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1. 发明授权

US11369657B2 Small molecule polypeptide for preventing and restraining inflammation and application of same 有权
公开(公告)号：US11369657B2
公开(公告)日：2022-06-28
申请号：US15633296
申请日：2017-06-26
申请人： SHANGHAI FIRST PEOPLE'S HOSPITAL , Xun Xu , Yan Xu
发明人： Xun Xu , Yan Xu , Qiao Sun
IPC分类号： A61K38/03 , C07K14/00 , C07K14/47 , A61K38/00
摘要： The present invention provides a polypeptide that is rich in leucine and used for preventing and restraining inflammation, and an application of same. The present invention further provides a method for preparing the polypeptide and a pharmaceutical composition containing the polypeptide. The advantage of the polypeptide comprises: small molecular weight, so as to permeate various eye tissue barriers; high water solubility, so as to have high dissolubility in neutral tears, aqueous humor and vitreous humor; and simple synthesis, so as to have a low preparation cost.

2. 发明申请

US20180116773A1 CUSTOM-MADE ORAL HYGIENE DEVICE FOR DAILY TEETH CLEANING AND POLISHING 审中-公开
公开(公告)号：US20180116773A1
公开(公告)日：2018-05-03
申请号：US15793349
申请日：2017-10-25
申请人： YONG CHEN , NICHOLAS FU , SHAUN XUN XU
发明人： YONG CHEN , NICHOLAS FU , SHAUN XUN XU
IPC分类号： A61C17/02 , A61C9/00
CPC分类号： A61C17/0211 , A61C9/0046 , A61C17/028
摘要： A custom dental irrigation device has: a user dentition model; a custom made mouthpiece made according to the user dentition model, a pump configured to pump fluid to the mouthpiece; a suction pump configured to remove fluid from the mouthpiece; a fluid tank; and a controller. The custom made mouthpiece is configured to deliver fluid to the dental target while removing used irrigation fluid. The mouthpiece is fabricated with 3-D print techniques. The mouthpiece is designed in two pieces to cover an upper portion of a dental target and a lower portion of a dental target separately. The mouthpiece has an inner surface following the shape of the user dentition model, wherein the inner surface touches the gingiva tissue to form a sealed space once the mouthpiece is set in a user's mouth, whereby fluid is delivered to the dental target, and removed from the sealed space.

3. 发明授权

US09688726B2 Small molecule polypeptide for inhibiting inflammation 有权
公开(公告)号：US09688726B2
公开(公告)日：2017-06-27
申请号：US14412497
申请日：2011-12-19
申请人： Xun Xu , Yan Xu
发明人： Xun Xu , Yan Xu
IPC分类号： C07K14/00 , C07K14/47 , A61K38/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/4705
摘要： The present invention provides a polypeptide that is rich in leucine and used for preventing and restraining inflammation, and an application of same. The present invention further provides a method for preparing the polypeptide and a pharmaceutical composition containing the polypeptide. The advantage of the polypeptide comprises: small molecular weight, so as to permeate various eye tissue barriers; high water solubility, so as to have high dissolubility in neutral tears, aqueous humor and vitreous humor; and simple synthesis, so as to have a low preparation cost.

4. 发明授权

US09238840B2 Method for single cell genome analysis and kit therefor 有权
标题翻译：单细胞基因组分析方法及其试剂盒
公开(公告)号：US09238840B2
公开(公告)日：2016-01-19
申请号：US13976845
申请日：2011-12-29
申请人： Xuyang Yin , Li Bao , Xun Xu , Hanjie Wu , Xiaoyu Liu , Xiuqing Zhang , Huanming Yang
发明人： Xuyang Yin , Li Bao , Xun Xu , Hanjie Wu , Xiaoyu Liu , Xiuqing Zhang , Huanming Yang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/6806 , C12Q1/6851 , C12Q1/6869 , C12Q1/6876 , C12Q2600/166 , C12Q2531/119 , C12Q2545/101
摘要： A method for analyzing a genome of a single cell is provided, and a kit is also provided. The method for analyzing the genome of the single cell may comprise separating and lysing the single cell to obtain a whole-genome DNA of the cell; subjecting the whole-genome DNA to a whole-genome amplification to obtain a whole-genome amplification product; performing a PCR amplification using the whole-genome amplification product as template and using housekeeping-gene-specific primers to detect the housekeeping gene of the whole-genome amplification product; and determining whether the whole genome amplification product meets a requirement for sequencing based on the detection result, wherein a uniform distribution of the amplification product in each chromosome is an indication of the amplification product meeting the requirement for sequencing.
摘要翻译：提供了用于分析单细胞的基因组的方法，并且还提供了试剂盒。用于分析单细胞基因组的方法可以包括分离和裂解单细胞以获得细胞的全基因组DNA; 对全基因组DNA进行全基因组扩增以获得全基因组扩增产物; 使用全基因组扩增产物作为模板进行PCR扩增，并使用管家基因特异性引物检测全基因组扩增产物的管家基因; 并且基于检测结果确定全基因组扩增产物是否满足测序要求，其中扩增产物在每个染色体中的均匀分布是满足测序要求的扩增产物的指示。

5. 发明授权

US08755580B2 Flourescent dot counting in digital pathology images 有权
标题翻译：数字病理图像中的荧光点计数
公开(公告)号：US08755580B2
公开(公告)日：2014-06-17
申请号：US13423208
申请日：2012-03-17
申请人： Su Wang , Xun Xu , Akira Nakamura
发明人： Su Wang , Xun Xu , Akira Nakamura
IPC分类号： G06K9/00
CPC分类号： G06K9/0014 , G06K9/00147
摘要： Fluorescence in situ hybridization (FISH) enables the detection of specific DNA sequences in cell chromosomes by the use of selective staining. Due to the high sensitivity, FISH allows the use of multiple colors to detect multiple targets simultaneously. The target signals are represented as colored dots, and enumeration of these signals is called dot counting. Using a two-stage segmentation framework guarantees locating all potential dots including overlapped dots.
摘要翻译：荧光原位杂交（FISH）能够通过选择性染色检测细胞染色体中的特定DNA序列。由于高灵敏度，FISH允许使用多种颜色同时检测多个目标。目标信号表示为彩色点，这些信号的枚举称为点计数。使用两阶段分割框架可确保定位所有可能的点，包括重叠点。

6. 发明申请

US20140017683A1 METHOD FOR SINGLE CELL GENOME ANALYSIS AND KIT THEREFOR 有权
标题翻译：单细胞基因组分析方法及其制备方法
公开(公告)号：US20140017683A1
公开(公告)日：2014-01-16
申请号：US13976845
申请日：2011-12-29
申请人： Xuyang Yin , Li Bao , Xun Xu , Hanjie Wu , Xiaoyu Liu , Xiuqing Zhang , Huanming Yang
发明人： Xuyang Yin , Li Bao , Xun Xu , Hanjie Wu , Xiaoyu Liu , Xiuqing Zhang , Huanming Yang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/6806 , C12Q1/6851 , C12Q1/6869 , C12Q1/6876 , C12Q2600/166 , C12Q2531/119 , C12Q2545/101
摘要： A method for analyzing a genome of a single cell is provided, and a kit is also provided. The method for analyzing the genome of the single cell may comprise separating and lysing the single cell to obtain a whole-genome DNA of the cell; subjecting the whole-genome DNA to a whole-genome amplification to obtain a whole-genome amplification product; performing a PCR amplification using the whole-genome amplification product as template and using housekeeping-gene-specific primers to detect the housekeeping gene of the whole-genome amplification product; and determining whether the whole genome amplification product meets a requirement for sequencing based on the detection result, wherein a uniform distribution of the amplification product in each chromosome is an indication of the amplification product meeting the requirement for sequencing.
摘要翻译：提供了用于分析单细胞的基因组的方法，并且还提供了试剂盒。用于分析单细胞基因组的方法可以包括分离和裂解单细胞以获得细胞的全基因组DNA; 对全基因组DNA进行全基因组扩增以获得全基因组扩增产物; 使用全基因组扩增产物作为模板进行PCR扩增，并使用管家基因特异性引物检测全基因组扩增产物的管家基因; 并且基于检测结果确定全基因组扩增产物是否满足测序要求，其中扩增产物在每个染色体中的均匀分布是满足测序要求的扩增产物的指示。

7. 发明申请

US20130243289A1 GRAPH CUTS-BASED INTERACTIVE SEGMENTATION OF TEETH IN 3-D CT VOLUMETRIC DATA 有权
标题翻译： 3-D CT体积数据中基于图形图的交互式分类
公开(公告)号：US20130243289A1
公开(公告)日：2013-09-19
申请号：US13423211
申请日：2012-03-17
申请人： Su Wang , Shengyang Dai , Xun Xu , Akira Nakamura
发明人： Su Wang , Shengyang Dai , Xun Xu , Akira Nakamura
IPC分类号： G06K9/00
CPC分类号： G06T7/162 , G06T7/11 , G06T7/194 , G06T2207/10081 , G06T2207/20041 , G06T2207/20096 , G06T2207/30036
摘要： An interactive segmentation framework for 3-D teeth CT volumetric data enables a user to segment an entire dental region or individual teeth depending upon the types of user input. Graph cuts-based interactive segmentation utilizes a user's scribbles which are collected on several 2-D representative CT slices and are expanded on those slices. Then, a 3-D distance transform is applied to the entire CT volume based on the expanded scribbles. Bony tissue enhancement is added before feeding 3-D CT raw image data into the graph cuts pipeline. The segmented teeth area is able to be directly utilized to reconstruct a 3-D virtual teeth model.
摘要翻译：用于3D牙齿CT体积数据的交互式分割框架使用户能够根据用户输入的类型来分割整个牙齿区域或单个牙齿。基于图切割的交互式分割利用用户的涂鸦，这些涂鸦被收集在几个二维代表性的CT切片上，并在这些切片上展开。然后，基于扩展的涂鸦将3-D距离变换应用于整个CT体积。在将3-D CT原始图像数据提供给图形切割管道之前，添加骨组织增强。分段牙齿区域能够直接用于重建3-D虚拟牙齿模型。

8. 发明申请

US20090224950A1 ENTROPY DECODING METHODS AND APPARATUS USING MOST PROBABLE AND LEAST PROBABLE SIGNAL CASES 有权
标题翻译：篡改解码方法和使用最可能和最可探测信号的设备
公开(公告)号：US20090224950A1
公开(公告)日：2009-09-10
申请号：US12469496
申请日：2009-05-20
申请人： Xun Xu
发明人： Xun Xu
IPC分类号： H03M7/30 , H03M7/00
CPC分类号： H03M7/4006 , H04N19/61 , H04N19/91
摘要： Methods and apparatus for entropy decoding are disclosed. Compressed input data representing one or more signals is loaded into one or more registers. A first candidate value for a most probable signal case is prepared from the input data. A second candidate value for a least probable signal case is prepared from the input data. A final signal value for the one or more signals is selected from the first and second candidate values and an output bin value is generated based on the final signal value. A processor readable medium having embodied therein processor readable instructions for implementing the method for entropy decoding is also disclosed. In addition, a method of avoiding a branch instruction in an electronic processing algorithm is disclosed.
摘要翻译：公开了用于熵解码的方法和装置。代表一个或多个信号的压缩输入数据被加载到一个或多个寄存器中。从输入数据准备最可能的信号情况的第一候选值。从输入数据准备最小可能信号情况的第二候选值。从第一和第二候选值中选择一个或多个信号的最终信号值，并且基于最终信号值生成输出bin值。还公开了一种其中包含用于实现用于熵解码的方法的处理器可读指令的处理器可读介质。此外，公开了一种避免电子处理算法中的分支指令的方法。

9. 发明申请

US20050063592A1 System and method for shape recognition of hand-drawn objects 有权
标题翻译：手绘体的形状识别系统和方法
公开(公告)号：US20050063592A1
公开(公告)日：2005-03-24
申请号：US10850718
申请日：2004-05-20
申请人： Yantao Li , Zhouchen Lin , Xun Xu , Jian Wang
发明人： Yantao Li , Zhouchen Lin , Xun Xu , Jian Wang
IPC分类号： G06T7/00 , G06K9/00 , G06K9/20 , G06K9/22 , G06K9/46 , G06K9/62 , G06K11/02 , G06K11/06 , G06T7/60
CPC分类号： G06K9/00476 , G06K9/222
摘要： A system and method for shape recognition of hand-drawn objects is provided. A shape recognizer may recognize a drawing such as a diagram or chart from ink input by recognizing closed containers and/or unclosed connectors in the drawing. The closed containers may represent any number of shapes that may be recognized including circles, ellipses, triangles, quadrilaterals, pentagons, hexagons, and so forth. The unclosed connectors may be any type of connector including lines, curves, arrows, and so forth. Polylines may be used to approximate a skeleton of a connector for handling continuation strokes, overlapping strokes and over-tracing strokes of the skeleton. By using the present invention, a user may draw diagrams and flow charts freely and without restrictions on the hand-drawn input.
摘要翻译：提供了一种用于手绘对象的形状识别的系统和方法。形状识别器可以通过识别附图中的封闭容器和/或非封闭连接器来识别来自墨水输入的图形，例如图表或图表。封闭的容器可以表示可以识别的任何数量的形状，包括圆形，椭圆形，三角形，四边形，五边形，六边形等。未封闭的连接器可以是包括线，曲线，箭头等的任何类型的连接器。折线可用于近似连接器的骨架，用于处理骨架的连续笔触，重叠笔触和超跟踪笔画。通过使用本发明，用户可以自由地绘制图表和流程图，而不限制手绘输入。

10. 发明授权

US10034005B2 Banding prediction for video encoding 有权
公开(公告)号：US10034005B2
公开(公告)日：2018-07-24
申请号：US14732551
申请日：2015-06-05
申请人： Xun Xu , Peng Ye
发明人： Xun Xu , Peng Ye
IPC分类号： H04N19/176 , H04N19/103 , H04N19/117 , H04N19/154
摘要： A system and method for facilitating inhibiting banding in video data, in part by anticipating when banding may occur given certain encoder parameters. An example method includes receiving an input stream of video data; extracting feature information characterizing the stream of video data; using a feed-forward neural network to process the feature information to estimate when a particular block of the stream of video data will exhibit an artifact when encoded using certain Quantization Parameters (QPs); incorporating the indication into metadata associated with the stream of video data; and transferring the stream of video data and metadata to a video encoder. In a more specific embodiment, the feature information includes color information and texture information, and the neural network includes a feed-forward neural network that includes a classifier with a sigmoid activation function, and which has been trained using a cross-entropy cost function.

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