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1. 发明申请

US20090101805A1 High Speed Scanning Platform for Microarray Scanner 有权
标题翻译：微阵列扫描仪高速扫描平台
公开(公告)号：US20090101805A1
公开(公告)日：2009-04-23
申请号：US11795652
申请日：2005-06-02
申请人： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
IPC分类号： H01J40/14
CPC分类号： G01N35/04 , G01N35/028
摘要： The invention provides a scanning platform for high speed scanning of microarrays. The platform uses a novel flexible a metal strip/wheel linear driving system to convert rotary movement of motors into linear movement, thereby drives movement of a stage/microarray in the direction of scanning. The platform of the present invention provides high movement speed, high resolution, and low return deviation. It is also simple in structure and low in manufacturing cost.
摘要翻译：本发明提供了用于微阵列高速扫描的扫描平台。该平台使用新颖的柔性金属条/轮线性驱动系统将马达的旋转运动转换为直线运动，从而驱动载物台/微阵列沿扫描方向的移动。本发明的平台提供高移动速度，高分辨率和低返回偏差。结构简单，制造成本低。

2. 发明授权

US07928357B2 High speed scanning platform for microarray scanner 有权
标题翻译：微阵列扫描仪高速扫描平台
公开(公告)号：US07928357B2
公开(公告)日：2011-04-19
申请号：US11795652
申请日：2005-06-02
申请人： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
IPC分类号： H01J3/14 , H04N1/04 , G01N33/50 , F21V9/16
CPC分类号： G01N35/04 , G01N35/028
摘要： The invention provides a scanning platform for high speed scanning of microarrays. The platform uses a novel flexible a metal strip/wheel linear driving system to convert rotary movement of motors into linear movement, thereby drives movement of a stage/microarray in the direction of scanning. The platform of the present invention provides high movement speed, high resolution, and low return deviation. It is also simple in structure and low in manufacturing cost.
摘要翻译：本发明提供了用于微阵列高速扫描的扫描平台。该平台使用新颖的柔性金属条/轮线性驱动系统将马达的旋转运动转换为直线运动，从而驱动载物台/微阵列沿扫描方向的移动。本发明的平台提供高移动速度，高分辨率和低返回偏差。结构简单，制造成本低。

3. 发明申请

US20080252954A1 Laser Confocal Microarray Scanner 有权
标题翻译：激光共聚焦微阵列扫描仪
公开(公告)号：US20080252954A1
公开(公告)日：2008-10-16
申请号：US11795660
申请日：2005-06-02
申请人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
IPC分类号： G02B26/08
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/6452 , G01N2021/6421 , G01N2201/10 , G01N2201/103
摘要： The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning
摘要翻译：本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描

4. 发明授权

US07706419B2 Optical systems for microarray scanning 有权
标题翻译：用于微阵列扫描的光学系统
公开(公告)号：US07706419B2
公开(公告)日：2010-04-27
申请号：US11795653
申请日：2005-06-03
申请人： Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
发明人： Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
IPC分类号： H01S3/10
CPC分类号： G02B21/002 , G01N21/6452
摘要： The invention provides a novel optical system for use in a microarray scanner, comprising an aperture-containing reflecting mirror comprising an aperture and a reflecting surface. The aperture of the aperture-containing reflecting mirror allows an excitation light to pass through, and the reflecting surface of the aperture-containing reflecting mirror allows emission light from a microarray to be reflected. The optical system may also comprises various other components such as laser generators, beam splitter, reflecting mirrors, excitation and emission light filters, excitation and emission objective lens, pinhole, and detector. The optical system described herein has high efficiency, high sensitivity, low background noise, structurally simple, and high versatility.
摘要翻译：本发明提供了一种用于微阵列扫描仪的新型光学系统，其包括一个包含孔和反射表面的孔径反射镜。含孔反射镜的孔径允许激发光通过，并且含孔反射镜的反射表面允许来自微阵列的发射光被反射。光学系统还可以包括诸如激光发生器，分束器，反射镜，激发和发射滤光器，激发和发射物镜，针孔和检测器的各种其它部件。本文描述的光学系统具有高效率，高灵敏度，低背景噪声，结构简单和高通用性。

5. 发明申请

US20090046756A1 Optical Systems for Microarray Scanning 有权
标题翻译：微阵列扫描光学系统
公开(公告)号：US20090046756A1
公开(公告)日：2009-02-19
申请号：US11795653
申请日：2005-06-03
申请人： Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
发明人： Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
IPC分类号： H01S3/08 , H01S3/10
CPC分类号： G02B21/002 , G01N21/6452
摘要： The invention provides a novel optical system for use in a microarray scanner, comprising an aperture-containing reflecting mirror comprising an aperture and a reflecting surface. The aperture of the aperture-containing reflecting mirror allows an excitation light to pass through, and the reflecting surface of the aperture-containing reflecting mirror allows emission light from a microarray to be reflected. The optical system may also comprises various other components such as laser generators, beam splitter, reflecting mirrors, excitation and emission light filters, excitation and emission objective lens, pinhole, and detector. The optical system described herein has high efficiency, high sensitivity, low background noise, structurally simple, and high versatility.
摘要翻译：本发明提供了一种用于微阵列扫描仪的新型光学系统，其包括一个包含孔和反射表面的孔径反射镜。含孔反射镜的孔径允许激发光通过，并且含孔反射镜的反射表面允许来自微阵列的发射光被反射。光学系统还可以包括诸如激光发生器，分束器，反射镜，激发和发射滤光器，激发和发射物镜，针孔和检测器的各种其它部件。本文描述的光学系统具有高效率，高灵敏度，低背景噪声，结构简单和高通用性。

6. 发明授权

US07615758B2 Laser confocal microarray scanner 有权
标题翻译：激光共焦微阵列扫描仪
公开(公告)号：US07615758B2
公开(公告)日：2009-11-10
申请号：US11795660
申请日：2005-06-02
申请人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
IPC分类号： F21V9/16
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/6452 , G01N2021/6421 , G01N2201/10 , G01N2201/103
摘要： The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning
摘要翻译：本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描

7. 发明授权

US08900530B2 Micro-volume liquid ejection system 有权
标题翻译：微量液体喷射系统
公开(公告)号：US08900530B2
公开(公告)日：2014-12-02
申请号：US11666032
申请日：2004-11-22
申请人： Dong Wang , Kun Zou , Jianxing Ye , Yelei Sun , Hui Zhu , Xianhua Wang , Jing Cheng
发明人： Dong Wang , Kun Zou , Jianxing Ye , Yelei Sun , Hui Zhu , Xianhua Wang , Jing Cheng
IPC分类号： B01L3/02
CPC分类号： B01L3/0265 , B01L2400/0487 , B01L2400/0666 , Y10T436/2575
摘要： The present invention relates to a micro-volume liquid ejection system, including an air pressure module, a micro-ejection unit which is connected with the air pressure module by a conduit, and a control circuit which is connected with the air pressure module and the micro-ejection unit respectively. The air is used as the pressure medium, resulting in improved cleaning process and reduced sample waste. The present invention includes an electric control circuit to pick up sample, eject sample and clean the conduits automatically, and enables handling of a multiplicity of samples. The present invention can be used for transferring or dispensing micro volume liquid including biological liquid on a nL and μL scale.
摘要翻译：微体积液体喷射系统技术领域本发明涉及一种微体积液体喷射系统，包括空气压力模块，通过导管与空气压力模块连接的微型喷射单元，以及与空气压力模块连接的控制电路，微型喷射装置。空气用作压力介质，从而改善清洗过程并减少样品废物。本发明包括一个电子控制电路，用于拾取样品，抽出样品并自动清洁导管，并能够处理多个样品。本发明可用于以nL和μL标度转移或分配包括生物液体的微量体积液体。

8. 发明申请

US20080267828A1 Micro-Volume Liquid Ejection System 有权
标题翻译：微量液体喷射系统
公开(公告)号：US20080267828A1
公开(公告)日：2008-10-30
申请号：US11666032
申请日：2004-11-22
申请人： Dong Wang , Kun Zou , Jianxing Ye , Yelei Sun , Hui Zhu , Xianhua Wang , Jing Cheng
发明人： Dong Wang , Kun Zou , Jianxing Ye , Yelei Sun , Hui Zhu , Xianhua Wang , Jing Cheng
IPC分类号： B65D83/00
CPC分类号： B01L3/0265 , B01L2400/0487 , B01L2400/0666 , Y10T436/2575
摘要： The present invention relates to a micro-volume liquid ejection system, including an air pressure module, a micro-ejection unit which is connected with the air pressure module by means of pipes, and a control circuit which is connected with the air pressure module and the micro-ejection unit respectively. In the present invention, due to air is used as the pressure medium, on one hand, as the sample does not contact with the pressure regulating module, the efficiency of cleaning process is improved, on the other hand, the volume of the sample needed in the sample ejecting process is only equal to the cavity-dimension of the micro-ejection unit by not need to fill the whole pipe with liquid. During the sample ejecting process, it is not need to regulate the pressure. After the sample ejecting is finished, the sample can be put into its original place, so as to greatly save the sample. The present invention is connected with the manipulator, so as to sample from the sample plate, eject sample and clean the pipes automatically, and it can also dispense a multiplicity of samples to micro-array substrate conveniently. The present invention can be used for transferring or dispensing the micro volume liquid of nL grade and L grade widely, and all kinds of the micro-volume liquid including biological liquid.
摘要翻译：微体积液体喷射系统技术领域本发明涉及一种微体积液体喷射系统，包括空气压力模块，通过管道与空气压力模块连接的微型喷射单元，以及与气压模块连接的控制电路和微型喷射单元。在本发明中，由于空气被用作压力介质，一方面由于样品不与压力调节模块接触，因此提高了清洗过程的效率，另一方面，样品的体积需要在样品喷射过程中，仅通过不需要用整个管道填充液体就等于微喷射单元的腔体尺寸。在样品喷射过程中，不需要调节压力。样品喷射完成后，样品可以放在原来的位置，大大节省样品。本发明与机械手连接，从样品板上取样，自动排出样品并清洗管道，方便地将多个样品分配给微阵列基板。本发明可广泛用于转移或分配nL级和L级微量液体，以及各种微体积液体，包括生物液体。

9. 发明申请

US20080124251A1 Sample Preparation Device for Extracting Drug Residue 有权
标题翻译：用于提取药物残留物的样品制备装置
公开(公告)号：US20080124251A1
公开(公告)日：2008-05-29
申请号：US11661019
申请日：2004-11-22
申请人： Renyuan Chen , Guoqing Wang , Feijun Xian , Wanli Xing , Xianhua Wang , Jing Cheng
发明人： Renyuan Chen , Guoqing Wang , Feijun Xian , Wanli Xing , Xianhua Wang , Jing Cheng
IPC分类号： B01L9/06 , B01L11/00 , B01L7/02
CPC分类号： G01N1/40 , G01N2001/2866
摘要： The present invention provides a sample preparation device for extracting drug residue. It comprises a case, in which a water bath, a vortex mixer, and a homogenizer are integrated. The case also has on it an integrated control panel for controlling heating temperature of the water bath and homogenization time of the homogenizer.
摘要翻译：本发明提供了用于提取药物残留物的样品制备装置。它包括其中集成了水浴，涡流混合器和均化器的壳体。该情况还具有用于控制水浴的加热温度和均化器的均化时间的集成控制面板。

10. 发明申请

US20100190663A1 DEVICE FOR WASHING AND HYBRIDIZATION OF BIOCHIPS 有权
标题翻译： BIOCHIPS洗涤和杂交装置
公开(公告)号：US20100190663A1
公开(公告)日：2010-07-29
申请号：US12527184
申请日：2007-10-09
申请人： Hang Li , Jianxin Ye , Xingling Al , Xianhua Wang , Liang Zhang , Jing Cheng
发明人： Hang Li , Jianxin Ye , Xingling Al , Xianhua Wang , Liang Zhang , Jing Cheng
IPC分类号： C40B60/00
CPC分类号： B08B3/044 , B01F11/0028 , B01J2219/00326 , B01J2219/00328 , B01J2219/00527 , B01J2219/00659 , B01L7/00 , B01L2300/0819 , B08B11/02 , Y10S435/809
摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.
摘要翻译：提供了用于生物芯片杂交或洗涤的装置，其包括圆盘传送带（12），平移运动控制器，旋转运动控制器和可选的加热室（13）。旋转运动控制器控制圆盘传送带的旋转运动，并允许其以摆动的方式移动，允许杂交或洗涤盒（11）在传送带上的生物芯片的杂交和/或洗涤期间的液体移动。一旦旋转运动控制器停止，平移运动控制器将转盘回到水平位置，从而确保液体不会溢出。加热室在装置内循环热空气，从而确保在恒温条件下进行杂交和洗涤。

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