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1. 发明申请

WO2007149363A2 RADIATION THERAPY APPARATUS WITH SELECTIVE SHIELDING CAPABILITY 审中-公开
标题翻译：具有选择性屏蔽能力的放射治疗装置
公开(公告)号：WO2007149363A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/014151
申请日：2007-06-15
申请人： XOFT, INC. , SMITH, Peter, C. , KLEIN, Michael , HAUSEN, Heike , LOVOI, Paul, A.
发明人： SMITH, Peter, C. , KLEIN, Michael , HAUSEN, Heike , LOVOI, Paul, A.
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B2017/22051 , A61B2090/0481 , A61N2005/1003 , A61N2005/1005 , A61N2005/1094
摘要： Brachytherapy applicators incorporate various forms of selective shielding devices for controlling the direction and intensity of radiation directed at a patient's tissue. In some forms the applicators include a retractable sheath, in some a series of retractable fingers. In other forms the applicator, having an inflatable balloon, has a shield which is retractable from a position adjacent to the balloon or retracted from the balloon, or a shield can itself be inflatable, separately or together with the balloon.
摘要翻译：近程放射治疗仪包括各种形式的选择性屏蔽装置，用于控制指向患者组织的辐射的方向和强度。在一些形式中，施用器包括可伸缩护套，在一些可伸缩的手指中。在其他形式中，具有可膨胀气囊的施用器具有可从邻近气囊的位置缩回或从球囊缩回的护罩，或者屏蔽件本身可以与气囊分开地或与气囊一起充气。

2. 发明公开

EP2004290A2 REAL TIME VERIFICATION IN RADIATION TREATMENT 审中-公开
标题翻译： REAL-TERM审评放射治疗
公开(公告)号：EP2004290A2
公开(公告)日：2008-12-24
申请号：EP07754677.8
申请日：2007-03-30
申请人： Xoft, Inc.
发明人： KLEIN, Michael , LOVOI, Paul, A.
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N5/1048 , A61N5/1067
摘要： A radiation therapy system and method, especially for brachytherapy, monitors and verifies dose delivered at a plurality of points at or near the region to be irradiated, integrating verification with radiation delivery. In one procedure, mapping is used to determine the shape and location of the region to be irradiated. A treatment plan is developed using the mapping information and a dose prescription. As radiation is delivered to the target region internally (56), the dose received at plural points is monitored (58) and continually fed to a central processor (60). As needed based on feedback (62), the system modifies the treatment plan and delivery of radiation accordingly (64, 66, 68), to arrive substantially at the prescribed dose at all locations in the region.

3. 发明申请

WO2007120532A2 REAL TIME VERIFICATION IN RADIATION TREATMENT 审中-公开
标题翻译：辐射治疗实时验证
公开(公告)号：WO2007120532A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/008192
申请日：2007-03-30
申请人： XOFT, INC.
发明人： KLEIN, Michael , LOVOI, Paul, A.
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N5/1048 , A61N5/1067
摘要： A radiation therapy system and method, especially for brachytherapy, monitors and verifies dose delivered at a plurality of points at or near the region to be irradiated, integrating verification with radiation delivery. In one procedure, mapping is used to determine the shape and location of the region to be irradiated. A treatment plan is developed using the mapping information and a dose prescription. As radiation is delivered to the target region internally, preferably using an electronic radiation source, the dose received at plural points is monitored and continually fed to a central processor. As needed based on feedback, the system modifies the treatment plan and delivery of radiation accordingly, to arrive substantially at the prescribed dose at all locations in the region. In a modified procedure the treatment is done according to a prescription dose but without a treatment plan by multiple iterations of source pullback and feedback and analysis of dose received in the tissue. Source radiation levels and/or pattern and dwell are modified for each successive iteration and preferably for different dwell points in an iteration.
摘要翻译：放射治疗系统和方法，特别是近距离放射治疗，监测和验证在待照射区域处或附近的多个点递送的剂量，将验证与放射递送集成。在一个过程中，使用映射来确定要照射的区域的形状和位置。使用映射信息和剂量处方开发治疗计划。随着辐射在内部，优选地使用电子辐射源被传送到目标区域，在多个点处接收的剂量被监测并且连续地馈送到中央处理器。根据反馈要求，系统相应地修改治疗计划和辐射传播，以达到该地区所有地点的规定剂量。在修改的程序中，根据处方剂量进行治疗，但是通过多次重复的来源回退和反馈以及组织中接收的剂量的分析来进行治疗计划。源辐射水平和/或图案和驻留对于每个连续的迭代进行修改，优选地对于迭代中的不同驻留点进行修改。

4. 发明申请

WO2008048521A3 BALLOON BRACHYTHERAPY APPLICATOR AND METHOD 审中-公开
公开(公告)号：WO2008048521A3
公开(公告)日：2008-04-24
申请号：PCT/US2007/021937
申请日：2007-10-12
申请人： XOFT, INC. , FRANCESCATTI, Darius , HOFFMAN, David, J. , KLEIN, Michael , TREMBERTH, Scott , JERVIS, James, E. , LOVOI, Paul, A.
发明人： FRANCESCATTI, Darius , HOFFMAN, David, J. , KLEIN, Michael , TREMBERTH, Scott , JERVIS, James, E. , LOVOI, Paul, A.
IPC分类号： A61N5/00
摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.

5. 发明公开

EP2035088A2 RADIATION THERAPY APPARATUS WITH SELECTIVE SHIELDING CAPABILITY 审中-公开
标题翻译：选择性筛选射线治疗设备
公开(公告)号：EP2035088A2
公开(公告)日：2009-03-18
申请号：EP07796199.3
申请日：2007-06-15
申请人： Xoft, Inc.
发明人： SMITH, Peter, C. , KLEIN, Michael , HAUSEN, Heike , LOVOI, Paul, A.
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B2017/22051 , A61B2090/0481 , A61N2005/1003 , A61N2005/1005 , A61N2005/1094
摘要： Brachytherapy applicators incorporate various forms of selective shielding devices for controlling the direction and intensity of radiation directed at a patient's tissue. In some forms the applicators include a retractable sheath, in some a series of retractable fingers. In other forms the applicator, having an inflatable balloon, has a shield which is retractable from a position adjacent to the balloon or retracted from the balloon, or a shield can itself be inflatable, separately or together with the balloon.

6. 发明公开

EP2077899A2 BALLOON BRACHYTHERAPY APPLICATOR AND METHOD 有权
标题翻译： BALLON-BRACHYTHERAPIE-APPLIKATOR
公开(公告)号：EP2077899A2
公开(公告)日：2009-07-15
申请号：EP07839535.7
申请日：2007-10-12
申请人： Xoft, Inc.
发明人： FRANCESCATTI, Darius , HOFFMAN, David J. , KLEIN, Michael , TREMBERTH, Scott , JERVIS, James E. , LOVOI, Paul A.
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61M2025/1063
摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.

7. 发明授权

EP2077899B1 BALLOON BRACHYTHERAPY APPLICATOR 有权
标题翻译：气球近距治疗涂抹
公开(公告)号：EP2077899B1
公开(公告)日：2011-05-18
申请号：EP07839535.7
申请日：2007-10-12
申请人： Xoft, Inc.
发明人： FRANCESCATTI, Darius , HOFFMAN, David J. , KLEIN, Michael , TREMBERTH, Scott , JERVIS, James E. , LOVOI, Paul A.
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61M2025/1063
摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.

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