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1. 发明申请

WO2007007327A3 IL-32 MODULATORS 审中-公开
标题翻译： IL-32调制器
公开(公告)号：WO2007007327A3
公开(公告)日：2007-06-21
申请号：PCT/IL2006000798
申请日：2006-07-10
申请人： YEDA RES & DEV , UNIV COLORADO , NOVICK DANIELA , RUBINSTEIN MENACHEM , DINARELLO CHARLES A , KIM SOO-HYUN
发明人： NOVICK DANIELA , RUBINSTEIN MENACHEM , DINARELLO CHARLES A , KIM SOO-HYUN
IPC分类号： G01N33/68 , A61K31/00 , A61K38/00 , C07K14/00
CPC分类号： C07K14/54 , G01N33/6869
摘要： The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein capable of deavege thereof. Inhibition of PR 3 activity to process IL-32 or neutralization of IL-32 by- inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases (e.g. inflammatory diseases).
摘要翻译：本发明涉及筛选白细胞介素32（IL-32）调节剂，IL-32调节剂及其用途的方法。蛋白酶3已经被鉴定为能够拯救它的IL-32结合蛋白。抑制PR 3活性来处理IL-32或中和IL-32非活性PR3或其片段可能会降低IL-32在免疫调节疾病（如炎性疾病）中的后果。

2. 发明专利

CA2614680C IL-32 MODULATORS 未知
公开(公告)号：CA2614680C
公开(公告)日：2015-07-07
申请号：CA2614680
申请日：2006-07-10
申请人： YEDA RES & DEV , UNIV COLORADO
发明人： NOVICK DANIELA , RUBINSTEIN MENACHEM , DINARELLO CHARLES A , KIM SOO-HYUN
IPC分类号： C12N9/64 , A61K38/20 , A61K38/48 , C07K14/54 , C12P21/06 , C12Q1/02 , C12Q1/37 , G01N33/573
摘要： The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein capable of deavege thereof. Inhibition of PR 3 activity to process IL-32 or neutralization of IL-32 by-inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases (e.g. inflammatory diseases).

3. 发明专利

CA2614680A1 IL-32 MODULATORS 未知
公开(公告)号：CA2614680A1
公开(公告)日：2007-01-18
申请号：CA2614680
申请日：2006-07-10
申请人： UNIV COLORADO , YEDA RES & DEV
发明人： DINARELLO CHARLES A , KIM SOO-HYUN , RUBINSTEIN MENACHEM , NOVICK DANIELA
IPC分类号： G01N33/68 , A61K31/00 , A61K38/00 , C07K14/00
摘要： The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein capable of deavege thereof. Inhibition of PR 3 activity to process IL-32 or neutralization of IL-32 by- inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases (e.g. inflammatory diseases).

4. 发明专利

AU2006267851B2 IL-32 modulators 未知
公开(公告)号：AU2006267851B2
公开(公告)日：2012-08-30
申请号：AU2006267851
申请日：2006-07-10
申请人： UNIV COLORADO REGENTS , YEDA RES & DEV
发明人： DINARELLO CHARLES A , NOVICK DANIELA , RUBINSTEIN MENACHEM , KIM SOO-HYUN
IPC分类号： G01N33/68 , A61K31/00 , A61K38/00 , C07K14/00
摘要： The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein capable of deavege thereof. Inhibition of PR 3 activity to process IL-32 or neutralization of IL-32 by- inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases (e.g. inflammatory diseases).

5. 发明专利

ES2353479T3 MODULADORES DE IL-32. 未知
公开(公告)号：ES2353479T3
公开(公告)日：2011-03-02
申请号：ES06766125
申请日：2006-07-10
申请人： YEDA RES & DEV , UNIV COLORADO
发明人： NOVICK DANIELA , RUBINSTEIN MENACHEM , DINARELLO CHARLES , KIM SOO-HYUN
IPC分类号： G01N33/68 , A61K31/00 , A61K38/00 , C07K14/00
摘要： Un procedimiento de cribado de un modulador de la actividad de interleucina 32 (IL-32) basado en la unión de IL-32 a la proteinasa 3 (PR-3), que comprende determinar la unión de IL-32 a PR-3 en presencia de un modulador candidato, comparar el nivel de dicha unión con el nivel de unión de IL-32 a PR-3 en ausencia de dicho modulador candidato, y seleccionar un modulador capaz de inhibir o potenciar dicha unión, en el que la actividad de IL-32 es al menos una seleccionada de la inducción de MIP-2, la inducción de TNF, y la inducción de IL-8.

6. 发明专利

AU2006267851A1 IL-32 modulators 未知
公开(公告)号：AU2006267851A1
公开(公告)日：2007-01-18
申请号：AU2006267851
申请日：2006-07-10
申请人： YEDA RES & DEV , UNIV COLORADO
发明人： NOVICK DANIELA , RUBINSTEIN MENACHEM , KIM SOO-HYUN , DINARELLO CHARLES A
IPC分类号： G01N33/68 , A61K31/00 , A61K38/00 , C07K14/00

8. 发明专利

DE602006018473D1 IL-32-MODULATOREN 未知
公开(公告)号：DE602006018473D1
公开(公告)日：2011-01-05
申请号：DE602006018473
申请日：2006-07-10
申请人： UNIV COLORADO , YEDA RES & DEV
发明人： NOVICK DANIELA , RUBINSTEIN MENACHEM , DINARELLO CHARLES A , KIM SOO-HYUN
IPC分类号： G01N33/68 , A61K31/00 , A61K38/00 , C07K14/00

9. 发明专利

JP2006136341A Soluble ldl receptor 有权
标题翻译：可溶低密度脂蛋白受体
公开(公告)号：JP2006136341A
公开(公告)日：2006-06-01
申请号：JP2006033546
申请日：2006-02-10
申请人： Yeda Res & Dev Co Ltd , イエダリサーチアンドデベロツプメントカンパニーリミテツド
发明人： RUBINSTEIN MENACHEM , NOVICK DANIELA , TAL NATHAN
IPC分类号： A61K38/00 , C12N15/09 , A61K38/21 , A61P31/12 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/555 , C07K14/705 , C07K14/715 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12R1/91
CPC分类号： C07K14/555 , A61K38/00 , C07K14/705
摘要： PROBLEM TO BE SOLVED: To provide a soluble LDL receptor which is isolated from interferon-treated cells or by a recombinant DNA method and which is capable of protecting mammalian cells from viral infection, another soluble low density lipoprotein (LDL) receptor, production methods therefor and to obtain pharmaceutical compositions comprising the same. SOLUTION: This soluble LDL receptor is produced by treating a human WISH cell with interferon and purifying it through a variety of chromatographic methods (including an affinity chromatography using an monoclonal antibody C7). A soluble LDL receptor comprising a DNA molecule encoding a soluble LDL receptor having an amino acid sequence practically corresponding to amino acid residue 4 to 292 of a mature LDL receptor is produced by culturing a cell line transformed by an expression vector. The soluble LDL receptor, muteins thereof, fused proteins, salts thereof, functional derivatives and active fractions thereof are used as active components of pharmaceutical compositions for protecting mammals from viral infection. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了提供从干扰素处理的细胞中分离的可溶性LDL受体，或通过重组DNA方法，其能够保护哺乳动物细胞免受病毒感染，另一种可溶性低密度脂蛋白（LDL）受体，制备方法，得到含有该组合物的药物组合物。解决方案：通过用干扰素处理人WISH细胞并通过各种色谱方法（包括使用单克隆抗体C7的亲和层析）纯化该可溶性LDL受体来产生。通过培养由表达载体转化的细胞系，产生包含编码具有实际上对应于成熟LDL受体的氨基酸残基4至292的氨基酸序列的可溶性LDL受体的DNA分子的可溶性LDL受体。可溶性LDL受体，其突变蛋白，融合蛋白，其盐，功能衍生物及其活性成分用作用于保护哺乳动物免受病毒感染的药物组合物的活性成分。版权所有（C）2006，JPO＆NCIPI

10. 发明专利

JPH07298886A INTERFERON ALPHA. / BETA BOND PROTEIN AND ITS PRODUCTION 失效
公开(公告)号：JPH07298886A
公开(公告)日：1995-11-14
申请号：JP4353995
申请日：1995-02-07
申请人： YEDA RES & DEV
发明人： COHEN BATYA , NOVICK DANIELA , RUBINSTEIN MENACHEM
IPC分类号： G01N33/53 , A61K38/00 , A61K38/17 , A61K38/21 , A61K39/395 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/52 , C07K14/555 , C07K14/715 , C07K16/00 , C07K16/24 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12N15/63 , C12P21/00 , C12P21/02 , C12R1/91 , G01N33/577
摘要： Interferon alpha / beta binding proteins are provided, which are capable of modulating the activity of interferon- alpha subtypes as well as interferon- beta . Cloning of DNA molecules encoding these proteins, expression in host cells and antibodies against the proteins are also provided.

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