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1. 发明申请

US20100049290A1 MRI COMPATIBLE LEAD 有权
标题翻译： MRI兼容导联
公开(公告)号：US20100049290A1
公开(公告)日：2010-02-25
申请号：US12197957
申请日：2008-08-25
申请人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
发明人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/086
摘要： Disclosed herein is an implantable medical lead. In one embodiment, the lead includes a ring electrode, a tip electrode, first and second helically wound coaxial conductor coils, and a distal coil transition. The coils extend between the proximal and distal ends of the lead. The distal coil transition is proximal to the ring electrode and near the distal end and is where the first coil transitions from being outside the second coil proximal of the distal coil transition to being inside the second coil distal of the distal coil transition.
摘要翻译：本文公开了可植入医疗引线。在一个实施例中，引线包括环形电极，尖端电极，第一和第二螺旋缠绕的同轴导体线圈和远端线圈转变。线圈在引线的近端和远端之间延伸。远侧线圈转变靠近环形电极并且靠近远端，并且是第一线圈从远端线圈过渡处的第二线圈的外侧转变到远端线圈转变远端的第二线圈内部的位置。

2. 发明授权

US08244375B2 MRI compatible lead 有权
标题翻译： MRI兼容铅
公开(公告)号：US08244375B2
公开(公告)日：2012-08-14
申请号：US12197957
申请日：2008-08-25
申请人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
发明人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/086
摘要： Disclosed herein is an implantable medical lead. In one embodiment, the lead includes a ring electrode, a tip electrode, first and second helically wound coaxial conductor coils, and a distal coil transition. The coils extend between the proximal and distal ends of the lead. The distal coil transition is proximal to the ring electrode and near the distal end and is where the first coil transitions from being outside the second coil proximal of the distal coil transition to being inside the second coil distal of the distal coil transition.
摘要翻译：本文公开了可植入医疗引线。在一个实施例中，引线包括环形电极，尖端电极，第一和第二螺旋缠绕的同轴导体线圈和远端线圈转变。线圈在引线的近端和远端之间延伸。远侧线圈转变靠近环形电极并且靠近远端，并且是第一线圈从远端线圈过渡处的第二线圈的外侧转变到远端线圈转变远端的第二线圈内部的位置。

3. 发明申请

US20110125240A1 BIOCOMPATIBLE INDUCTOR FOR IMPLANTABLE LEAD AND METHOD OF MAKING SAME 审中-公开
标题翻译：用于可植入铅的生物电解电容器及其制造方法
公开(公告)号：US20110125240A1
公开(公告)日：2011-05-26
申请号：US12622847
申请日：2009-11-20
申请人： Yong D. Zhao , Xiaoyi Min , Virote Indravudh , Ingmar Viohl , J. Christopher Moulder , Kevin L. Morgan , Phong D. Doan
发明人： Yong D. Zhao , Xiaoyi Min , Virote Indravudh , Ingmar Viohl , J. Christopher Moulder , Kevin L. Morgan , Phong D. Doan
IPC分类号： A61N1/05
CPC分类号： A61N1/0573 , A61N1/086
摘要： A biocompatible inductor for an implantable medical lead is disclosed herein. In one embodiment the biocompatible inductor may include a biocompatible bobbin and a wire wound about a barrel of the biocompatible bobbin to form a coil. The wire may include an electrically conductive core, an electrically conductive biocompatible jacket extending over the core, and a coating of high dielectric strength insulation material extending over the jacket. Additionally, the biocompatible inductor may include medical adhesive located in gaps within the coil and a polyester shrink tube covering the coil.
摘要翻译：本文公开了用于可植入医疗引线的生物相容性电感器。在一个实施方案中，生物相容性感应器可以包括生物相容的线轴和缠绕在生物相容线圈架的筒上的线以形成线圈。线可以包括导电芯，在芯上延伸的导电生物相容性护套，以及在护套上延伸的高介电强度绝缘材料的涂层。此外，生物相容性电感器可以包括位于线圈内的间隙中的医用粘合剂和覆盖线圈的聚酯收缩管。

4. 发明申请

US20120215271A1 SYSTEMS AND METHODS FOR DISCONNECTING ELECTRODES OF LEADS OF IMPLANTABLE MEDICAL DEVICES DURING AN MRI TO REDUCE LEAD HEATING 审中-公开
标题翻译：用于断开MRI中的可植入医疗器械引线电极的系统和方法，以减少引线加热
公开(公告)号：US20120215271A1
公开(公告)日：2012-08-23
申请号：US13450127
申请日：2012-04-18
申请人： Xiaoyi Min , Martin Cholette , J. Christopher Moulder
发明人： Xiaoyi Min , Martin Cholette , J. Christopher Moulder
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3718 , A61N1/086
摘要： Systems and methods are provided for reducing heating within pacing/sensing leads of a pacemaker or implantable, cardioverter-defibrillator that occurs due to induced loop currents during a magnetic resonance imaging (MRI) procedure, or in the presence of other sources of strong radio frequency (RF) fields. For example, bipolar coaxial leads are described herein wherein the ring conductor of the lead is disconnected from the ring electrode in response to detection of MRI fields so as to convert the ring conductor into an RF shield for shielding the inner tip conductor of the lead so as to reduce the strength of loop currents induced therein and hence reduce tip heating.
摘要翻译：提供的系统和方法用于减少起搏器或可植入的心律转复除颤器的起搏/感测引线内的加热，由于在磁共振成像（MRI）程序期间由于感应回路电流而发生，或者存在其他强射频源（RF）领域。例如，这里描述了双极同轴引线，其中响应于MRI场的检测，引线的环形导体与环形电极断开，以便将环形导体转换成用于屏蔽引线的内部尖端导体的RF屏蔽以减少其中引起的环路电流的强度，从而减少尖端加热。

5. 发明申请

US20100106227A1 Systems and Methods for Disconnecting Electrodes of Leads of Implantable Medical Devices During an MRI to Reduce Lead Heating 审中-公开
标题翻译：在MRI期间断开可植入医疗器械引线电极的系统和方法，以减少引线加热
公开(公告)号：US20100106227A1
公开(公告)日：2010-04-29
申请号：US12257245
申请日：2008-10-23
申请人： Xiaoyi Min , Martin Cholette , J. Christopher Moulder
发明人： Xiaoyi Min , Martin Cholette , J. Christopher Moulder
IPC分类号： A61N1/05 , A61N1/372 , A61N1/36
CPC分类号： A61N1/3718 , A61N1/086
摘要： Systems and methods are provided for reducing heating within pacing/sensing leads of a pacemaker or implantable cardioverter-defibrillator that occurs due to induced loop currents during a magnetic resonance imaging (MRI) procedure, or in the presence of other sources of strong radio frequency (RF) fields. For example, bipolar coaxial leads are described herein wherein the ring conductor of the lead is disconnected from the ring electrode in response to detection of MRI fields so as to convert the ring conductor into an RF shield for shielding the inner tip conductor of the lead so as to reduce the strength of loop currents induced therein and hence reduce tip heating. Techniques are also described herein for selectively disconnecting the tip electrode of the lead during an MRI procedure, except during actual delivery of pacing pulses, so as to permit delivery of individual pacing pulses to pacemaker dependent patients during the MRI. Still other techniques describe the use of both RF shielding and tip switching.
摘要翻译：提供了系统和方法，用于减少起搏器或植入式心律转复除颤器的起搏/感应引线内的加热，由于在磁共振成像（MRI）程序期间由于感应回路电流而发生，或者存在其他强射频源（ RF）字段。例如，这里描述了双极同轴引线，其中响应于MRI场的检测，引线的环形导体与环形电极断开，以便将环形导体转换成用于屏蔽引线的内部尖端导体的RF屏蔽以减少其中引起的环路电流的强度，从而减少尖端加热。本文还描述了在MRI过程期间选择性地断开引线的尖端电极的技术，除了在实际递送起搏脉冲之前，以便允许在MRI期间将起搏器依赖患者的单个起搏脉冲输送到起搏器依赖患者。其他技术还描述了使用RF屏蔽和尖端切换。

6. 发明申请

US20100114276A1 MRI COMPATIBLE IMPLANTABLE MEDICAL LEAD AND METHOD OF MAKING SAME 有权
标题翻译： MRI兼容可植入医疗用铅及其制造方法
公开(公告)号：US20100114276A1
公开(公告)日：2010-05-06
申请号：US12262047
申请日：2008-10-30
申请人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Virote Indravudh , Ingmar Viohl
发明人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Virote Indravudh , Ingmar Viohl
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/086 , H01F17/00
摘要： An implantable medical lead is disclosed herein. In one embodiment, the lead includes a body and an electrical pathway. The body may include a distal portion with an electrode and a proximal portion with a lead connector end. The electrical pathway may extend between the electrode and lead connector end and include a coiled inductor including a first portion and a second portion at least partially magnetically decoupled from the first portion. The first portion may include a first configuration having a first SRF. The second portion may include a second configuration different from the first configuration. The second configuration may have a second SRF different from the first SRF. For example, the first SRF may be near 64 MHz and the second SRF may be near 128 MHz.
摘要翻译：本文公开了可植入医疗引线。在一个实施例中，引线包括主体和电路径。主体可以包括具有电极的远端部分和具有引线连接器端部的近端部分。电路可以在电极和引线连接器端之间延伸，并且包括线圈电感器，其包括至少部分地与第一部分磁耦合的第一部分和第二部分。第一部分可以包括具有第一SRF的第一配置。第二部分可以包括不同于第一配置的第二配置。第二配置可以具有与第一SRF不同的第二SRF。例如，第一SRF可以接近64MHz，而第二SRF可以接近128MHz。

7. 发明授权

US08634931B2 MRI compatible implantable medical lead and method of making same 有权
标题翻译： MRI兼容的植入式医用引线及其制造方法
公开(公告)号：US08634931B2
公开(公告)日：2014-01-21
申请号：US12262047
申请日：2008-10-30
申请人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Virote Indravudh , Ingmar Viohl
发明人： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Virote Indravudh , Ingmar Viohl
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/086 , H01F17/00
摘要： An implantable medical lead is disclosed herein. In one embodiment, the lead includes a body and an electrical pathway. The body may include a distal portion with an electrode and a proximal portion with a lead connector end. The electrical pathway may extend between the electrode and lead connector end and include a coiled inductor including a first portion and a second portion at least partially magnetically decoupled from the first portion. The first portion may include a first configuration having a first SRF. The second portion may include a second configuration different from the first configuration. The second configuration may have a second SRF different from the first SRF. For example, the first SRF may be near 64 MHz and the second SRF may be near 128 MHz.
摘要翻译：本文公开了可植入医疗引线。在一个实施例中，引线包括主体和电路径。主体可以包括具有电极的远端部分和具有引线连接器端部的近端部分。电路可以在电极和引线连接器端之间延伸，并且包括线圈电感器，其包括至少部分地与第一部分磁耦合的第一部分和第二部分。第一部分可以包括具有第一SRF的第一配置。第二部分可以包括不同于第一配置的第二配置。第二配置可以具有与第一SRF不同的第二SRF。例如，第一SRF可以接近64MHz，而第二SRF可以接近128MHz。

8. 发明授权

US08099173B2 Implantable medical lead circuitry and methods for reducing heating and/or induced current 有权
标题翻译：可植入医疗引线电路和减少加热和/或感应电流的方法
公开(公告)号：US08099173B2
公开(公告)日：2012-01-17
申请号：US12393972
申请日：2009-02-26
申请人： J. Christopher Moulder , Martin Cholette
发明人： J. Christopher Moulder , Martin Cholette
IPC分类号： A61N1/00
CPC分类号： A61N1/37 , A61N1/3718
摘要： An implantable medical lead for coupling to an implantable pulse generator may be configured for improved safety. The lead may include: a first electrode; a second electrode in electrical communication with the first electrode; and an active circuit element in electrical communication with the first electrode and the second electrode. The active circuit element may be configured to change an impedance of the lead. The active circuit element may be configured to change the impedance of the lead in response to a pacing signal or a signal having opposite polarity to a pacing signal. A method of using an implantable medical lead for improved safety may include changing an impedance of an implantable medical lead from a relatively high impedance to a relatively low impedance and/or changing an impedance of an implantable medical lead from a relatively low impedance to a relatively high impedance.
摘要翻译：用于耦合到可植入脉冲发生器的可植入医疗引线可以被配置为提高安全性。引线可以包括：第一电极; 与所述第一电极电连通的第二电极; 以及与第一电极和第二电极电连通的有源电路元件。有源电路元件可以被配置为改变引线的阻抗。有源电路元件可以被配置为响应于起搏信号或与起搏信号具有相反极性的信号来改变引线的阻抗。使用可植入医疗引线以改善安全性的方法可包括将可植入医疗引线的阻抗从相对高的阻抗改变为相对较低的阻抗和/或将可植入医疗引线的阻抗从相对较低的阻抗改变为相对较低的阻抗高阻抗。

9. 发明申请

US20100217366A1 Implantable Medical Lead Circuitry and Methods for Reducing Heating and/or Induced Current 有权
标题翻译：可植入医疗铅电路和减少加热和/或诱导电流的方法
公开(公告)号：US20100217366A1
公开(公告)日：2010-08-26
申请号：US12393972
申请日：2009-02-26
申请人： J. Christopher Moulder , Martin Cholette
发明人： J. Christopher Moulder , Martin Cholette
IPC分类号： A61N1/05
CPC分类号： A61N1/37 , A61N1/3718
摘要： An implantable medical lead for coupling to an implantable pulse generator may be configured for improved safety. The lead may include: a first electrode; a second electrode in electrical communication with the first electrode; and an active circuit element in electrical communication with the first electrode and the second electrode. The active circuit element may be configured to change an impedance of the lead. The active circuit element may be configured to change the impedance of the lead in response to a pacing signal or a signal having opposite polarity to a pacing signal. A method of using an implantable medical lead for improved safety may include changing an impedance of an implantable medical lead from a relatively high impedance to a relatively low impedance and/or changing an impedance of an implantable medical lead from a relatively low impedance to a relatively high impedance.
摘要翻译：用于耦合到可植入脉冲发生器的可植入医疗引线可以被配置为提高安全性。引线可以包括：第一电极; 与所述第一电极电连通的第二电极; 以及与第一电极和第二电极电连通的有源电路元件。有源电路元件可以被配置为改变引线的阻抗。有源电路元件可以被配置为响应于起搏信号或与起搏信号具有相反极性的信号来改变引线的阻抗。使用可植入医疗引线以改善安全性的方法可包括将可植入医疗引线的阻抗从相对高的阻抗改变为相对较低的阻抗和/或将可植入医疗引线的阻抗从相对较低的阻抗改变为相对较低的阻抗高阻抗。

10. 发明授权

US08718750B2 Heart stimulator and method for A-V delay optimization 有权
标题翻译：心脏刺激器和A-V延时优化方法
公开(公告)号：US08718750B2
公开(公告)日：2014-05-06
申请号：US13462134
申请日：2012-05-02
申请人： Jie Lian , J. Christopher Moulder , Dirk Muessig
发明人： Jie Lian , J. Christopher Moulder , Dirk Muessig
IPC分类号： A61B5/04
CPC分类号： A61N1/3684 , A61N1/3627 , A61N1/36521 , A61N1/36578 , A61N1/36592 , A61N1/3682
摘要： Exemplary methods and apparatuses are disclosed that provide for determination of an atrio-ventricular delay on a beat-to-beat basis by determining a P-wave duration from electric signals corresponding to electric potentials in a heart, and determining the atrio-ventricular delay on a beat-to-beat basis such that the atrio-ventricular delay for an individual heart cycle depends on the P-wave duration of a same or an immediately preceding heart cycle.
摘要翻译：公开了示例性方法和装置，其通过从对应于心脏中的电位的电信号确定P波持续时间来提供基于节拍的心房延迟的确定，并且确定心室上的心室延迟以心跳为基础，使得个体心脏周期的心室延迟取决于相同或紧接在前的心脏周期的P波持续时间。

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