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1. 发明申请

US20120226140A1 SYSTEMS AND METHODS FOR REMOTE MONITORING OF SIGNALS SENSED BY AN IMPLANTABLE MEDICAL DEVICE DURING AN MRI 有权
标题翻译：用于远程监测MRI期间由可植入医疗器械传感的信号的系统和方法
公开(公告)号：US20120226140A1
公开(公告)日：2012-09-06
申请号：US13471018
申请日：2012-05-14
申请人： Xiaoyi Min , Gabriel A. Mouchawar
发明人： Xiaoyi Min , Gabriel A. Mouchawar
IPC分类号： A61B5/055
CPC分类号： A61N1/3718 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/0422 , A61B5/686 , A61B5/7203
摘要： Systems and methods are provided for allowing an implantable medical device, such as pacemaker, to properly sense electrophysiological signals and hemodynamic signals within a patient during a magnetic resonance imaging (MRI) procedure. Systems and methods are also provided for allowing the implantable medical device to transmit the sensed data to an external monitoring system during the MRI procedure so that attending medical personnel can closely monitor the health of the patient and the operation of the implantable device during the MRI. These improvements provide the attending personnel with information needed to determine whether the MRI should be suspended in response to induced tachyarrhythmias or other adverse conditions within the patient.
摘要翻译：提供了系统和方法，用于允许诸如起搏器的可植入医疗装置在磁共振成像（MRI）程序期间适当地感测患者内的电生理信号和血液动力学信号。还提供了系统和方法，以允许可植入医疗设备在MRI过程期间将感测到的数据传送到外部监视系统，使得参加医务人员可以在MRI期间密切监视患者的健康状况和可植入装置的操作。这些改进为主管人员提供了确定是否应该根据感染性快速性心律失常或患者其他不良情况暂停MRI的信息。

2. 发明申请

US20130116741A1 DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH INTRA-CARDIAC EXTENSION 有权
标题翻译：双室无胸腔内科医疗器械与心脏扩张
公开(公告)号：US20130116741A1
公开(公告)日：2013-05-09
申请号：US13352136
申请日：2012-01-17
申请人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
发明人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/057 , A61N1/0573 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3688 , A61N1/3756
摘要： A leadless intra-cardiac medical device includes a housing that is configured to be implanted entirely within a single local chamber of the heart. A first electrode is provided on the housing at a first position such that when the housing is implanted in the local chamber, the first electrode engages the local wall tissue at a local activation site within the conduction network of the local chamber. An intra-cardiac extension is coupled to the housing and configured to extend from the local chamber into an adjacent chamber of the heart. A stabilization arm of the intra-cardiac extension engages the adjacent chamber. A second electrode on the intra-cardiac extension engages distal wall tissue at a distal activation site within the conduction network of the adjacent chamber.
摘要翻译：无引线心脏内心脏医疗设备包括被配置为完全植入心脏的单个局部腔室内的壳体。第一电极在第一位置处设置在壳体上，使得当壳体被植入局部腔室时，第一电极在局部腔室的传导网络内的局部激活位置接合局部壁组织。心脏内延伸部分耦合到壳体并且构造成从局部腔室延伸到心脏的相邻室中。心脏内延伸部的稳定臂与相邻的腔室相接合。心脏延伸部分上的第二个电极与相邻腔室的传导网络内的远端活化位点处的远端壁组织接合。

3. 发明授权

US08620446B2 Systems and methods for remote monitoring of signals sensed by an implantable medical device during an MRI 有权
标题翻译：用于在MRI期间远程监测由可植入医疗装置感测的信号的系统和方法
公开(公告)号：US08620446B2
公开(公告)日：2013-12-31
申请号：US13471018
申请日：2012-05-14
申请人： Xiaoyi Min , Gabriel A. Mouchawar
发明人： Xiaoyi Min , Gabriel A. Mouchawar
IPC分类号： A61N1/08
CPC分类号： A61N1/3718 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/0422 , A61B5/686 , A61B5/7203
摘要： Systems and methods are provided for allowing an implantable medical device, such as pacemaker, to properly sense electrophysiological signals and hemodynamic signals within a patient during a magnetic resonance imaging (MRI) procedure. Systems and methods are also provided for allowing the implantable medical device to transmit the sensed data to an external monitoring system during the MRI procedure so that attending medical personnel can closely monitor the health of the patient and the operation of the implantable device during the MRI. These improvements provide the attending personnel with information needed to determine whether the MRI should be suspended in response to induced tachyarrhythmias or other adverse conditions within the patient.
摘要翻译：提供了系统和方法，用于允许诸如起搏器的可植入医疗装置在磁共振成像（MRI）程序期间适当地感测患者内的电生理信号和血液动力学信号。还提供了系统和方法，以允许可植入医疗设备在MRI过程期间将感测到的数据传送到外部监视系统，使得参加医务人员可以在MRI期间密切监视患者的健康状况和可植入装置的操作。这些改进为主管人员提供了确定是否应该根据感染性快速性心律失常或患者其他不良情况暂停MRI的信息。

4. 发明授权

US08200334B1 Systems and methods for remote monitoring of signals sensed by an implantable medical device during an MRI 有权
标题翻译：用于在MRI期间远程监测由可植入医疗装置感测的信号的系统和方法
公开(公告)号：US08200334B1
公开(公告)日：2012-06-12
申请号：US11938088
申请日：2007-11-09
申请人： Xiaoyi Min , Gabriel A. Mouchawar
发明人： Xiaoyi Min , Gabriel A. Mouchawar
IPC分类号： A61N1/08
CPC分类号： A61N1/3718 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/0422 , A61B5/686 , A61B5/7203
摘要： Systems and methods are provided for allowing an implantable medical device, such as pacemaker, to properly sense electrophysiological signals and hemodynamic signals within a patient during a magnetic resonance imaging (MRI) procedure. Systems and methods are also provided for allowing the implantable medical device to transmit the sensed data to an external monitoring system during the MRI procedure so that attending medical personnel can closely monitor the health of the patient and the operation of the implantable device during the MRI. These improvements provide the attending personnel with information needed to determine whether the MRI should be suspended in response to induced tachyarrhythmias or other adverse conditions within the patient.
摘要翻译：提供了系统和方法，用于允许诸如起搏器的可植入医疗装置在磁共振成像（MRI）程序期间适当地感测患者内的电生理信号和血液动力学信号。还提供了系统和方法，以允许可植入医疗设备在MRI过程期间将感测到的数据传送到外部监视系统，使得参加医务人员可以在MRI期间密切监视患者的健康状况和可植入装置的操作。这些改进为主管人员提供了确定是否应该根据感染性快速性心律失常或患者其他不良情况暂停MRI的信息。

5. 发明授权

US09008777B2 Leadless intra-cardiac medical device with reduced number of feed-thrus 有权
标题翻译：无铅心脏内心脏医疗器械，饲料数量减少
公开(公告)号：US09008777B2
公开(公告)日：2015-04-14
申请号：US13529226
申请日：2012-06-21
申请人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
发明人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
IPC分类号： A61N1/00 , A61N1/375 , A61N1/368
CPC分类号： A61N1/3756 , A61B5/042 , A61N1/362 , A61N1/368 , Y10T29/49002
摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.
摘要翻译：无引线植入式医疗装置（LIMD）包括由电池和端盖形成的壳体。端盖的近端形成LIMD近端，并且电池壳体的远端形成LIMD远端。非导电耦合器将电池壳体的终端机械地固定到端盖的配合端，同时保持电池壳体和端盖电气分离。第一电极从端盖的近端突出。心脏内（IC）装置延伸部从电池盒的远端伸出。该延伸部包括电连接到电池壳体的第二电极。第二电极远离LIMD远端。电子模块位于端盖的内部空腔内并与第一和第二电极连通。

6. 发明授权

US08634912B2 Dual-chamber leadless intra-cardiac medical device with intra-cardiac extension 有权
标题翻译：具有心脏扩张的双室无引导心脏内心脏医疗器械
公开(公告)号：US08634912B2
公开(公告)日：2014-01-21
申请号：US13352136
申请日：2012-01-17
申请人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
发明人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/057 , A61N1/0573 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3688 , A61N1/3756
摘要： A leadless intra-cardiac medical device includes a housing that is configured to be implanted entirely within a single local chamber of the heart. A first electrode is provided on the housing at a first position such that when the housing is implanted in the local chamber, the first electrode engages the local wall tissue at a local activation site within the conduction network of the local chamber. An intra-cardiac extension is coupled to the housing and configured to extend from the local chamber into an adjacent chamber of the heart. A stabilization arm of the intra-cardiac extension engages the adjacent chamber. A second electrode on the intra-cardiac extension engages distal wall tissue at a distal activation site within the conduction network of the adjacent chamber.
摘要翻译：无引线心脏内心脏医疗设备包括被配置为完全植入心脏的单个局部腔室内的壳体。第一电极在第一位置处设置在壳体上，使得当壳体被植入局部腔室时，第一电极在局部腔室的传导网络内的局部激活位置接合局部壁组织。心脏内延伸部分耦合到壳体并且构造成从局部腔室延伸到心脏的相邻室中。心脏内延伸部的稳定臂与相邻的腔室相接合。心脏延伸部分上的第二个电极与相邻腔室的传导网络内的远端活化位点处的远端壁组织接合。

7. 发明申请

US20110301676A1 REDUCING RESONANT CURRENTS IN A RESONATING CIRCUIT DURING MRI SCANS 审中-公开
标题翻译：在MRI扫描期间在谐振电路中降低谐振电流
公开(公告)号：US20110301676A1
公开(公告)日：2011-12-08
申请号：US12792616
申请日：2010-06-02
申请人： Jin Zhang , Xiaoyi Min , Ingmar Viohl , Gabriel A. Mouchawar , Xiangqun Chen
发明人： Jin Zhang , Xiaoyi Min , Ingmar Viohl , Gabriel A. Mouchawar , Xiangqun Chen
IPC分类号： A61N1/05 , H01R43/20
CPC分类号： A61N1/0573 , A61N1/086 , Y10T29/49208
摘要： An implantable medical lead configured to reduce resonant currents in a resonating circuit during MRI scans and a method of manufacturing the same are disclosed herein. The method of manufacturing includes providing a medical lead comprising an electrical pathway from a tip electrode located at a distal end of the lead to a lead connector located at a proximal end and coupling a resonating circuit to the tip electrode such that the resonating circuit is in the electrical pathway for the tip electrode. Further, the method includes coupling a capacitive element to a proximal end of the resonating circuit. The capacitive element is configured to shunt at least part of an RF current induced on the electrical pathway into surrounding tissue or fluid and also works as a heat sink to spread the heat from the internal LC resonant circuit.
摘要翻译：本文公开了一种被配置为在MRI扫描期间减小谐振电路中的谐振电流的可植入医疗引线及其制造方法。该制造方法包括提供一种医疗引线，其包括从位于引线的远端处的尖端电极到位于近端处的引线连接器的电路径，并将谐振电路耦合到尖端电极，使得谐振电路处于尖端电极的电路。此外，该方法包括将电容元件耦合到谐振电路的近端。电容元件被配置为将在电通路上感应的RF电流的至少一部分分流到周围的组织或流体中，并且还用作散热器以散热来自内部LC谐振电路的热量。

8. 发明申请

US20130345770A1 LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH REDUCED NUMBER OF FEED-THRUS 有权
公开(公告)号：US20130345770A1
公开(公告)日：2013-12-26
申请号：US13529226
申请日：2012-06-21
申请人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
发明人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
IPC分类号： A61N1/375
CPC分类号： A61N1/3756 , A61B5/042 , A61N1/362 , A61N1/368 , Y10T29/49002
摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.

9. 发明申请

US20130073020A1 HEADER EMBEDDED FILTER FOR IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗器械的HEADER嵌入式过滤器
公开(公告)号：US20130073020A1
公开(公告)日：2013-03-21
申请号：US13233966
申请日：2011-09-15
申请人： Gabriel A. Mouchawar , Ramez Shehada , Xiaoyi Min
发明人： Gabriel A. Mouchawar , Ramez Shehada , Xiaoyi Min
IPC分类号： A61N1/00
CPC分类号： A61N1/3718 , A61N1/3754
摘要： A filter circuit embedded into a header of an implantable medical device attenuates energy that may otherwise enter the implantable medical device. At MRI frequencies, the impedance of the filter circuit is much higher than the impedance of the feedthrough capacitor of the implantable medical device. Thus, MRI-induced current that would otherwise enter the implantable medical device is limited by the filter circuit. Consequently, localized device heating that may otherwise occur during MRI scanning is significantly reduced by operation of the filter circuit. In some implementations, the header embedded filter circuit is electrically isolated from the header housing. In this way, localized heating of the header housing also may be avoided.
摘要翻译：嵌入可植入医疗装置的头部中的滤波器电路衰减可能进入可植入医疗装置的能量。在MRI频率下，滤波电路的阻抗远高于可植入医疗器械的穿通电容器的阻抗。因此，否则将进入可植入医疗装置的MRI感应电流受到滤波器电路的限制。因此，通过滤波器电路的操作可以显着地减少在MRI扫描期间可能发生的局部器件加热。在一些实施方式中，头部嵌入式滤波器电路与插头外壳电隔离。以这种方式，也可以避免集管壳体的局部加热。

10. 发明授权

US08886319B2 MRI signal filtering for implantable medical device 有权
标题翻译：可植入医疗器械的MRI信号滤波
公开(公告)号：US08886319B2
公开(公告)日：2014-11-11
申请号：US12617532
申请日：2009-11-12
申请人： Jin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
发明人： Jin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
IPC分类号： A61N1/08 , G01R33/28 , A61N1/37 , A61N1/375 , A61N1/365 , G01R33/36
CPC分类号： G01R33/288 , A61N1/36521 , A61N1/3718 , A61N1/3754 , G01R33/3685
摘要： A filtering scheme for an implantable medical device mitigates potentially adverse effects that may be caused by MRI-induced signals. In some aspects filtering is provided to attenuate MRI-induced signals on an implanted cardiac lead that is coupled to an implanted device. In some aspects the filter may be configured to complement a capacitor circuit (e.g., a feedthrough capacitor) that reduces the amount of EMI that enters the implanted device via the cardiac lead. In some implementations the filter consists of a LC tank circuit and a series LC circuit, where the LC tank circuit is in series with the cardiac lead and a cardiac stimulation circuit and the series LC circuit is in a shunt configuration across the cardiac stimulation circuit.
摘要翻译：用于可植入医疗装置的过滤方案减轻了可能由MRI诱导的信号引起的潜在的不利影响。在一些方面，提供过滤以减少与植入装置耦合的植入心脏引线上的MRI诱导信号。在一些方面，滤波器可以被配置为补充通过心脏引线减少进入植入装置的EMI量的电容器电路（例如，馈通电容器）。在一些实施方式中，滤波器由LC谐振电路和串联LC电路组成，其中LC谐振电路与心脏引线和心脏刺激电路串联，并且串联LC电路处于穿过心脏刺激电路的分流配置。

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