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1. 发明专利

IL158866A USE OF IL-18 INHIBITORS IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF SEPSIS 未知
公开(公告)号：IL158866A
公开(公告)日：2011-01-31
申请号：IL15886603
申请日：2003-11-13
申请人： YEDA RES & DEV , RUBINSTEIN MENACHEM , NOVICK DANIELA , DINARELLO CHARLES , KIM SOO-HYUN , REZNIKOV LEONID , SCWARTSBURD BORIS , FANTUZZI GIAMILA
发明人： RUBINSTEIN MENACHEM , NOVICK DANIELA , DINARELLO CHARLES , KIM SOO-HYUN , REZNIKOV LEONID , SCWARTSBURD BORIS , FANTUZZI GIAMILA
IPC分类号： A61K45/00 , A61K31/7088 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/55 , A61K39/395 , A61K47/48 , A61K48/00 , A61P7/00 , A61P9/04 , A61P29/00 , A61P31/04 , A61P43/00 , C07K16/24 , C07K16/28
摘要： The present invention provides a method of treatment and/or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrone (SIRS), including severe sepsis, septic shock and sepsis related to cardiac dysfunction.

2. 发明专利

SG193135A1 GROWING PLANT TYPE KEYWORD SYSTEM 未知
公开(公告)号：SG193135A1
公开(公告)日：2013-09-30
申请号：SG2013022744
申请日：2013-03-27
申请人： KIM SOO-HYUN , NEOUX CO LTD
发明人： KIM SOO-HYUN , KIM TAE-HWAN
摘要： GROWING PLANT TYPE KEYWORD SYSTEMThe present invention relates to a growing plant typekeyword system.An input search word is inputted to the search window of a client including an Internet function, e.g. a mobile or a smart phone. Search word cookies stored in cookiefiles, and keywords used by an user for web surfing in web pages are aggregated into interested keywords, the aggregated interested keywords are displayed in the wallpaper of the client in the form of an image having a plant shape (hereinafter called a 'plant image'), such as atree. The plant image and the keyword grow in real time over time so that a user can promptly check his interests. The keyword system includes an input search word determination unit; a cookie information generation unit; a web page keyword analysis unit; an interested keyworddetermination unit; an interested keyword display unit; an interested keyword selection recognition unit; and a search result display unit.Fig. 2

4. 发明专利

IL151388A USE OF IL-18 INHIBITORS 未知
公开(公告)号：IL151388A
公开(公告)日：2009-09-01
申请号：IL15138802
申请日：2002-08-21
申请人： RUBINSTEIN MENACHEM , NOVICK DANIELA , CHVATCHKO YOLANDE , DINARELLO CHARLES , PLATER-ZYBERK CHRISTINE , VAN-DEVENTER SANTER , KIM SOO-HYUN , SERONO LAB , YEDA RES & DEV , APPLIED RESEARCH SYSTEMS
发明人： RUBINSTEIN MENACHEM , NOVICK DANIELA , CHVATCHKO YOLANDE , DINARELLO CHARLES , PLATER-ZYBERK CHRISTINE , VAN-DEVENTER SANTER , KIM SOO-HYUN
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/17 , A61K38/21 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/16 , A61P19/02 , A61P19/08 , A61P25/32 , A61P29/00 , A61P31/12 , A61P37/00 , A61P37/02 , A61P43/00 , C07K16/24 , C12N15/63
摘要： The invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for treatment and/or prevention of liver injury. The invention further relates to the use of IL-18 inhibitors in the preparation of a medicament for treatment and/or prevention of arthritis, in particular rheumatoid arthritis. In addition to this, the invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for treatment and/or prevention of inflammatory bowel diseases, in particular of Crohn's disease and ulcerative colitis.

5. 发明专利

IL167769A Use of il-1f7b which binds il-18r together with il-18bp in the manufacture of medicaments 未知
公开(公告)号：IL167769A
公开(公告)日：2013-10-31
申请号：IL16776905
申请日：2005-03-31
申请人： ARES TRADING SA , DINARELLO CHARLES , KIM SOO-HYUN , BUFLER PHILIP
发明人： DINARELLO CHARLES , KIM SOO-HYUN , BUFLER PHILIP
IPC分类号： A61K20060101 , A61K38/17 , A61K38/19 , A61K38/20 , C07K20060101
摘要： The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof capable of binding to IL-18BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.

6. 发明专利

IL157800A IL-18 MUTANTS, THEIR PRODUCTION AND USE 未知
公开(公告)号：IL157800A
公开(公告)日：2009-08-03
申请号：IL15780003
申请日：2003-09-08
申请人： ARES TRADING SA , DINARELLO CHARLES , KIM SOO-HYUN
发明人： DINARELLO CHARLES , KIM SOO-HYUN
IPC分类号： C12N15/09 , A61K38/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07K14/54 , C12N15/24
摘要： The invention provides mutants of IL-18 with lower affinity to IL-18BP than the wild type IL-18 molecule.

7. 发明申请

WO2011021746A1 MULTI-CORE SYSTEM AND METHOD FOR TASK ALLOCATION IN THE SYSTEM 审中-公开
标题翻译：系统中任务分配的多核系统和方法
公开(公告)号：WO2011021746A1
公开(公告)日：2011-02-24
申请号：PCT/KR2009/006615
申请日：2009-11-11
申请人： IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) , SHIN, Hyun-Chul , KIM, Jong-Dae , KIM, Soo-Hyun
发明人： SHIN, Hyun-Chul , KIM, Jong-Dae , KIM, Soo-Hyun
IPC分类号： G06F9/46 , G06F9/50 , G06F9/38
CPC分类号： G06F9/4881 , G06F2209/483
摘要： A multi-core system and a method for allocating tasks in the multi-core system are provided. The method includes initial mapping a plurality of tasks to a plurality of processors; primary scheduling the initial mapped tasks so that a processing completion time of each of the tasks is maximized in the initial mapped processors, while a maximum of processing completion times of the initial mapped tasks is kept unchanged; grouping the primary scheduled tasks into r groups, G1 to Gr (r is a natural number satisfying r=2), and secondary mapping and scheduling tasks of each group to the plurality of processors so that when the secondary mapping and scheduling of the groups from G1 to Gr is completed, a slack resulting from the secondary mapping and scheduling is maximized; and allocating the plurality of tasks to the plurality of processors according to a result of the secondary mapping and scheduling.
摘要翻译：提供了一种用于在多核系统中分配任务的多核系统和方法。该方法包括将多个任务初始映射到多个处理器; 主调度初始映射任务，使得每个任务的处理完成时间在初始映射处理器中最大化，而初始映射任务的处理完成时间的最大值保持不变; 将主要调度任务分组为r组，G1到Gr（r是满足r = 2的自然数），以及每个组对多个处理器的辅助映射和调度任务，使得当组的二次映射和调度 G1至Gr完成，二次映射和调度产生的松弛最大化; 以及根据所述辅助映射和调度的结果将所述多个任务分配给所述多个处理器。

8. 发明申请

WO2008147005A1 COMPOSITIONS COMPRISING AN EXTRACT OF TIARELLA POLYPHYLLA OR COMPOUNDS ISOLATED THEREFROM FOR PREVENTING AND TREATING CANCER DISEASES 审中-公开
标题翻译：包含TIARELLA POLYPHYLLA或其化合物提取物的组合物，用于预防和治疗癌症疾病
公开(公告)号：WO2008147005A1
公开(公告)日：2008-12-04
申请号：PCT/KR2007/006169
申请日：2007-11-30
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Hyeong-Kyu , OH, Sei-Ryang , AHN, Kyungseop , LEE, Joongku , LEE, Sangku , LEE, Ho-Jae , KIM, Doo-Young , KIM, Jung-Hee , KIM, Eun-Ah , CHOI, Soon-Ja , KIM, Soo Hyun , LEE, Jung Weon , CHOI, Su-Yong
发明人： LEE, Hyeong-Kyu , OH, Sei-Ryang , AHN, Kyungseop , LEE, Joongku , LEE, Sangku , LEE, Ho-Jae , KIM, Doo-Young , KIM, Jung-Hee , KIM, Eun-Ah , CHOI, Soon-Ja , KIM, Soo Hyun , LEE, Jung Weon , CHOI, Su-Yong
IPC分类号： A61K36/185 , A23L1/29 , A61P35/00
CPC分类号： A61K36/185 , A23L33/105
摘要： The present invention relates to an anoikis-inducing agent comprising a Tiarella polyphylla extract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. The Tiarella polyphylla extract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen Lβ or a homolog thereof.
摘要翻译：本发明涉及一种脱氧诱导剂，其包含与其分离的天竺葵多酚提取物，从其分离的噻托溴酸化合物或其药学上可接受的盐，其对表达肿瘤相关抗原L6的癌细胞或其同源物是特异性的。本发明的天竺葵多酚提取物，从其分离的噻托溴酸化合物或其药学上可接受的盐导致细胞粘附丧失，以减少癌细胞增殖，并表现出在表达肿瘤相关抗原L6的癌细胞中诱导细胞死亡的作用其同系物，因此用于预防和治疗由于肿瘤相关抗原Lβ或其同源物引起的癌症疾病。

9. 发明申请

WO2008023871A3 PROCESS FOR CO-PRODUCTION OF ISOPROPANOL AND NORMAL PARAFFINS HAVING HIGH PURITY 审中-公开
标题翻译：共同生产高纯度的异丙醇和正构烷烃的方法
公开(公告)号：WO2008023871A3
公开(公告)日：2008-08-21
申请号：PCT/KR2007000626
申请日：2007-02-06
申请人： ISU CHEMICAL CO LTD , OH IN-CHUL , KIM CHANG-GOOK , RHIE DAE-YONG , KIM LEE-HO , KIM JUN-SOO , KIM SOO-HYUN , HWANG CHAN-KOO
发明人： OH IN-CHUL , KIM CHANG-GOOK , RHIE DAE-YONG , KIM LEE-HO , KIM JUN-SOO , KIM SOO-HYUN , HWANG CHAN-KOO
IPC分类号： C07C29/145 , C07C7/163 , C07C31/10
CPC分类号： C07C7/163 , C07C29/145 , C07C31/10
摘要： The present invention relates to a process for co-producing isopropanol and normal paraffins of high purity, and, more particularly, to a process including the stage of conducting liquid-phase hydrogenation of a mixture comprising hydrogen, acetone, and normal paraffins containing aromatic compounds as impurities, in the presence of a hydrogenation catalyst.
摘要翻译：本发明涉及共同生产高纯度异丙醇和正链烷烃的方法，并且更具体地涉及包括对包含氢气，丙酮和含有芳族化合物的正链烷烃的混合物进行液相氢化的阶段的方法作为杂质，在氢化催化剂存在下进行。

10. 发明申请

WO2002092008A3 USE OF IL-18 INHIBITORS FOR THE TREATEMENT OR PREVENTION OF SEPSIS 审中-公开
公开(公告)号：WO2002092008A3
公开(公告)日：2002-11-21
申请号：PCT/US2002/015556
申请日：2002-05-16
申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD. , DINARELLO, Charles, A. , FANTUZZI, Giamila , KIM, Soo-Hyun , REZNIKOV, Leonid , RUBINSTEIN, Menachem , NOVICK, Daniela , SCHWARTSBURD, Boris
发明人： DINARELLO, Charles, A. , FANTUZZI, Giamila , KIM, Soo-Hyun , REZNIKOV, Leonid , RUBINSTEIN, Menachem , NOVICK, Daniela , SCHWARTSBURD, Boris
IPC分类号： A61K38/00
摘要： The present invention relates to the use of an inhibitor of IL.18 in the manufacture of a medicament for the treatment and/or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS) selected from severe sepsis and septic shock, and also for sepsis related cardiac dysfunction.

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