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1. 发明申请

US20150266926A1 SMALL MOLECULE POLYPEPTIDE FOR PREVENTING AND RESTRAINING INFLAMMATION AND APPLICATION OF SAME 有权
标题翻译：用于预防和限制其相容性和应用的小分子聚合物
公开(公告)号：US20150266926A1
公开(公告)日：2015-09-24
申请号：US14412497
申请日：2011-12-19
申请人： Xun Xu , Yan Xu
发明人： Xun Xu , Yan Xu
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/4705
摘要： The present invention provides a polypeptide that is rich in leucine and used for preventing and restraining inflammation, and an application of same. The present invention further provides a method for preparing the polypeptide and a pharmaceutical composition containing the polypeptide. The advantage of the polypeptide comprises: small molecular weight, so as to permeate various eye tissue barriers; high water solubility, so as to have high dissolubility in neutral tears, aqueous humor and vitreous humor; and simple synthesis, so as to have a low preparation cost.
摘要翻译：本发明提供富含亮氨酸并用于预防和抑制炎症的多肽及其应用。本发明还提供了制备多肽的方法和含有多肽的药物组合物。多肽的优点包括：分子量小，以渗透各种眼组织屏障; 水溶性高，以至于在中性眼泪，房水和玻璃体液中具有高溶解性; 和简单的合成，从而具有较低的制备成本。

2. 发明授权

US11369657B2 Small molecule polypeptide for preventing and restraining inflammation and application of same 有权
公开(公告)号：US11369657B2
公开(公告)日：2022-06-28
申请号：US15633296
申请日：2017-06-26
申请人： SHANGHAI FIRST PEOPLE'S HOSPITAL , Xun Xu , Yan Xu
发明人： Xun Xu , Yan Xu , Qiao Sun
IPC分类号： A61K38/03 , C07K14/00 , C07K14/47 , A61K38/00
摘要： The present invention provides a polypeptide that is rich in leucine and used for preventing and restraining inflammation, and an application of same. The present invention further provides a method for preparing the polypeptide and a pharmaceutical composition containing the polypeptide. The advantage of the polypeptide comprises: small molecular weight, so as to permeate various eye tissue barriers; high water solubility, so as to have high dissolubility in neutral tears, aqueous humor and vitreous humor; and simple synthesis, so as to have a low preparation cost.

3. 发明授权

US09688726B2 Small molecule polypeptide for inhibiting inflammation 有权
公开(公告)号：US09688726B2
公开(公告)日：2017-06-27
申请号：US14412497
申请日：2011-12-19
申请人： Xun Xu , Yan Xu
发明人： Xun Xu , Yan Xu
IPC分类号： C07K14/00 , C07K14/47 , A61K38/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/4705
摘要： The present invention provides a polypeptide that is rich in leucine and used for preventing and restraining inflammation, and an application of same. The present invention further provides a method for preparing the polypeptide and a pharmaceutical composition containing the polypeptide. The advantage of the polypeptide comprises: small molecular weight, so as to permeate various eye tissue barriers; high water solubility, so as to have high dissolubility in neutral tears, aqueous humor and vitreous humor; and simple synthesis, so as to have a low preparation cost.

4. 发明申请

US20140206006A1 SINGLE CELL CLASSIFICATION METHOD, GENE SCREENING METHOD AND DEVICE THEREOF 审中-公开
标题翻译：单细胞分类方法，基因筛选方法及其装置
公开(公告)号：US20140206006A1
公开(公告)日：2014-07-24
申请号：US14239650
申请日：2012-08-24
申请人： Xun Xu , Li Bao , Weiming He , Yong Hou , Ye Tao
发明人： Xun Xu , Li Bao , Weiming He , Yong Hou , Ye Tao
IPC分类号： G06F19/22
CPC分类号： G16B30/00 , C12Q1/6827 , C12Q1/6869 , G16B20/00
摘要： Provided are a single cell classification method, a gene screening method and a device for implementing the method. In that, the single cell classification method includes the following steps: sequencing the whole genomes of a plurality of single cell samples from the same group, respectively, so as to obtain reads from each single cell sample; aligning the reads from each single cell sample to the sequence of a reference genome, respectively, and performing data filtering on said reads; on the basis of the filtered reads, determining a consistent genotype of each single cell sample, in which consistent genotypes of all the single cell samples constitute an SNP dataset of said group; aimed at said each single cell, on the basis of the SNP dataset of said group, determining a corresponding genotype for each cell at a site corresponding to a position in an SNP dataset of the reference genome; and selecting an SNP site associated with cell mutation, and on the basis of the genotype of said single cell at the site, classifying said single cell.
摘要翻译：提供单细胞分类方法，基因筛选方法和实施该方法的装置。其中，单细胞分类方法包括以下步骤：从同一组分别测序多个单细胞样品的全基因组，从而获得每个单细胞样品的读数; 将每个单个细胞样本的读数分别对准参考基因组的序列，并对所述读取执行数据过滤; 基于经过滤的读数，确定每个单细胞样品的一致的基因型，其中所有单细胞样品的一致基因型构成所述组的SNP数据集; 针对所述每个单细胞，基于所述组的SNP数据集，在对应于参照基因组的SNP数据集中的位置的位点处确定每个细胞的相应基因型; 并选择与细胞突变相关的SNP位点，并且基于所述单细胞在所述位点处的基因型，对所述单细胞进行分类。

5. 发明授权

US08749409B2 Entropy decoding methods and apparatus using most probable and least probable signal cases 有权
标题翻译：使用最可能和最不可能的信号情况的熵解码方法和装置
公开(公告)号：US08749409B2
公开(公告)日：2014-06-10
申请号：US13113918
申请日：2011-05-23
申请人： Xun Xu
发明人： Xun Xu
IPC分类号： H03M7/00
CPC分类号： H03M7/4018
摘要： An entropy decoding apparatus may include a data structure stored in memory. The data structure may include a decoding engine vector or context engine vector. The decoding engine vector many have a first set of bits representing a value corresponding to a state of a coding engine, a second set of bits representing an offset value, and a third set of bits representing the contents of an input stream buffer. The context vector may have a first set of bits representing an addresses of a context most probable state, a second set of bits representing a plurality of possible values corresponding to a least probable symbol state of a coding engine, a third set of bits representing an addresses of a context least probable state, a fourth set of bits representing a binary most probable symbol value, and a fifth set of bits representing a binary least probable symbol value.
摘要翻译：熵解码装置可以包括存储在存储器中的数据结构。数据结构可以包括解码引擎向量或上下文引擎向量。解码引擎向量许多具有表示对应于编码引擎的状态的值的第一组比特，表示偏移值的第二比特组，以及表示输入流缓冲器的内容的第三组比特。上下文矢量可以具有表示上下文最可能状态的地址的第一组位，表示与编码引擎的最小可能符号状态对应的多个可能值的第二组位，表示第一组位的第三组位上下文最小可能状态的地址，表示二进制最可能符号值的第四组位，以及表示二进制最小可能符号值的第五组位。

6. 发明授权

US08472718B2 Superpixel segmentation methods and systems 有权
标题翻译：超像素分割方法和系统
公开(公告)号：US08472718B2
公开(公告)日：2013-06-25
申请号：US13204574
申请日：2011-08-05
申请人： Xutao Lv , Su Wang , Shengyang Dai , Xun Xu , Akira Nakamura
发明人： Xutao Lv , Su Wang , Shengyang Dai , Xun Xu , Akira Nakamura
IPC分类号： G06K9/34 , G06K9/00
CPC分类号： G06T3/4053
摘要： Systems and methods for implementing a superpixel image segmentation technique using a boundary preserving distance metric are disclosed. The disclosed technique segments a digital image into superpixels comprising contiguous pixel regions sharing similar characteristics. Superpixel image segmentation techniques presented herein utilize a boundary preserving distance metric. A boundary preserving distance metric presented herein measures the similarity between two pixels of a digital image at least partially based on a boundary probability values of the two pixels and surrounding pixels.
摘要翻译：公开了使用边界保留距离度量来实现超像素图像分割技术的系统和方法。所公开的技术将数字图像分割成包含具有相似特征的相邻像素区域的超像素。本文提出的超像素图像分割技术利用边界保留距离度量。这里给出的边界保持距离度量至少部分地基于两个像素和周围像素的边界概率值来测量数字图像的两个像素之间的相似度。

7. 发明申请

US20110034387A1 POLYPEPTIDE INHIBITING ANGIOGENESIS AND APPLICATION THEREOF 有权
标题翻译：多肽抑制血管生成及其应用
公开(公告)号：US20110034387A1
公开(公告)日：2011-02-10
申请号：US12866166
申请日：2008-02-04
申请人： Hui Zhao , Xun Xu
发明人： Hui Zhao , Xun Xu
IPC分类号： A61K38/10 , C07K7/06 , C07K7/08 , C07H21/00 , A61K38/08 , A61P27/02 , A61P9/00
CPC分类号： C07K14/775 , A61K38/00
摘要： Provided is a low molecular polypeptide that can inhibit angiogenesis consisting of amino acid sequence YRGKKA, which is same to one portion sequence in apolipoprotein (a) Kringle V. Also provided are pharmaceutical composition and the uses for preventing or treating diseases relating to angiogenesis.
摘要翻译：本发明提供能够抑制血管发生的低分子多肽，其由氨基酸序列YRGKKA组成，其与载脂蛋白（a）Kringle V中的一部分序列相同。还提供了药物组合物和用于预防或治疗与血管发生有关的疾病的用途。

8. 发明授权

US07092550B2 Implementation of hough transform and its application in video motion analysis 有权
公开(公告)号：US07092550B2
公开(公告)日：2006-08-15
申请号：US10318697
申请日：2002-12-12
申请人： Xun Xu
发明人： Xun Xu
IPC分类号： G06K9/00
CPC分类号： G06K9/4633 , G06T7/262
摘要： An implementation of Hough transform is described. According to one aspect, the Hough transform is used to perform motion analysis of patterns in a video using two-dimensional primary data items and a two-dimensional voting array.

9. 发明授权

US09202281B2 Integrated interactive segmentation with spatial constraint for digital image analysis 有权
标题翻译：用于数字图像分析的集成交互式分割与空间约束
公开(公告)号：US09202281B2
公开(公告)日：2015-12-01
申请号：US13423209
申请日：2012-03-17
申请人： Su Wang , Shengyang Dai , Xun Xu , Akira Nakamura , Takeshi Ohashi , Jun Yokono
发明人： Su Wang , Shengyang Dai , Xun Xu , Akira Nakamura , Takeshi Ohashi , Jun Yokono
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0081 , G06K9/00 , G06T7/11 , G06T7/143 , G06T7/162 , G06T7/194 , G06T2207/20081
摘要： An integrated interactive segmentation with spatial constraint method utilizes a combination of several of the most popular online learning algorithms into one and implements a spatial constraint which defines a valid mask local to the user's given marks. Additionally, both supervised learning and statistical analysis are integrated, which are able to compensate each other. Once prediction and activation are obtained, pixel-wised multiplication is conducted to fully indicate how likely each pixel belongs to the foreground or background.
摘要翻译：具有空间约束方法的集成交互式分割将几种最流行的在线学习算法的组合应用于一种，并实现了定义用户给定标记本地的有效掩码的空间约束。此外，监督学习和统计分析都是综合的，可以相互补偿。一旦获得了预测和激活，就进行像素增益乘法以完全指示每个像素属于前景或背景的可能性。

10. 发明授权

US09023795B2 Angiogenesis-inhibiting peptide and application thereof 有权
标题翻译：血管发生抑制肽及其应用
公开(公告)号：US09023795B2
公开(公告)日：2015-05-05
申请号：US13819175
申请日：2011-07-01
申请人： Xun Xu , Ying Zheng , Hui Zhao
发明人： Xun Xu , Ying Zheng , Hui Zhao
IPC分类号： C07K14/00 , C07K7/08 , C07K14/47 , C07K14/475 , C07K14/52 , A61K38/18 , A61K38/17 , A61K38/00
CPC分类号： C07K14/00 , A61K38/00 , A61K38/179 , A61K38/18 , A61K38/1891 , C07K7/08 , C07K14/4715 , C07K14/4753 , C07K14/52
摘要： Provided is a polypeptide having angiogenesis inhibiting activity. The polypeptide is derived from Placenta Growth Factor-1. Also provided are a derivative polypeptide of the polypeptide, a preparation method for polypeptide, and a pharmaceutical composition containing the polypeptide.
摘要翻译：提供了具有血管生成抑制活性的多肽。多肽衍生自胎盘生长因子-1。还提供了多肽的衍生多肽，多肽的制备方法和含有多肽的药物组合物。

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