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1. 发明申请

US20080241862A1 PROPIONYL AND BUTYRYL LYSINE MODIFICATIONS IN PROTEINS 审中-公开
标题翻译：蛋白质中的丙酸和丁基赖氨酸修饰
公开(公告)号：US20080241862A1
公开(公告)日：2008-10-02
申请号：US12021960
申请日：2008-01-29
申请人： YINGMING ZHAO , John Falck , Yue Chen
发明人： YINGMING ZHAO , John Falck , Yue Chen
IPC分类号： G01N33/574 , G01N33/566 , C07K14/00 , C12P13/08 , C07K16/18 , G01N33/53
CPC分类号： C07K16/44 , C07K16/18 , G01N33/6812 , G01N33/6842
摘要： While the identification of acetylated lysine residues on proteins is well-known, the modification of lysine residues through propionylation and butyrylation is not very well understood. A method for the identification and mapping of propionylated and butyrylated lysine residues has been developed. Anti-acetyllysine antibody, normally used to affinity purify a protein mixture based on the presence of acetylated lysine, can also be used to affinity purity proteins having propionylated and butyrylated lysine residues due to the structural similarity. The method involves searching protein databases to locate mass spectrometry datasets for those proteins purified by anti-acetyllysine antibody. The located spectra are manually reviewed to identify those peptides having propionyllysine and butyryllysine residues. These identified peptides are synthesized, with the lysine modifications added at the appropriate positions. The synthesized proteins are then analyzed with mass spectrometry and the resultant spectra are compared to those located in the protein databases to confirm the location of the lysine modifications.
摘要翻译：虽然蛋白质上的乙酰化赖氨酸残基的鉴定是众所周知的，但是通过丙酰化和丁酰化修饰赖氨酸残基不是很好地理解。已经开发了用于鉴定和测定丙酰化和丁酰化赖氨酸残基的方法。通常用于亲和纯化基于乙酰化赖氨酸存在的蛋白质混合物的抗乙酰赖氨酸抗体也可用于由于结构相似性而具有丙酰化和丁酰化赖氨酸残基的亲和纯度蛋白质。该方法包括搜索蛋白质数据库来定位由抗乙酰赖氨酸抗体纯化的蛋白质的质谱数据集。手工检查定位的光谱，以鉴定具有丙酰赖氨酸和丁酰赖氨酸残基的那些肽。合成这些鉴定的肽，其中在适当位置加入赖氨酸修饰。然后通过质谱分析合成的蛋白质，并将所得光谱与位于蛋白质数据库中的蛋白质进行比较，以确认赖氨酸修饰的位置。

2. 发明授权

US08907002B2 Coatings for use in high humidity conditions 有权
标题翻译：用于高湿度条件下的涂料
公开(公告)号：US08907002B2
公开(公告)日：2014-12-09
申请号：US13721973
申请日：2012-12-20
申请人： Yue Chen , Navin Tilara , Jean Frederick Mauck , Shijun Yang , Yakov Freidzon , Robert J. Sheerin
发明人： Yue Chen , Navin Tilara , Jean Frederick Mauck , Shijun Yang , Yakov Freidzon , Robert J. Sheerin
IPC分类号： C08K3/34 , C08F8/30 , C09D133/04
CPC分类号： C08F218/08 , C09D131/04 , C08F2220/1825 , C08F218/10 , C08F220/36 , C08L83/00
摘要： The present invention is directed to a coating composition comprising a vinyl acrylic copolymer latex wherein said copolymer latex has a water contact angle of about 60° or higher on the dried latex film surface, wherein said copolymer latex further has a specific water vapor permeability of about 0.5 mg/cm2/mm/24 hr. The invention is also directed to the copolymer latex itself. Further, the invention is a method of improving a coating's ability to withstand a high humidity environment comprising adding a vinyl acrylic copolymer latex to the coating composition wherein said copolymer latex has a water contact angle of about 60° or higher on the dried latex film surface, and wherein said copolymer latex further has a specific water vapor permeability of about 0.5 mg/cm2/mm/24 hr.
摘要翻译：本发明涉及包含乙烯基丙烯酸共聚物胶乳的涂料组合物，其中所述共聚物胶乳在干燥的胶乳膜表面上具有约60°或更高的水接触角，其中所述共聚物胶乳进一步具有约为 0.5mg / cm 2 / mm 2/24小时。本发明还涉及共聚物胶乳本身。此外，本发明是一种提高涂层承受高湿度环境的能力的方法，包括向涂料组合物中加入乙烯基丙烯酸共聚物胶乳，其中所述共聚物胶乳在干燥的胶乳膜表面上具有约60°或更高的水接触角，并且其中所述共聚物胶乳的特定水蒸气透过率为约0.5mg / cm 2 / mm / 24小时。

3. 发明授权

US08522167B2 Relationship visualization and graphical interaction model in it client management 有权
标题翻译：客户管理中的关系可视化和图形交互模型
公开(公告)号：US08522167B2
公开(公告)日：2013-08-27
申请号：US12853079
申请日：2010-08-09
申请人： Chuanbo Zhang , Huajun Luo , Yue Chen , Daniel D. Ward , Justin K. Stanton , Chung Man Yiu , Jie Du , David C. James , Leyu Feng
发明人： Chuanbo Zhang , Huajun Luo , Yue Chen , Daniel D. Ward , Justin K. Stanton , Chung Man Yiu , Jie Du , David C. James , Leyu Feng
IPC分类号： G06F3/048
CPC分类号： H04L41/22 , H04L41/12
摘要： Displaying a hierarchy. A method includes identifying a set of nodes representing sites in a hierarchy. The set of nodes share one or more common characteristics not shared by any other nodes in the hierarchy. The method further includes determining that the set of nodes, as a set, meet a predetermined condition. As a result of the nodes sharing the one or more common characteristics not shared by any other nodes in the hierarchy and as a result of the set meeting the predetermined condition, the method further includes aggregating at least a portion of the set of nodes. The method further includes displaying in a graphical user interface a representation of the hierarchy including displaying the aggregated portion as a single entity in the hierarchy.
摘要翻译：显示层次结构。一种方法包括识别表示层次结构中的站点的一组节点。节点集合共享一层或多层不被共享的共同特征。该方法还包括确定作为一组的节点集合满足预定条件。作为节点共享一个或多个不是分层中的任何其他节点共享的共同特征的结果，以及作为满足预定条件的集合的结果，该方法还包括聚集该组节点的至少一部分。该方法还包括在图形用户界面中显示层次结构的表示，包括将聚合部分显示为层次结构中的单个实体。

4. 发明申请

US20120142847A1 AQUEOUS CROSS-LINKING COMPOSITIONS AND METHODS 有权
标题翻译：水质交联组合物和方法
公开(公告)号：US20120142847A1
公开(公告)日：2012-06-07
申请号：US13152856
申请日：2011-06-03
申请人： Yong Yang , Yue Chen , Robert J. Sheerin , Jean Fredrick Mauck , Navin Tilara , Johanna Garcia de Visicaro
发明人： Yong Yang , Yue Chen , Robert J. Sheerin , Jean Fredrick Mauck , Navin Tilara , Johanna Garcia de Visicaro
IPC分类号： C09D167/00 , C08F220/06 , C09J133/08 , C09D11/00
CPC分类号： C09D5/024 , C08G59/4014 , C08L2201/56 , C09D133/02 , C09D133/068 , C09D163/00 , C08K5/30
摘要： Water-borne cross-linking polymeric compositions and related embodiments, such as methods of making and using the compositions, as well as products formed with said compositions are described. For example, the water-borne composition may comprise polymers incorporating cross-linking functionality such as, but not limited to, carbonyl or epoxy functionality, and a blocked cross-linking agent, for example, a hydrazone. The cross-linking functionality does not react with the blocked cross-linking agent; however, the blocked cross-linking agent is capable of reacting with the alternative form cross-linking agent such as, but not limited to, a hydrazide, to yield a cross-linked polymer. The alternative form cross-linking agent may be formed in an equilibrium reaction including the blocked cross-linking agent.
摘要翻译：描述了水性交联聚合物组合物和相关实施方案，例如制备和使用组合物的方法，以及与所述组合物形成的产品。例如，水性组合物可以包含掺入交联官能团的聚合物，例如但不限于羰基或环氧官能团，以及封端的交联剂，例如腙。交联官能团不与阻断的交联剂反应; 然而，封端交联剂能够与替代形式的交联剂反应，例如但不限于酰肼，以产生交联聚合物。交替形成的交联剂可以在包括封端交联剂的平衡反应中形成。

5. 发明授权

US08060620B2 Profile deployment using a generic format 有权
标题翻译：配置文件部署使用通用格式
公开(公告)号：US08060620B2
公开(公告)日：2011-11-15
申请号：US11599126
申请日：2006-11-14
申请人： Yi Lu , Olivier Contant , Wei Zhao , Abhishek Abhishek , Yue Chen , Taroon Mandhana , Hong Liu
发明人： Yi Lu , Olivier Contant , Wei Zhao , Abhishek Abhishek , Yue Chen , Taroon Mandhana , Hong Liu
IPC分类号： G06F15/16
CPC分类号： H04L67/14
摘要： A network enabled computer receives connection profile information in a generic form and creates one or more native mode profiles to establish connections. By accepting profile information in a generic form, profile information can be readily provided from one or more ways, including from a policy server, through a user interface or from a third party application. The profile information can be provided with an order of precedence so that profile information from different sources may be combined appropriately. Additionally, the profile information may be provided in an extensible format to allow profile information to be distributed to multiple computers, even if some have different hardware or software configurations and are not programmed to recognize extensions of the profile information.
摘要翻译：启用网络的计算机以通用形式接收连接配置文件信息，并创建一个或多个本机模式配置文件以建立连接。通过以通用形式接受简档信息，可以从一种或多种方式容易地提供简档信息，包括从策略服务器，用户界面或第三方应用程序。配置文件信息可以提供优先顺序，从而可以适当地组合来自不同来源的配置文件信息。此外，可以以可扩展的格式提供简档信息，以允许简档信息被分发到多个计算机，即使一些具有不同的硬件或软件配置并且不被编程以识别简档信息的扩展。

6. 发明授权

US08023597B2 Methods for selecting a coarse frequency offset estimation for an orthogonal frequency division multiplexing modulated signal 有权
标题翻译：用于选择正交频分复用调制信号的粗频偏估计的方法
公开(公告)号：US08023597B2
公开(公告)日：2011-09-20
申请号：US12103698
申请日：2008-04-15
申请人： Jianxuan Du , Yue Chen , Baoguo Yang
发明人： Jianxuan Du , Yue Chen , Baoguo Yang
IPC分类号： H04L27/06
CPC分类号： H04L27/2657 , H04L25/0212 , H04L27/2695
摘要： The present invention provides methods for selecting the coarse frequency offset estimation in an orthogonal frequency division multiplexing system that may include: searching within a predefined subset for a set of frequency offset candidates; selectively searching outside the predefined subset for additional frequency offset candidates; and combining one or more ICDC method and CIR based method to select the coarse frequency offset.
摘要翻译：本发明提供了用于在正交频分复用系统中选择粗频偏估计的方法，所述正交频分复用系统可包括：在预定义子集内搜索一组频偏候选; 选择性地在预定义子集之外搜索额外的频率偏移候选; 并组合一个或多个ICDC方法和基于CIR的方法来选择粗频偏移。

7. 发明授权

US07903728B2 Equalize training method using re-encoded bits and known training sequences 有权
标题翻译：使用重新编码的比特和已知的训练序列来均衡训练方法
公开(公告)号：US07903728B2
公开(公告)日：2011-03-08
申请号：US12431605
申请日：2009-04-28
申请人： Yue Chen , Arkady Molev-Shteiman , Arie Heiman , Nelson R. Sollenberger , Huaiyu (Hanks) Zeng , Baoguo Yang
发明人： Yue Chen , Arkady Molev-Shteiman , Arie Heiman , Nelson R. Sollenberger , Huaiyu (Hanks) Zeng , Baoguo Yang
IPC分类号： H03H7/30 , H04B1/10
CPC分类号： H04L25/03171 , H04L25/03133
摘要： Equalizer training method using re-encoded bits and known training sequences. A multi-branch equalizer processing module is operable to cancel interference associated with received radio frequency (RF) burst(s) (e.g., using at least a first equalizer processing branch and a second equalizer processing branch). The first equalizer processing branch is operable to be trained based upon known training sequences and to equalize the received RF burst. The second equalizer processing branch uses at least partially re-encoded data bits to train linear equalizer(s) within the second equalizer processing branch. A buffer may initially store the received RF burst(s), which are retrieved and equalized by the second equalizer processing branch once the linear equalizer(s) are trained. The cooperation operation of these and other various components allows interfering signals to be cancelled and for more accurate processing of the received RF bursts to occur.
摘要翻译：均衡器训练方法使用重新编码的位和已知的训练序列。多分支均衡器处理模块可操作以消除与接收的射频（RF）突发相关联的干扰（例如，使用至少第一均衡器处理分支和第二均衡器处理分支）。第一均衡器处理分支可操作以基于已知的训练序列进行训练，并均衡所接收的RF突发。第二均衡器处理分支使用至少部分重新编码的数据位来训练第二均衡器处理分支内的线性均衡器。缓冲器可以初始地存储所接收的RF突发，一旦训练了线性均衡器，其将被第二均衡器处理分支检索和均衡。这些和其他各种组件的协作操作允许消除干扰信号并且为了更准确地处理接收的RF突发而发生。

8. 发明授权

US07601852B2 Macrocyclic kinase inhibitors 有权
标题翻译：大环激酶抑制剂
公开(公告)号：US07601852B2
公开(公告)日：2009-10-13
申请号：US11729327
申请日：2007-03-27
申请人： Hong Fu , Yue Chen , Daniel V. Santi
发明人： Hong Fu , Yue Chen , Daniel V. Santi
IPC分类号： C07D313/00
CPC分类号： C07D321/00 , C12N9/1205
摘要： A compound having a structure according to formula I wherein R1, R2, R3, R4, and R5 are as defined herein, are useful as kinase inhibitors.
摘要翻译：具有根据式I的结构的化合物，其中R 1，R 2，R 3，R 4和R 5如本文所定义，可用作激酶抑制剂。

9. 发明申请

US20090168930A1 Methods and Systems for Doppler Estimation and Adaptive Channel Filtering in a Communication System 审中-公开
标题翻译：通信系统中多普勒估计和自适应信道滤波的方法和系统
公开(公告)号：US20090168930A1
公开(公告)日：2009-07-02
申请号：US12345658
申请日：2008-12-29
申请人： Junqiang Li , Baoguo Yang , Yue Chen
发明人： Junqiang Li , Baoguo Yang , Yue Chen
IPC分类号： H03D1/04
CPC分类号： H04L1/0026
摘要： A method for Doppler shift estimation for channel estimation of a received signal, comprising the steps of: calculating time domain correlations; providing a Hamming window over the calculated time domain correlations; calculating a power spectrum by using FFT; calculating an adaptive threshold based on a noise floor and an average power density calculated from the power spectrum; and estimating a Doppler shift based on the adaptive threshold.
摘要翻译：一种用于接收信号的信道估计的多普勒频移估计的方法，包括以下步骤：计算时域相关; 在计算的时域相关性上提供汉明窗; 使用FFT计算功率谱; 基于从功率谱计算的噪声基底和平均功率密度来计算自适应阈值; 以及基于所述自适应阈值估计多普勒频移。

10. 发明申请

US20090110135A1 Methods for PRS-Based Symbol Timing Adjustment for OFDM Systems 审中-公开
标题翻译： OFDM系统基于PRS的符号定时调整方法
公开(公告)号：US20090110135A1
公开(公告)日：2009-04-30
申请号：US12258362
申请日：2008-10-24
申请人： Jianxuan Du , Yue Chen , Baoguo Yang
发明人： Jianxuan Du , Yue Chen , Baoguo Yang
IPC分类号： H04L7/00
CPC分类号： H04L27/2675 , H04L27/2665 , H04L27/2695
摘要： This invention relates to methods for determining symbol timing shift for a received signal, comprising the steps of: demodulating a received signal; removing a phase reference sequence from the demodulated signal to generate a channel frequency response; converting said channel frequency response to the time domain to generate a channel impulse response; determining a detection threshold; determining a first path and a last path as a function of the detection threshold; and calculating a timing shift as a function of the first path and the last path.
摘要翻译：本发明涉及用于确定接收信号的符号定时偏移的方法，包括以下步骤：解调所接收的信号; 从解调信号中去除相位参考序列以产生信道频率响应; 将所述信道频率响应转换成时域以产生信道脉冲响应; 确定检测阈值; 确定作为所述检测阈值的函数的第一路径和最后路径; 以及计算作为所述第一路径和所述最后路径的函数的定时偏移。

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