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1. 发明授权

US08182679B2 Organosilanes and substrate bonded with same 有权
标题翻译：有机硅烷和与其粘合的底物
公开(公告)号：US08182679B2
公开(公告)日：2012-05-22
申请号：US12111059
申请日：2008-04-28
申请人： Xiaodong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
发明人： Xiaodong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
IPC分类号： B01D15/08
CPC分类号： B01J20/288 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3285 , C07F7/1804
摘要： The present invention, provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.
摘要翻译：本发明提供新的硅化合物，制备这些新型硅化合物的方法，包含这些新型硅化合物附着在基底上的组合物，将新型硅化合物附着于底物的方法以及在各种色谱应用中使用该组合物的方法。

2. 发明授权

US07074491B2 Polar silanes for binding to substrates and use of the bound substrates 有权
标题翻译：用于结合底物的极性硅烷和使用结合的底物
公开(公告)号：US07074491B2
公开(公告)日：2006-07-11
申请号：US10702109
申请日：2003-11-04
申请人： Xiaodong Liu , Andrei V. Bordunov , Christopher A. Pohl
发明人： Xiaodong Liu , Andrei V. Bordunov , Christopher A. Pohl
IPC分类号： C07F7/10 , C07F7/18
CPC分类号： B01J20/3242 , B01J20/286 , B01J20/287 , B01J2220/54 , C07F7/1804 , Y10T428/31663
摘要： Polyfunctional silicon compounds of one of the following formula: in which N-PG is a nitrogen containing function group. Also, such compounds bound to substrates for use as chromatography packing.
摘要翻译：下列化学式的多官能硅化合物：其中N-PG是含氮官能团。此外，这些化合物与底物结合，用作色谱填充。

3. 发明授权

US07147891B2 Polymer substrate coated with weak cationic-exchange functional layer 有权
标题翻译：涂有弱阳离子交换功能层的聚合物基材
公开(公告)号：US07147891B2
公开(公告)日：2006-12-12
申请号：US10778007
申请日：2004-02-11
申请人： Andrei V. Bordunov , Maria Rey , Christopher A. Pohl
发明人： Andrei V. Bordunov , Maria Rey , Christopher A. Pohl
IPC分类号： C08J3/24
CPC分类号： B01D15/362 , B01J20/28097 , B01J20/3208 , B01J20/3268 , B01J20/327 , B01J20/3282 , B01J39/26 , B01J47/018 , Y10T428/2998 , Y10T428/31536 , Y10T428/31931
摘要： A method for making a weak cation-exchange (carboxylic acid) medium comprising contacting a solution of a functional organic polymer having carbon to carbon double bond unsaturation and having weak cationic exchange functional moieties or precursors thereof in a solvent with a substrate having an organic polymer surface, evaporating said solvent and breaking said double bond under conditions to cause the functional organic polymer to covalently bond to the substrate surface and to cross-link to form a cross-linked functional polymer layer covalently bound to the substrate surface. The medium produced by the method.
摘要翻译：一种制备弱阳离子交换（羧酸）培养基的方法，包括使具有碳 - 碳双键不饱和键的官能有机聚合物溶液和具有弱阳离子交换官能团或其前体的溶液与具有有机聚合物表面，蒸发所述溶剂并在条件下破坏所述双键以使功能性有机聚合物共价键合到基材表面并交联以形成共价结合到基材表面的交联官能聚合物层。该方法生产的培养基。

4. 发明授权

US07402243B2 Organosilanes and substrate bonded with same 有权
标题翻译：有机硅烷和与其粘合的底物
公开(公告)号：US07402243B2
公开(公告)日：2008-07-22
申请号：US10938172
申请日：2004-09-10
申请人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
发明人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
IPC分类号： B01D15/08
CPC分类号： B01J20/288 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3285 , C07F7/1804
摘要： The present invention provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.
摘要翻译：本发明提供新颖的硅化合物，制备这些新型硅化合物的方法，包含这些新型硅化合物附着在底物上的组合物，将新型硅化合物附着于底物的方法以及在各种色谱应用中使用该组合物的方法。

5. 发明授权

US06867295B2 Ion exchange cryptands covalently bound to substrates 有权
标题翻译：离子交换穴位共价结合到底物上
公开(公告)号：US06867295B2
公开(公告)日：2005-03-15
申请号：US09949010
申请日：2001-09-07
申请人： L. Andy Woodruff , Andrei V. Bordunov , Christopher A. Pohl
发明人： L. Andy Woodruff , Andrei V. Bordunov , Christopher A. Pohl
IPC分类号： G01N30/02 , B01D15/08 , B01J20/281 , B01J20/285 , B01J41/14 , B01J45/00 , C08J5/20 , G01N30/26 , G01N30/34 , G01N30/64 , G01N30/88 , C08B37/16
CPC分类号： B01J45/00 , B01J41/14
摘要： One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween.In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.
摘要翻译：本发明的一个实施方案包括通过使自由基活化条件下的不饱和碳与衍生的离子结合穴状物侧基的碳部分与支持底物反应而形成的离子交换组合物，在其间形成共价键。在另一个实施方案中，穴状离子交换组合物是通过共价键合不饱和碳与从不饱和碳衍生的衍生化离子结合穴状结构的碳部分与自由基激活条件下从载体底物侧基形成共价键的碳部分共价键合。

6. 发明授权

US07166226B2 Ion exchange cryptands covalently bound to substrates 有权
标题翻译：离子交换穴位共价结合到底物上
公开(公告)号：US07166226B2
公开(公告)日：2007-01-23
申请号：US11046477
申请日：2005-01-28
申请人： L. Andy Woodruff , Andrei V. Bordunov , Christopher A. Pohl
发明人： L. Andy Woodruff , Andrei V. Bordunov , Christopher A. Pohl
IPC分类号： C08B37/16
CPC分类号： B01J45/00 , B01J41/14
摘要： One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween. In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.
摘要翻译：本发明的一个实施方案包括通过使自由基活化条件下的不饱和碳与衍生化的离子结合穴状物侧链的碳部分与支持底物反应形成的离子交换组合物，以在它们之间形成共价键。在另一个实施方案中，通过共价键合不饱和碳与从自由基活化条件下从支持底物悬挂的不饱和碳与碳部分的衍生化离子结合穴状结构的碳部分共价键合而形成穴状离子交换组合物以形成共价键。

7. 发明授权

US08425778B2 Organosilanes and substrate bonded with same 有权
标题翻译：有机硅烷和与其粘合的底物
公开(公告)号：US08425778B2
公开(公告)日：2013-04-23
申请号：US13464644
申请日：2012-05-04
申请人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
发明人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
IPC分类号： B01D15/08
CPC分类号： B01J20/288 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3285 , C07F7/1804
摘要： The present invention provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.
摘要翻译：本发明提供了新颖的硅化合物，制备这些新型硅化合物的方法，包含这些新型硅化合物附着在底物上的组合物，将新型硅化合物附着于底物的方法以及在各种色谱应用中使用该组合物的方法。

8. 发明申请

US20130026099A1 ORGANOSILANES AND SUBSTRATE BONDED WITH SAME 有权
标题翻译：有机硅和底物与其结合
公开(公告)号：US20130026099A1
公开(公告)日：2013-01-31
申请号：US13464644
申请日：2012-05-04
申请人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
发明人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
IPC分类号： B01D15/08 , G01N30/00
CPC分类号： B01J20/288 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3285 , C07F7/1804
摘要： The present invention provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.
摘要翻译：本发明提供了新颖的硅化合物，制备这些新型硅化合物的方法，包含这些新型硅化合物附着在底物上的组合物，将新型硅化合物附着于底物的方法以及在各种色谱应用中使用该组合物的方法。

9. 发明申请

US20080203027A1 Organosilanes and substrate bonded with same 有权
标题翻译：有机硅烷和与其粘合的底物
公开(公告)号：US20080203027A1
公开(公告)日：2008-08-28
申请号：US12111059
申请日：2008-04-28
申请人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
发明人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
IPC分类号： B01D15/08 , C07F7/10
CPC分类号： B01J20/288 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3285 , C07F7/1804
摘要： The present invention, provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.
摘要翻译：本发明提供新的硅化合物，制备这些新型硅化合物的方法，包含这些新型硅化合物附着在基底上的组合物，将新型硅化合物附着于底物的方法以及在各种色谱应用中使用该组合物的方法。

10. 发明授权

US09314712B2 Functionalized substrates with ion-exchange properties 有权
标题翻译：具有离子交换性能的功能化底物
公开(公告)号：US09314712B2
公开(公告)日：2016-04-19
申请号：US12118447
申请日：2008-05-09
申请人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen , L. Andy Woodruff
发明人： Xiaodong Liu , Christopher A. Pohl , Jinhua Chen , L. Andy Woodruff
IPC分类号： B01D15/36 , B01D15/32 , B01J20/28 , B01J20/32 , B01J39/26 , B01J43/00 , B01D15/38
CPC分类号： B01D15/362 , B01D15/325 , B01D15/361 , B01D15/363 , B01D15/3847 , B01J20/28097 , B01J20/3221 , B01J20/3285 , B01J20/3295 , B01J39/26 , B01J43/00 , B01J41/20
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces). The micro-particles have a size that is sufficient to minimize the number of particles that can enter the pores of the support thereby reducing or essentially preventing binding of the micro-particles to the interior walls of the pores. While the pores are essentially too small for the micro-particles, they can still be accessed by the analytes present in a chromatographic sample. The physical separation of ion-exchange groups located within the pores and the surface of the micro-particles, respectively, prevents reactions (e.g., formation of salt-bridges) between the oppositely charged groups and provides compositions with both anion-exchange and cation-exchange capabilities within the same stationary phase. The ligands bound to the solid support can optionally include additional (e.g., reverse-phase) functionalities creating multi-modal (e.g., trimodal) stationary phases.
摘要翻译：本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。组合物包括具有由“内壁”限定的外表面和孔开口的多孔固体支持物（例如硅胶，二氧化硅整料或合成有机树脂）。固体支持物是共价结合的有机离子交换配体（例如，甲硅烷基配体），其结合至少一个离子交换基团（例如离子或可离子化基团）。组合物还包括结合离子交换基团的微粒（例如胶乳颗粒），其具有与载体上发现的电荷相反的电荷。微粒子结合到支撑体的外表面（例如通过静电力）。微粒具有足以使能够进入载体的孔的颗粒数量最小化的尺寸，从而减少或基本上防止微粒与孔内壁的结合。虽然孔对于微粒基本上太小，但是它们仍然可以通过色谱样品中存在的分析物进行访问。分别位于孔和微粒表面之间的离子交换基团的物理分离防止相反电荷基团之间的反应（例如，形成盐桥），并提供具有阴离子交换和阳离子交换的组合物，交换能力在同一个固定阶段。与固体支持物结合的配体可以任选地包括产生多模态（例如，三峰）固定相的另外的（例如反相）官能团。

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