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1. 发明授权

US6107522A Process for the preparation of cyclopropylamine 失效
标题翻译：制备环丙胺的方法
公开(公告)号：US6107522A
公开(公告)日：2000-08-22
申请号：US350289
申请日：1999-07-09
申请人： Wolfgang Kleemiss , Marcel Feld , Manfred Kaufhold
发明人： Wolfgang Kleemiss , Marcel Feld , Manfred Kaufhold
IPC分类号： C07C209/56 , C07B61/00 , C07C51/363 , C07C67/00 , C07C67/333 , C07C69/74 , C07C209/58 , C07C211/17 , C07C211/35 , C07C231/02 , C07C233/58 , C07L209/00
CPC分类号： C07C231/02 , C07C209/58 , C07C51/363 , C07C67/00 , C07C2101/02
摘要： Cyclopropylamine is prepared from butyrolactone by a process comprising:(a) reacting butyrolactone with hydrogen chloride, thereby yielding chlorobutyric acid, (b) esterifying said chlorobutyric acid with a primary or secondary alcohol having 4-8 carbon atoms, (c) cyclizing the ester with an alkali metal alcoholate of a primary alcohol having 1-3 carbon atoms to give a mixture of cyclopropanecarboxylic acid esters, (d) converting the cyclopropanecarboxylic acid ester mixture into cyclopropanecarboxylic acid amide by reacting the ester mixture with ammonia, and (e) reacting said cyclopropanecarboxylic acid amide with hypohalite ion in a basic medium, thereby forming cyclopropylamine.
摘要翻译：环丙胺由丁内酯制备，包括：（a）使丁内酯与氯化氢反应，从而产生氯代丁酸，（b）用具有4-8个碳原子的伯或仲醇酯化所述氯代丁酸，（c）使酯与具有1-3个碳原子的伯醇的碱金属醇化物反应得到环丙烷羧酸酯的混合物，（d）通过使酯混合物与氨反应将环丙烷羧酸酯混合物转化为环丙烷羧酸酰胺，和（e）使所述环丙烷羧酸酰胺与碱式介质中的次卤酸离子形成环丙胺。

2. 发明授权

US6002046A Process for the preparation of cyclopropyl alkyl ketones 失效
标题翻译：制备环丙基烷基酮的方法
公开(公告)号：US6002046A
公开(公告)日：1999-12-14
申请号：US263876
申请日：1999-03-08
申请人： Manfred Kaufhold , Wolfgang Kleemiss , Udo Jegelka , Michael Korell
发明人： Manfred Kaufhold , Wolfgang Kleemiss , Udo Jegelka , Michael Korell
IPC分类号： C07B61/00 , C07C45/59 , C07C45/67 , C07C45/82 , C07C45/85 , C07C49/293 , C07C45/54
CPC分类号： C07C45/82 , C07C45/676 , C07C45/85
摘要： Cyclopropyl alkyl ketones are separated from 3-acyltetrahydrofuran-2-ones by adding an alcohol, water or a water/alcohol mixture to a reaction product containing C.sub.1-4 -alkyl cyclopropyl ketone and 4,5-dihydro-2-alkylfuran by-product and an acid catalyst and reacting the by-product with the added alcohol, water of water/alcohol mixture before, during or after distilling said reaction product; and effectively separating C.sub.1 -.sub.4 -alkyl cyclopropyl ketone from reaction by-products.In the preparation of cyclopropyl alkyl ketones from 3-acyltetrahydrofuran-2-ones very reactive 4,5-dihydro-2-alkylfurans are also produced. By reacting such compounds with nucleophilic compounds, such as alcohols or water, before, during or after distillation of the reaction products, it is possible reliably to separate off the 4,5-dihydro-2-alkylfurans as high-boiling addition compounds. The offgas which is produced in the production process for cyclopropyl alkyl ketones can be simply and reliably purified by reactive washing. The byproducts, which are difficult to handle for a production process, can thus be reliably eliminated.
摘要翻译：通过向含有C 1-4 - 烷基环丙基酮和4,5-二氢-2-烷基呋喃副产物的反应产物中加入醇，水或水/醇混合物将环丙基烷基酮与3-酰基四氢呋喃-2-酮分离和酸催化剂，在蒸馏所述反应产物之前，期间或之后使副产物与所加入的醇，水/醇混合物的水反应; 并有效地将C1-4烷基环丙基酮与反应副产物分离。在制备3-酰基四氢呋喃-2-酮的环丙基烷基酮时，也产生非常活泼的4,5-二氢-2-烷基呋喃。通过使这些化合物与亲核化合物如醇或水反应，在反应产物蒸馏之前，期间或之后，可以可靠地将4,5-二氢-2-烷基呋喃分离成高沸点加成化合物。在环丙基烷基酮的生产过程中生产的废气可以通过反应性洗涤简单可靠地纯化。因此，可以可靠地消除对生产过程难以处理的副产物。

3. 发明授权

US5629455A Process for preparing cyclopropyl alkyl ketones and 4,5-dihydroalkylfurans 失效
标题翻译：制备环丙基烷基酮和4,5-二氢烷基呋喃的方法
公开(公告)号：US5629455A
公开(公告)日：1997-05-13
申请号：US589952
申请日：1996-01-23
申请人： Manfred Kaufhold , Marcel Feld
发明人： Manfred Kaufhold , Marcel Feld
IPC分类号： C07C45/59 , C07C45/67 , C07C49/293 , C07C49/317 , C07C49/792 , C07D307/28 , C07C45/54
CPC分类号： C07D307/28 , C07C45/676
摘要： The invention relates to a novel process for the simultaneous preparation of cyclopropyl alkyl ketones and 4,5-dihydroalkylfurans from 3-acyltetrahydrofuran-2-ones using a metal salt according to the diagram ##STR1## In the reaction, N-alkyllactams and/or N-acylmorpholines which are high-boiling and only slightly miscible with water are used. By charging the solvent, the metal salt and the 3-acyltetrahydrofuran-2-one in a molar excess with respect to the metal salt, heating the mixture to 160.degree. to 220.degree. C. and metering in further 3-acyl-tetrahydrofuran-2-one, the desired products are obtained in high yields. The metal salt can moreover be recovered in a simple manner by washing with water.
摘要翻译：本发明涉及一种根据图中使用金属盐从3-酰基四氢呋喃-2-酮同时制备环丙基烷基酮和4,5-二氢烷基呋喃的新方法。在反应中，N - 烷基内酰胺和/或N-酰基吗啉，它们是高沸点且仅与水轻微混溶。通过将溶剂，金属盐和3-酰基四氢呋喃-2-酮相对于金属盐摩尔过量地加入，将混合物加热至160℃至220℃，并进一步计量3-酰基 - 四氢呋喃-2 - 一种，以高产率获得所需的产物。此外，金属盐可以通过用水洗涤以简单的方式回收。

4. 发明授权

US06730804B1 Process for preparing cyclopropanecarboxylates of lower alcohols 失效
标题翻译：制备低级醇的环丙烷羧酸酯的方法
公开(公告)号：US06730804B1
公开(公告)日：2004-05-04
申请号：US09141163
申请日：1998-08-27
申请人： Manfred Kaufhold , Marcel Feld
发明人： Manfred Kaufhold , Marcel Feld
IPC分类号： C07C6974
CPC分类号： C07C67/08 , C07C69/74
摘要： Cyclopropanecarboxylates of lower alcohols are prepared by esterification of the corresponding cyclopropanecarboxylic acids with the corresponding lower alcohols in the presence of an acid catalyst, while maintaining a considerable stoichiometric excess of the cyclopropanecarboxylic acid with respect to the lower alcohol, keeping the temperature at from 100 to 200° C. and distilling off the cyclopropanecarboxylate together with the water of reaction and small amounts of alcohol. Cyclopropanecarboxylates of lower alcohols are valuable intermediates in the pharmaceutical and agrochemical sectors.
摘要翻译：低级醇的环丙烷羧酸酯通过相应的环丙烷羧酸与相应的低级醇在酸催化剂存在下酯化而制备，同时相对于低级醇维持相当大的化学计量过量的环丙烷羧酸，保持温度为100至 200℃，并与反应水和少量酒精一起蒸馏出环丙烷羧酸酯。低级醇的环丙烷羧酸盐是制药和农业部门的有价值的中间体。

5. 发明授权

US5412146A Process for the preparation of 2-cyanoacetoxypropionic esters 失效
标题翻译： 2-氰基乙酰氧基丙酸酯的制备方法
公开(公告)号：US5412146A
公开(公告)日：1995-05-02
申请号：US253347
申请日：1994-06-03
申请人： Manfred Kaufhold , Marcel Feld
发明人： Manfred Kaufhold , Marcel Feld
IPC分类号： B01J31/02 , C07B61/00 , C07C253/30 , C07C255/19
CPC分类号： C07C255/19 , C07C253/30
摘要： For the preparation of 2-cyanoacetoxypropionic esters, a mixture of lactic ester and cyanoacetic ester is introduced, an alkali metal alcoholate is added as catalyst and the mixture is heated while the alcohol eliminated during the course of the reaction is distilled off. The course of the reaction is followed by means of gas chromatographic analysis and the reaction is terminated prior to eliminating the theoretical amount of alcohol by destroying the catalyst by acidification. The reaction mixture is worked up by distillation and the product easily separated from the reaction mass due to the substantial absence of high boiling components.
摘要翻译：为了制备2-氰基乙酰氧基丙酸酯，引入乳酸酯和氰基乙酸酯的混合物，加入碱金属醇化物作为催化剂，加热混合物，同时蒸馏除去反应过程中的醇。反应过程之后是气相色谱分析，在通过酸化破坏催化剂消除理论量的醇之前终止反应。通过蒸馏处理反应混合物，由于实质上不存在高沸点组分，产物容易与反应物质分离。

6. 发明授权

US06423189B1 Process for the preparation of 1,3-dichloropropane 失效
标题翻译： 1,3-二氯丙烷的制备方法
公开(公告)号：US06423189B1
公开(公告)日：2002-07-23
申请号：US09580562
申请日：2000-05-30
申请人： Manfred Kaufhold
发明人： Manfred Kaufhold
IPC分类号： B01D300
CPC分类号： C07C17/00 , C07C17/093 , C07C19/01
摘要： A process for the preparation of 1,3-dichloropropane by reacting bis(3-hydroxypropyl)ether with hydrogen chloride, optionally in the presence of tertiary basic nitrogen compounds or other tertiary aliphatic bases as catalysts, distilling off the 1,3-dichloropropane and the water of reaction and working up the two phases.
摘要翻译：一种通过使双（3-羟丙基）醚与氯化氢反应制备1,3-二氯丙烷的方法，任选在叔碱式氮化合物或其它叔脂族基团作为催化剂的存在下，蒸除1,3-二氯丙烷和反应的水和两个阶段的工作。

7. 发明授权

US5527969A Process for preparing acetaldehyde diethyl acetal 失效
标题翻译：制备乙醛二乙缩醛的方法
公开(公告)号：US5527969A
公开(公告)日：1996-06-18
申请号：US384871
申请日：1995-02-07
申请人： Manfred Kaufhold , Moustafa El-Chahawi
发明人： Manfred Kaufhold , Moustafa El-Chahawi
IPC分类号： C07C41/54 , C07B61/00 , C07C41/56 , C07C43/303 , C07C47/09
CPC分类号： C07C41/56
摘要： A process for preparing acetaldehyde diethyl acetal is provided which involves:reacting acetaldehyde with ethanol in the presence of an acid catalyst and in the presence of an entrainer having a boiling point of from 25.degree. to 75.degree. C.
摘要翻译：提供了制备乙醛二乙缩醛的方法，该方法包括：在酸催化剂存在下和在沸点为25-75℃的夹带剂的存在下使乙醛与乙醇反应。

8. 发明授权

US5371270A Method of manufacturing chlorine-free cyclopropanecarboxylic acid methyl ester 失效
标题翻译：无氯环丙烷甲酸甲酯的制备方法
公开(公告)号：US5371270A
公开(公告)日：1994-12-06
申请号：US59319
申请日：1993-05-11
申请人： Manfred Kaufhold , Josef Metz
发明人： Manfred Kaufhold , Josef Metz
IPC分类号： B01J31/02 , C07B61/00 , C07C67/317 , C07C67/333 , C07C67/54 , C07C69/74
CPC分类号： C07C67/317
摘要： A method of manufacturing chlorine-free cyclopropanecarboxylic acid methyl ester is described wherein a first portion of alkali methoxide is added to a high-boiling solvent, followed by a second portion of methoxide with an equimolar portion of 4-chlorobutyric acid. The ester product can be readily hydrogenated catalytically to the corresponding carbinol.
摘要翻译：描述了制备无氯环丙烷甲酸甲酯的方法，其中将第一部分碱金属甲醇加入到高沸点溶剂中，然后加入第二部分甲醇与等摩尔份的4-氯丁酸。酯产物可以容易地氢化成相应的甲醇。

9. 发明授权

US4772758A Process for the production of technically pure, chlorine-free cyclohexadecadiene 失效
标题翻译：用于生产技术上纯的无氯环己烷的方法
公开(公告)号：US4772758A
公开(公告)日：1988-09-20
申请号：US37891
申请日：1987-04-13
申请人： Manfred Kaufhold
发明人： Manfred Kaufhold
IPC分类号： C07C2/00 , C07C1/00 , C07C7/148 , C07C13/02 , C07C67/00 , C10G19/02 , C07C7/00
CPC分类号： C07C13/02 , C07C7/14875
摘要： A process for producing technically pure, chlorine-free cyclohexadecadiene by purifying the product mixture obtained preferably from the metathesis of cyclooctene by first removing by distillation the low boiling C.sub.6 hydrocarbons and any water that may be present, then treating the sump product with a solution of a strongly alkaline compound at about 100.degree.-250.degree. C. After separation of the thus-formed salts, the thus-pretreated product mixture may be subjected to fractional distillation in the usual way.
摘要翻译：通过首先通过蒸馏除去低沸点C 6烃和可能存在的任何水来纯化优选从环辛烯的复分解得到的产物混合物来生产技术上纯的无氯环己烷的方法，然后用溶液在约100-250℃下是强碱性化合物。在分离如此形成的盐之后，如此预处理的产物混合物可以以常规方式进行分馏。

10. 发明授权

US4385965A Process for the recovery of pure methylal from methanol-methylal mixtures 失效
标题翻译：从甲醇 - 甲缩醛混合物中回收纯甲缩醛的方法
公开(公告)号：US4385965A
公开(公告)日：1983-05-31
申请号：US342975
申请日：1982-01-26
申请人： Wolfgang H. E. Muller , Manfred Kaufhold
发明人： Wolfgang H. E. Muller , Manfred Kaufhold
IPC分类号： C07C41/00 , C07C41/58 , C07C43/303 , C07C67/00 , B01D3/26
CPC分类号： C07C41/58
摘要： In a process for recovering pure methylal from methanol-methylal mixtures, which can optionally contain still further compounds, the separation conducted in a rectification device comprising two rectifying columns. In the first rectifying column, the mixture to be separated is rectified under a pressure lower than that in the second column, into a methylal-rich, methanol-poor distillate, and into a practically methylal-free, methanol-rich sump product. The methylal-rich distillate of the first rectification is then separated in a second rectifying column, operated under a higher pressure than the first rectification column, into a compound stream containing methanol and methylal, which is then recycled to the first rectifying column, and into pure methylal as the sump product. In a specific refinement, the first rectification is preferably operated under a pressure of 1-22 bar absolute and the second rectification preferably under a pressure of 9-30 bar absolute, with the second rectification being operated under a pressure which is at least 8 bar higher than that of the first rectification.
摘要翻译：在从可以任选地含有其它化合物的甲醇 - 甲缩醛混合物中回收纯甲缩醛的方法中，在包括两个精馏塔的精馏装置中进行分离。在第一精馏塔中，将待分离的混合物在低于第二塔的压力下进行精馏，成为富含甲缩醛的不饱和甲醇的馏出物，并进入实际上无甲醛的富含甲醇的油槽产物。然后将第一精馏的甲缩醛馏出物在比第一精馏塔高的压力下操作的第二精馏塔中分离成含有甲醇和甲缩醛的复合物流，然后将其再循环至第一精馏塔，并进入纯甲缩醛作为贮槽产品。在特定的改进中，第一精馏优选在1-22巴绝对压力下操作，优选在9-30巴绝对压力下进行第二次精馏，第二次精馏在至少8巴的压力下操作高于首次整改。

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