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1. 发明申请

US20060118319A1 Magnetic resonance imaging coated assembly 失效
公开(公告)号：US20060118319A1
公开(公告)日：2006-06-08
申请号：US11331928
申请日：2006-01-13
申请人： Xingwu Wang , Howard Greenwald , Jeffrey Helfer , Robert Gray , Michael Weiner
发明人： Xingwu Wang , Howard Greenwald , Jeffrey Helfer , Robert Gray , Michael Weiner
IPC分类号： H01B11/06
CPC分类号： G01R33/286 , A61K49/1818 , A61N1/16 , B82Y5/00 , B82Y25/00 , H01B11/10 , H01B11/1083 , H01F10/007 , H01F10/324
摘要： An assembly for shielding an implanted medical device from the effects of high-frequency radiation and for emitting magnetic resonance signals during magnetic resonance imaging. The assembly includes an implanted medical device and a magnetic shield comprised of nanomagnetic material disposed between the medical device and the high-frequency radiation. In one embodiment, the magnetic resonance signals are detected by a receiver, which is thus able to locate the implanted medical device within a biological organism.

2. 发明申请

US20060140867A1 Coated stent assembly and coating materials 审中-公开
标题翻译：涂层支架组件和涂层材料
公开(公告)号：US20060140867A1
公开(公告)日：2006-06-29
申请号：US11128591
申请日：2005-05-13
申请人： Jeffrey Helfer , Xingwu Wang , Robert Gray , Howard Greenwald
发明人： Jeffrey Helfer , Xingwu Wang , Robert Gray , Howard Greenwald
IPC分类号： A61K49/06
CPC分类号： A61K49/1821 , B82Y5/00
摘要： A high magnetic susceptibility nanomagnetic material that may be attached to recognition molecules and other therapeutic biological materials so as to be targeted to specific biologic tissues, thereby enabling the presence of the targeted tissue to be detected under magnetic resonance imaging with much greater sensitivity. Also a stent coated with such nanomagnetic material to enable artifact free imaging of such stent under magnetic resonance imaging.
摘要翻译：可以附着到识别分子和其他治疗生物材料上以便靶向特定生物组织的高磁化率纳米磁性材料，从而使得能够以更高的灵敏度在磁共振成像下存在待检测的靶组织。还有一种涂有这种纳米磁性材料的支架，以在磁共振成像下能够对这种支架进行无伪影成像。

3. 发明申请

US20050178584A1 Coated stent and MR imaging thereof 审中-公开
标题翻译：涂层支架及其MR成像
公开(公告)号：US20050178584A1
公开(公告)日：2005-08-18
申请号：US11052263
申请日：2005-02-07
申请人： Xingwu Wang , Robert Gray , Jeffrey Helfer
发明人： Xingwu Wang , Robert Gray , Jeffrey Helfer
IPC分类号： A61F2/06
CPC分类号： A61L31/088 , A61F2/82 , A61L31/14 , A61L2400/12
摘要： Disclosed in this specification is a stent coated with a layer comprised of particulates which have an average particle size of less than 100 nanometers; a saturation magnetization of at least 2,000 gauss; and where the average coherence length between the particulates is from about 1 nanometer to about 50 nanometers.
摘要翻译：在本说明书中公开了一种涂覆有平均粒径小于100纳米的颗粒的层的支架; 至少2,000高斯的饱和磁化强度; 并且其中颗粒之间的平均相干长度为约1纳米至约50纳米。

4. 发明申请

US20060118758A1 Material to enable magnetic resonance imaging of implantable medical devices 审中-公开
标题翻译：用于实现可植入医疗器械的磁共振成像的材料
公开(公告)号：US20060118758A1
公开(公告)日：2006-06-08
申请号：US11227590
申请日：2005-09-15
申请人： Xingwu Wang , Howard Greenwald , Robert Gray
发明人： Xingwu Wang , Howard Greenwald , Robert Gray
IPC分类号： H01F1/00 , H01F1/20
CPC分类号： H01F1/0063 , A61K49/18 , A61K49/1818 , A61K51/1244 , A61L29/18 , A61L31/18 , A61L2400/12 , B82Y5/00 , B82Y25/00
摘要： In accordance with the present invention, there is provided a composition of matter comprised of about 90% by weight of particles smaller than about 100 nanometers comprised of magnetic atoms. These nanomagnetic particles have a first magnetic moment between about 2 to about 3,000 emu per cubic centimeter, and a magnetic durability such that after about 6 months the magnetic moment does not vary by more than 5%. The nanomagnetic material, when used with implantable medical devices, upon exposure to magnetic resonance imaging (MRI) radiation, reduces the eddy currents, improves the imageability, cancels the positive susceptibility, improves the magnetic field about such devices, and may be used to modify the magnetic susceptibility of such devices. Also provided in accordance with the present invention is a preferred process for preparing such nanomagnetic material, certain preferred devices that comprise the nanomagnetic material, and a process for preparing certain flexible implantable medical devices that comprise the nanomagnetic material.
摘要翻译：根据本发明，提供了由约90重量％的由磁性原子组成的小于约100纳米的颗粒组成的物质组合物。这些纳米磁性颗粒具有约2至约3,000emu /立方厘米之间的第一磁矩和磁性耐久性，使得在约6个月后，磁矩不变化大于5％。当纳米磁性材料与可植入医疗器械一起使用时，在暴露于磁共振成像（MRI）辐射时，可减少涡流，改善成像性，消除正磁敏感，改善这种器件的磁场，并可用于修改这种器件的磁化率。根据本发明还提供了制备这种纳米磁性材料的优选方法，包含纳米磁性材料的某些优选装置，以及用于制备包含纳米磁性材料的某些柔性可植入医疗装置的方法。

5. 发明授权

US07091412B2 Magnetically shielded assembly 失效
标题翻译：磁屏蔽组装
公开(公告)号：US07091412B2
公开(公告)日：2006-08-15
申请号：US10780045
申请日：2004-02-17
申请人： Xingwu Wang , Howard J. Greenwald , Ronald E. Miller , Jeffrey L. Helfer , Robert Gray
发明人： Xingwu Wang , Howard J. Greenwald , Ronald E. Miller , Jeffrey L. Helfer , Robert Gray
IPC分类号： H05K9/00
CPC分类号： A61M25/0045 , A61M25/005 , A61M2025/0004 , A61M2025/0039 , A61M2025/004 , A61N1/3718 , A61N1/375 , B82Y25/00 , H01F10/007
摘要： A shielded medical device implanted in a biological organism. The device has a magnetic shield, and the magnetic shield contains a layer of nanomagnetic material; such layer has a morphological density of at least 98 percent. The nanomagnetic material in such layer has a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5,000 Oersteds, a a relative magnetic permeability of from about 1 to about 500,000, and an average particle size of less than about 100 nanometers.
摘要翻译：植入生物体内的屏蔽医疗器械。该器件具有磁屏蔽，磁屏蔽包含一层纳米磁性材料; 该层的形态密度至少为98％。该层中的纳米磁性材料具有约1至约36,000高斯的饱和磁化强度，约0.01至约5,000奥斯特的矫顽力，约1至约500,000的相对导磁率，平均粒径较小比约100纳米。

6. 发明授权

US07162302B2 Magnetically shielded assembly 失效
标题翻译：磁屏蔽组装
公开(公告)号：US07162302B2
公开(公告)日：2007-01-09
申请号：US10786198
申请日：2004-02-25
申请人： Xingwu Wang , Howard J. Greenwald , Ronald E. Miller , Jeffrey L. Helfer , Robert Gray
发明人： Xingwu Wang , Howard J. Greenwald , Ronald E. Miller , Jeffrey L. Helfer , Robert Gray
IPC分类号： A61N1/00
CPC分类号： A61F2/90 , A61F2210/0076 , A61F2210/009 , A61L29/10 , A61L29/14 , A61L31/082 , A61L31/14 , A61N1/16 , B82Y25/00 , H01F10/007 , Y10S977/931
摘要： A shielded medical device implanted in a biological organism. The device has a magnetic shield, and the magnetic shield contains a layer of nanomagnetic material; such layer has a morphological density of at least 98 percent; and it is bonded to the medical device by means of an interlayer with a thickness of less than about 10 microns. The nanomagnetic material in such layer has a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5,000 Oersteds, a relative magnetic permeability of from about 1 to about 500,000, and an average particle size of less than about 100 nanometers.
摘要翻译：植入生物体内的屏蔽医疗器械。该器件具有磁屏蔽，磁屏蔽包含一层纳米磁性材料; 该层的形态密度至少为98％; 并且通过厚度小于约10微米的中间层将其粘合到医疗装置上。该层中的纳米磁性材料具有约1至约36,000高斯的饱和磁化强度，约0.01至约5,000奥斯特的矫顽力，约1至约500,000的相对磁导率和较小的平均粒径比约100纳米。

7. 发明申请

US20060030774A1 Magnetic resonance imaging interference immune device 有权
标题翻译：磁共振成像干扰免疫装置
公开(公告)号：US20060030774A1
公开(公告)日：2006-02-09
申请号：US11248862
申请日：2005-10-12
申请人： Robert Gray , Jeffrey Helfer
发明人： Robert Gray , Jeffrey Helfer
IPC分类号： A61B6/00 , A61M25/00
CPC分类号： A61N1/37 , A61N1/05 , A61N1/086 , A61N1/3718 , G01R33/3685
摘要： A medical assembly includes a multi-wire lead having a plurality of coiling loops. The multi-wire lead has a gap region and a non-gap region. The gap region has adjacent coiling loops of the multi-wire lead with gaps therebetween so as to form different impedance in the gap region than impedance in the non-gap region. The non-gap region has adjacent coiling loops of the multi-wire lead with no gaps therebetween. The gaps may provide inter-loop capacitance. The multi-wire lead may have a plurality of gap regions, each gap region having a non-gap region therebetween.
摘要翻译：医疗组件包括具有多个卷绕环的多线引线。多线引线具有间隙区域和非间隙区域。间隙区域具有在其间具有间隙的多线引线的相邻卷绕环，以便在间隙区域中形成与非间隙区域中的阻抗不同的阻抗。非间隙区域具有多线引线的相邻卷绕环，其间没有间隙。间隙可以提供环路间电容。多线引线可以具有多个间隙区域，每个间隙区域之间具有非间隙区域。

8. 发明申请

US20050197563A1 Optical MRI catheter system 失效
标题翻译：光学MRI导管系统
公开(公告)号：US20050197563A1
公开(公告)日：2005-09-08
申请号：US11119677
申请日：2005-05-02
申请人： Jeffrey Helfer , Stuart MacDonald , Robert Gray , Christopher Thomas
发明人： Jeffrey Helfer , Stuart MacDonald , Robert Gray , Christopher Thomas
IPC分类号： A61B5/055 , A61M25/095 , G01R33/28 , A61B5/05
CPC分类号： A61B5/055 , G01R33/285 , G01R33/34084 , G01R33/3692
摘要： An assembly for delivering optical signals comprising a nuclear magnetic resonance system comprised of magnets, an NMR programmable logic unit, a signal input channel, and a command output channel; an optical interface assembly electrically connected to the nuclear magnetic resonance system, the optical interface assembly comprising a first laser modulated so as to produce laser optical signals, an interface optical to electrical signal convertor; and a catheter assembly connected to said optical interface assembly, the catheter assembly comprising a proximal end, a distal end, a fiber optic cable assembly, an electronics assembly disposed at the distal end comprised of a catheter electrical to optical signal convertor and a catheter optical to electrical signal convertor, and a first receiving coil disposed at the distal end.
摘要翻译：一种用于传送光信号的组件，包括由磁体组成的核磁共振系统，NMR可编程逻辑单元，信号输入通道和命令输出通道; 光学接口组件，其电连接到所述核磁共振系统，所述光学接口组件包括被调制以产生激光光信号的第一激光器，光信号到电信号转换器的接口; 以及连接到所述光学接口组件的导管组件，所述导管组件包括近端，远端，光纤电缆组件，设置在远端处的电子组件，所述电子组件包括电导向光信号转换器的导管和导管光学到电信号转换器，以及设置在远端的第一接收线圈。

9. 发明申请

US20050049685A1 Electromagnetic radiation transparent device and method of making thereof 有权
公开(公告)号：US20050049685A1
公开(公告)日：2005-03-03
申请号：US10923292
申请日：2004-08-20
申请人： Robert Gray , Stuart MacDonald , Jeffrey Helfer
发明人： Robert Gray , Stuart MacDonald , Jeffrey Helfer
IPC分类号： A61B5/05 , A61B5/055 , A61B19/00 , A61F2/00 , A61F2/86 , A61F2/90 , A61L31/02 , A61L31/12 , A61L31/18 , A61N1/16 , A61N2/00 , G01R33/28 , A61F2/06
CPC分类号： A61B5/02007 , A61B5/055 , A61B2090/374 , A61F2/86 , A61F2/90 , A61F2/91 , A61F2210/009 , A61F2220/0016 , A61L31/022 , A61L31/124 , A61L31/18 , A61N1/16 , A61N2/00 , G01R33/285
摘要： A medical device includes a pattern of electrically conductive material. The pattern of electrically conductive material has an anti-antenna geometrical shape such that the anti-antenna geometrical shape substantially prevents the medical device from creating an imaging artifact and/or substantially allows imaging of a volume within the medical device. The pattern may be formed by multiple “figure-8” shaped electrical conductors, multiple “figure-8” emulating electrical conductors, multiple sine-wave-like shaped electrical conductors, multiple zig-zag patterned electrical conductors, by multiple electrical conductors, each having sequential conductive loops, and/or a single conductor weaved into a loop mesh. The electrically conductive material may be titanium, tantalum, nitinol, stainless steel, and/or NbZr.

10. 发明申请

US20050049686A1 Electromagnetic radiation transparent device and method of making thereof 审中-公开
标题翻译：电磁辐射透明装置及其制造方法
公开(公告)号：US20050049686A1
公开(公告)日：2005-03-03
申请号：US10923411
申请日：2004-08-20
申请人： Robert Gray , Jeffrey Helfer
发明人： Robert Gray , Jeffrey Helfer
IPC分类号： A61B5/05 , A61B5/055 , A61B19/00 , A61F2/00 , A61F2/86 , A61F2/90 , A61L31/02 , A61L31/12 , A61L31/18 , A61N1/16 , A61N2/00 , G01R33/28 , A61F2/06
CPC分类号： A61B5/02007 , A61B5/055 , A61B2090/374 , A61F2/86 , A61F2/90 , A61F2/91 , A61F2210/009 , A61F2220/0016 , A61L31/022 , A61L31/124 , A61L31/18 , A61N1/16 , A61N2/00 , G01R33/285
摘要： A medical device includes a pattern of electrically conductive material. The pattern of electrically conductive material has an anti-antenna geometrical shape such that the anti-antenna geometrical shape substantially prevents the medical device from creating an imaging artifact and/or substantially allows imaging of a volume within the medical device. The pattern may be formed by multiple “figure-8” shaped electrical conductors, multiple “figure-8” emulating electrical conductors, multiple sine-wave-like shaped electrical conductors, multiple zig-zag patterned electrical conductors, by multiple electrical conductors, each having sequential conductive loops, and/or a single conductor weaved into a loop mesh. The electrically conductive material may be titanium, tantalum, nitinol, stainless steel, and/or NbZr.
摘要翻译：医疗装置包括导电材料的图案。导电材料的图案具有抗天线几何形状，使得反天线几何形状基本上防止医疗装置产生成像伪影和/或基本上允许医疗装置内的体积成像。该图案可以由多个“图8”形电导体，多个“图8”仿真电导体，多个正弦波状电导体，多个锯齿形图案电导体，由多个电导体，每个具有顺序导电回路，和/或编织成环网的单个导体。导电材料可以是钛，钽，镍钛诺，不锈钢和/或NbZr。

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