OXIDANTS AND/OR ANTIOXIDANTS IN THE SKIN 审中-公开
标题翻译：非侵入性装置和用于定量测定皮肤中的氧化物和/或抗氧化剂的方法
公开(公告)号：WO1996013193A2
公开(公告)日：1996-05-09
申请号：PCT/US1995013550
申请日：1995-10-10
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , KOHEN, Ron , FANBERSTEIN, David , TIROSH, Oren
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： A61B00/00
CPC分类号： A61B5/1477 , A61B5/14542 , A61B5/442
摘要： A non-invasive device for the quantitative determination of the level of oxidants and/or antioxidants in the skin of a subject includes a reference electrode and a working electrode which are connected to an electrical voltage measuring device; and a test solution container which is open at a bottom side thereof and which is placed on the skin of the subject and is sealingly but releasably affixed to the skin, is filled with a test solution, and which permits contact between the test solution and the skin. The test solution container further includes a top opening through which the electrodes are immersed in the test solution.
摘要翻译：用于定量测定受试者皮肤中氧化剂和/或抗氧化剂水平的非侵入性装置包括连接到电压测量装置的参比电极和工作电极; 以及在其底侧开口并被放置在被检体的皮肤上并且密封地但可剥离地固定在皮肤上的试液容器，填充有试验溶液，并且允许试验溶液与皮肤。测试溶液容器还包括顶部开口，电极浸入测试溶液中。

4. 发明申请

WO2013103826A1 ANTI-INFLAMMATORY COMPOUNDS IN COMBINATION WITH HYDROGEN FOR THE TREATMENT OF INFLAMMATION 审中-公开
标题翻译：用于治疗炎症的氢组合物的抗炎化合物
公开(公告)号：WO2013103826A1
公开(公告)日：2013-07-11
申请号：PCT/US2013/020298
申请日：2013-01-04
申请人： TOSHIHISA, Kawai , KOHN, Kenneth, I. , SKYVIEW ENTERPRISE LTD.
发明人： TOSHIHISA, Kawai , KOHN, Kenneth, I.
IPC分类号： A01N37/10 , A61K31/19
CPC分类号： A61K31/7016 , A61K9/08 , A61K9/167 , A61K9/48 , A61K31/192 , A61K31/197 , A61K31/365 , A61K31/40 , A61K31/415 , A61K31/635 , A61K31/7004 , A61K31/715 , A61K31/733 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： A composition for treating inflammation and pain, including an antiinflammatory/ anti-pain agent in combination with a hydrogen- generating compound. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A composition for treating inflammation and pain, including a drug that produces inflammation as an unwanted side effect in combination with a hydrogen-generating compound. A method of treating inflammation and pain, by administering an effective amount of the composition including an anti-inflammatory/anti-pain agent and a hydrogen-generating compound to an individual. A method of potentiating the response of an antiinflammatory/ anti-pain agent. A composition including a hydrogen-generating compound for reducing inflammation.
摘要翻译：用于治疗炎症和疼痛的组合物，包括与产生氢的化合物组合的抗炎/抗疼痛剂。用于治疗炎症和疼痛的组合物，包括协同有效量的普瑞巴林和乳果糖。用于治疗炎症和疼痛的组合物，包括与产生氢的化合物组合产生作为不需要的副作用的炎症的药物。通过向个体施用有效量的包含抗炎/抗疼痛剂和产氢化合物的组合物来治疗炎症和疼痛的方法。一种增强抗炎/抗疼痛剂反应的方法。包含用于减少炎症的产氢化合物的组合物。

5. 发明申请

WO1998026062A2 SYNTHETIC ANTISENSE OLIGODEOXYNUCLEOTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：合成抗体寡糖氧化酶和含有它们的药物组合物
公开(公告)号：WO1998026062A2
公开(公告)日：1998-06-18
申请号：PCT/US1997023598
申请日：1997-12-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , SOREQ, Hermona , SEIDMAN, Shlomo , ECKSTEIN, Fritz , FRIEDMAN, Alon , KAUFER, Daniela
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： C12N15/00
CPC分类号： C12Y301/01007 , A01K2217/05 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/53 , C12N2310/3521
摘要： A synthetic nuclease resistant antisense oligodeoxynucleotide (AS-ODN) capable of selectively modulating human acetylcholinesterase (AChE) production and a pharmaceutical or medical composition comprising at least one AD-ODN as an active ingredient. In an embodiment the AS-ODN can be selected from 5'ACGCTTTCTTGAGGC 3' (SEQ ID NO.1), 5'GGCACCCTGGGCAGC 3' (SEQ ID NO.2); 5'CCACGTCCTCCTGCACCGTC 3' (SEQ ID NO.6); 5'ATGAACTCGATCTCGTAGCC 3' (SEQ ID NO.7); 5'GCCAGAGGAGGAGGAGAAGG 3' (SEQ ID NO.4); 5'TAGCGTCTACCACCCCTGAC 3' (SEQ ID NO.5), 5'TCTGTGTTATAGCCCAGCCC 3' (SEQ ID NO.17); and 5'GGCCTGTAACAGTTTATTT 3' (SEQ ID NO.18). A nuclease resistant antisense targeted against the splice junction in the AChEmRNA post splice message is disclosed. In an embodiment, a nuclease resistant AS-ODN targeted against the E4-E6 junction in the E1-E4-E6 splice variant AChEmRNA is disclosed as being highly specific for the muscle and central nervous system splice variant of AChE. The synthetic nuclease resistant AS-ODNs are capable of selectively modulating human AChE production in the central nervous system or capable of selectively reducing human AChE deposition in the neuromuscular junction. The present invention also provides a method to restore balanced cholinergic signaling in the brain and spinal cord or reduce AChE in the neuromuscular junction in patients in need of such treatment comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one of the synthetic nuclease resistant AS-ODN capable of selectively modulating human AChE production.
摘要翻译：能够选择性调节人乙酰胆碱酯酶（AChE）生产的合成核酸酶抗性反义寡脱氧核苷酸（AS-ODN）和包含至少一种AD-ODN作为活性成分的药物或医药组合物。在一个实施方案中，AS-ODN可以选自5'ACGCTTTCTTGAGGC 3'（SEQ ID NO.1），5'GGCACCCTGGGCAGC 3'（SEQ ID NO.2）; 5'CCACGTCCTCCTGCACCGTC 3'（SEQ ID NO.6）; 5'ATGAACTCGATCTCGTAGCC 3'（SEQ ID NO.7）; 5'GCCAGAGGAGGAGGAGAAGG 3'（SEQ ID NO.4）; 5'TAGCGTCTACCACCCCTGAC 3'（SEQ ID NO.5），5'TCTGTGTTATAGCCCAGCCC 3'（SEQ ID NO.17）; 和5'GGCCTGTAACAGTTTATTT 3'（SEQ ID NO.18）。公开了针对针对AChEmRNA后剪接消息中的剪接连接的核酸酶抗性反义。在一个实施方案中，公开了针对E1-E4-E6剪接变体AChEmRNA中的E4-E6连接的核酸酶抗性AS-ODN作为AChE的肌肉和中枢神经系统剪接变体的高度特异性。合成的核酸酶抗性AS-ODNs能够选择性调节中枢神经系统中的人AChE产生或能够选择性地降低神经肌肉接头中的人类AChE沉积。本发明还提供一种在需要这种治疗的患者中恢复脑和脊髓中的平衡胆碱能信号传导或减少神经肌肉接头中的AChE的方法，包括向需要这种治疗的患者施用治疗有效量的至少一种的能够选择性调节人AChE生产的合成核酸酶抗性AS-ODN。

6. 发明申请

WO1998004274A1 RECOMBINANT MOSQUITO SALIVARY ALLERGENS 审中-公开
标题翻译：重组莫斯科唾液过敏症
公开(公告)号：WO1998004274A1
公开(公告)日：1998-02-05
申请号：PCT/US1997013573
申请日：1997-07-31
申请人： UNIVERSITY OF MANITOBA , KOHN, Kenneth, I. , PENG, Zhikang , SIMONS, F., Estelle, R.
发明人： UNIVERSITY OF MANITOBA , KOHN, Kenneth, I.
IPC分类号： A61K35/64
CPC分类号： C07K14/43563 , A61K39/00 , C07K16/18
摘要： A recombinant mosquito salivary allergen for use in skin tests, immunoassays and allergy immunotherapy for allergic reactions to mosquito bites is provided. The recombinant allergen is produced by a cDNA encoding and IgE-binding protein or fragment thereof or analogue thereof which is found in mosquito saliva. The recombinant allergen may share common allergenicity among at least two species of mosquitos or may be species-specific. The present invention also provides a method of skin testing, an immunoassay and undertaking immunotherapy utilizing the recombinant salivary allergen and kits for practicing the methods of the invention. The present invention further provides antibodies directed against the recombinant salivary allergens.
摘要翻译：提供了一种用于皮肤试验，免疫测定和过敏免疫治疗对蚊子叮咬过敏反应的重组蚊子唾液过敏原。重组变应原是通过在蚊子唾液中发现的cDNA编码和IgE结合蛋白或其片段或其类似物产生的。重组变应原可能在至少两种蚊子中分享共同的过敏原，或者可能是物种特异性的。本发明还提供一种皮肤试验方法，免疫测定法和利用重组唾液变应原和用于实施本发明方法的试剂盒进行免疫治疗。本发明还提供针对重组唾液变应原的抗体。

7. 发明申请

WO1996033096A1 A METHOD FOR THE LONG-TERM PRESERVATION OF MEAT AND THE MEAT PROCESSED THEREBY 审中-公开
标题翻译：一种长期保存肉类及其加工过程的方法
公开(公告)号：WO1996033096A1
公开(公告)日：1996-10-24
申请号：PCT/US1996005373
申请日：1996-04-18
申请人： RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH AND INDUSTRIAL DEVELOPMENT LTD. , KOHN, Kenneth, I. , SHAKLAI, Nurith
发明人： RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH AND INDUSTRIAL DEVELOPMENT LTD. , KOHN, Kenneth, I.
IPC分类号： B65B31/02
CPC分类号： A23L3/3409 , A23L3/3445 , B65B25/067
摘要： A method for preserving meat and the meat processed thereby is disclosed. The method includes the steps of exposing raw meat to an atmosphere consisting essentially of carbon monoxide and maintaining the meat in a sealed container to maintain color and freshness while retarding bacterial growth.
摘要翻译：公开了一种保存肉类及其加工过的肉的方法。该方法包括以下步骤：将生肉暴露于基本上由一氧化碳组成的气氛中，并将肉保持在密封容器中以保持颜色和新鲜度，同时延缓细菌生长。

8. 发明申请

WO1996021744A1 METHOD OF SCREENING FOR GENETIC PREDISPOSITION TO ANTICHOLINESTERASE THERAPY 审中-公开
标题翻译：筛选用于抗胆碱酯酶治疗的遗传性预测方法
公开(公告)号：WO1996021744A1
公开(公告)日：1996-07-18
申请号：PCT/US1996000322
申请日：1996-01-11
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , SOREQ, Hermona , ZAKUT, Haim
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/142 , C12Q2600/156
摘要： A method of screening for a genetic predisposition to anticholinesterase exposure. The method includes the steps of obtaining a peripheral blood sample, and then analysing serum from the blood sample for BuChE levels and inhibitor-susceptibilities. The DNA of peripheral white blood cells from the blood sample is also screened for the presence of BuChE alleles thereby identifying patients who have a genetic predisposition to anticholinesterase exposure.
摘要翻译：筛选抗胆碱酯酶暴露的遗传易感性的方法。该方法包括获得外周血样品，然后分析血样中血清BuChE水平和抑制剂敏感性的步骤。还筛选来自血液样品的外周白细胞的DNA，以观察BuChE等位基因的存在，从而鉴定具有抗胆碱酯酶暴露的遗传易感性的患者。

9. 发明申请

WO1996016663A1 THIONOPHOSPHATE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：硫代磷酸酯衍生物，其制备方法及含有它们的药物组合物
公开(公告)号：WO1996016663A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015199
申请日：1995-11-13
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , TIROSH, Oren , KATZHENDLER, Joshua , GINSBURG, Isaac , BARENHOLZ, Yehezkel , KOHEN, Ron
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： A61K31/66
CPC分类号： C07F9/2458 , A61K8/55 , A61K2800/522 , A61Q17/00
摘要： The invention relates to a compound of formula (I) in which X1 and X2 each independently represents an oxygen or nitrogen atom; p, m and n are each independently an integer of at least 2; R, R1 and R2 each independently represents a hydrogen atom; a halogen atom; an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; a group R3O in which R3 is hydrogen atom, an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; optionally substituted acyl or optionally substituted aryl or heteroaryl; a group R4O(O)C in which R4 is a hydrogen atom or an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; a group -SR5 in which R5 is a hydrogen atom or an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; a group -NR6R7 in which R6 and R7 each independently represents a hydrogen atom, an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; optionally substituted acyl; or an optionally substituted phosphate ester group. The invention also relates to processes for the preparation of compounds of the formula and to pharmaceutical compositions containing the same.
摘要翻译：本发明涉及式（I）化合物，其中X 1和X 2各自独立地表示氧或氮原子; p，m和n各自独立地为至少2的整数; R，R 1和R 2各自独立地表示氢原子; 卤素原子; 任选取代的直链或支链烷基，烯基或炔基; R3为氢原子的基团R3O，任意取代的直链或支链烷基，链烯基或炔基; 任选取代的酰基或任选取代的芳基或杂芳基; R 4为氢原子的基团R 4 O（O）C或任选取代的直链或支链烷基，链烯基或炔基; R5为氢原子的基团-SR5或任意取代的直链或支链烷基，链烯基或炔基; R 6和R 7各自独立地表示氢原子的基团-NR 6 R 7，任选取代的直链或支链烷基，烯基或炔基; 任选取代的酰基; 或任选取代的磷酸酯基团。本发明还涉及制备式的化合物的方法和含有该化合物的药物组合物。

10. 发明申请

WO1995029666A1 SUSTAINED-RELEASE PHARMACEUTICAL SYSTEM FOR THE DELIVERY OF ANTIOXIDANTS 审中-公开
标题翻译：用于递送抗氧化剂的持续释放药物系统
公开(公告)号：WO1995029666A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005504
申请日：1995-05-03
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , FRIEDMAN, Michael , KOHEN, Ron
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： A61K09/22
CPC分类号： A61K31/375 , A61K9/2031 , A61K9/2054 , A61K9/2063 , A61K9/7007 , A61K31/015 , A61K31/355 , A61K33/04 , A61K2300/00
摘要： The invention relates to a sustained-release pharmaceutical delivery system for the administration of an antioxidant drug to a patient in need of such drug, wherein said delivery system comprises said drug in combination with a polymeric matrix, said matrix comprising a polymer which does not interact with said drug or a mixture of such polymers. The pharmaceutical delivery system of the invention is useful for the treatment of pathological conditions involving pathologically increased formation of active oxygen species.
摘要翻译：本发明涉及用于向需要这种药物的患者施用抗氧化药物的持续释放药物递送系统，其中所述递送系统包括与聚合物基质组合的所述药物，所述基质包含不相互作用的聚合物与所述药物或这些聚合物的混合物。本发明的药物递送系统可用于治疗涉及病理增加的活性氧形成的病理状况。

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