基本信息:
- 专利标题： AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS
- 申请号：PCT/US2004/040352 申请日：2004-12-01
- 公开(公告)号：WO2005056554A3 公开(公告)日：2005-06-23
- 发明人： BUSCH, Brett , FLATT, Brenton, T. , GU, Xiao-Hui , MARTIN, Richard , MOHAN, Raju , WANG, Tie-Lin , WU, Jason, H.
- 申请人： X-CEPTOR THERAPEUTICS, INC. , BUSCH, Brett , FLATT, Brenton, T. , GU, Xiao-Hui , MARTIN, Richard , MOHAN, Raju , WANG, Tie-Lin , WU, Jason, H.
- 申请人地址： 4757 Nexus Center Drive, San Diego, California 92121 US
- 专利权人： X-CEPTOR THERAPEUTICS, INC.,BUSCH, Brett,FLATT, Brenton, T.,GU, Xiao-Hui,MARTIN, Richard,MOHAN, Raju,WANG, Tie-Lin,WU, Jason, H.
- 当前专利权人： X-CEPTOR THERAPEUTICS, INC.,BUSCH, Brett,FLATT, Brenton, T.,GU, Xiao-Hui,MARTIN, Richard,MOHAN, Raju,WANG, Tie-Lin,WU, Jason, H.
- 当前专利权人地址： 4757 Nexus Center Drive, San Diego, California 92121 US
- 代理机构： ROTH, Carol, J.
- 优先权： US10/895,431 20031202
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
摘要：
Compounds for use in pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, compounds for use in compositions and methods for modulating the farnesoid X receptor, and/or orphan nuclear receptors, are provided.: formula (I) or a pharmaceutically acceptable derivative thereof; wherein: R 1 is -C(J)OR 14 , -C(J)SR 14 and -C(J)N(R 15 )R 16 , J is O, S or NR 17 , R 2 is hydrogen, halo or optionally substituted alkyl; R 3 is -C(O)R 9 , R 4 , R 5 , R 6 and R 7 and R 8 are as described in the claims.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D487/00 | 在稠环系中含有氮原子作为仅有的杂环原子的杂环化合物，不包含在C07D451/00至C07D477/00组中 |
| --------C07D487/02 | .在稠合系中含有两个杂环 |
| ----------C07D487/04 | ..邻位稠合系 |