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1. 发明授权

US06423296B1 Constrast media 有权
标题翻译：调适媒体
公开(公告)号：US06423296B1
公开(公告)日：2002-07-23
申请号：US09101528
申请日：1999-02-22
申请人： Wolfgang Gunther , Kenneth Kellar , Dennis Kiyoshi Fujii , Vinay Desai , Christopher Black , Marshall Beeber , Jennifer Wellons , Anne Kjersti Fahlvik , Jasbir Singh , Edward Richard Bacon , Gregory Lynn McIntire , Robert Alan Snow , Brian Weekley , Torgrim Engell , Michel Gacek , David Lee Ladd , Anne Naevestad , George Na , Barbara Yuan , Jack Stevens
发明人： Wolfgang Gunther , Kenneth Kellar , Dennis Kiyoshi Fujii , Vinay Desai , Christopher Black , Marshall Beeber , Jennifer Wellons , Anne Kjersti Fahlvik , Jasbir Singh , Edward Richard Bacon , Gregory Lynn McIntire , Robert Alan Snow , Brian Weekley , Torgrim Engell , Michel Gacek , David Lee Ladd , Anne Naevestad , George Na , Barbara Yuan , Jack Stevens
IPC分类号： A61B5055
CPC分类号： B82Y5/00 , A61K49/049 , A61K49/1842 , A61K49/186 , A61K49/1863
摘要： The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.
摘要翻译：本发明涉及含有复合纳米颗粒的MR造影剂，优选包含超顺磁性氧化铁芯，其具有包含氧化分解的淀粉涂层的涂层，任选与功能化的聚环氧烷一起延长血液停留。

2. 发明申请

US20090260536A1 Paintball and method of manufacture 审中-公开
标题翻译：彩弹和制造方法
公开(公告)号：US20090260536A1
公开(公告)日：2009-10-22
申请号：US12457830
申请日：2009-06-23
申请人： Christopher Black
发明人： Christopher Black
IPC分类号： F42B12/40 , F42B12/72
CPC分类号： F42B12/40
摘要： The present invention relates to a paintball comprising a shell containing an inner filler composition. The shell comprises a mixture of gelatin and mineral oil; the inner filler composition comprises a mixture of starch, oil, an emulsifying agent and a spreading and surfacting agent. The shell further comprises a non-crystallizing polyhydric alcohol, glycerine, and water. The inner filler composition may further comprise a pigment. The non-crystallizing polyhydric alcohol may be sorbitol, the oil is Soya oil and the emulsifying agent is emulsifying wax. The spreading and surfacting agent may be Tween® 20 and the pigment may be TiO2.
摘要翻译：本发明涉及一种彩弹，其包括含有内填料组合物的壳。壳包含明胶和矿物油的混合物; 内填料组合物包括淀粉，油，乳化剂和铺展剂和表面活性剂的混合物。壳还包含非结晶多元醇，甘油和水。内填料组合物还可以包含颜料。非结晶多元醇可以是山梨糖醇，油是大豆油，乳化剂是乳化蜡。铺展剂和表面活性剂可以是Tween 20，颜料可以是TiO 2。

3. 发明授权

US06962803B2 Process for production diphtheria toxin 失效
标题翻译：生产白喉毒素的方法
公开(公告)号：US06962803B2
公开(公告)日：2005-11-08
申请号：US10690855
申请日：2003-10-22
申请人： Henry Wolfe , Fahar Merchant , Rosemina Merchant , Christopher Black , Harry Storflor , Geir Stokke , Halldis Hellebust
发明人： Henry Wolfe , Fahar Merchant , Rosemina Merchant , Christopher Black , Harry Storflor , Geir Stokke , Halldis Hellebust
IPC分类号： A61K38/00 , A61P35/00 , C07K14/34 , C12N15/31 , C12P21/02 , C12P21/04
CPC分类号： A61K38/164 , C07K14/34 , C07K2319/00 , C07K2319/55 , C12P21/02
摘要： The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
摘要翻译：本发明提供了一种纯化白喉毒素的方法，其包括（1）使用葡萄糖作为碳源发酵能够产生白喉毒素的微生物菌株，所述方法包括向生长培养物中加入葡萄糖，由此加入葡萄糖保持微生物生长有效支持白喉毒素生产; 和（2）通过使来自其的含毒素制剂与离子交换基质接触来纯化白喉毒素，洗脱含有毒素的级分，将洗脱液应用于疏水性基质，并洗脱含有毒素的级分。

4. 发明申请

US20110253009A1 PAINTBALL FILL MATERIAL 审中-公开
标题翻译：油漆填充材料
公开(公告)号：US20110253009A1
公开(公告)日：2011-10-20
申请号：US13090822
申请日：2011-04-20
申请人： Christopher Black , Michael J. Ratko , Richmond Italia
发明人： Christopher Black , Michael J. Ratko , Richmond Italia
IPC分类号： C08L89/00
CPC分类号： C08L99/00 , A63B37/08 , A63B43/00 , A63B2037/085 , C08L71/02 , C08L89/00 , F42B6/10
摘要： According to principles of this invention, flour can be used as a filler for either an oil-based or PEG-based paintball fill material. In one embodiment of the present invention, a paintball fill material preferably comprises flour. More particularly, a paintball according to principles of the present invention can comprise a gelatin capsule defining an interior chamber which, upon formation of the paintball, houses a fill material. The fill material can comprise, for instance, 1%-65% polyethylene glycol, 25%-45% flour, and up to 0.5% dye, with the balance water. Accordingly, unlike conventional paintballs, the paintball fill material of the present invention preferably contains flour rather than starch to reduce the amount of polyethylene glycol required for the fill material. In alternative formulations, an oil can be used in addition to, or instead of, polyethylene glycol. According to another aspect of the present invention, the gelatin capsule for the paintball can also utilize flour in its composition. As with the fill material, the use of flour rather than starch in the paintball shell composition can reduce equipment maintenance and production costs.
摘要翻译：根据本发明的原理，面粉可以用作油基或基于PEG的彩弹填充材料的填料。在本发明的一个实施例中，彩弹填充材料优选地包括面粉。更具体地说，根据本发明原理的彩弹球可以包括限定内腔的明胶胶囊，其在形成彩弹时容纳填充材料。填充材料可以包括例如1％-65％的聚乙二醇，25％-45％的面粉和至多0.5％的染料，余量为水。因此，与传统的彩弹球不同，本发明的彩弹填充材料优选含有面粉而不是淀粉，以减少填充材料所需的聚乙二醇的量。在替代制剂中，除了聚乙二醇之外或代替聚乙二醇可以使用油。根据本发明的另一方面，用于彩弹的明胶胶囊也可以在其组成中使用面粉。与填充材料一样，在彩弹球壳组合物中使用面粉而不是淀粉可以减少设备维护和生产成本。

5. 发明申请

US20080010045A1 Method and System for Non-Linear State Estimation 审中-公开
标题翻译：非线性状态估计方法与系统
公开(公告)号：US20080010045A1
公开(公告)日：2008-01-10
申请号：US11846211
申请日：2007-08-28
申请人： Christopher Black , J. Hines
发明人： Christopher Black , J. Hines
IPC分类号： G06F17/10
CPC分类号： G06Q30/02 , G06Q10/067 , G06Q30/0201
摘要： An NSET method and system for modeling the behavior of a visitor to an e-commerce location are disclosed. The method of one embodiment of this invention comprises the steps of: obtaining one or more visitor characteristic values; developing a model of the visitor's behavior according to a nonlinear state estimation technique (NSET); and estimating a set of visitor behavior characteristic to model the visitor's behavior using the developed model. The method further comprises predicting the visitor's future behavior at the e-commerce location based on the set of behavior characteristic values and known statistical behavior characteristic values. The method of this invention can further comprise measuring a set of actual behavior values for a visitor based on the visitor's actual behavior at an e-commerce location, and comparing the set of estimated behavior characteristic values and the set of actual behavior values with at least one similarity operator. The method of this invention can be implemented as a system of operational instructions that can be stored in a memory and executed by a processing module.
摘要翻译：公开了一种用于将访问者的行为建模到电子商务位置的NSET方法和系统。本发明的一个实施例的方法包括以下步骤：获得一个或多个访问者特征值; 根据非线性状态估计技术（NSET）开发访问者行为模型; 并使用开发的模型估计一组访客行为特征来模拟访客的行为。该方法还包括基于一组行为特征值和已知的统计行为特征值来预测访问者在电子商务位置处的未来行为。本发明的方法还可以包括基于访问者在电子商务位置处的实际行为来测量访问者的一组实际行为值，并将至少一组估计行为特征值与实际行为值集合至少一个相似度算子。本发明的方法可以被实现为可以存储在存储器中并由处理模块执行的操作指令的系统。

6. 发明申请

US20060085850A1 System and methods for providing network quarantine using IPsec 审中-公开
标题翻译：使用IPsec提供网络隔离的系统和方法
公开(公告)号：US20060085850A1
公开(公告)日：2006-04-20
申请号：US11056276
申请日：2005-02-14
申请人： Paul Mayfield , Christopher Black , Jesper Johansson , Karthik Murthy , Brian Swander
发明人： Paul Mayfield , Christopher Black , Jesper Johansson , Karthik Murthy , Brian Swander
IPC分类号： G06F15/16
CPC分类号： H04L63/0823 , G06F21/335 , H04L63/1433 , H04L63/164 , H04L63/20
摘要： A system and method for ensuring that machines having invalid or corrupt states are restricted from accessing host resources are provided. A quarantine agent (QA) located on a client machine acquires statements of health from a plurality of quarantine policy clients. The QA packages the statements and provides the package to a quarantine enforcement client (QEC). The QEC sends the package to a quarantine Health Certificate Server (HCS) with a request for a health certificate. If the client provided valid statements of health, the HCS grants the client health certificate that may be used in IPsec session negotiation.
摘要翻译：提供了一种用于确保具有无效或损坏状态的机器被限制访问主机资源的系统和方法。位于客户端机器上的隔离代理（QA）从多个隔离策略客户端获取健康声明。 QA打包语句，并将包提供给隔离执行客户端（QEC）。 QEC将该包发送到具有健康证书请求的隔离健康证书服务器（HCS）。如果客户端提供了有效的健康声明，则HCS授予可能在IPsec会话协商中使用的客户端健康证书。

7. 发明授权

US07575891B2 Process for production of diphtheria toxin 失效
标题翻译：白喉毒素生产工艺
公开(公告)号：US07575891B2
公开(公告)日：2009-08-18
申请号：US11854683
申请日：2007-09-13
申请人： Henry Wolfe , Fahar Merchant , Rosemina Merchant , Christopher Black , Harry Storflor , Geir Stokke , Halldis Hellebust
发明人： Henry Wolfe , Fahar Merchant , Rosemina Merchant , Christopher Black , Harry Storflor , Geir Stokke , Halldis Hellebust
IPC分类号： C12P1/00
CPC分类号： A61K38/164 , C07K14/34 , C07K2319/00 , C07K2319/55 , C12P21/02
摘要： The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
摘要翻译：本发明提供了一种纯化白喉毒素的方法，其包括（1）使用葡萄糖作为碳源发酵能够产生白喉毒素的微生物菌株，所述方法包括向生长培养物中加入葡萄糖，由此加入葡萄糖保持微生物生长有效支持白喉毒素生产; 和（2）通过使来自其的含毒素制剂与离子交换基质接触来纯化白喉毒素，洗脱含有毒素的级分，将洗脱液应用于疏水性基质，并洗脱含有毒素的级分。

8. 发明申请

US20070148380A1 Paintball and method of manufacture 审中-公开
标题翻译：彩弹和制造方法
公开(公告)号：US20070148380A1
公开(公告)日：2007-06-28
申请号：US11640944
申请日：2006-12-19
申请人： Christopher Black
发明人： Christopher Black
IPC分类号： B31B45/00
CPC分类号： F42B12/40 , Y10T428/13
摘要： The present invention relates to a paintball comprising a shell containing an inner filler composition. The shell comprises a mixture of gelatin and mineral oil; the inner filler composition comprises a mixture of starch, oil, an emulsifying agent and a spreading and surfacting agent. The shell further comprises a non-crystallizing polyhydric alcohol, glycerine, and water. The inner filler composition may further comprise a pigment. The non-crystallizing polyhydric alcohol may be sorbitol, the oil is Soya oil and the emulsifying agent is emulsifying wax. The spreading and surfacting agent may be Tween® 20 and the pigment may be TiO2.
摘要翻译：本发明涉及一种彩弹，其包括含有内填料组合物的壳。壳包含明胶和矿物油的混合物; 内填料组合物包括淀粉，油，乳化剂和铺展剂和表面活性剂的混合物。壳还包含非结晶多元醇，甘油和水。内填料组合物还可以包含颜料。非结晶多元醇可以是山梨糖醇，油是大豆油，乳化剂是乳化蜡。铺展剂和表面活性剂可以是Tween 20，颜料可以是TiO 2。

9. 发明授权

US06689043B1 Products and methods for brachytherapy 失效
标题翻译：近距离放射疗法的产品和方法
公开(公告)号：US06689043B1
公开(公告)日：2004-02-10
申请号：US09831229
申请日：2001-07-23
申请人： Gregory McIntire , Robert Snow , Edward Bacon , Morten Eriksen , Auden Tornes , Geraldine Cooney , Christopher Black , Joel Cornacoff , Virginia Ann Gates
发明人： Gregory McIntire , Robert Snow , Edward Bacon , Morten Eriksen , Auden Tornes , Geraldine Cooney , Christopher Black , Joel Cornacoff , Virginia Ann Gates
IPC分类号： A61N500
CPC分类号： G21G4/08 , A61B2090/3925 , A61N5/1027 , A61N2005/1024
摘要： Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of a surface of the container is roughened, shaped or otherwise treated so that it is no longer smooth. The surface treatment may enhance the ultrasound visibility of the source and/or reduce the tendency of the source to migrate once implanted in a patient's body. Preferred radioisotopes are palladium-103 and iodine-125.
摘要翻译：用于近距离放射治疗的放射源，优选放射性种子，其包括在密封的生物相容性容器内的放射性同位素，其中容器的表面的至少一部分被粗糙化，成形或以其它方式处理，使得其不再光滑。表面处理可以增强源的超声可见性和/或减少一旦植入患者体内的源迁移的趋势。优选的放射性同位素是钯-103和碘-125。

10. 发明授权

US06482949B1 Colormetric sensor compositions and methods 有权
标题翻译：比色传感器组成和方法
公开(公告)号：US06482949B1
公开(公告)日：2002-11-19
申请号：US09579040
申请日：2000-05-26
申请人： Jonathan Sessler , Bruno Andrioletti , Andrew Carl Try , Christopher Black
发明人： Jonathan Sessler , Bruno Andrioletti , Andrew Carl Try , Christopher Black
IPC分类号： C07D40314
CPC分类号： C07D207/333 , C07D403/14 , C07D471/14 , C07D487/22
摘要： The present invention provides novel compounds exemplified by pyrrolic nitrogens used as anion and neutral species recognition elements with an aromatic core as a signal group. Described are methods for the synthesis of various pyrrole aryl compounds as well as various applications for these compounds. Methods of use include the binding and detection of specific analytes in a mixture and, in some examples, the separation of the analyte from the mixture. Additional methods of use include the transport of therapeutic agents and the sensing of components, degradants, and impurities in foodstuffs.
摘要翻译：本发明提供用作阴离子和中性物种识别元素的芳基核作为信号基团的新颖化合物。描述了用于合成各种吡咯芳基化合物的方法以及这些化合物的各种应用。使用方法包括混合物中特定分析物的结合和检测，在一些实例中，分析物与混合物的分离。其他使用方法包括治疗剂的运输和食品中组分，降解物和杂质的检测。

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