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1. 发明授权

US09249088B2 Continuous production and reaction of a diazo compound 有权
标题翻译：连续生产和重氮化合物的反应
公开(公告)号：US09249088B2
公开(公告)日：2016-02-02
申请号：US13879889
申请日：2011-11-01
申请人： Peter Poechlauer , Rafael Wilhelmus Elisabeth Ghislain Reintjens , Hubertus Johannes Adrianus Dielemans , Mehul Thathagar , Jeroen Hubertina Gerardus Konings
发明人： Peter Poechlauer , Rafael Wilhelmus Elisabeth Ghislain Reintjens , Hubertus Johannes Adrianus Dielemans , Mehul Thathagar , Jeroen Hubertina Gerardus Konings
IPC分类号： C07C245/16 , C07C67/00 , C07C245/14 , C07D231/06
CPC分类号： C07C245/16 , C07C67/00 , C07C245/14 , C07D231/06 , C07C69/78
摘要： A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.
摘要翻译：一种制备重氮化合物的反应产物的方法，该方法包括：a。向第一反应器连续供应重氮化合物的前体; 水溶性溶剂; 基地和水; b。混合重氮化合物的前体; 水溶性溶剂; 碱和水生成重氮化合物; C。连续地从第一反应器中通过疏水膜除去形成的重氮化合物的第二反应器; d。从第一反应器中连续除去未进入第二反应器的所有反应产物; e。在非水混溶性溶剂中连续向第二反应器供给基材; F。混合上述组分以产生重氮化合物的反应产物; 和g。从第二反应器中连续除去非水混溶性溶剂和重氮化合物的反应产物，以及适于进行这种方法的设备。

2. 发明申请

US20140100360A1 CONTINUOUS PRODUCTION AND REACTION OF A DIAZO COMPOUND 有权
标题翻译：连续生产和反应的DIAZO化合物
公开(公告)号：US20140100360A1
公开(公告)日：2014-04-10
申请号：US13879889
申请日：2011-11-01
申请人： Peter Poechlauer , Rafael Wilhelmus Elisabeth Ghislain Reintjens , Hubertus Johannes Adrianus Dielemans , Mehul Thathagar , Jeroen Hubertina Gerardus Konings
发明人： Peter Poechlauer , Rafael Wilhelmus Elisabeth Ghislain Reintjens , Hubertus Johannes Adrianus Dielemans , Mehul Thathagar , Jeroen Hubertina Gerardus Konings
IPC分类号： C07C245/16
CPC分类号： C07C245/16 , C07C67/00 , C07C245/14 , C07D231/06 , C07C69/78
摘要： A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.
摘要翻译：一种制备重氮化合物的反应产物的方法，该方法包括：a。向第一反应器连续供应重氮化合物的前体; 水溶性溶剂; 基地和水; b。混合重氮化合物的前体; 水溶性溶剂; 碱和水生成重氮化合物; C。连续地从第一反应器中通过疏水膜除去形成的重氮化合物的第二反应器; d。从第一反应器中连续除去未进入第二反应器的所有反应产物; e。在非水混溶性溶剂中连续向第二反应器供给基材; F。混合上述组分以产生重氮化合物的反应产物; 和g。从第二反应器中连续除去非水混溶性溶剂和重氮化合物的反应产物，以及适于进行这种方法的设备。

3. 发明授权

US08106242B2 Process for the production of compounds via hazardous intermediates in a series of microreactors 有权
标题翻译：通过一系列微反应器中的危险中间体生产化合物的方法
公开(公告)号：US08106242B2
公开(公告)日：2012-01-31
申请号：US12301113
申请日：2007-05-23
申请人： Rafael Wilhelmus Elisabeth Ghislain Reintjens , Quirinus Bernardus Broxterman , Martina Kotthaus , Peter Poechlauer
发明人： Rafael Wilhelmus Elisabeth Ghislain Reintjens , Quirinus Bernardus Broxterman , Martina Kotthaus , Peter Poechlauer
IPC分类号： C07C209/42 , C07C45/40 , C07C29/132
CPC分类号： C07C29/132 , C07C45/40 , C07C45/517 , C07C45/53 , C07C209/42 , C07C247/04 , C07C47/546 , C07C211/27 , C07C33/20
摘要： Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.
摘要翻译：用于通过有害中间体制备化合物的多步骤方法，包括以下步骤：a）在微反应器中制备危险中间体，和b）任选地在一种或多种另外的微反应器中对危险中间体进行一个或多个反应步骤，和c）进一步转化该危险中间体在随后的微反应器中具有合适的反应剂，直到形成稳定的最终产物。

4. 发明申请

US20100029990A1 PROCESS FOR THE PRODUCTION OF COMPOUNDS VIA HAZARDOUS INTERMEDIATES IN A SERIES OF MICROREACTORS 有权
标题翻译：在一系列微生物中通过危险中间体生产化合物的方法
公开(公告)号：US20100029990A1
公开(公告)日：2010-02-04
申请号：US12301113
申请日：2007-05-23
申请人： Rafael Wilhelmus Elisabeth Ghislain Reintjens , Quirinus Bernardus Broxterman , Martina Kotthaus , Peter Poechlauer
发明人： Rafael Wilhelmus Elisabeth Ghislain Reintjens , Quirinus Bernardus Broxterman , Martina Kotthaus , Peter Poechlauer
IPC分类号： C07C209/42 , C07C45/00 , C07C29/132
CPC分类号： C07C29/132 , C07C45/40 , C07C45/517 , C07C45/53 , C07C209/42 , C07C247/04 , C07C47/546 , C07C211/27 , C07C33/20
摘要： Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.
摘要翻译：用于通过有害中间体制备化合物的多步骤方法，包括以下步骤：a）在微反应器中制备危险中间体，和b）任选地在一种或多种另外的微反应器中对危险中间体进行一个或多个反应步骤，和c）进一步转化该危险中间体在随后的微反应器中具有合适的反应剂，直到形成稳定的最终产物。

5. 发明申请

US20110034720A1 FORMATION OF NITRATE ESTERS IN MICROREACTORS AND MILLIREACTORS USING A CONTINUOUS PRODUCT EXTRACTION IN A TURBULENT FLOW REGIME 有权
标题翻译：在湍流流程中使用连续产物萃取在微生物和乳清液中形成硝酸酯
公开(公告)号：US20110034720A1
公开(公告)日：2011-02-10
申请号：US12808829
申请日：2008-12-19
申请人： Sascha Braune , Stefan Steinhofer , Peter Poechlauer , Rafael Wilhelmus E.G. Reintjens , Nicole Theodora W. Linssen , Mehul Thathagar
发明人： Sascha Braune , Stefan Steinhofer , Peter Poechlauer , Rafael Wilhelmus E.G. Reintjens , Nicole Theodora W. Linssen , Mehul Thathagar
IPC分类号： C07C201/02
CPC分类号： B01J19/0093 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00966 , B01J2219/00984 , C07C201/02 , C07C203/04
摘要： A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.
摘要翻译：在二相溶剂系统中连续制备其中R 1为具有3至6个碳原子的直链烷基的式（II）化合物HO-R1-ONO2（Ⅱ）的方法，包括使式（I）化合物，其中R 1如上定义的HO-R 1 -OH（I）与硝酸在第一溶剂存在下反应，其中将式（II）化合物连续萃取到第二溶剂中，反应在混合微反应器中进行，该混合微反应器通过圆形截面直通微反应器提供至少1.3相同条件下功率损耗的功率损失，该反应器的内径等于混合微反应器的平均水力直径长度等于混合微反应器的长度。

6. 发明授权

US08497384B2 Process for the production of cyclopropane derivatives 有权
标题翻译：制备环丙烷衍生物的方法
公开(公告)号：US08497384B2
公开(公告)日：2013-07-30
申请号：US13129213
申请日：2009-11-12
申请人： Mehul Thathagar , Peter Poechlauer , Sascha Braune
发明人： Mehul Thathagar , Peter Poechlauer , Sascha Braune
IPC分类号： C07D333/78
CPC分类号： C07B37/10 , C07D333/78 , Y02P20/582
摘要： A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula:CR1R2, in a reaction vessel, optionally in the presence of a solvent, wherein, R1 and R2 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R7 or —NR82; R3, R4, R5 and R6 are each independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R9, —NR102, —SR11, —S(O)R11, or —SO2R11, or R3 and R6 are as defined above and R4 and R5 together form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; R7 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy, heteroaryl or —NR102; R8 is hydrogen, C1-C6 alkyl, C1-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; R9 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy or heteroaryl; R10 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl, heterocyclyl or C(O)R12; R11 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; and R12 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, or aryloxy, in the presence of copper metal or copper oxide, wherein the process is a continuous process.
摘要翻译：一种制备式（I）的环丙烷衍生物的方法，通过使式（II）的烯烃与式CR1R2的卡宾反应在反应容器中，任选地在溶剂存在下，其中R 1 C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，杂环基，碳环基，杂环基，-C（O）R 7或-NR 82; R3，R4，R5和R6各自独立地为氢，C1-C6烷基，C1-C6烷氧基，C2-C6烯基，芳基，芳氧基，杂芳基，杂环基，碳环基，杂环基，-C（O）R9，-NR102， SR11，-S（O）R11或-SO2R11，或R3和R6如上定义，R4和R5一起形成环，该环是碳环基，杂环基，芳族或杂芳族; R 7是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基，芳氧基，杂芳基或-NR 102; R 8是氢，C 1 -C 6烷基，C 1 -C 6烯基，芳基，杂芳基，碳环基或杂环基; R9是氢，羟基，C1-C6烷基，C1-C6烷氧基，芳基，芳氧基或杂芳基; R 10是氢，C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，碳环基，杂环基或C（O）R 12; R11是氢，C1-C6烷基，C2-C6烯基，芳基，杂芳基，碳环基或杂环基; 并且在铜金属或氧化铜的存在下，R 12是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基或芳氧基，其中该方法是连续方法。

7. 发明授权

US08536366B2 Formation of nitrate esters in microreactors and millireactors using a continuous product extraction in a turbulent flow regime 有权
标题翻译：在湍流状态下，使用连续的产物萃取法在微反应器和磨粒反应器中形成硝酸酯
公开(公告)号：US08536366B2
公开(公告)日：2013-09-17
申请号：US12808829
申请日：2008-12-19
申请人： Sascha Braune , Stefan Steinhofer , Peter Poechlauer , Rafael Wilhelmus E. G. Reintjens , Nicole Theodora W. Linssen , Mehul Thathagar
发明人： Sascha Braune , Stefan Steinhofer , Peter Poechlauer , Rafael Wilhelmus E. G. Reintjens , Nicole Theodora W. Linssen , Mehul Thathagar
IPC分类号： C07C201/02 , C07C201/16 , B01J14/00 , B01D11/04
CPC分类号： B01J19/0093 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00966 , B01J2219/00984 , C07C201/02 , C07C203/04
摘要： A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.
摘要翻译：在二相溶剂系统中连续制备其中R 1为具有3至6个碳原子的直链烷基的式（II）化合物HO-R1-ONO2（Ⅱ）的方法，包括使式（I）化合物，其中R 1如上定义的HO-R 1 -OH（I）与硝酸在第一溶剂存在下反应，其中将式（II）化合物连续萃取到第二溶剂中，反应在混合微反应器中进行，该混合微反应器通过圆形截面直通微反应器提供至少1.3相同条件下功率损耗的功率损失，该反应器的内径等于混合微反应器的平均水力直径长度等于混合微反应器的长度。

8. 发明申请

US20110301359A1 PROCESS FOR THE PRODUCTION OF CYCLOPROPANE DERIVATIVES 有权
标题翻译：生产环丙基衍生物的方法
公开(公告)号：US20110301359A1
公开(公告)日：2011-12-08
申请号：US13129213
申请日：2009-11-12
申请人： Mehul Thathagar , Peter Poechlauer , Sascha Braune
发明人： Mehul Thathagar , Peter Poechlauer , Sascha Braune
IPC分类号： C07D333/78
CPC分类号： C07B37/10 , C07D333/78 , Y02P20/582
摘要： A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula: CR1R2, in a reaction vessel, optionally in the presence of a solvent, wherein, R1 and R2 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R7 or —NR82; R3, R4, R5 and R6 are each independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R9, —NR102, —SR11, —S(O)R11, or —SO2R11, or R3 and R6 are as defined above and R4 and R5 together form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; R7 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy, heteroaryl or —NR102; R8 is hydrogen, C1-C6 alkyl, C1-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; R9 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy or heteroaryl; R10 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl, heterocyclyl or C(O)R12; R11 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; and R12 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, or aryloxy, in the presence of copper metal or copper oxide, wherein the process is a continuous process.
摘要翻译：一种制备式（I）的环丙烷衍生物的方法，通过使式（II）的烯烃与式CR1R2的卡宾反应在反应容器中，任选地在溶剂存在下，其中R 1 C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，杂环基，碳环基，杂环基，-C（O）R 7或-NR 82; R3，R4，R5和R6各自独立地为氢，C1-C6烷基，C1-C6烷氧基，C2-C6烯基，芳基，芳氧基，杂芳基，杂环基，碳环基，杂环基，-C（O）R9，-NR102， SR11，-S（O）R11或-SO2R11，或R3和R6如上定义，R4和R5一起形成环，该环是碳环基，杂环基，芳族或杂芳族; R 7是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基，芳氧基，杂芳基或-NR 102; R 8是氢，C 1 -C 6烷基，C 1 -C 6烯基，芳基，杂芳基，碳环基或杂环基; R9是氢，羟基，C1-C6烷基，C1-C6烷氧基，芳基，芳氧基或杂芳基; R 10是氢，C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，碳环基，杂环基或C（O）R 12; R11是氢，C1-C6烷基，C2-C6烯基，芳基，杂芳基，碳环基或杂环基; 并且在铜金属或氧化铜的存在下，R 12是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基或芳氧基，其中该方法是连续方法。

9. 发明申请

US20070196904A1 Method for the production of chiral secondary alcohols 审中-公开
公开(公告)号：US20070196904A1
公开(公告)日：2007-08-23
申请号：US10592758
申请日：2005-02-25
申请人： Thomas Dax , Michael Stanek , Peter Poechlauer
发明人： Thomas Dax , Michael Stanek , Peter Poechlauer
IPC分类号： C12P13/00
CPC分类号： C12P41/004 , C07B2200/07 , C07C29/143 , C12P7/02 , Y02P20/55 , C07C33/46
摘要： Disclosed is a method for producing chiral, secondary alcohols of formula (I), wherein A represents an aromatic, heterocyclic, or alicyclic ring or a ring system with 4 to 20 C atoms, n represents 0, 1, 2, 3, 4, or 5, R represents halogen, OH, an O— protective group, NO2, N,N—R2,R3 amine, R2 and R3 representing C1-C6 alkyl, phenyl, or benzyl, N,N—R2,R3-amino-C1-C6 alkyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C4 alkoxycarbonyl, or CN, and R1 represents N,N—R2,R3 amine, N,N—R2,R3-amino-C1-C6 alkyl, C1-C12 alkyl, C1-C6-haloalkyl, C1-C4 alkoxycarbonyl, C1-C6 alkoxy-C1-C6 alkyl, or a C2-C5 alkylene radical that forms a ring system along with the A radical. According to the inventive method, a) a ketone of formula (II) is optionally reduced to the corresponding racemic alcohol of formula (III) by means of an aliphatic C1-C6 alcohol in the presence of a transition metal catalyst and a base, and b) the alcohol of formula (III) is reacted to a mixture of (R) ester of formula (IV), wherein R4 represents H or C1-C5 alkyl, and (S) alcohol of formula (I) in the presence of an esterification catalyst and an acyl donor, whereupon the (S) alcohol is isolated from the reaction mixture by means of crystallization or distillation according to the aggregate state thereof.

10. 发明授权

US08221708B2 Tube bundle falling film microreactor for performing gas liquid reactions 有权
标题翻译：用于进行气液反应的管束降膜微反应器
公开(公告)号：US08221708B2
公开(公告)日：2012-07-17
申请号：US12600513
申请日：2008-05-29
申请人： Florian Seebauer , Peter Poechlauer , Sascha Braune , Stefan Steinhofer
发明人： Florian Seebauer , Peter Poechlauer , Sascha Braune , Stefan Steinhofer
IPC分类号： B01J10/02
CPC分类号： B01J19/0093
摘要： A tube bundle falling film microreactor for performing gas-liquid reactions, which has: a) at least one vertical tube with b) a device for distributing the liquid on the inside of the tube and c) a liquid collecting system, and d) a device for gas supply and removal, and use thereof.
摘要翻译：一种用于进行气液反应的管束降膜微反应器，其具有：a）至少一个垂直管，其具有b）用于在所述管内部分配液体的装置，以及c）液体收集系统，以及d）气体供应和清除装置及其用途。

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