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    • 2. 发明申请
    • ABUSE RESISTANT MELT EXTRUDED FORMULATION HAVING REDUCED ALCOHOL INTERACTION
    • 具有降低酒精相互作用的抗菌熔体挤压配方
    • US20100172989A1
    • 2010-07-08
    • US12631010
    • 2009-12-04
    • Wolfgang RothAlexander BurstMartina ZietschWei LiuSandeep Dutta
    • Wolfgang RothAlexander BurstMartina ZietschWei LiuSandeep Dutta
    • A61K9/14A61K31/485A61P25/04
    • A61K9/2027A61K9/2031A61K9/2054A61K9/209A61K9/2095A61K31/167A61K31/192A61K31/277A61K31/485
    • The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. Most preferably, the dosage form includes verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
    • 本发明涉及用于口服给药的组合物。 本发明优选包含至少一种用于递送具有在醇中倾倒剂量的药物的药物递送组合物,制备这些剂型的相关方法和治疗有需要的患者的方法包括将本发明组合物施用于患者 。 最优选地,剂型包括维拉帕米。 这些制剂减少了滥用的可能性。 在另一种制剂中,优选滥用相关药物是阿片样物质,非滥用相关药物是对乙酰氨基酚或布洛芬。 更优选地,阿片样物质是氢可酮,非滥用相关镇痛药是对乙酰氨基酚。 在某些优选的实施方案中,剂型的特征在于耐溶剂萃取; 篡改,破碎或研磨。 本发明的某些实施方案提供剂型,其提供药物释放的初始爆发,随后延长药物释放时间。
    • 3. 发明授权
    • Facility for introducing hop into a tank
    • 将啤酒池引入坦克的设施
    • US08875616B2
    • 2014-11-04
    • US13065255
    • 2011-03-17
    • Wolfgang Roth
    • Wolfgang Roth
    • C12C3/00C12C11/11C12C13/00
    • C12C3/00C12C11/11C12C13/00
    • A facility for introducing hop into a tank has a hop receiving tank that can be hermetically sealed and has an outflow and an inert gas supply at its bottom. The facility furthermore has a mixing apparatus that has two inlet pipes on its inflow side and an outlet pipe on the outflow side. This facility is adapted to a method for introducing hop into a tank, in which hop is put into a hop receiving container, air is expelled from the hop receiving container by inert gas and the hop with beer or “young beer” is supplied to the mixing apparatus.
    • 将啤酒池引入罐中的设施具有可以密封的啤酒花接收罐,其底部具有流出和惰性气体供应。 该设备还具有混合装置,其流入侧具有两个入口管和在流出侧上具有出口管。 该设施适用于将啤酒花引入罐中的方法,其中啤酒花放入啤酒花接收容器中,空气通过惰性气体从啤酒花接收容器中排出,并将具有啤酒或“年轻啤酒”的啤酒供应给 混合装置。
    • 4. 发明申请
    • Facility and method for introducing hop into a tank
    • 将啤酒花引入水箱的设施和方法
    • US20120237654A1
    • 2012-09-20
    • US13065255
    • 2011-03-17
    • Wolfgang Roth
    • Wolfgang Roth
    • C12C3/00
    • C12C3/00C12C11/11C12C13/00
    • A facility for introducing hop into a tank has a hop receiving tank that can be hermetically sealed and has an outflow and an inert gas supply at its bottom. The facility furthermore has a mixing apparatus that has two inlet pipes on its inflow side and an outlet pipe on the outflow side. This facility is adapted to a method for introducing hop into a tank, in which hop is put into a hop receiving container, air is expelled from the hop receiving container by means of inert gas and the hop with beer or “young beer” is supplied to the mixing apparatus.
    • 将啤酒池引入罐中的设施具有可以密封的啤酒花接收罐,其底部具有流出和惰性气体供应。 该设备还具有混合装置,其流入侧具有两个入口管和在流出侧上具有出口管。 该设施适用于将啤酒花引入罐中的方法,其中啤酒花放入啤酒花接收容器中,空气通过惰性气体从啤酒花接收容器中排出,并且提供具有啤酒或“年轻啤酒”的啤酒花 到混合装置。
    • 9. 发明授权
    • Method for producing polymer-free area on a substrate
    • 在基板上制造无聚合物区域的方法
    • US07026186B2
    • 2006-04-11
    • US10481848
    • 2002-06-17
    • Wolfgang Roth
    • Wolfgang Roth
    • H01L51/40
    • H01L51/56H01L51/0016H01L51/5253
    • The invention relates to a method for producing a polymer-free area, characterized by applying at least one peelable layer to the substrate, and/or to one or more polymer layer(s) situated on the substrate, in those areas where a polymer-free area is formed on the substrate by removing the peelable layer. The invention thus provides a method for producing polymer-free bonding areas or, by placing a diode-protecting cap on the polymer-free area of the substrate, a hermetically sealed connection between the substrate and the diode-protecting cap.
    • 本发明涉及一种生产无聚合物区域的方法,其特征在于在基底上施加至少一个可剥离层,和/或向位于基底上的一个或多个聚合物层施用聚合物 - 通过除去可剥离层而在基板上形成自由区域。 因此,本发明提供了一种用于生产无聚合物结合区域的方法,或者通过在衬底的无聚合物区域上放置二极管保护帽,在衬底和二极管保护帽之间形成气密密封的连接。