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    • 7. 发明申请
    • COMPOSITIONS USEFUL AS CHROMATOGRAPHY STATIONARY PHASES
    • 组合物作为色谱固定相使用
    • US20080293959A1
    • 2008-11-27
    • US11753934
    • 2007-05-25
    • Xiaodong LiuChristopher A. PohlJinhua Chen
    • Xiaodong LiuChristopher A. PohlJinhua Chen
    • C07F7/08
    • B01J20/288B01J20/289B01J20/3204B01J20/3208B01J20/3219B01J20/3257B01J20/3259B01J20/3263B01J20/3285
    • The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC). The compositions include a substrate (e.g., silica gel), covalently bound to a compound, which includes both a hydrophobic moiety and a hydrophilic moiety, which is preferably a 1,2-diol moiety. The hydrophobic moiety is sufficiently hydrophobic for the compositions to exhibit reversed phase characteristics and typically incorporates at least 5 carbon atoms in sequence. Based on having both hydrophilic and hydrophobic functionalities, the new stationary phases exhibit unique chromatographic properties. For example, these media can be used in either hydrophilic (HILIC) mode, in which the mobile phase includes a high percentage of an organic solvent, or in reversed phase mode, in which the mobile phase contains a higher percentage of an aqueous solvent. The current invention also provides methods of making and using the compounds and compositions of the invention.
    • 本发明提供组合物,其可用作多种色谱应用的固定相,例如高效液相色谱(HPLC)。 组合物包括与包含疏水部分和亲水部分的化合物共价结合的底物(例如硅胶),其优选为1,2-二醇部分。 疏水部分足够疏水以使组合物显示反相特性,并通常依次包含至少5个碳原子。 基于具有亲水和疏水官能度,新的固定相显示出独特的色谱性质。 例如,这些介质可用于亲水(HILIC)模式,其中流动相包含高百分比的有机溶剂,或以相反模式使用,其中流动相含有较高百分比的水性溶剂。 本发明还提供了制备和使用本发明化合物和组合物的方法。