专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07052885B2 Process for preparing heterocyclic (R)- and (S)-cyanohydrins 失效
标题翻译：制备杂环（R） - 和（S） - 氰基醇的方法
公开(公告)号：US07052885B2
公开(公告)日：2006-05-30
申请号：US10325922
申请日：2002-12-23
申请人： Peter Poechlauer , Wolfgang Skranc , Herbert Mayrhofer , Irma Wirth , Rudolf Neuhofer , Herfried Griengl , Martin Fechter
发明人： Peter Poechlauer , Wolfgang Skranc , Herbert Mayrhofer , Irma Wirth , Rudolf Neuhofer , Herfried Griengl , Martin Fechter
IPC分类号： C12P17/00 , C12P17/02 , C12P17/04 , C12P17/06 , C12P17/18
CPC分类号： C12P13/004 , C12P17/00 , C12P17/04
摘要： A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C24-alkyl, alkenyl or alkynyl radical, where one or more carbon atoms in the chain can be replaced by an oxygen atom, a nitrogen atom, a sulfur atom, an SO or an SO2 group, an unsubstituted or substituted aryl or heteroaryl radical or heterocyclic radical or halogen, hydroxyl, NR5R6, acetyl, oxo, C1–C6-carbalkoxy, C1–C6-carbalkoxyamino, COOR7, cyano, amide, benzoylamino or NO2,R5 and R6 are H, C1–C6-alkyl radical, phenyl radical, benzyl radical or COOR7, or together form a C2–C8-alkylene or heteroalkylene radical,R7 is H or C1–C6-alkyl,n is 0, 1, 2 or 3,X, Y and Z can be an unsubstituted or substituted carbon atom or a radical selected from the group consisting of N, O, S or NR5R6, where R5 and R6 are as defined above, SO or SO2, and at least one of the radicals X, Y and Z is not a carbon atom, where the compounds of the formula (I) can have one or more double bonds in the ring, with the proviso that in a 5-membered ring the double bond is not conjugated with the —C(OH)CN-group, and/or can be anellated and/or bridged,by reacting a ketone of the formula (II), where R1, R2, R3, R4, X, Y, Z and n have the meanings above, with an (R)- or (S)-hydroxynitrile lyase in an organic, aqueous or two-phase system, or in emulsion, in the presence of a cyanide group donor.
摘要翻译：制备式（I）的对映异构体富集的杂环（R） - 和（S） - 氰基醇的方法，其中R 1，R 2，R 3，R 4彼此独立地是H，未取代或取代的C 1 - 链烯基或炔基，其中链中的一个或多个碳原子可以被氧原子，氮原子，硫原子，SO或 SO 2 2基团，未取代或取代的芳基或杂芳基或杂环基或卤素，羟基，NR 5 R 6，乙酰基，氧代C 1 -C 6 - 亚烷基氧基，C 1 -C 6 - 烷氧基氨基，COOR 7，氰基，酰胺，苯甲酰氨基或NO 2，R 5和R 6是H C 1 -C 6 - 烷基，苯基，苄基或COOR 7，或一起形成C 1 -C 6 - 8亚烷基或杂亚烷基，R 7是H或C 1 -C 6 - 烷基，n是0,1,2或3，X，Y 并且Z可以是未取代或取代的碳原子或选自它的基团由N，O，S或NR5R6组成的基团，其中R 5和R 6如上定义，SO或SO 2，并且基团X，Y和Z中的至少一个不是碳原子，其中式（I）的化合物可以在环中具有一个或多个双键，条件是在5元环中双键不与-C（OH）CN-基团共轭，并且 /或可以通过使式（II）的酮（其中R 1，R 2，R 3，R 4，X，Y，Z和n具有上述含义）与（R） - 或（ S） - 羟基腈裂解酶在有机，水相或两相体系中，或在乳液中，在氰化物基团给体存在下。

2. 发明授权

US06909011B2 Process for preparing protected, enantiomer-enriched cyanohydrins by in-situ derivatization 失效
标题翻译：通过原位衍生制备保护的富含对映异构体的氰醇的方法
公开(公告)号：US06909011B2
公开(公告)日：2005-06-21
申请号：US10325923
申请日：2002-12-23
申请人： Wolfgang Skranc , Peter Poechlauer , Irma Wirth , Rudolf Neuhofer , Herbert Mayrhofer
发明人： Wolfgang Skranc , Peter Poechlauer , Irma Wirth , Rudolf Neuhofer , Herbert Mayrhofer
IPC分类号： C12P13/00 , C12R1/91 , C07C253/16 , C12P13/16
CPC分类号： C12P13/004
摘要： A process for preparing protected, enantiomer-enriched cyanohydrins of the formula where R1 and R2 independently of one another can be an unsubstituted, monosubstituted or polysubstituted C1-C20-alkyl, C5-C20-aryl, C5-C20-heteroaryl, C5-C20-alkaryl, C5-C20-alkylheteroaryl or C5-C20-aralkyl radical or an unsubstituted, monosubstituted or polysubstituted C5-C20-heterocycle, or C5-C20-alkylheterocycle or together can be an unsubstituted or substituted C4-C20-alkylene radical, which can contain one or more heteroatoms in the chain, or one of the radicals is hydrogen, and R3 can be an unsubstituted or substituted C1-C20-alkyl, C5-C20-aryl or C5-C20-heteroaryl radical, by reacting an aldehyde or ketone of the formula where R1 and R2 are defined as above, in the presence of an (R)- or (S)-hydroxynitrile lyase in an organic, aqueous or 2-phase system or in emulsion at a temperature of −5 to +40° C. with a carbonic ester nitrile of the formula where R3 is defined as above.
摘要翻译：制备具有下式的受保护的对映异构体富含氰醇的方法其中R 1和R 2彼此独立地可以是未取代的，单取代的或多取代的C 1 -C 20 - 烷基 C 5 -C 20 - 芳基，C 5 -C 20 - 杂芳基，C 5 - C 20 -C 20 - 烷芳基，C 5 -C 20 - 烷基杂芳基或C 5 -C 或是未取代的单取代或多取代的C 5 -C 20 - 杂环或C 5 - -C 20 - 烷基杂环或一起可以是未取代或取代的C 4 -C 20 - 亚烷基，其可以含有一个或多个杂原子在链中，或者一个基团是氢，并且R 3可以是未取代或取代的C 1 -C 20 - 烷基，C 5 C 20 -C 20 - 芳基或C 5 -C 20 - 杂芳基，通过使下式的醛或酮反应其中R1和R2 在有机，水相或两相体系中的（R） - 或（S） - 羟基腈裂解酶存在下，或在-5至+ 40℃的温度下与碳酸酯腈，其中R3如上定义。

3. 发明授权

US06818423B2 Process for the preparation of chiral &agr;-hydroxycarboxylic acids 失效
标题翻译：制备手性α-羟基羧酸的方法
公开(公告)号：US06818423B2
公开(公告)日：2004-11-16
申请号：US10286892
申请日：2002-11-04
申请人： Herbert Mayrhofer , Rudolf Neuhofer , Peter Poechlauer , Wolfgang Skranc , Irma Wirth
发明人： Herbert Mayrhofer , Rudolf Neuhofer , Peter Poechlauer , Wolfgang Skranc , Irma Wirth
IPC分类号： C12P742
CPC分类号： C12P13/004 , C07B2200/07 , C07C51/377 , C07C319/18 , C07C319/20 , C07C319/28 , C07C59/01 , C07C323/22 , C07C323/60 , C07C323/52
摘要： A process for the preparation of chiral &agr;-hydroxycarboxylic acids: in which R1 is optionally halogen substituted C1-C2-alkyl and R2 is optionally halogen substituted C2-C3-alkyl from a compound: in which R′2 is optionally halogen substituted C2-C3-alkylene, m is 0 or 1 and R is optionally substituted alkyl, aryl, heteroaryl or heterocyclyl and X can be oxygen, sulfur, sulfinyl, sulfonyl, imino, C1-C6-alkylimino, xanthate, silyl, or, if m is equal to 0, halogen, which is reacted in the presence of a cyanide group donor to give the corresponding (R)- or (S)-cyanohydrin or its racemate: which then is converted by means of acidic hydrolysis into an acid: or its racemate, and by cleavage of the group: (R)m-X (V), and optional resolution, whereby the desired chiral &agr;-hydroxycarboxylic acid of the formula (I) is obtained.
摘要翻译：一种制备手性α-羟基羧酸的方法：其中R 1任选为卤素取代的C 1 -C 2 - 烷基，R 2为卤素取代的C 2 -C 3 - 烷基，其中R'2任选为卤素取代的C2- C3-亚烷基，m是0或1，R是任选取代的烷基，芳基，杂芳基或杂环基，X可以是氧，硫，亚磺酰基，磺酰基，亚氨基，C 1 -C 6烷基亚氨基，黄原酸酯，甲硅烷基，或者，如果m是等于0，卤素，其在氰化物基团供体的存在下反应，得到相应的（R） - 或（S） - 氰基氢茚或其外消旋物，然后通过酸性水解转化成酸：或其通过裂解所述基团：任选的分辨率，由此获得所需的式（I）手性α-羟基羧酸。

4. 发明申请

US20110034720A1 FORMATION OF NITRATE ESTERS IN MICROREACTORS AND MILLIREACTORS USING A CONTINUOUS PRODUCT EXTRACTION IN A TURBULENT FLOW REGIME 有权
标题翻译：在湍流流程中使用连续产物萃取在微生物和乳清液中形成硝酸酯
公开(公告)号：US20110034720A1
公开(公告)日：2011-02-10
申请号：US12808829
申请日：2008-12-19
申请人： Sascha Braune , Stefan Steinhofer , Peter Poechlauer , Rafael Wilhelmus E.G. Reintjens , Nicole Theodora W. Linssen , Mehul Thathagar
发明人： Sascha Braune , Stefan Steinhofer , Peter Poechlauer , Rafael Wilhelmus E.G. Reintjens , Nicole Theodora W. Linssen , Mehul Thathagar
IPC分类号： C07C201/02
CPC分类号： B01J19/0093 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00966 , B01J2219/00984 , C07C201/02 , C07C203/04
摘要： A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.
摘要翻译：在二相溶剂系统中连续制备其中R 1为具有3至6个碳原子的直链烷基的式（II）化合物HO-R1-ONO2（Ⅱ）的方法，包括使式（I）化合物，其中R 1如上定义的HO-R 1 -OH（I）与硝酸在第一溶剂存在下反应，其中将式（II）化合物连续萃取到第二溶剂中，反应在混合微反应器中进行，该混合微反应器通过圆形截面直通微反应器提供至少1.3相同条件下功率损耗的功率损失，该反应器的内径等于混合微反应器的平均水力直径长度等于混合微反应器的长度。

5. 发明申请

US20070196904A1 Method for the production of chiral secondary alcohols 审中-公开
公开(公告)号：US20070196904A1
公开(公告)日：2007-08-23
申请号：US10592758
申请日：2005-02-25
申请人： Thomas Dax , Michael Stanek , Peter Poechlauer
发明人： Thomas Dax , Michael Stanek , Peter Poechlauer
IPC分类号： C12P13/00
CPC分类号： C12P41/004 , C07B2200/07 , C07C29/143 , C12P7/02 , Y02P20/55 , C07C33/46
摘要： Disclosed is a method for producing chiral, secondary alcohols of formula (I), wherein A represents an aromatic, heterocyclic, or alicyclic ring or a ring system with 4 to 20 C atoms, n represents 0, 1, 2, 3, 4, or 5, R represents halogen, OH, an O— protective group, NO2, N,N—R2,R3 amine, R2 and R3 representing C1-C6 alkyl, phenyl, or benzyl, N,N—R2,R3-amino-C1-C6 alkyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C4 alkoxycarbonyl, or CN, and R1 represents N,N—R2,R3 amine, N,N—R2,R3-amino-C1-C6 alkyl, C1-C12 alkyl, C1-C6-haloalkyl, C1-C4 alkoxycarbonyl, C1-C6 alkoxy-C1-C6 alkyl, or a C2-C5 alkylene radical that forms a ring system along with the A radical. According to the inventive method, a) a ketone of formula (II) is optionally reduced to the corresponding racemic alcohol of formula (III) by means of an aliphatic C1-C6 alcohol in the presence of a transition metal catalyst and a base, and b) the alcohol of formula (III) is reacted to a mixture of (R) ester of formula (IV), wherein R4 represents H or C1-C5 alkyl, and (S) alcohol of formula (I) in the presence of an esterification catalyst and an acyl donor, whereupon the (S) alcohol is isolated from the reaction mixture by means of crystallization or distillation according to the aggregate state thereof.

6. 发明授权

US08497384B2 Process for the production of cyclopropane derivatives 有权
标题翻译：制备环丙烷衍生物的方法
公开(公告)号：US08497384B2
公开(公告)日：2013-07-30
申请号：US13129213
申请日：2009-11-12
申请人： Mehul Thathagar , Peter Poechlauer , Sascha Braune
发明人： Mehul Thathagar , Peter Poechlauer , Sascha Braune
IPC分类号： C07D333/78
CPC分类号： C07B37/10 , C07D333/78 , Y02P20/582
摘要： A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula:CR1R2, in a reaction vessel, optionally in the presence of a solvent, wherein, R1 and R2 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R7 or —NR82; R3, R4, R5 and R6 are each independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R9, —NR102, —SR11, —S(O)R11, or —SO2R11, or R3 and R6 are as defined above and R4 and R5 together form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; R7 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy, heteroaryl or —NR102; R8 is hydrogen, C1-C6 alkyl, C1-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; R9 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy or heteroaryl; R10 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl, heterocyclyl or C(O)R12; R11 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; and R12 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, or aryloxy, in the presence of copper metal or copper oxide, wherein the process is a continuous process.
摘要翻译：一种制备式（I）的环丙烷衍生物的方法，通过使式（II）的烯烃与式CR1R2的卡宾反应在反应容器中，任选地在溶剂存在下，其中R 1 C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，杂环基，碳环基，杂环基，-C（O）R 7或-NR 82; R3，R4，R5和R6各自独立地为氢，C1-C6烷基，C1-C6烷氧基，C2-C6烯基，芳基，芳氧基，杂芳基，杂环基，碳环基，杂环基，-C（O）R9，-NR102， SR11，-S（O）R11或-SO2R11，或R3和R6如上定义，R4和R5一起形成环，该环是碳环基，杂环基，芳族或杂芳族; R 7是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基，芳氧基，杂芳基或-NR 102; R 8是氢，C 1 -C 6烷基，C 1 -C 6烯基，芳基，杂芳基，碳环基或杂环基; R9是氢，羟基，C1-C6烷基，C1-C6烷氧基，芳基，芳氧基或杂芳基; R 10是氢，C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，碳环基，杂环基或C（O）R 12; R11是氢，C1-C6烷基，C2-C6烯基，芳基，杂芳基，碳环基或杂环基; 并且在铜金属或氧化铜的存在下，R 12是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基或芳氧基，其中该方法是连续方法。

7. 发明授权

US08221708B2 Tube bundle falling film microreactor for performing gas liquid reactions 有权
标题翻译：用于进行气液反应的管束降膜微反应器
公开(公告)号：US08221708B2
公开(公告)日：2012-07-17
申请号：US12600513
申请日：2008-05-29
申请人： Florian Seebauer , Peter Poechlauer , Sascha Braune , Stefan Steinhofer
发明人： Florian Seebauer , Peter Poechlauer , Sascha Braune , Stefan Steinhofer
IPC分类号： B01J10/02
CPC分类号： B01J19/0093
摘要： A tube bundle falling film microreactor for performing gas-liquid reactions, which has: a) at least one vertical tube with b) a device for distributing the liquid on the inside of the tube and c) a liquid collecting system, and d) a device for gas supply and removal, and use thereof.
摘要翻译：一种用于进行气液反应的管束降膜微反应器，其具有：a）至少一个垂直管，其具有b）用于在所述管内部分配液体的装置，以及c）液体收集系统，以及d）气体供应和清除装置及其用途。

8. 发明申请

US20140100360A1 CONTINUOUS PRODUCTION AND REACTION OF A DIAZO COMPOUND 有权
标题翻译：连续生产和反应的DIAZO化合物
公开(公告)号：US20140100360A1
公开(公告)日：2014-04-10
申请号：US13879889
申请日：2011-11-01
申请人： Peter Poechlauer , Rafael Wilhelmus Elisabeth Ghislain Reintjens , Hubertus Johannes Adrianus Dielemans , Mehul Thathagar , Jeroen Hubertina Gerardus Konings
发明人： Peter Poechlauer , Rafael Wilhelmus Elisabeth Ghislain Reintjens , Hubertus Johannes Adrianus Dielemans , Mehul Thathagar , Jeroen Hubertina Gerardus Konings
IPC分类号： C07C245/16
CPC分类号： C07C245/16 , C07C67/00 , C07C245/14 , C07D231/06 , C07C69/78
摘要： A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.
摘要翻译：一种制备重氮化合物的反应产物的方法，该方法包括：a。向第一反应器连续供应重氮化合物的前体; 水溶性溶剂; 基地和水; b。混合重氮化合物的前体; 水溶性溶剂; 碱和水生成重氮化合物; C。连续地从第一反应器中通过疏水膜除去形成的重氮化合物的第二反应器; d。从第一反应器中连续除去未进入第二反应器的所有反应产物; e。在非水混溶性溶剂中连续向第二反应器供给基材; F。混合上述组分以产生重氮化合物的反应产物; 和g。从第二反应器中连续除去非水混溶性溶剂和重氮化合物的反应产物，以及适于进行这种方法的设备。

9. 发明授权

US08106242B2 Process for the production of compounds via hazardous intermediates in a series of microreactors 有权
标题翻译：通过一系列微反应器中的危险中间体生产化合物的方法
公开(公告)号：US08106242B2
公开(公告)日：2012-01-31
申请号：US12301113
申请日：2007-05-23
申请人： Rafael Wilhelmus Elisabeth Ghislain Reintjens , Quirinus Bernardus Broxterman , Martina Kotthaus , Peter Poechlauer
发明人： Rafael Wilhelmus Elisabeth Ghislain Reintjens , Quirinus Bernardus Broxterman , Martina Kotthaus , Peter Poechlauer
IPC分类号： C07C209/42 , C07C45/40 , C07C29/132
CPC分类号： C07C29/132 , C07C45/40 , C07C45/517 , C07C45/53 , C07C209/42 , C07C247/04 , C07C47/546 , C07C211/27 , C07C33/20
摘要： Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.
摘要翻译：用于通过有害中间体制备化合物的多步骤方法，包括以下步骤：a）在微反应器中制备危险中间体，和b）任选地在一种或多种另外的微反应器中对危险中间体进行一个或多个反应步骤，和c）进一步转化该危险中间体在随后的微反应器中具有合适的反应剂，直到形成稳定的最终产物。

10. 发明申请

US20110301359A1 PROCESS FOR THE PRODUCTION OF CYCLOPROPANE DERIVATIVES 有权
标题翻译：生产环丙基衍生物的方法
公开(公告)号：US20110301359A1
公开(公告)日：2011-12-08
申请号：US13129213
申请日：2009-11-12
申请人： Mehul Thathagar , Peter Poechlauer , Sascha Braune
发明人： Mehul Thathagar , Peter Poechlauer , Sascha Braune
IPC分类号： C07D333/78
CPC分类号： C07B37/10 , C07D333/78 , Y02P20/582
摘要： A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula: CR1R2, in a reaction vessel, optionally in the presence of a solvent, wherein, R1 and R2 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R7 or —NR82; R3, R4, R5 and R6 are each independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R9, —NR102, —SR11, —S(O)R11, or —SO2R11, or R3 and R6 are as defined above and R4 and R5 together form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; R7 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy, heteroaryl or —NR102; R8 is hydrogen, C1-C6 alkyl, C1-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; R9 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy or heteroaryl; R10 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl, heterocyclyl or C(O)R12; R11 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; and R12 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, or aryloxy, in the presence of copper metal or copper oxide, wherein the process is a continuous process.
摘要翻译：一种制备式（I）的环丙烷衍生物的方法，通过使式（II）的烯烃与式CR1R2的卡宾反应在反应容器中，任选地在溶剂存在下，其中R 1 C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，杂环基，碳环基，杂环基，-C（O）R 7或-NR 82; R3，R4，R5和R6各自独立地为氢，C1-C6烷基，C1-C6烷氧基，C2-C6烯基，芳基，芳氧基，杂芳基，杂环基，碳环基，杂环基，-C（O）R9，-NR102， SR11，-S（O）R11或-SO2R11，或R3和R6如上定义，R4和R5一起形成环，该环是碳环基，杂环基，芳族或杂芳族; R 7是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基，芳氧基，杂芳基或-NR 102; R 8是氢，C 1 -C 6烷基，C 1 -C 6烯基，芳基，杂芳基，碳环基或杂环基; R9是氢，羟基，C1-C6烷基，C1-C6烷氧基，芳基，芳氧基或杂芳基; R 10是氢，C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，碳环基，杂环基或C（O）R 12; R11是氢，C1-C6烷基，C2-C6烯基，芳基，杂芳基，碳环基或杂环基; 并且在铜金属或氧化铜的存在下，R 12是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基或芳氧基，其中该方法是连续方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式