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1. 发明授权

US5182306A Use of colchicine for the control of retroviruses 失效
标题翻译：使用秋水仙碱控制逆转录病毒
公开(公告)号：US5182306A
公开(公告)日：1993-01-26
申请号：US746283
申请日：1991-08-12
申请人： William W. Hall , Stanley E. Read , Michael Lyons , John B. Zabriskie
发明人： William W. Hall , Stanley E. Read , Michael Lyons , John B. Zabriskie
IPC分类号： A61K31/165
CPC分类号： A61K31/165
摘要： This invention relates to treating vetrovirus of the leutivirous group with colchicine.
摘要翻译：本发明涉及用秋水仙素治疗嗜酸性组的病毒。

2. 发明授权

US07332173B2 Group A streptococcal polysaccharide immunogenic compositions and methods 失效
标题翻译： A组链球菌多糖免疫原性组成及方法
公开(公告)号：US07332173B2
公开(公告)日：2008-02-19
申请号：US11086214
申请日：2005-03-21
申请人： Milan S. Blake , John B. Zabriskie , Joseph Y. Tai , Francis Michon
发明人： Milan S. Blake , John B. Zabriskie , Joseph Y. Tai , Francis Michon
IPC分类号： A61K39/02 , A61K39/00 , A61K38/00 , C07H1/00
CPC分类号： A61K39/092 , A61K9/1271 , A61K2039/55505 , A61K2039/55555 , A61K2039/6037 , Y10S424/831
摘要： This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or liposomes to form immunogenic conjugates. The method of immunization for this invention comprises administering to an individual an immunogenic amount of group A polysaccharide. The group A polysaccharide may be administered as a vaccine either on its own, conjugated to proteins or conjugated to liposomes. Additionally, the group A polysaccharides may be associated with an adjuvant. This invention is particularly useful for providing both active and passive immunogenic protection for those populations most at risk of contracting group A Streptococcal infections and disease namely adults, pregnant women and in particular infants and children.
摘要翻译：本发明提供了一种新型的免疫原性组合物和疫苗，其制备方法以及针对由A组链球菌引起的感染和疾病的免疫方法。组合物包括与蛋白质或脂质体共价连接以形成免疫原性缀合物的A组链球菌多糖。本发明的免疫方法包括向个体施用免疫原性量的A组多糖。 A组多糖可以单独作为疫苗施用，与蛋白缀合或与脂质体缀合。另外，A组多糖可以与佐剂结合。本发明特别可用于为那些最具有承担A型链球菌感染和疾病风险的群体，即成年人，孕妇，特别是婴儿和儿童提供主动和被动免疫原性保护。

3. 发明授权

US6075119A Peptides useful for reducing symptoms of toxic shock syndrome 失效
标题翻译：可用于减轻中毒性休克综合征症状的肽
公开(公告)号：US6075119A
公开(公告)日：2000-06-13
申请号：US838413
申请日：1997-04-07
申请人： Jason D. Bannan , John B. Zabriskie
发明人： Jason D. Bannan , John B. Zabriskie
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/085 , A61K39/09 , A61K39/395 , A61K48/00 , A61P31/00 , A61P37/04 , A61P43/00 , C07K14/31 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/31 , C12R1/44 , C07K5/00
CPC分类号： C07K16/1275 , C07K14/31 , C07K14/315 , C07K16/1271 , A61K38/00 , A61K39/00
摘要： This invention relates to compositions and methods for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity, of toxic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, which may be polymeric, and carrier-conjugates thereof, and their use to induce serum antibodies. The invention also relates to serum antibodies induced by the peptides and carrier-conjugates and their use to prevent, treat, or protect against the toxic effects of most, if not all, of the staphylococcal and streptococcal toxins.The invention also relates to diagnostic assays and kits to detect the presence of staphylococcal and streptococcal toxins, or antibodies thereto. The invention also relates isolated and purified to nucleic acids encoding the peptides of the invention and transformed host cells containing those nucleic acids.
摘要翻译：本发明涉及在哺乳动物中引发免疫原性应答的组合物和方法，包括提供针对细菌感染的中毒性休克的保护或降低其严重程度的应答。更具体地说，它涉及衍生自葡萄球菌和链球菌毒素家族的同源序列的肽，其可以是聚合物，以及它们的载体缀合物，以及它们用于诱导血清抗体的用途。本发明还涉及由肽和载体缀合物诱导的血清抗体及其用于预防，治疗或保护大多数（如果不是全部）葡萄球菌和链球菌毒素的毒性作用的用途。本发明还涉及用于检测葡萄球菌和链球菌毒素或其抗体的存在的诊断测定和试剂盒。本发明还涉及分离和纯化的编码本发明的肽的核酸和含有这些核酸的转化的宿主细胞。

4. 发明授权

US5866135A Group A streptococcal polysaccharide immunogenic compositions and methods 失效
标题翻译： A组链球菌多糖免疫原性组成及方法
公开(公告)号：US5866135A
公开(公告)日：1999-02-02
申请号：US231229
申请日：1994-04-21
申请人： Milan S. Blake , John B. Zabriskie , Joseph Y. Tai , Francis Michon
发明人： Milan S. Blake , John B. Zabriskie , Joseph Y. Tai , Francis Michon
IPC分类号： A61K9/127 , A61K39/09 , A61K39/385 , A61P31/04
CPC分类号： A61K39/092 , A61K9/1271 , A61K2039/55505 , A61K2039/55555 , A61K2039/6037 , Y10S424/831
摘要： This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or liposomes to form immunogenic conjugates. The method of immunization for this invention comprises administering to an individual an immunogenic amount of group A polysaccharide. The group A polysaccharide may be administered as a vaccine either on its own, conjugated to proteins or conjugated to liposomes. Additionally, the group A polysaccharides may be associated with an adjuvant. This invention is particularly useful for providing both active and passive immunogenic protection for those populations most at risk of contracting group A Streptococcal infections and disease namely adults, pregnant women and in particular infants and children.
摘要翻译：本发明提供了一种新型的免疫原性组合物和疫苗，其制备方法以及针对由A组链球菌引起的感染和疾病的免疫方法。组合物包括与蛋白质或脂质体共价连接以形成免疫原性缀合物的A组链球菌多糖。本发明的免疫方法包括向个体施用免疫原性量的A组多糖。 A组多糖可以单独作为疫苗施用，与蛋白缀合或与脂质体缀合。另外，A组多糖可以与佐剂结合。本发明特别可用于为那些最具有承担A型链球菌感染和疾病风险的群体，即成年人，孕妇，特别是婴儿和儿童提供主动和被动免疫原性保护。

5. 发明申请

US20080305109A1 Method of passive immunization 审中-公开
标题翻译：被动免疫方法
公开(公告)号：US20080305109A1
公开(公告)日：2008-12-11
申请号：US11542774
申请日：2006-10-03
申请人： Jason D. Bannan , Kumar Visvanathan , John B. Zabriskie
发明人： Jason D. Bannan , Kumar Visvanathan , John B. Zabriskie
IPC分类号： A61K39/40 , A61P31/04
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/00 , C07K14/31 , C07K14/315 , C07K16/1271
摘要： This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, which may be polymeric, and carrier-conjugates thereof. The invention also relates to serum antibodies induced by the peptides and carrier-conjugates and their use to prevent, treat, or protect against the toxic effects of most, if not all, of the staphylococcal and streptococcal toxins.The invention also relates to diagnostic assays and kits to detect the presence of staphylococcal and streptococcal toxins, or antibodies thereto. The invention also relates isolated and purified to nucleic acids encoding the peptides of the invention and Transformed host cells containing those nucleic acids.
摘要翻译：本发明涉及提供针对或减轻细菌感染引起的中毒性休克和败血性休克的严重性的组合物和方法。更具体地说，它涉及衍生自葡萄球菌和链球菌毒素家族的同源序列的肽，其可以是聚合物的，以及其载体缀合物。本发明还涉及由肽和载体缀合物诱导的血清抗体及其用于预防，治疗或保护大多数（如果不是全部）葡萄球菌和链球菌毒素的毒性作用的用途。本发明还涉及用于检测葡萄球菌和链球菌毒素或其抗体的存在的诊断测定和试剂盒。本发明还涉及分离和纯化的编码本发明的肽的核酸和含有这些核酸的转化的宿主细胞。

6. 发明授权

US07115268B1 Peptides useful for reducing symptoms of toxic shock syndrome and septic shock 失效
标题翻译：可用于减轻中毒性休克综合征和败血性休克症状的肽
公开(公告)号：US07115268B1
公开(公告)日：2006-10-03
申请号：US09335581
申请日：1999-06-18
申请人： Jason D. Bannan , Kumar Visvanathan , John B. Zabriskie
发明人： Jason D. Bannan , Kumar Visvanathan , John B. Zabriskie
IPC分类号： A61K39/02 , A61K39/395 , A61K39/40 , A61K39/42 , A61B5/055
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/00 , C07K14/31 , C07K14/315 , C07K16/1271
摘要： This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, which may be polymeric, and carrier-conjugates thereof. The invention also relates to serum antibodies induced by the peptides and carrier-conjugates and their use to prevent, treat, or protect against the toxic effects of most, if not all, of the staphylococcal and streptococcal toxins.The invention also relates to diagnostic assays and kits to detect the presence of staphylococcal and streptococcal toxins, or antibodies thereto. The invention also relates isolated and purified to nucleic acids encoding the peptides of the invention and transformed host cells containing those nucleic acids.
摘要翻译：本发明涉及提供针对或减轻细菌感染引起的中毒性休克和败血性休克的严重性的组合物和方法。更具体地说，它涉及衍生自葡萄球菌和链球菌毒素家族的同源序列的肽，其可以是聚合物的，以及其载体缀合物。本发明还涉及由肽和载体缀合物诱导的血清抗体及其用于预防，治疗或保护大多数（如果不是全部）葡萄球菌和链球菌毒素的毒性作用的用途。本发明还涉及用于检测葡萄球菌和链球菌毒素或其抗体的存在的诊断测定和试剂盒。本发明还涉及分离和纯化的编码本发明的肽的核酸和含有这些核酸的转化的宿主细胞。

7. 发明授权

US5866347A Method of identifying persons susceptible to autoimmune neuropsychiatric disorders 失效
标题翻译：识别易患自身免疫性神经精神障碍的人的方法
公开(公告)号：US5866347A
公开(公告)日：1999-02-02
申请号：US833653
申请日：1997-04-08
申请人： Susan E. Swedo , Henrietta L. Leonard , John B. Zabriskie
发明人： Susan E. Swedo , Henrietta L. Leonard , John B. Zabriskie
IPC分类号： G01N33/53 , G01N33/569 , G01N33/68 , G01N33/543 , G01N33/564 , G01N33/577
CPC分类号： G01N33/56944 , G01N33/56972 , G01N33/6896 , G01N2800/301 , Y10S435/96 , Y10S436/811
摘要： A method of identifying individuals who have, or who are at risk of developing, autoimmune neuropsychiatric disorders is disclosed. The invented method relies on detection of the B lymphocyte antigen, D8/17. The invented method can conveniently be carried out as a simple blood test.
摘要翻译：公开了一种识别具有发展自身免疫性神经精神障碍或有发展自身免疫性神经精神障碍风险的个体的方法。本发明方法依赖于B淋巴细胞抗原D8 / 17的检测。本发明的方法可以方便地作为简单的血液检测来进行。

8. 发明授权

US4743538A Test for rheumatic fever and monoclonal antibodies useful therefor 失效
标题翻译：测试风湿热和有用的单克隆抗体
公开(公告)号：US4743538A
公开(公告)日：1988-05-10
申请号：US724076
申请日：1985-04-17
申请人： John B. Zabriskie , Daniel R. Buskirk
发明人： John B. Zabriskie , Daniel R. Buskirk
IPC分类号： G01N33/564 , C07K1/22 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12Q1/14 , C12R1/91 , G01N33/577 , C07K15/04 , G01N33/554
CPC分类号： C07K16/28 , C12Q1/14 , Y10S435/81 , Y10S435/975 , Y10S436/81 , Y10S530/868
摘要： Monoclonal antibodies which react specifically with a complementary rheumatic fever associated antigen on human B-lymphocytes derived from hybridoma cell line HB8783, process for preparing such antibodies, the use of antibodies for detecting rheumatic fever in mammals and test kit containing the antibodies.
摘要翻译：与来自杂交瘤细胞系HB8783的人B淋巴细胞上的互补性风湿热相关抗原特异性反应的单克隆抗体，制备此类抗体的方法，使用用于检测哺乳动物风湿热的抗体和含有抗体的测试试剂盒。

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