专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003076418A1 QUINAZOLINONE MODULATORS OF NUCLEAR RECEPTORS 审中-公开
标题翻译：喹诺酮调节剂的核受体
公开(公告)号：WO2003076418A1
公开(公告)日：2003-09-18
申请号：PCT/US2003/006793
申请日：2003-03-04
申请人： X-CEPTOR THERAPEUTICS, INC. , MARTIN, Richard , KAHL, Jeffery, Dean , FLATT, Brenton, Todd , GRIFFITH, Ronald
发明人： MARTIN, Richard , KAHL, Jeffery, Dean , FLATT, Brenton, Todd , GRIFFITH, Ronald
IPC分类号： C07D239/91
CPC分类号： C07D409/12 , C07D239/90 , C07D239/91 , C07D413/12
摘要： Compounds, pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, quinazolinones are provided for modulating the activity of farnesoid X receptor (FXR) and/or orphan nuclear receptors.
摘要翻译：提供了用于调节核受体活性的化合物，药物组合物和方法。特别地，喹唑啉酮被用于调节法呢酯X受体（FXR）和/或孤儿核受体的活性。

2. 发明申请

WO2003060078A2 HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS 审中-公开
标题翻译：核受体的HETROCYCLIC调节剂
公开(公告)号：WO2003060078A2
公开(公告)日：2003-07-24
申请号：PCT/US2002/041224
申请日：2002-12-20
申请人： X-CEPTOR THERAPEUTICS, INC. , MARTIN, Richard , FLATT, Brenton, Todd , WANG, Tie-Lin , KAHL, Jeffery, Dean
发明人： MARTIN, Richard , FLATT, Brenton, Todd , WANG, Tie-Lin , KAHL, Jeffery, Dean
IPC分类号： C12N
CPC分类号： C07D277/20 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/64 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要： Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.
摘要翻译：提供了调节核受体活性的化合物，组合物和方法。特别地，提供杂环化合物用于调节法呢甾X受体FXR，肝X受体LXR和/或孤儿核受体的活性。在某些实施方案中，化合物是噻唑烷酮衍生物。

3. 发明申请

WO2003060078A3 HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS 审中-公开
公开(公告)号：WO2003060078A3
公开(公告)日：2003-07-24
申请号：PCT/US2002/041224
申请日：2002-12-20
申请人： X-CEPTOR THERAPEUTICS, INC. , MARTIN, Richard , FLATT, Brenton, Todd , WANG, Tie-Lin , KAHL, Jeffery, Dean
发明人： MARTIN, Richard , FLATT, Brenton, Todd , WANG, Tie-Lin , KAHL, Jeffery, Dean
IPC分类号： C07D277/60
摘要： Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.

4. 发明申请

WO2003099821A1 AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：作为药物代谢物的亚氨基二吡啶并吡啶衍生物
公开(公告)号：WO2003099821A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/016767
申请日：2003-05-27
申请人： X-CEPTOR THERAPEUTICS, INC. , MARTIN, Richard , WANG, Tie-Lin , FLATT, Brenton, Todd , GU, Xiao-Hui , GRIFFITH, Ronald
发明人： MARTIN, Richard , WANG, Tie-Lin , FLATT, Brenton, Todd , GU, Xiao-Hui , GRIFFITH, Ronald
IPC分类号： C07D487/04
CPC分类号： C07D471/04 , C07D487/10 , C07D491/04
摘要： The present invention is directed to compounds of formula (I) and formula (II): formula (I) and (II), wherein R 1 -R 8 , A and n are as described in the description. These compounds are used in pharmaceutical compositions and methods for modulating the activity of orphan nuclear receptors.
摘要翻译：本发明涉及式（I）和式（II）的化合物：式（I）和（II），其中R 1 -R 8，A和n如说明书所述。这些化合物用于调节孤儿核受体活性的药物组合物和方法中。

5. 发明申请

WO2006020680A2 HETEROCYCLIC COMPOUNDS AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：杂环化合物作为药物制剂
公开(公告)号：WO2006020680A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/028357
申请日：2005-08-09
申请人： EXELIXIS, INC. , MARTIN, Richard , FLATT, Brenton, Todd , KAHL, Jeffrey, Dean
发明人： MARTIN, Richard , FLATT, Brenton, Todd , KAHL, Jeffrey, Dean
IPC分类号： A61K31/426
CPC分类号： C07D417/06 , C07D277/54
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of the disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译：提供了用于调节受体活性的化合物，组合物和方法。具体而言，提供了用于调节受体活性并用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状的化合物和组合物。

6. 发明申请

WO2005047268A2 SUBSTITUTED PYRIMIDINE COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：取代的嘧啶组合物和使用方法
公开(公告)号：WO2005047268A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/037642
申请日：2004-11-09
申请人： X-CEPTOR THERAPEUTICS, INC. , MARTIN, Richard , MOHAN, Raju , ORDENTLICH, Peter
发明人： MARTIN, Richard , MOHAN, Raju , ORDENTLICH, Peter
IPC分类号： C07D239/00
CPC分类号： A61K31/505 , A61K31/519
摘要： Novel compositions and methods of using substituted pyrimidines which have the general formula: (I)
摘要翻译：（I）的新型组合物和使用取代的嘧啶的方法

7. 发明申请

WO2005009387A2 AZEPINE DERIVATIVES AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：药物衍生物作为药物代谢物
公开(公告)号：WO2005009387A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023745
申请日：2004-07-23
申请人： X-CEPTOR THERAPEUTICS INC. , MARTIN, Richard , WANG, Tie-Lin , FLATT, Brenton, T. , GU, Xiao-Hui
发明人： MARTIN, Richard , WANG, Tie-Lin , FLATT, Brenton, T. , GU, Xiao-Hui
IPC分类号： A61K
CPC分类号： C07D495/04 , C07D487/04
摘要： Compounds, compositions and methods are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activity of the receptors.
摘要翻译：提供化合物，组合物和方法用于调节受体的活性和用于治疗，预防或改善与受体活性相关的疾病或病症的一种或多种症状。

8. 发明申请

WO2003106435A1 FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF 审中-公开
标题翻译：熔融吡啶二酮-4（3H） - 酮衍生物，其制备方法及其用途
公开(公告)号：WO2003106435A1
公开(公告)日：2003-12-24
申请号：PCT/JP2003/007677
申请日：2003-06-17
申请人： SANKYO COMPANY, LIMITED , X-CEPTOR THERAPEUTICS, INC. , KANEKO, Satoru , WATANABE, Tsuyoshi , ODA, Kozo , MOHAN, Raju , SCHWEIGER, Edwin, J. , MARTIN, Richard
发明人： KANEKO, Satoru , WATANABE, Tsuyoshi , ODA, Kozo , MOHAN, Raju , SCHWEIGER, Edwin, J. , MARTIN, Richard
IPC分类号： C07D239/91
CPC分类号： C07D401/06 , C07D239/70 , C07D239/91 , C07D403/06 , C07D409/06 , C07D417/06 , C07D471/04 , C07D495/04
摘要： AbstractNovel compounds of the following formula (I) and pharmacologically acceptable salt and esters thereof can modulate LXR function and as a result show excellent anti-arteriosclerotic and anti-inflammatory activity:wherein:A represents aryl or heteroaryl;R 1 , R 2 and R 3 are the same or different and each represents hydrogen, hydroxyl, nitro, cyano, amino, halogen, carboxy, carbamoyl, mercapto, alkyl, haloalkyl, alkylcarbonyloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, alkylcarbonylamino, N-(alkylcarbonyl)-N-(alkyl)amino, alkoxycarbonylamino, N-(alkoxycarbonyl)-N-(alkyl)amino, alkylsulfonylamino, N-(alkylsulfonyl)-N-(alkyl)amino, haloalkylsulfonylamino, N-(haloalkylsulfonyl)-N-(alkyl)amino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group, or R 1 and R 2 together are alkylenedioxy;R 4 and R 5 are the same or different and each represents hydrogen, hydroxyl, amino, halogen, mercapto, alkyl, haloalkyl, alkoxy, alkoxycarbonyl or alkylthio;X represents hydrogen, hydroxyl, halogen, alkoxy or haloalkoxy; andY represents an optionally substituted alkyl, cycloalkyl, heterocyclyl, aryl, cycloalkylalkyl, heterocyclylalkyl or aralkyl group.
摘要翻译：摘要新的下式（I）化合物及其药理学上可接受的盐和酯可以调节LXR功能，结果显示出优异的抗动脉硬化和抗炎活性：其中：A代表芳基或杂芳基; R1，R2和R3是烷基，卤代烷基，烷基羰基氧基，烷氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，烷基氨基，二烷基氨基，烷基羰基氨基，N-（烷基羰基） - N-（烷基）氨基，烷氧基羰基氨基，N-（烷氧基羰基）-N-（烷基）氨基，烷基磺酰基氨基，N-（烷基磺酰基）-N-（烷基）氨基，卤代烷基磺酰基氨基，N-（卤代烷基磺酰基）氨基，烷基羰基，烷氧基羰基，烷基氨基羰基或二烷基氨基羰基，或R 1和R 2一起是亚烷基二氧基; R 4和R 5相同或不同，各自表示氢，羟基，氨基，卤素，巯基，烷基，卤代烷基，烷氧基，或烷硫基; X表示氢，羟基，卤素，烷氧基或卤代烷氧基; 并且Y表示任选取代的烷基，环烷基，杂环基，芳基，环烷基烷基，杂环基烷基或芳烷基。

9. 发明申请

WO2005056554A3 AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS 审中-公开
公开(公告)号：WO2005056554A3
公开(公告)日：2005-06-23
申请号：PCT/US2004/040352
申请日：2004-12-01
申请人： X-CEPTOR THERAPEUTICS, INC. , BUSCH, Brett , FLATT, Brenton, T. , GU, Xiao-Hui , MARTIN, Richard , MOHAN, Raju , WANG, Tie-Lin , WU, Jason, H.
发明人： BUSCH, Brett , FLATT, Brenton, T. , GU, Xiao-Hui , MARTIN, Richard , MOHAN, Raju , WANG, Tie-Lin , WU, Jason, H.
IPC分类号： C07D487/04
摘要： Compounds for use in pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, compounds for use in compositions and methods for modulating the farnesoid X receptor, and/or orphan nuclear receptors, are provided.: formula (I) or a pharmaceutically acceptable derivative thereof; wherein: R 1 is -C(J)OR 14 , -C(J)SR 14 and -C(J)N(R 15 )R 16 , J is O, S or NR 17 , R 2 is hydrogen, halo or optionally substituted alkyl; R 3 is -C(O)R 9 , R 4 , R 5 , R 6 and R 7 and R 8 are as described in the claims.

10. 发明申请

WO2005072731A1 3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS 审中-公开
标题翻译： 3-苯基-N-（（1,3,4）噻二唑-2-基） - 丙烯酰胺衍生物和相关化合物作为用于治疗E.G.的雌激素相关受体的调节剂。癌症，湿疹性神经病或神经病变
公开(公告)号：WO2005072731A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/002736
申请日：2005-01-28
申请人： X-CEPTOR THERAPEUTICS, INC. , BUSCH, Brett , JOHNSON, Alan, T. , MARTIN, Richard , MOHAN, Raju , STEVENS, William, C., Jr.
发明人： BUSCH, Brett , JOHNSON, Alan, T. , MARTIN, Richard , MOHAN, Raju , STEVENS, William, C., Jr.
IPC分类号： A61K31/433
CPC分类号： C07D271/113 , C07C47/575 , C07C205/44 , C07D277/46 , C07D285/135
摘要： Compounds of formula (I) are provided as well as compositions and methods of using compounds of formula (I) for modulating the activity of the estrogen-related receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activity of the estrogen-related receptor. Considering the wide range of activity of the nuclear hormone receptor ERRα, the compounds described herein which are capable of modulating ERRα activity, are useful for treating a range of disease states including cancer, diabetes, obesity, hyperlipidermia, arthritis, atherosclerosis, osteoporosis, anxiety, depression, Parkinson’s disease and Alzheimer’s disease. Formula (I). The substituents are defined in the claims.
摘要翻译：提供式（I）化合物以及使用式（I）化合物调节雌激素相关受体的活性以及治疗，预防或改善一种或多种疾病或病症症状的组合物和方法与雌激素相关受体的活性有关。考虑到核激素受体ERRalpha的广泛活性，本文所述的能够调节ERRα活性的化合物可用于治疗一系列疾病状态，包括癌症，糖尿病，肥胖症，高脂血症，关节炎，动脉粥样硬化，骨质疏松症，焦虑症，抑郁症，帕金森病和阿尔茨海默病。式（I）。取代基在权利要求中限定。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式