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1. 发明申请

WO2017179053A1 COMBINATIONAL THERAPIES FOR TREATMENT OF CANCER COMPRISING A BACTERIOCHLOROPHYLL DERIVATIVE 审中-公开
标题翻译：用于治疗包含细菌叶绿素衍生物的癌症的组合治疗
公开(公告)号：WO2017179053A1
公开(公告)日：2017-10-19
申请号：PCT/IL2017/050440
申请日：2017-04-10
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MEMORIAL SLOAN-KETTERING CANCER CENTER
发明人： SCHERZ, Avigdor , SALOMON, Yoram , AGEMY, LiIach , HAMRI, Rachel , PREISE, Dina , KIM, Kwanghee , COLEMAN, Jonathan
IPC分类号： A61K45/06 , A61K31/409 , A61K31/675 , A61K31/7068 , A61K31/7135 , A61P35/00
摘要： An anti-myeloid-derived suppressor cells agent ("anti-MDSCs agent") and a bacteriochlorophyll derivative (hereinafter "Bchl-D) for use in combination therapy for cancer, wherein the anti-MDSC agent and the Bchl-D are administered sequentially and the administration of the Bchl-D is followed by photodynamic therapy (PDT) or vascular targeted PDT (VTP).
摘要翻译：用于癌症联合疗法的抗骨髓衍生的抑制细胞剂（“抗MDSCs剂”）和细菌叶绿素衍生物（下文称为“Bch1-D”）， MDSC试剂和Bchl-D依次施用，并且Bchl-D的施用之后是光动力疗法（PDT）或血管靶向PDT（VTP）。

3. 发明申请

WO2009095912A1 ENDOSCOPIC IMAGING PHOTODYNAMIC THERAPY SYSTEM AND METHODS OF USE 审中-公开
标题翻译：内窥镜成像光化疗治疗系统及其使用方法
公开(公告)号：WO2009095912A1
公开(公告)日：2009-08-06
申请号：PCT/IL2009/000108
申请日：2009-01-28
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , GEVA, Eli , SALOMON, Yoram , SCHERZ, Avigdor , GLINERT, Itai
发明人： GEVA, Eli , SALOMON, Yoram , SCHERZ, Avigdor , GLINERT, Itai
IPC分类号： A61N5/06 , A61B18/22 , A61B18/20
CPC分类号： A61B18/22 , A61B10/0233 , A61B90/37 , A61B2018/2266 , A61B2090/3782 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N2005/0611 , A61N2005/063 , A61N2005/0651 , A61N2005/067
摘要： The invention provides an endoscopic imaging photodynamic therapy system (EIPS) for focused tissue ablation by illumination of a photosensitizer drug in a target tissue, said system comprising an endoscopic assembly, a real-time imaging component for locating the target tissue and monitoring the ablation intervention, a therapeutic light system and, optionally, a drug delivery module, wherein said imaging component comprises a flexible transducer with an operative channel for insertion of a flexible light guide of the therapeutic light system and, optionally, a flexible drug delivery catheter of the drug delivery module. This EIPS may be used in various medical applications where tissue ablation is required and photodynamic therapy may be applied, in particular, in the treatment of extrauterine pregnancy (EUP).
摘要翻译：本发明提供一种内窥镜成像光动力治疗系统（EIPS），用于通过照射目标组织中的光敏药物来聚焦组织消融，所述系统包括内窥镜组件，用于定位靶组织的实时成像组件和监测消融干预，治疗光系统和任选的药物递送模块，其中所述成像部件包括具有用于插入治疗光系统的柔性光导的可操作通道的柔性换能器，以及可选地，药物的柔性药物输送导管交货模块该EIPS可以用于需要组织消融的各种医疗应用，并且可以应用光动力学治疗，特别是在宫外孕（EUP）的治疗中。

4. 发明申请

WO2008023378A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO)CHLOROPHYLL PHOTOSYNTHESIZERS AND THEIR USES 审中-公开
标题翻译： RGD肽和卟啉或（细菌）叶绿素光合作用的偶联物及其用途
公开(公告)号：WO2008023378A1
公开(公告)日：2008-02-28
申请号：PCT/IL2007/001055
申请日：2007-08-23
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , SCHERZ, Avigdor , SALOMON, Yoram , RUBINSTEIN, Efrat , BRANDIS, Alexander , EREN, Doron , NEIMANN, Karin
发明人： SCHERZ, Avigdor , SALOMON, Yoram , RUBINSTEIN, Efrat , BRANDIS, Alexander , EREN, Doron , NEIMANN, Karin
IPC分类号： A61K41/00 , A61K47/48 , C07K5/103 , C07K7/06 , C07K7/08
CPC分类号： C07K5/123 , A61K41/0071 , A61K47/64 , C07K5/0817 , C07K5/10 , C07K5/126 , C07K7/06 , C07K7/64
摘要： Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.
摘要翻译：提供了卟啉，叶绿素和细菌叶绿素光敏剂与含有RGD的肽或RGD拟肽的缀合物，其可用于光动力治疗（PDT），特别是血管靶向的PDT（VTP），肿瘤和非肿瘤血管疾病如年龄相关性黄斑变性，以及通过不同技术诊断肿瘤。

5. 发明申请

WO2003094695A2 SENSITIZED ONLINE BOLD-MRI IMAGING METHOD 审中-公开
标题翻译： SENSITIZED ONLINE BOLD-MRI成像方法
公开(公告)号：WO2003094695A2
公开(公告)日：2003-11-20
申请号：PCT/IL2003/000371
申请日：2003-05-08
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , SALOMON, Yoram , NEEMAN, Michal , SCHERZ, Avigdor , GROSS, Shimon , GILEAD, Assaf
发明人： SALOMON, Yoram , NEEMAN, Michal , SCHERZ, Avigdor , GROSS, Shimon , GILEAD, Assaf
IPC分类号： A61B
CPC分类号： A61B5/055 , A61B5/4839 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61N5/062 , G01R33/4806
摘要： An online Blood Oxygenation Level-Dependent (BOLD)-magnetic resonance imaging (MRI) method for functional clinical guidance or monitoring a therapeutic modality involving treatment by a sensitizer which, upon excitation by the appropriate sensitizing radiation, initiates local oxygen consumption, comprising: (i) generating a BOLD-weighted MR-image of the target region of interest within the patient's body (time t0); (ii) administering said sensitizer to the patient; (iii) irradiating the target region while the patient is subjected to continuous MR imaging; (iv) generating a sole or a plurality of T2* weighted sequential BOLD MR-images during and/or after irradiation (time t); (v) processing the data generated at time t0 and time t and generating a color-coded difference or ratio map on a pixel by pixel basis; and (vi) analyzing the processed data. The method is preferably applied to photodynamic therapy (PDT).
摘要翻译：一种用于功能性临床指导或监测涉及由敏化剂治疗的治疗方式的在线血液氧合依赖性（BOLD） - 磁共振成像（MRI）方法，其在通过适当的敏化辐射激发时引发局部耗氧，包括： i）产生患者体内目标区域的BOLD加权MR图像（时间t0）; （ii）将所述致敏剂施用于患者; （iii）在患者进行连续MR成像的同时照射目标区域; （iv）在照射期间和/或之后产生唯一或多个T2 *加权顺序BOLD MR图像（时间t）; （v）处理在时间t0和时间t产生的数据，并逐个像素地产生颜色编码的差分或比例图; 和（vi）分析处理后的数据。该方法优选应用于光动力疗法（PDT）。

6. 发明申请

WO2001040232A1 CHLOROPHYLL AND BACTERIOCHLOROPHYLL ESTERS, AND THEIR PREPARATION 审中-公开
标题翻译：氯丙醇和细菌胆碱酯，其制备和包含它们的药物组合物
公开(公告)号：WO2001040232A1
公开(公告)日：2001-06-07
申请号：PCT/IL2000/000811
申请日：2000-12-01
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , SCHEER, Hugo , KAMMHUBER, Nina , SCHERZ, Avigdor , BRANDIS, Alexander , SALOMON, Yoram
发明人： SCHEER, Hugo , KAMMHUBER, Nina , SCHERZ, Avigdor , BRANDIS, Alexander , SALOMON, Yoram
IPC分类号： C07D487/22
CPC分类号： C07D487/22 , A61K41/0019 , A61K41/0071 , C07H13/04 , C07H13/10
摘要： Novel C-13 2 -COXR 1 , C-17 2 -COXR 2 and C-13 2 -COXR 1 , C-17 2 -COXR 1 derivatives of chlorophyll and bacteriochlorophyll compounds are provided wherein X is O, S or N and R 1 and R 2 , the same or different, may be an optionally substituted hydrocarbyl , amino acid, peptide, protein or saccharide radical. The compounds are for use in photodynamic therapy (PDT), for diagnosis of tumors, and for killing cells and infectious agents such as bacteria and virus, both in biological products and in living tissues.
摘要翻译：提供新的C-13 2 -COXR1，C-17 2 -COXR2和C-13 2 -COXR1，叶绿素和细菌叶绿素化合物的C-17 2 -COXR1衍生物，其中X是O，S 或N和R 1和R 2相同或不同，可以是任选取代的烃基，氨基酸，肽，蛋白质或糖基。该化合物用于光动力治疗（PDT），用于诊断肿瘤，以及用于杀死生物制品和活组织中的细胞和感染因子如细菌和病毒。

7. 发明申请

WO2009107139A1 RGD-(BACTERIO)CHLOROPHYLL CONJUGATES FOR PHOTODYNAMIC THERAPY AND IMAGING OF NECROTIC TUMORS 审中-公开
标题翻译： RGD-（BACTERIO）氯吡格雷配合物用于光动力治疗和成像肿瘤
公开(公告)号：WO2009107139A1
公开(公告)日：2009-09-03
申请号：PCT/IL2009/000228
申请日：2009-03-01
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , SCHERZ, Avigdor , GOLDSHAID, Liat , SALOMON, Yoram
发明人： SCHERZ, Avigdor , GOLDSHAID, Liat , SALOMON, Yoram
IPC分类号： A61K41/00 , A61P35/00 , A61K49/00 , A61K49/08 , A61K49/14 , A61K51/08 , A61K51/04
CPC分类号： A61K51/0485 , A61K41/0057 , A61K41/0071 , A61K49/0036 , A61K49/0056 , A61K49/085 , A61K49/14 , A61K51/044 , A61K51/0446 , A61K51/0451 , A61K51/082 , A61K51/088 , C07D257/04
摘要： RGD-chlorophyll and RGD-bacteriochlorophyll conjugates that home and accumulate in necrotic tumor domains much longer than in tumor non-necrotic domains are provided for use in minimally invasive tumor-targeted imaging, tumor-targeted photodynamic therapy, and/or on-line prognosis of necrotic tumors.
摘要翻译：家庭和积累在坏死肿瘤域中的RGD-叶绿素和RGD-细菌叶绿素缀合物比在肿瘤非坏死区域中长得多的时间被提供用于微创肿瘤靶向成像，肿瘤靶向光动力学治疗和/或在线预后的坏死性肿瘤。

8. 发明申请

WO2004011821A2 METHOD USING A SYNTHETIC MOLECULAR SPRING DEVICE IN A SYSTEM FOR DYNAMICALLY CONTROLLING A SYSTEM PROPERTY AND A CORRESPONDING SYSTEM THEREOF 审中-公开
标题翻译：使用合成分子弹簧装置在系统中动态控制系统属性的方法及其相关系统
公开(公告)号：WO2004011821A2
公开(公告)日：2004-02-05
申请号：PCT/IL2003/000612
申请日：2003-07-24
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , SCHERZ, Avigdor , YERUSHALMI, Roie
发明人： SCHERZ, Avigdor , YERUSHALMI, Roie
IPC分类号： F16F
CPC分类号： F16F1/00 , F16F3/00 , G02F2001/01791
摘要： Using a synthetic molecular spring device in a system for dynamically controlling a system property, such as momentum, topography, and electronic behavior. System features (a) the synthetic molecular spring device having (i) at least one synthetic molecular assembly each featuring at least one chemical unit including at least one: (1) atom; (2) complexing group complexed to at least one atom; (3) axial ligand reversibly physicochemically paired with at least one complexed atom; and (4) substantially elastic molecular linker; and, (ii) an activating mechanism directed to at least one atom-axial ligand pair; and, (b) a selected unit operatively coupled to synthetic molecular assembly, and exhibiting the system property. Activating mechanism sends an activating signal to atom-axial ligand pairs, for physicochemically modifying atom-axial ligand pairs, thereby activating at least one cycle of spring-type elastic reversible transitions between contracted and expanded linear conformational states of substantially elastic molecular linkers, causing dynamically controllable change in the system property.
摘要翻译：在系统中使用合成分子弹簧装置来动态地控制系统属性，例如动量，地形和电子行为。系统特征（a）合成分子弹簧装置，其具有（i）至少一个合成分子组合，每个合成分子组合具有包含至少一个：（1）原子的至少一个化学单元; （2）与至少一个原子络合的络合基团; （3）轴向配体与至少一个复合原子可逆地物理化学配对; 和（4）基本上弹性的分子接头; 和（ii）针对至少一个原子 - 轴配体对的激活机制; 和（b）选择的单元，其可操作地耦合到合成分子组件，并显示出系统性质。激活机制将激活信号发送到原子 - 轴配体对，用于物理化学修饰原子 - 轴配体对，由此激活基本上弹性的分子接头的收缩和扩展的线性构象状态之间的弹簧型弹性可逆转换的至少一个循环，系统性能的可控变化。

9. 发明申请

WO2008010228A2 PHOTOSYNTHETICORGANISMS AND COMPOSITIONS AND METHODS OF GENERATING SAME 审中-公开
标题翻译：光合作用及其组合物及其生成方法
公开(公告)号：WO2008010228A2
公开(公告)日：2008-01-24
申请号：PCT/IL2007/000920
申请日：2007-07-22
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , SCHERZ, Avigdor , SHLYK-KERNER, Oksana , SAMISH, Ilan , KAFTAN, David , DINAMARCA, Jorge
发明人： SCHERZ, Avigdor , SHLYK-KERNER, Oksana , SAMISH, Ilan , KAFTAN, David , DINAMARCA, Jorge
IPC分类号： A01H5/00
CPC分类号： C07K14/405 , C07K14/195
摘要： An isolated polynucleotide is provided. The isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide of a Type II reaction center of a photosynthetic organism, the nucleic acid sequence being capable of imparting the type II reaction center with an activity under a temperature range different than that of the type II reaction center endogenous to the photosynthetic organism. Also provided are methods of using the sequences for generating photosynthetic organisms or tailor-made thermotolerance.
摘要翻译：提供了分离的多核苷酸。分离的多核苷酸包含编码光合生物的II型反应中心的多肽的核酸序列，所述核酸序列能够使II型反应中心在不同于II型反应的温度范围内具有活性对光合生物体内生的中心。还提供了使用序列产生光合生物或定制耐热性的方法。

10. 发明申请

WO2005120573A2 CATIONIC BACTERIOCHLOROPHYLL DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：阳离子型溴代乙烯衍生物及其用途
公开(公告)号：WO2005120573A2
公开(公告)日：2005-12-22
申请号：PCT/IL2005/000602
申请日：2005-06-07
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , SCHERZ, Avigdor , BRANDIS, Alexander , SALOMON, Yoram , EREN, Doron , COHEN, Avraham
发明人： SCHERZ, Avigdor , BRANDIS, Alexander , SALOMON, Yoram , EREN, Doron , COHEN, Avraham
IPC分类号： A61K41/00
CPC分类号： A61K31/409 , A61K41/0071 , Y02A50/406
摘要： The invention provides cationic tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one positively charged group and/or at least one basic group that is converted to a positively charged group under physiological conditions, preferably Bchls having an onium group derived from a N-containing aliphatic or heterocyclic radical such as ammonium, guanidinium, imidazolium, pyridinium, and the like or a phosphonium, arsonium, oxonium, sulfonium, selenonium, telluronium, stibonium, or bismuthonium group, or a basic group that is converted to such onium groups under physiological conditions, said groups being bound to one or more of the positions 17 3 , 13 3 and 3 2 of the Bchl molecule by ester or amide bond. The Bchls are useful for photodynamic therapy and diagnosis.
摘要翻译：本发明提供了含有至少一个带正电基团和/或至少一个碱性基团的阳离子四环和五环类细菌叶绿素衍生物（Bchls），其在生理条件下转化为带正电荷的基团，优选具有衍生自N- 含有脂族或杂环基团如铵，胍，咪唑鎓，吡啶鎓等，或鏻，ium，氧鎓，锍，硒鎓，碲鎓，锑或铋鎓基团，或转化为这种鎓基团的碱性基团生理条件，所述基团通过酯或酰胺键与Bchl分子的一个或多个位置17 3，13 3和3 2结合。 Bchls可用于光动力疗法和诊断。

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