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1. 发明申请

US20110238174A1 ACCOMMODATING INTRAOCULAR LENS USING TRAPEZOIDAL PHASE SHIFT 有权
标题翻译：使用TRAPEZOIDAL相位移位调节内窥镜
公开(公告)号：US20110238174A1
公开(公告)日：2011-09-29
申请号：US13042688
申请日：2011-03-08
申请人： Xin Hong , Mutlu Karakelle , Son Tran , Xiaoxiao Zhang , Myoung-Taek Choi
发明人： Xin Hong , Mutlu Karakelle , Son Tran , Xiaoxiao Zhang , Myoung-Taek Choi
IPC分类号： A61F2/16
CPC分类号： A61F2/1629 , A61F2/1648 , A61F2/1694 , A61F2002/1683 , A61F2002/1699
摘要： An accommodating intraocular lens (AIOL) includes an optic adapted to produce a trapezoidal phase shift and a plurality of haptics. Each haptic extends from a haptic-optic junction to at least one transverse arm contacting a capsular bag of the eye, and each haptic has sufficient length and rigidity to stretch a capsular bag of the eye to contact ciliary muscles of the eye. The haptic-optic junctions vault the optic forward relative to the haptics and compression of the haptics by the ciliary muscles moves the anterior optic forward. A combined accommodative power produced by the motion of the anterior optic and the trapezoidal phase shift is at least 0.5 Diopters.
摘要翻译：适应性眼内透镜（AIOL）包括适于产生梯形相移和多个触觉的光学元件。每个触觉件从触觉 - 视觉连接处延伸到至少一个与眼睛囊袋接触的横向臂，并且每个触觉具有足够的长度和刚度，以拉伸眼睛的囊袋以接触眼睛的睫状肌。触觉视觉交叉点相对于触觉件向前保持视线，并且由睫状肌压迫襻部，使前视镜向前移动。通过前视镜和梯形相移的运动产生的组合调节力至少为0.5屈光度。

2. 发明授权

US09039762B2 Accommodating intraocular lens using trapezoidal phase shift 有权
标题翻译：使用梯形相移容纳人工晶状体
公开(公告)号：US09039762B2
公开(公告)日：2015-05-26
申请号：US13042688
申请日：2011-03-08
申请人： Xin Hong , Mutlu Karakelle , Son Tran , Xiaoxiao Zhang , Myoung-Taek Choi
发明人： Xin Hong , Mutlu Karakelle , Son Tran , Xiaoxiao Zhang , Myoung-Taek Choi
IPC分类号： A61F2/16
CPC分类号： A61F2/1629 , A61F2/1648 , A61F2/1694 , A61F2002/1683 , A61F2002/1699
摘要： An accommodating intraocular lens (AIOL) includes an optic adapted to produce a trapezoidal phase shift and a plurality of haptics. Each haptic extends from a haptic-optic junction to at least one transverse arm contacting a capsular bag of the eye, and each haptic has sufficient length and rigidity to stretch a capsular bag of the eye to contact ciliary muscles of the eye. The haptic-optic junctions vault the optic forward relative to the haptics and compression of the haptics by the ciliary muscles moves the anterior optic forward. A combined accommodative power produced by the motion of the anterior optic and the trapezoidal phase shift is at least 0.5 Diopters.
摘要翻译：适应性眼内透镜（AIOL）包括适于产生梯形相移和多个触觉的光学元件。每个触觉件从触觉 - 视觉连接处延伸到至少一个与眼睛囊袋接触的横向臂，并且每个触觉具有足够的长度和刚度，以拉伸眼睛的囊袋以接触眼睛的睫状肌。触觉视觉交叉点相对于触觉件向前保持视线，并且由睫状肌压迫襻部，使前视镜向前移动。通过前视镜和梯形相移的运动产生的组合调节力至少为0.5屈光度。

3. 发明申请

US20100016965A1 Accommodative IOL with Toric Optic and Extended Depth of Focus 审中-公开
标题翻译：适应性IOL与Toric Optic和扩展的焦点深度
公开(公告)号：US20100016965A1
公开(公告)日：2010-01-21
申请号：US12503307
申请日：2009-07-15
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Myoung-Taek Choi , Yan Zhang , Son Tran
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Myoung-Taek Choi , Yan Zhang , Son Tran
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1629 , A61F2/1645 , A61F2/1648 , G02C7/088
摘要： In one aspect, the present invention provides an intraocular lens (IOL), which comprises at least two optics disposed in tandem along an optical axis, and an accommodative mechanism that is coupled to at least one of the optics and is adapted to adjust a combined optical power of the optics in response to natural accommodative forces of an eye in which the optics are implanted so as to provide accommodation. At least one of the optics has a surface characterized by a first refractive region, a second refractive region and transition region therebetween, where an optical phase shift of incident light having a design wavelength (e.g., 550 nm) across the transition region corresponds to a non-integer fraction of that wavelength.
摘要翻译：在一个方面，本发明提供了一种眼内透镜（IOL），其包括沿着光轴串联设置的至少两个光学器件，以及调节机构，其耦合到所述光学器件中的至少一个并且适于调整组合响应于眼睛的自然调节力，光学器件的光学功率，其中植入光学器件以提供适应。至少一个光学元件具有由第一折射区域，第二折射区域和它们之间的过渡区域表征的表面，其中穿过过渡区域的具有设计波长（例如，550nm）的入射光的光学相移对应于该波长的非整数分数。

4. 发明授权

US08241354B2 Extended depth of focus (EDOF) lens to increase pseudo-accommodation by utilizing pupil dynamics 有权
标题翻译：扩展焦距（EDOF）镜头，通过利用瞳孔动力学增加伪适应度
公开(公告)号：US08241354B2
公开(公告)日：2012-08-14
申请号：US12503267
申请日：2009-07-15
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
IPC分类号： A61F2/16
CPC分类号： G02C7/044 , A61F2/1613 , G02C7/042
摘要： In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
摘要翻译：一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有围绕光轴设置的前表面和后表面的光学元件。至少一个表面（例如，前表面）具有由基体轮廓和辅助轮廓叠加来表征的轮廓。辅助轮廓可以包括内部区域，外部区域和内部区域和外部区域之间的过渡区域，其中穿过过渡区域的光程差（即，内部和外部径向边界之间的光程差）过渡区域）对应于设计波长（例如，约550nm的波长）的非整数分数（例如，1/2）。

5. 发明授权

US08100527B2 Intermediate vision with phakic multifocal optics utilizing residual accommodations 有权
标题翻译：中间视觉与复式多焦点光学利用残留住宿
公开(公告)号：US08100527B2
公开(公告)日：2012-01-24
申请号：US12522949
申请日：2008-01-11
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang
IPC分类号： G02C7/02 , A61F2/16
CPC分类号： A61F2/1602 , A61F2/1618 , A61F2/1654
摘要： In one aspect, the present invention provides a method of correcting vision, which comprises determining a residual accommodation exhibited by a natural, crystalline lens of an eye, and selecting a multifocal intraocular lens (IOL), which exhibits a far-focus optical power (e.g., in a range of about −15 to about +50 Diopters (D)) and an add power (e.g., in a range of about 1 D to about 4 D), for implantation in the eye while retaining the natural lens. The add power of the IOL is selected as a function of the residual accommodation such that a combination of the IOL and the natural lens provides a visual contrast greater than about 10% at a spatial frequency of about 20 cycles/degree for viewing objects at a distance greater than about 30 cm from the eye.
摘要翻译：一方面，本发明提供了一种矫正视力的方法，其包括确定由天然眼晶体显示的残留调节物，以及选择呈现远焦光功率的多焦点眼内透镜（IOL）例如，在约-15至约+50屈光度（D）的范围内）和附加功率（例如，在约1至约4D的范围内），用于植入眼睛同时保持天然晶状体。选择IOL的附加功率作为残余调节的函数，使得IOL和自然透镜的组合在大约20个循环/度的空间频率处提供大于约10％的视觉对比度，以便在距离距离眼睛约30厘米。

6. 发明申请

US20080147185A1 Correction of chromatic aberrations in intraocular lenses 审中-公开
标题翻译：眼内透镜色差校正
公开(公告)号：US20080147185A1
公开(公告)日：2008-06-19
申请号：US11444113
申请日：2006-05-31
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Joseph Weinschenk , Daniel R. Carson
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Joseph Weinschenk , Daniel R. Carson
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1637 , A61F2/1648 , A61F2250/0053 , G02B27/0025
摘要： In one aspect, the present invention provides an intraocular lens that includes a posterior optic and anterior optic. The optics have different chromatic dispersions adapted to cooperatively provide compensation for natural chromatic aberrations of the eye over a wavelength range of interest, e.g., over a wavelength range of about 400 nm to about 700 nm.
摘要翻译：一方面，本发明提供一种眼内透镜，其包括后视镜和前视镜。光学器件具有不同的色散，适于在感兴趣的波长范围（例如在约400nm至约700nm的波长范围内）协调地为眼睛的自然色差提供补偿。

7. 发明申请

US20070282438A1 Intraocular lenses with enhanced off-axis visual performance 审中-公开
标题翻译：具有增强的离轴视觉性能的人工晶状体
公开(公告)号：US20070282438A1
公开(公告)日：2007-12-06
申请号：US11443766
申请日：2006-05-31
申请人： Xin Hong , Mutlu Karakelle , XiaoXiao Zhang
发明人： Xin Hong , Mutlu Karakelle , XiaoXiao Zhang
IPC分类号： A61F2/16
CPC分类号： A61F2/1637 , A61F2/1648
摘要： The present invention is generally directed to multi-surface and/or multi-element intraocular lenses (IOLs) in which a plurality of surfaces are adapted to provide compensation for a variety of aberrations, and in particular, for off-axis aberrations such as coma or spherical aberration. In one aspect, an intraocular lens is disclosed that includes a posterior optic and an anterior optic. One optic provides compensation for a radially symmetric aberration and the other provides compensation for a radially asymmetric aberration.
摘要翻译：本发明通常涉及多表面和/或多元素眼内透镜（IOL），其中多个表面适于为各种像差提供补偿，特别是针对诸如彗差的偏轴像差或球面像差。一方面，公开了一种眼内透镜，其包括后视镜和前视镜。一个光学器件提供对于径向对称像差的补偿，另一个为径向非对称像差提供补偿。

8. 发明申请

US20100134754A1 ALTERNATING OPTICAL SYSTEM: MIXING AND MATCHING OPTICS TO MAXIMIZE BINOCULAR VISUAL BENEFITS 有权
标题翻译：交替光学系统：混合和匹配光学最大化双目视觉效益
公开(公告)号：US20100134754A1
公开(公告)日：2010-06-03
申请号：US12522824
申请日：2008-01-11
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Arthur Bradley
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Arthur Bradley
IPC分类号： G02C7/04 , G02C7/06 , A61F2/16
CPC分类号： A61F2/1613 , A61F2/1621 , A61F2/1648 , G02C7/027 , G02C7/028 , G02C7/04 , G02C2202/20
摘要： In one aspect, the present invention provides a method for correcting vision that employs two lenses, at least one of which is a multifocal lens, with different focusing characteristics for use in the two eyes of the patient. The visual performance of each lens (e.g., visual contrast or acuity) is selected in accordance with a predefined relation so as to optimize the binocular visual performance provided by the combination of the lenses.
摘要翻译：一方面，本发明提供了一种用于矫正视力的方法，该方法采用两个透镜，其中至少一个是多焦点透镜，具有不同的聚焦特性，用于患者的两只眼睛。根据预定关系来选择每个透镜的视觉性能（例如，视觉对比度或锐度），以便优化由透镜的组合提供的双目视觉性能。

9. 发明授权

US07350916B2 Intraocular lens 有权
标题翻译：人工晶状体
公开(公告)号：US07350916B2
公开(公告)日：2008-04-01
申请号：US11397332
申请日：2006-04-04
申请人： Xin Hong , Jihong Xie , Stephen J. Van Noy , Dan Stanley , Mutlu Karakelle , Xiaoxiao Zhang , Michael J. Simpson
发明人： Xin Hong , Jihong Xie , Stephen J. Van Noy , Dan Stanley , Mutlu Karakelle , Xiaoxiao Zhang , Michael J. Simpson
IPC分类号： G02C7/02 , A61F2/16
CPC分类号： A61F2/1613 , A61F2/1637 , G02C7/02
摘要： In one aspect, the present invention provide an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior optical surface and a posterior optical surface, where the optic provides an optical power in a range of about 16 D to about 25 D as measured in a medium having an index of refraction substantially similar to that of the eye's aqueous humor (e.g., about 1.336). At least one of the optical surfaces is characterized by an aspherical base profile such that the optic exhibits a negative spherical aberration in a range of about −0.202 microns to about −0.190 microns across the power range.
摘要翻译：一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有前光学表面和后光学表面的光学元件，其中所述光学元件提供在约16D至约25D的范围内的光焦度如在具有基本上类似于眼睛房水的折射率的介质中测量的（例如，约1.336）。至少一个光学表面的特征在于非球面基部轮廓，使得光学器件在功率范围内在约-0.202微米至约-0.190微米的范围内呈现负球面像差。

10. 发明申请

US20080004698A1 Correction of surgically-induced astigmatism during intraocular lens implants 审中-公开
标题翻译：人工晶状体植入物中外科手术引起的散光矫正
公开(公告)号：US20080004698A1
公开(公告)日：2008-01-03
申请号：US11479223
申请日：2006-06-30
申请人： Kamal K. Das , Xiaoxiao Zhang , Mutlu Karakelle , Xin Hong
发明人： Kamal K. Das , Xiaoxiao Zhang , Mutlu Karakelle , Xin Hong
IPC分类号： A61F2/16
CPC分类号： A61F2/142 , A61F2/145 , A61F2/16 , A61F9/007 , A61F2009/00848 , A61F2009/00851 , A61F2240/00 , A61F2240/001 , A61F2240/002
摘要： In one aspect, the present invention provides a method of designing an ocular implant (e.g., an IOL), which comprises establishing corneal topography of a patient's eye, e.g., by performing one or more wavefront aberration measurements of the eye, prior to an ocular surgery. The method further includes ascertaining an astigmatic aberration of the cornea that is expected to be induced by the surgery and determining a toricity of a surface of an ocular implant, which is intended for implantation in the patient's eye, so as to enable the implant to compensate for the surgically-induced aberration.
摘要翻译：一方面，本发明提供了一种设计眼部植入物（例如，IOL）的方法，其包括建立患者眼睛的角膜形貌，例如通过在眼睛之前执行眼睛的一个或多个波前像差测量手术。该方法还包括确定期望由手术引起的角膜的像散像差，并确定旨在植入患者眼睛中的眼部植入物的表面的复曲面，以使植入物能够补偿用于手术诱发的像差。

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