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1. 发明申请

US20110284465A1 FUNCTIONALIZED SUBSTRATES WITH AROMATIC STACKING PROPERTIES 有权
标题翻译：具有芳香堆积性能的功能化基底
公开(公告)号：US20110284465A1
公开(公告)日：2011-11-24
申请号：US13111882
申请日：2011-05-19
申请人： Xiaodong Liu , Jinhua Chen , Christopher A. Pohl
发明人： Xiaodong Liu , Jinhua Chen , Christopher A. Pohl
IPC分类号： B01D15/08 , C07F7/18 , C08F212/36 , B01D15/26
CPC分类号： B01D15/327 , B01J20/287 , B01J20/289 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3259 , B01J20/3263 , B01J20/3265 , B01J2220/82
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions provide both strong aromatic and hydrophobic interactions with components of a sample. Moreover, the invention provides compositions of new silanes, their immobilization on a solid substrate, such as silica, to form new stationary phases.
摘要翻译：本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。该组合物与样品的组分提供强烈的芳族和疏水相互作用。此外，本发明提供新的硅烷的组合物，它们固定在固体基质如二氧化硅上以形成新的固定相。

2. 发明申请

US20080293959A1 COMPOSITIONS USEFUL AS CHROMATOGRAPHY STATIONARY PHASES 有权
标题翻译：组合物作为色谱固定相使用
公开(公告)号：US20080293959A1
公开(公告)日：2008-11-27
申请号：US11753934
申请日：2007-05-25
申请人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen
发明人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen
IPC分类号： C07F7/08
CPC分类号： B01J20/288 , B01J20/289 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3257 , B01J20/3259 , B01J20/3263 , B01J20/3285
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC). The compositions include a substrate (e.g., silica gel), covalently bound to a compound, which includes both a hydrophobic moiety and a hydrophilic moiety, which is preferably a 1,2-diol moiety. The hydrophobic moiety is sufficiently hydrophobic for the compositions to exhibit reversed phase characteristics and typically incorporates at least 5 carbon atoms in sequence. Based on having both hydrophilic and hydrophobic functionalities, the new stationary phases exhibit unique chromatographic properties. For example, these media can be used in either hydrophilic (HILIC) mode, in which the mobile phase includes a high percentage of an organic solvent, or in reversed phase mode, in which the mobile phase contains a higher percentage of an aqueous solvent. The current invention also provides methods of making and using the compounds and compositions of the invention.
摘要翻译：本发明提供组合物，其可用作多种色谱应用的固定相，例如高效液相色谱（HPLC）。组合物包括与包含疏水部分和亲水部分的化合物共价结合的底物（例如硅胶），其优选为1,2-二醇部分。疏水部分足够疏水以使组合物显示反相特性，并通常依次包含至少5个碳原子。基于具有亲水和疏水官能度，新的固定相显示出独特的色谱性质。例如，这些介质可用于亲水（HILIC）模式，其中流动相包含高百分比的有机溶剂，或以相反模式使用，其中流动相含有较高百分比的水性溶剂。本发明还提供了制备和使用本发明化合物和组合物的方法。

3. 发明授权

US09314712B2 Functionalized substrates with ion-exchange properties 有权
标题翻译：具有离子交换性能的功能化底物
公开(公告)号：US09314712B2
公开(公告)日：2016-04-19
申请号：US12118447
申请日：2008-05-09
申请人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen , L. Andy Woodruff
发明人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen , L. Andy Woodruff
IPC分类号： B01D15/36 , B01D15/32 , B01J20/28 , B01J20/32 , B01J39/26 , B01J43/00 , B01D15/38
CPC分类号： B01D15/362 , B01D15/325 , B01D15/361 , B01D15/363 , B01D15/3847 , B01J20/28097 , B01J20/3221 , B01J20/3285 , B01J20/3295 , B01J39/26 , B01J43/00 , B01J41/20
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces). The micro-particles have a size that is sufficient to minimize the number of particles that can enter the pores of the support thereby reducing or essentially preventing binding of the micro-particles to the interior walls of the pores. While the pores are essentially too small for the micro-particles, they can still be accessed by the analytes present in a chromatographic sample. The physical separation of ion-exchange groups located within the pores and the surface of the micro-particles, respectively, prevents reactions (e.g., formation of salt-bridges) between the oppositely charged groups and provides compositions with both anion-exchange and cation-exchange capabilities within the same stationary phase. The ligands bound to the solid support can optionally include additional (e.g., reverse-phase) functionalities creating multi-modal (e.g., trimodal) stationary phases.
摘要翻译：本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。组合物包括具有由“内壁”限定的外表面和孔开口的多孔固体支持物（例如硅胶，二氧化硅整料或合成有机树脂）。固体支持物是共价结合的有机离子交换配体（例如，甲硅烷基配体），其结合至少一个离子交换基团（例如离子或可离子化基团）。组合物还包括结合离子交换基团的微粒（例如胶乳颗粒），其具有与载体上发现的电荷相反的电荷。微粒子结合到支撑体的外表面（例如通过静电力）。微粒具有足以使能够进入载体的孔的颗粒数量最小化的尺寸，从而减少或基本上防止微粒与孔内壁的结合。虽然孔对于微粒基本上太小，但是它们仍然可以通过色谱样品中存在的分析物进行访问。分别位于孔和微粒表面之间的离子交换基团的物理分离防止相反电荷基团之间的反应（例如，形成盐桥），并提供具有阴离子交换和阳离子交换的组合物，交换能力在同一个固定阶段。与固体支持物结合的配体可以任选地包括产生多模态（例如，三峰）固定相的另外的（例如反相）官能团。

4. 发明授权

US09310344B2 HILIC/anion-exchange/cation-exchange multimodal media 有权
标题翻译： HILIC /阴离子交换/阳离子交换多峰介质
公开(公告)号：US09310344B2
公开(公告)日：2016-04-12
申请号：US13918481
申请日：2013-06-14
申请人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen
发明人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen
IPC分类号： G01N31/02 , B01J20/281
CPC分类号： G01N30/482 , B01D15/305 , B01D15/362 , B01D15/363 , B01D15/3847 , B01J20/288 , B01J20/3285 , B01J39/26 , B01J41/20 , B01J43/00
摘要： The present invention provides an agglomerated multimodal chromatographic medium. the medium of the invention includes groups active in anion exchange, cation exchange and hydrophilic interaction chromatographic modalities. The invention provides methods of making these media and using them in separations of analytes. Also provided are separations devices incorporating the medium and systems incorporating these separations devices.
摘要翻译：本发明提供了聚集的多峰色谱介质。本发明的介质包括在阴离子交换，阳离子交换和亲水相互作用层析方式中有活性的基团。本发明提供了制备这些介质并将其用于分析物分离的方法。还提供了并入介质的分离装置和并入这些分离装置的系统。

5. 发明授权

US09144756B2 Functionalized substrates with aromatic stacking properties 有权
标题翻译：具有芳香堆叠性能的功能化基材
公开(公告)号：US09144756B2
公开(公告)日：2015-09-29
申请号：US13111882
申请日：2011-05-19
申请人： Xiaodong Liu , Jinhua Chen , Christopher A. Pohl
发明人： Xiaodong Liu , Jinhua Chen , Christopher A. Pohl
IPC分类号： B01D15/32 , B01J20/287 , B01J20/32 , B01J20/289
CPC分类号： B01D15/327 , B01J20/287 , B01J20/289 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3259 , B01J20/3263 , B01J20/3265 , B01J2220/82
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions provide both strong aromatic and hydrophobic interactions with components of a sample. Moreover, the invention provides compositions of new silanes, their immobilization on a solid substrate, such as silica, to form new stationary phases.
摘要翻译：本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。该组合物与样品的组分提供强烈的芳族和疏水相互作用。此外，本发明提供新的硅烷的组合物，它们固定在固体基质如二氧化硅上以形成新的固定相。

6. 发明申请

US20090277838A1 Functionalized substrates with ion-exchange properties 有权
标题翻译：具有离子交换性能的功能化底物
公开(公告)号：US20090277838A1
公开(公告)日：2009-11-12
申请号：US12118447
申请日：2008-05-09
申请人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen , L. Andy Woodruff
发明人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen , L. Andy Woodruff
IPC分类号： B01D15/08 , B01J39/26
CPC分类号： B01D15/362 , B01D15/325 , B01D15/361 , B01D15/363 , B01D15/3847 , B01J20/28097 , B01J20/3221 , B01J20/3285 , B01J20/3295 , B01J39/26 , B01J43/00 , B01J41/20
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces). The micro-particles have a size that is sufficient to minimize the number of particles that can enter the pores of the support thereby reducing or essentially preventing binding of the micro-particles to the interior walls of the pores. While the pores are essentially too small for the micro-particles, they can still be accessed by the analytes present in a chromatographic sample. The physical separation of ion-exchange groups located within the pores and the surface of the micro-particles, respectively, prevents reactions (e.g., formation of salt-bridges) between the oppositely charged groups and provides compositions with both anion-exchange and cation-exchange capabilities within the same stationary phase. The ligands bound to the solid support can optionally include additional (e.g., reverse-phase) functionalities creating multi-modal (e.g., trimodal) stationary phases.
摘要翻译：本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。组合物包括具有由“内壁”限定的外表面和孔开口的多孔固体支持物（例如硅胶，二氧化硅整料或合成有机树脂）。固体支持物是共价结合的有机离子交换配体（例如，甲硅烷基配体），其结合至少一个离子交换基团（例如离子或可离子化基团）。组合物还包括结合离子交换基团的微粒（例如胶乳颗粒），其具有与载体上发现的电荷相反的电荷。微粒子结合到支撑体的外表面（例如通过静电力）。微粒具有足以使能够进入载体的孔的颗粒数量最小化的尺寸，从而减少或基本上防止微粒与孔内壁的结合。虽然孔对于微粒基本上太小，但是它们仍然可以通过色谱样品中存在的分析物进行访问。分别位于孔和微粒表面之间的离子交换基团的物理分离防止相反电荷基团之间的反应（例如，形成盐桥），并提供具有阴离子交换和阳离子交换的组合物，交换能力在同一个固定阶段。与固体支持物结合的配体可以任选地包括产生多模态（例如，三峰）固定相的另外的（例如反相）官能团。

7. 发明授权

US07557232B2 Compositions useful as chromatography stationary phases 有权
标题翻译：用作色谱固定相的组合物
公开(公告)号：US07557232B2
公开(公告)日：2009-07-07
申请号：US11753934
申请日：2007-05-25
申请人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen
发明人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen
IPC分类号： C07F7/02 , C07F7/08 , C07F7/18
CPC分类号： B01J20/288 , B01J20/289 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3257 , B01J20/3259 , B01J20/3263 , B01J20/3285
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC). The compositions include a substrate (e.g., silica gel), covalently bound to a compound, which includes both a hydrophobic moiety and a hydrophilic moiety, which is preferably a 1,2-diol moiety. The hydrophobic moiety is sufficiently hydrophobic for the compositions to exhibit reversed phase characteristics and typically incorporates at least 5 carbon atoms in sequence. Based on having both hydrophilic and hydrophobic functionalities, the new stationary phases exhibit unique chromatographic properties. For example, these media can be used in either hydrophilic (HILIC) mode, in which the mobile phase includes a high percentage of an organic solvent, or in reversed phase mode, in which the mobile phase contains a higher percentage of an aqueous solvent. The current invention also provides methods of making and using the compounds and compositions of the invention.
摘要翻译：本发明提供组合物，其可用作多种色谱应用的固定相，例如高效液相色谱（HPLC）。组合物包括与包含疏水部分和亲水部分的化合物共价结合的底物（例如硅胶），其优选为1,2-二醇部分。疏水部分足够疏水以使组合物显示反相特性，并通常依次包含至少5个碳原子。基于具有亲水和疏水官能度，新的固定相显示出独特的色谱性质。例如，这些介质可用于亲水（HILIC）模式，其中流动相包含高百分比的有机溶剂，或以相反模式使用，其中流动相含有较高百分比的水性溶剂。本发明还提供了制备和使用本发明化合物和组合物的方法。

8. 发明授权

US08372558B2 Highly proton-conductive polymer electrolyte membranes that excel in mechanical strength and a process for producing the same 有权
标题翻译：机械强度优异的高质子导电聚合物电解质膜及其制造方法
公开(公告)号：US08372558B2
公开(公告)日：2013-02-12
申请号：US12230103
申请日：2008-08-22
申请人： Jinhua Chen , Yasunari Maekawa , Masaharu Asano , Masaru Yoshida
发明人： Jinhua Chen , Yasunari Maekawa , Masaharu Asano , Masaru Yoshida
IPC分类号： H01M8/10
CPC分类号： H01M8/1025 , C08F8/12 , C08F2810/20 , C08J3/28 , C08J2351/08 , H01M8/1027 , H01M8/103 , H01M8/1032 , H01M8/1039 , H01M8/1067 , H01M8/1072 , H01M2008/1095 , H01M2300/0082 , Y02P70/56 , C08F285/00
摘要： A vinyl monomer is graft polymerized on an aromatic hydrocarbon-based polymer film substrate to introduce graft chains into the substrate and thereafter a functional monomer represented by the following formula and having sulfonic acid groups or functional groups capable of conversion to sulfonic acid groups is graft polymerized to introduce the sulfonic acid groups or the functional groups capable of conversion to sulfonic acid groups: where R is an aromatic ring or an aliphatic chain; X is (1) —OH, (2) —OLi, —ONa or —OK, (3) —F or —Cl, or (4) —OCnH2n+1 where n is an integer of 1 to 7. Since the graft chains obtained by graft polymerization of the vinyl monomer can also be utilized as scaffold polymers, the graft polymerizability of the functional monomer to the aromatic hydrocarbon-based polymer film substrate is sufficiently improved to enable the preparation of a polymer electrolyte membrane that excels not only in proton conductivity and mechanical strength but also in dimensional stability.
摘要翻译：乙烯基单体在芳烃类聚合物膜基材上接枝聚合以将接枝链引入基材中，然后将由下式表示的具有磺酸基或能够转化为磺酸基的官能团的官能单体接枝聚合引入磺酸基团或能够转化为磺酸基团的官能团：其中R是芳环或脂族链; X是（1）-OH，（2）-OLi，-ONa或-OK，（3）-F或-Cl或（4）-OCnH 2 + 1，其中n是1至7的整数。通过乙烯基单体的接枝聚合获得的链也可以用作支架聚合物，功能性单体对芳族烃类聚合物膜基材的接枝聚合性得到充分改善，能够制备高分子电解质膜，质子传导性和机械强度，而且尺寸稳定性。

9. 发明申请

US20100190875A1 Crosslinked aromatic polymer electrolyte membrane 审中-公开
标题翻译：交联芳香族聚合物电解质膜
公开(公告)号：US20100190875A1
公开(公告)日：2010-07-29
申请号：US12662160
申请日：2010-04-01
申请人： Jinhua Chen , Yasunari Maekawa , Masaharu Asano , Masaru Yoshida
发明人： Jinhua Chen , Yasunari Maekawa , Masaharu Asano , Masaru Yoshida
IPC分类号： B01J41/12
CPC分类号： H01M8/1018 , H01M8/0289 , H01M8/04197 , H01M8/1011 , H01M8/1025 , H01M8/1027 , H01M8/103 , H01M8/1032 , H01M8/1088 , Y02E60/523 , Y02P70/56
摘要： An aromatic polymer film substrate, or a grafted aromatic polymer film substrate having a monomer introduced therein as graft chains is irradiated with ionizing radiation to impart a crosslinked structure. The aromatic polymer film substrate or the grafted aromatic polymer film substrate, provided with the crosslinked structure, is directly sulfonated to obtain a crosslinked aromatic polymer electrolyte membrane. The crosslinked aromatic polymer electrolyte membrane has low water uptake, high proton conductivity, low methanol permeability, high chemical stability, and excellent mechanical characteristics.
摘要翻译：将具有引入其中的单体作为接枝链的芳族聚合物膜基材或其接枝的芳族聚合物膜基材用电离辐射照射以赋予交联结构。具有交联结构的芳香族聚合物膜基材或接枝芳香族聚合物膜基材直接磺化，得到交联的芳族聚合物电解质膜。交联芳香族聚合物电解质膜吸水率低，质子传导率高，甲醇渗透性低，化学稳定性高，机械特性优良。

10. 外观设计

USD954351S1 Shaver 有权
公开(公告)号：USD954351S1
公开(公告)日：2022-06-07
申请号：US29756973
申请日：2020-11-02
申请人： Jinhua Chen
设计人： Jinhua Chen

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