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1. 发明授权

US08031335B2 Non-invasive disease diagnosis using light scattering probe 有权
标题翻译：使用光散射探针的非侵入性疾病诊断
公开(公告)号：US08031335B2
公开(公告)日：2011-10-04
申请号：US12176383
申请日：2008-07-20
申请人： Hong Wang , Xun Guo
发明人： Hong Wang , Xun Guo
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/02 , G01J3/021 , G01N21/658 , G08B21/12
摘要： A method for non-invasive detection of a disease, a status of illicit-drug use, or smoking status includes transferring a body fluid obtained from a patient to a sensor comprising a nano-scale surface structure to allow the body fluid to come in contact with the nano-scale surface structure, illuminating the body fluid and the nano-scale surface structure by a laser beam, scattering the laser beam by the body fluid and the nano-scale surface structure to produce a scattered light, and analyzing the scattered light using a spectral analyzer to diagnose a disease, the status of illicit-drug use, or smoking status in the patient.
摘要翻译：用于非侵入性检测疾病，非法药物使用状况或吸烟状态的方法包括将从患者获得的体液转移到包括纳米级表面结构的传感器以允许体液接触通过纳米级表面结构，通过激光照射体液和纳米级表面结构，通过体液和纳米级表面结构散射激光束产生散射光，并分析散射光使用光谱分析仪诊断疾病，非法药物使用状况或患者的吸烟状况。

2. 发明申请

US20080309918A1 INTEGRATED CHEMICAL SEPARATION LIGHT SCATTERING DEVICE 有权
标题翻译：集成化学分离光散射装置
公开(公告)号：US20080309918A1
公开(公告)日：2008-12-18
申请号：US11761453
申请日：2007-06-12
申请人： Xun Guo , Hong Wang
发明人： Xun Guo , Hong Wang
IPC分类号： G01N21/00
CPC分类号： G01N21/65 , G01N21/658
摘要： An integrated chemical separation device includes a single device body, a chemical separation unit configured to separate a chemical from a fluid, a Raman sensor substrate comprising one or more surfaces configured to be adsorbed by molecules of the chemical from the fluid, and a Raman scattering spectrometer unit that can emit a laser beam to illuminate the Raman sensor substrate and to detect the chemical from the light scattered from the Raman sensor substrate. The chemical separation unit, the Raman sensor substrate, and the Raman scattering spectrometer unit are held in or mounted to the single device body.
摘要翻译：集成的化学分离装置包括单个装置主体，被配置为将化学品与流体分离的化学分离单元，包括被配置为被来自流体的化学物质的分子吸附的一个或多个表面的拉曼传感器基板以及拉曼散射可以发射激光束照射拉曼传感器基板并从拉曼传感器基板散射的光中检测化学物质的光谱仪单元。化学分离单元，拉曼传感器基板和拉曼散射光谱仪单元被保持在或安装到单个设备主体。

3. 发明授权

US08213007B2 Spectrally sensing chemical and biological substances 有权
标题翻译：光谱传感化学和生物物质
公开(公告)号：US08213007B2
公开(公告)日：2012-07-03
申请号：US12625970
申请日：2009-11-25
申请人： Hong Wang , Xun Guo , Chunwei Liu
发明人： Hong Wang , Xun Guo , Chunwei Liu
IPC分类号： G01J3/28
CPC分类号： G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0264 , G01J3/44 , G01N21/65 , G01N21/658 , G01N21/7703 , G01N2021/7773 , G01N2201/084 , G01N2201/129
摘要： A sensor-network system for spectrally sensing a chemical or biological substance includes a plurality of probe assemblies that each includes a sensor comprising a nano structured surface, wherein the nano structured surface can adsorb molecules of a sample material captured adjacent to the sensor; a laser configured to emit a laser beam to illuminate the molecules adsorbed to the nano structured surface, and a spectrometer that can obtain spectral data from light scattered by the molecules adsorbed to the nano structured surface. A control center includes a computer storage configured to store spectral signatures each associated with a chemical or biological substance and a spectral analyzer that can determine a spectral signature matching at least one of the spectral signatures stored in the computer storage thereby to identify, in the sample material, the chemical or biological substance associated with the one of the spectral signatures.
摘要翻译：用于光谱感测化学或生物物质的传感器网络系统包括多个探针组件，每个探针组件包括包含纳米结构化表面的传感器，其中所述纳米结构化表面可以吸附邻近所述传感器捕获的样品材料的分子; 配置为发射激光束以照射吸附到纳米结构化表面的分子的激光器，以及可以由吸附到纳米结构化表面的分子散射的光获得光谱数据的光谱仪。控制中心包括被配置为存储每个与化学或生物物质相关联的光谱特征的计算机存储器，以及光谱分析器，其可以确定与存储在计算机存储器中的至少一个光谱特征匹配的光谱特征，从而在样本中识别材料，与光谱特征之一相关联的化学或生物物质。

4. 发明授权

US08081308B2 Detecting chemical and biological impurities by nano-structure based spectral sensing 有权
标题翻译：通过纳米结构的光谱感测检测化学和生物杂质
公开(公告)号：US08081308B2
公开(公告)日：2011-12-20
申请号：US12643689
申请日：2009-12-21
申请人： Hong Wang , Xun Guo
发明人： Hong Wang , Xun Guo
IPC分类号： G01J3/30
CPC分类号： G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0264 , G01J3/44 , G01N21/65
摘要： A method is disclosed for providing quality assurance in an industrial process. The method includes obtaining a manufacturing material from the industrial process, allowing the manufacturing material to contact with a nano-scale surface, which allows the harmful substance to adsorb to the nano-scale surface. The method also includes obtaining a Raman spectrum from the manufacturing material and the nano-scale surface using a spectrometer, searching for, using a spectral analyzer, a spectral signature of a harmful substance in a predetermined spectral region in the Raman spectrum to determine the existence of the harmful substance in the manufacturing material, determining the concentration of the manufacturing material if the spectral signature is found in the Raman spectrum, and rejecting the manufacturing material from the industrial process if the concentration of the manufacturing material is determined to be above a predetermined tolerance level.
摘要翻译：公开了一种在工业过程中提供质量保证的方法。该方法包括从工业过程获得制造材料，允许制造材料与允许有害物质吸附到纳米级表面的纳米级表面接触。该方法还包括使用光谱仪从制造材料和纳米级表面获得拉曼光谱，使用光谱分析仪搜索在拉曼光谱中的预定光谱区域中的有害物质的光谱特征，以确定存在的制造材料中的有害物质，如果在拉曼光谱中发现光谱特征，则确定制造材料的浓度，并且如果将制造材料的浓度确定为高于预定值，则拒绝来自工业过程的制造材料公差水平

5. 发明授权

US08582099B2 Monitoring network based on nano-structured sensing devices 失效
标题翻译：基于纳米结构感测器件的监控网络
公开(公告)号：US08582099B2
公开(公告)日：2013-11-12
申请号：US13080142
申请日：2011-04-05
申请人： Xun Guo , Hong Wang , Chunwei Liu
发明人： Xun Guo , Hong Wang , Chunwei Liu
IPC分类号： G01J3/28
CPC分类号： G01N21/658 , B82Y20/00 , B82Y40/00 , G01N33/54346
摘要： A monitoring network system for inspecting and controlling harmful substances includes probe assemblies that each includes a sensor comprising nano structured surfaces or nano particles in a solution, configured to adsorb molecules of a sample material captured adjacent to the sensor, a laser that can emit a laser beam to illuminate the molecules adsorbed to the nano structured surfaces, a spectrometer that can produce spectral data from light scattered by the molecules adsorbed to the nano structured surfaces, and a ID reader that can retrieve identification information about the sample material. A central office can determine a spectral signature matching spectral signatures stored in a database and to identify a harmful substance in the sample material. An alert and response system can send out an alert signal about the sample material when the harmful substance is identified in the sample material.
摘要翻译：用于检查和控制有害物质的监测网络系统包括探针组件，每个探针组件包括在溶液中包含纳米结构化表面或纳米颗粒的传感器，其被配置为吸附邻近传感器捕获的样品材料的分子，可以发射激光光束照射吸附到纳米结构化表面的分子，可以由吸附到纳米结构化表面的分子散射的光产生光谱数据的光谱仪，以及可以检索关于样品材料的识别信息的ID读取器。中心局可以确定与数据库中存储的光谱签名相匹配的光谱签名，并识别样品中的有害物质。当在样品材料中识别有害物质时，警报和响应系统可以发出关于样品材料的警报信号。

6. 发明授权

US08441631B2 Integrated device capable of performing chemical separation and light scattering 失效
标题翻译：能够进行化学分离和光散射的集成装置
公开(公告)号：US08441631B2
公开(公告)日：2013-05-14
申请号：US12848893
申请日：2010-08-02
申请人： Hong Wang , Xun Guo
发明人： Hong Wang , Xun Guo
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An integrated chemical separation device includes a single device body, a chemical separation unit configured to separate a chemical from a fluid, a Raman sensor substrate comprising one or more surfaces configured to be adsorbed by molecules of the chemical from the fluid, and a Raman scattering spectrometer unit that can emit a laser beam to illuminate the Raman sensor substrate and to detect the chemical from the light scattered from the Raman sensor substrate. The chemical separation unit, the Raman sensor substrate, and the Raman scattering spectrometer unit are held in or mounted to the single device body.
摘要翻译：集成的化学分离装置包括单个装置主体，被配置为将化学品与流体分离的化学分离单元，包括被配置为被来自流体的化学物质的分子吸附的一个或多个表面的拉曼传感器基板以及拉曼散射可以发射激光束照射拉曼传感器基板并从拉曼传感器基板散射的光中检测化学物质的光谱仪单元。化学分离单元，拉曼传感器基板和拉曼散射光谱仪单元被保持在或安装到单个设备主体。

7. 发明申请

US20100296086A1 INTEGRATED DEVICE CAPABLE OF PERFORMING CHEMICAL SEPARATION AND LIGHT SCATTERING 失效
标题翻译：能够进行化学分离和光散射的集成装置
公开(公告)号：US20100296086A1
公开(公告)日：2010-11-25
申请号：US12848893
申请日：2010-08-02
申请人： Hong Wang , Xun Guo
发明人： Hong Wang , Xun Guo
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An integrated chemical separation device includes a single device body, a chemical separation unit configured to separate a chemical from a fluid, a Raman sensor substrate comprising one or more surfaces configured to be adsorbed by molecules of the chemical from the fluid, and a Raman scattering spectrometer unit that can emit a laser beam to illuminate the Raman sensor substrate and to detect the chemical from the light scattered from the Raman sensor substrate. The chemical separation unit, the Raman sensor substrate, and the Raman scattering spectrometer unit are held in or mounted to the single device body.
摘要翻译：集成的化学分离装置包括单个装置主体，被配置为将化学品与流体分离的化学分离单元，包括被配置为被来自流体的化学物质的分子吸附的一个或多个表面的拉曼传感器基板以及拉曼散射可以发射激光束照射拉曼传感器基板并从拉曼传感器基板散射的光中检测化学物质的光谱仪单元。化学分离单元，拉曼传感器基板和拉曼散射光谱仪单元被保持在或安装到单个设备主体。

8. 发明申请

US20100070197A1 SPECTRALLY SENSING CHEMICAL AND BIOLOGICAL SUBSTANCES 有权
标题翻译：光谱传感化学和生物物质
公开(公告)号：US20100070197A1
公开(公告)日：2010-03-18
申请号：US12625970
申请日：2009-11-25
申请人： Hong Wang , Xun Guo , Chunwei Liu
发明人： Hong Wang , Xun Guo , Chunwei Liu
IPC分类号： G01J3/44 , G06F19/00 , G01J3/30
CPC分类号： G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0264 , G01J3/44 , G01N21/65 , G01N21/658 , G01N21/7703 , G01N2021/7773 , G01N2201/084 , G01N2201/129
摘要： A sensor-network system for spectrally sensing a chemical or biological substance includes a plurality of probe assemblies that each includes a sensor comprising a nano structured surface, wherein the nano structured surface can adsorb molecules of a sample material captured adjacent to the sensor; a laser configured to emit a laser beam to illuminate the molecules adsorbed to the nano structured surface, and a spectrometer that can obtain spectral data from light scattered by the molecules adsorbed to the nano structured surface. A control center includes a computer storage configured to store spectral signatures each associated with a chemical or biological substance and a spectral analyzer that can determine a spectral signature matching at least one of the spectral signatures stored in the computer storage thereby to identify, in the sample material, the chemical or biological substance associated with the one of the spectral signatures.
摘要翻译：用于光谱感测化学或生物物质的传感器网络系统包括多个探针组件，每个探针组件包括包含纳米结构化表面的传感器，其中所述纳米结构化表面可以吸附邻近所述传感器捕获的样品材料的分子; 配置为发射激光束以照射吸附到纳米结构化表面的分子的激光器，以及可以由吸附到纳米结构化表面的分子散射的光获得光谱数据的光谱仪。控制中心包括被配置为存储每个与化学或生物物质相关联的光谱特征的计算机存储器，以及光谱分析器，其可以确定与存储在计算机存储器中的至少一个光谱特征匹配的光谱签名，从而在样本中识别材料，与光谱特征之一相关联的化学或生物物质。

9. 发明申请

US20090086202A1 NON-INVASIVE DISEASE DIAGNOSIS USING LIGHT SCATTERING PROBE 有权
标题翻译：使用光散射探头进行非侵入性疾病诊断
公开(公告)号：US20090086202A1
公开(公告)日：2009-04-02
申请号：US12176383
申请日：2008-07-20
申请人： Hong Wang , Xun Guo
发明人： Hong Wang , Xun Guo
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/02 , G01J3/021 , G01N21/658 , G08B21/12
摘要： A method for non-invasive detection of a disease, a status of illicit-drug use, or smoking status includes transferring a body fluid obtained from a patient to a sensor comprising a nano-scale surface structure to allow the body fluid to come in contact with the nano-scale surface structure, illuminating the body fluid and the nano-scale surface structure by a laser beam, scattering the laser beam by the body fluid and the nano-scale surface structure to produce a scattered light, and analyzing the scattered light using a spectral analyzer to diagnose a disease, the status of illicit-drug use, or smoking status in the patient.
摘要翻译：用于非侵入性检测疾病，非法药物使用状况或吸烟状态的方法包括将从患者获得的体液转移到包括纳米级表面结构的传感器以允许体液接触通过纳米级表面结构，通过激光照射体液和纳米级表面结构，通过体液和纳米级表面结构散射激光束产生散射光，并分析散射光使用光谱分析仪诊断疾病，非法药物使用状况或患者的吸烟状况。

10. 发明授权

US07460224B2 Arrays of nano structures for surface-enhanced Raman scattering 有权
标题翻译：用于表面增强拉曼散射的纳米结构阵列
公开(公告)号：US07460224B2
公开(公告)日：2008-12-02
申请号：US11562409
申请日：2006-11-21
申请人： Hong Wang , Xindi Wu , Xun Guo
发明人： Hong Wang , Xindi Wu , Xun Guo
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , B82Y20/00 , G01N21/648
摘要： Disclosed herein is a SERS sensing surface device comprising a substrate supporting a plurality of nano structures, an exposed sensing surface upon the nano structures, wherein said surface includes at least one active SERS nano surface and at least one inactive SERS nano surface established in proximity to the active SERS nano. Also disclosed are methods for forming the array device, systems based on the array device, as well as methods for performing SERS with the array device.
摘要翻译：本文公开了一种SERS感测表面装置，其包括支撑多个纳米结构的衬底，纳米结构上的暴露的感测表面，其中所述表面包括至少一个活性SERS纳米表面和至少一个非活性SERS纳米表面，活性SERS纳米。还公开了用于形成阵列器件的方法，基于阵列器件的系统以及用阵列器件执行SERS的方法。

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