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1. 发明授权

US4144129A Cholesteroloxidase and method for its production from microorganisms 失效
标题翻译：胆固醇酶及其从微生物产生的方法
公开(公告)号：US4144129A
公开(公告)日：1979-03-13
申请号：US360490
申请日：1973-05-15
申请人： Wolfgang Gruber , Hans U. Bergmeyer , Michael Nelbock-Hochstetter , Klaus Beaucamp , Gunter Holz , Johanna Gramsall , Gunter Lang
发明人： Wolfgang Gruber , Hans U. Bergmeyer , Michael Nelbock-Hochstetter , Klaus Beaucamp , Gunter Holz , Johanna Gramsall , Gunter Lang
IPC分类号： G01N33/92 , C12N9/04 , C12Q1/26 , C12Q1/60 , C12R1/01 , C12R1/325 , C12R1/365 , C12R1/645 , C07G7/028
CPC分类号： C12N9/0006 , C12Q1/60 , Y10S435/814 , Y10S435/826 , Y10S435/872
摘要： A new enzyme, cholesteroloxidase, is prepared by recovering same from microorganisms, preferably by washing a cholesterol-converting microorganism with butanol/water, disintegrating the microorganism culture and extracting same with a buffer solution containing a non-ionic surface-active agent, and isolating cholesterol oxidase from the extract.
摘要翻译：通过从微生物中回收相应的新酶胆固醇氧化酶，优选通过用丁醇/水洗涤胆固醇转化微生物，分解微生物培养物并用含有非离子表面活性剂的缓冲液进行提取，并分离来自提取物的胆固醇氧化酶。

2. 发明授权

US3969287A Carrier-bound protein prepared by reacting the protein with an acylating or alkylating compound having a carrier-bonding group and reacting the product with a carrier 失效
标题翻译：通过使蛋白质与具有载体键合基团的酰化或烷基化化合物反应制备的载体结合蛋白质，并使产物与载体
公开(公告)号：US3969287A
公开(公告)日：1976-07-13
申请号：US420510
申请日：1973-11-30
申请人： Dieter Jaworek , Michael Nelbock-Hochstetter , Klaus Beaucamp , Hans Ulrich Bergmeyer , Karl-Heinz Botsch
发明人： Dieter Jaworek , Michael Nelbock-Hochstetter , Klaus Beaucamp , Hans Ulrich Bergmeyer , Karl-Heinz Botsch
IPC分类号： C12N9/00 , C08F289/00 , C12N9/04 , C12N9/76 , C12N11/06 , C12N11/08 , C12N11/18 , G01N33/545 , C08L89/00
CPC分类号： C12N11/18 , C08F289/00 , C12N11/06 , C12N11/08 , G01N33/545 , Y10S530/816
摘要： Carrier-bound proteins are prepared by reacting a protein in aqueous solution with a coupling compound having at least one group capable of acylating or alkylating proteins and at least one additional group capable of producing a bond with a carrier material, and reacting the resulting product with a carrier material, optionally forming the carrier material in situ by polymerization of a monomer or monomer mixture in the presence of said product.
摘要翻译：通过使水溶液中的蛋白质与具有至少一个能够酰化或烷化蛋白质的基团的偶联化合物反应制备载体结合的蛋白质，以及至少一个能够与载体材料形成结合的另外的基团，并使所得产物与载体材料，任选地通过在所述产物存在下聚合单体或单体混合物原位形成载体材料。

3. 发明授权

US4038140A Process for binding biologically active proteins 失效
标题翻译：结合生物活性蛋白的方法
公开(公告)号：US4038140A
公开(公告)日：1977-07-26
申请号：US582495
申请日：1975-05-30
申请人： Dieter Jaworek , Joseph Maier , Michael Nelbock-Hochstetter
发明人： Dieter Jaworek , Joseph Maier , Michael Nelbock-Hochstetter
IPC分类号： C08F8/00 , C08F8/30 , C08F251/00 , C12N11/10 , C12N11/12 , C12K1/00 , C07G7/02 , C08L5/00
CPC分类号： C12N11/10 , C08F251/00 , C08F8/00 , C08F8/30
摘要： Biologically active proteins are bound onto an insoluble carrier by reacting such protein in an aqueous phase with a carrier comprising an activated polysaccharide having a hydrophilic graft co-polmyer grafted thereinto.

4. 发明授权

US4182695A Polyamide-fixed biologically active protein 失效
标题翻译：聚酰胺固定生物活性蛋白
公开(公告)号：US4182695A
公开(公告)日：1980-01-08
申请号：US878545
申请日：1978-02-16
申请人： Jurgen Horn , Winfried Albert , Hans-Georg Batz , Michael Nelbock-Hochstetter
发明人： Jurgen Horn , Winfried Albert , Hans-Georg Batz , Michael Nelbock-Hochstetter
IPC分类号： C08G69/00 , C08G69/48 , C08G69/50 , C08H1/00 , C12N11/08 , A61K31/765 , A61K31/775
CPC分类号： C08G69/50 , C12N11/08 , Y10S530/816
摘要： Biologically active protein compositions comprising protein or a protein substrate bound onto a polyamide of the general formula: ##STR1## in which R and R.sub.1, which may be the same or different, are polyamide residues bound onto the amido group,R.sub.2 is the residue of a compound which can be condensed with formaldehyde and which contains at least one further reactive group,R.sub.3 is the residue of a bi- or poly-functional protein reagent,n is 0 or 1, andP is a biologically active protein;these compositions are obtainable by the reaction of a polyamides with amounts, equimolar to one another, of formaldehyde and of a compound condensable with formaldehyde, in a solvent for polyamides, reacting the product thereby obtained with a bi- or poly-functional protein reagent and coupling the resulting reaction product with the biologically active protein or protein substrate.
摘要翻译：生物活性蛋白质组合物，其包含结合到以下通式的聚酰胺上的蛋白质或蛋白质底物：其中R和R 1可以相同或不同，是结合到酰胺基上的聚酰胺残基，R2是残基可与甲醛缩合并含有至少一个其它反应性基团的化合物，R3是双功能或多功能蛋白质试剂的残基，n为0或1，P为生物活性蛋白; 这些组合物可以通过聚酰胺与等量的甲醛和与甲醛缩合的化合物的量与聚酰胺的溶剂反应，使由此获得的产物与双功能或多功能蛋白质试剂和将所得反应产物与生物活性蛋白质或蛋白质底物偶联。

5. 发明授权

US4081329A Preparation of carrier-bound macromolecular compounds 失效
标题翻译：制备载体结合的大分子化合物
公开(公告)号：US4081329A
公开(公告)日：1978-03-28
申请号：US655363
申请日：1976-02-05
申请人： Dieter Jaworek , Karl-Heinz Botsch , Gunter Weimann , Michael Nelbock-Hochstetter , Helmut Determann
发明人： Dieter Jaworek , Karl-Heinz Botsch , Gunter Weimann , Michael Nelbock-Hochstetter , Helmut Determann
IPC分类号： C08F2/44 , C12N11/10 , C07G7/02
CPC分类号： C08F2/44 , C12N11/10 , Y10S530/813
摘要： Carrier-bound macromolecular compounds, especially bioactive macromolecular compounds, are produced by reacting a macromolecular compound A with a coupling compound B containing at least one reactive function capable of coupling with compound A and at least one further reactive function capable of polymerization, adding to the resulting coupled reaction product AB an unswollen molecular sieve material having cross-linking sufficient to exclude penetration by compound A, and polymerizing the polymerizable group of the coupled product AB in the molecular sieve material to form a polymer body in the molecular sieve material and fix compound A on the surface of the molecular sieve material. Compound A can be, e.g., an enzyme, antibody or hormone, and coupling compound B typically contains, as the coupable function, an alkylation or acylation group such as oxirane, ethyleneimine, halide, acid halide, azide or anhydride groups, and, as the polymerizable function, a carbon-carbon or carbon-oxygen double bond.
摘要翻译：载体结合的大分子化合物，特别是生物活性高分子化合物，通过使大分子化合物A与能够与化合物A偶联的至少一种反应性官能团的偶联化合物B和至少一种能够聚合的反应性官能团反应，所得到的偶联反应产物AB是具有足以排除化合物A穿透的交联的未溶胀分子筛材料，并且在分子筛材料中聚合偶联产物AB的可聚合基团以在分子筛材料中形成聚合物体并固定化合物 A在分子筛材料的表面。化合物A可以是例如酶，抗体或激素，偶联化合物B通常含有烷基化或酰化基团如环氧乙烷，乙烯亚胺，卤化物，酰卤，叠氮化物或酸酐基团作为可交联的官能团，并且作为可聚合的功能，碳 - 碳或碳 - 氧双键。

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