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1. 发明授权

US07332173B2 Group A streptococcal polysaccharide immunogenic compositions and methods 失效
标题翻译： A组链球菌多糖免疫原性组成及方法
公开(公告)号：US07332173B2
公开(公告)日：2008-02-19
申请号：US11086214
申请日：2005-03-21
申请人： Milan S. Blake , John B. Zabriskie , Joseph Y. Tai , Francis Michon
发明人： Milan S. Blake , John B. Zabriskie , Joseph Y. Tai , Francis Michon
IPC分类号： A61K39/02 , A61K39/00 , A61K38/00 , C07H1/00
CPC分类号： A61K39/092 , A61K9/1271 , A61K2039/55505 , A61K2039/55555 , A61K2039/6037 , Y10S424/831
摘要： This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or liposomes to form immunogenic conjugates. The method of immunization for this invention comprises administering to an individual an immunogenic amount of group A polysaccharide. The group A polysaccharide may be administered as a vaccine either on its own, conjugated to proteins or conjugated to liposomes. Additionally, the group A polysaccharides may be associated with an adjuvant. This invention is particularly useful for providing both active and passive immunogenic protection for those populations most at risk of contracting group A Streptococcal infections and disease namely adults, pregnant women and in particular infants and children.
摘要翻译：本发明提供了一种新型的免疫原性组合物和疫苗，其制备方法以及针对由A组链球菌引起的感染和疾病的免疫方法。组合物包括与蛋白质或脂质体共价连接以形成免疫原性缀合物的A组链球菌多糖。本发明的免疫方法包括向个体施用免疫原性量的A组多糖。 A组多糖可以单独作为疫苗施用，与蛋白缀合或与脂质体缀合。另外，A组多糖可以与佐剂结合。本发明特别可用于为那些最具有承担A型链球菌感染和疾病风险的群体，即成年人，孕妇，特别是婴儿和儿童提供主动和被动免疫原性保护。

2. 发明授权

US5866135A Group A streptococcal polysaccharide immunogenic compositions and methods 失效
标题翻译： A组链球菌多糖免疫原性组成及方法
公开(公告)号：US5866135A
公开(公告)日：1999-02-02
申请号：US231229
申请日：1994-04-21
申请人： Milan S. Blake , John B. Zabriskie , Joseph Y. Tai , Francis Michon
发明人： Milan S. Blake , John B. Zabriskie , Joseph Y. Tai , Francis Michon
IPC分类号： A61K9/127 , A61K39/09 , A61K39/385 , A61P31/04
CPC分类号： A61K39/092 , A61K9/1271 , A61K2039/55505 , A61K2039/55555 , A61K2039/6037 , Y10S424/831
摘要： This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or liposomes to form immunogenic conjugates. The method of immunization for this invention comprises administering to an individual an immunogenic amount of group A polysaccharide. The group A polysaccharide may be administered as a vaccine either on its own, conjugated to proteins or conjugated to liposomes. Additionally, the group A polysaccharides may be associated with an adjuvant. This invention is particularly useful for providing both active and passive immunogenic protection for those populations most at risk of contracting group A Streptococcal infections and disease namely adults, pregnant women and in particular infants and children.
摘要翻译：本发明提供了一种新型的免疫原性组合物和疫苗，其制备方法以及针对由A组链球菌引起的感染和疾病的免疫方法。组合物包括与蛋白质或脂质体共价连接以形成免疫原性缀合物的A组链球菌多糖。本发明的免疫方法包括向个体施用免疫原性量的A组多糖。 A组多糖可以单独作为疫苗施用，与蛋白缀合或与脂质体缀合。另外，A组多糖可以与佐剂结合。本发明特别可用于为那些最具有承担A型链球菌感染和疾病风险的群体，即成年人，孕妇，特别是婴儿和儿童提供主动和被动免疫原性保护。

3. 发明授权

US5879686A Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis 失效
公开(公告)号：US5879686A
公开(公告)日：1999-03-09
申请号：US853504
申请日：1997-05-08
申请人： Milan S. Blake , Joseph Y. Tai , Huilin L. Qi , Shu-Mei Liang , Lucjan J. J. Hronowski , Jeffrey K. Pullen
发明人： Milan S. Blake , Joseph Y. Tai , Huilin L. Qi , Shu-Mei Liang , Lucjan J. J. Hronowski , Jeffrey K. Pullen
IPC分类号： C12N15/09 , A61K39/00 , A61K39/095 , A61P31/04 , C07K1/18 , C07K14/01 , C07K14/22 , C12N1/21 , C12N15/31 , C12N15/70 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/36
CPC分类号： C07K14/005 , C07K14/22 , C12N15/70 , A61K39/00 , C07K2319/00 , C12N2795/10022 , Y10S435/849
摘要： The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins and fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.

4. 发明授权

US06280738B1 Non-IgA Fc binding forms of the group B streptococcal &bgr; antigens 失效
标题翻译： B组链球菌β抗原的非IgA Fc结合形式
公开(公告)号：US06280738B1
公开(公告)日：2001-08-28
申请号：US08923992
申请日：1997-09-05
申请人： Joseph Y. Tai , Milan S Blake
发明人： Joseph Y. Tai , Milan S Blake
IPC分类号： A61K3909
CPC分类号： C07K14/315 , A61K39/00 , Y10S424/831 , Y10S530/825
摘要： A-X202X203X204X205X206X207X208X209X210X211X212X213-B, wherein A represents amino acid residues 38-201 of SEQ ID NO: 2, B represents a sequence starting from amino acid 214 of SEQ ID NO: 2 and terminating at an amino acid between residues 1131 and 1164, inclusive, of SEQ ID NO: 2, and X202 through X213 are each selected independently from Ala, Val, Leu, Ile, Pro, Met, Phe, Trp, a bond, or a wild-type amino acid as found at a corresponding position of residues 202-213 of SEQ ID NO: 2, with the proviso that at least one of X202 through X213, inclusive, is other than the wild type amino acid found at the corresponding position of SEQ ID NO: 2. The LPXTG motif, as found in the native protein at amino acid residues corresponding to residues 1132-1136 of SEQ ID NO: 2, may be deleted in the sequence of the mutant C&bgr; protein. The mutant C&bgr; protein is conjugated to a streptococcal capsular polysacharide in a vaccine composition, also having an acceptable pharmaceutical carrier, for use in a method of including an immune response in an animal. Nucleic acid molecules encoding the mutant protein, vectors containing these molecules, and host cells transformed therewith are also disclosed.
摘要翻译： A-X202X203X204X205X206X207X208X209X210X211X212X213-B，其中A表示SEQ ID NO：2的氨基酸残基38-201，B表示从SEQ ID NO：2的氨基酸214开始并终止于残基1131和1164之间的氨基酸，SEQ ID NO：2，X202〜X213各自独立地选自Ala，Val，Leu，Ile，Pro，Met，Phe，Trp，键或野生型氨基酸， SEQ ID NO：2的残基202-213，条件是X202至X213中的至少一个不包括在SEQ ID NO：2的相应位置发现的野生型氨基酸。LPXTG基序作为在对应于SEQ ID NO：2的残基1132-1136的氨基酸残基处的天然蛋白质中发现的，可以在突变型Cbeta蛋白质的序列中缺失。在具有可接受的药物载体的疫苗组合物中，突变体Cbeta蛋白质与链球菌荚膜多糖偶联，用于在动物中包含免疫应答的方法。还公开了编码突变蛋白的核酸分子，含有这些分子的载体和用其转化的宿主细胞。

5. 发明授权

US6153406A Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B 失效
标题翻译：来自流感嗜血杆菌B型的外膜蛋白P2的高水平表达，纯化和重折叠的方法
公开(公告)号：US6153406A
公开(公告)日：2000-11-28
申请号：US96181
申请日：1993-07-23
申请人： Joseph Y. Tai , Jeffrey K. Pullen , Thomas Soper , Shu-Mei Liang , Milan S. Blake
发明人： Joseph Y. Tai , Jeffrey K. Pullen , Thomas Soper , Shu-Mei Liang , Milan S. Blake
IPC分类号： C12N15/09 , A61K39/00 , A61K39/102 , A61P31/04 , C07K1/34 , C07K14/01 , C07K14/11 , C07K14/285 , C07K16/10 , C12N1/21 , C12P21/02 , C12P21/04 , C12R1/19 , C12R1/92 , C12N1/20
CPC分类号： C07K14/005 , C07K14/285 , A61K39/00 , C07K2319/00 , C12N2795/10222
摘要： The present invention relates, in general, to a method of expressing the outer membrane protein P2 from Haemophilus influenzae type b (Hib-P2) and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein P2 from Haemophilus influenzae type b or fusion protein thereof in E. coli wherein the Hib-P2 protein or fusion protein comprises more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of Hib-P2 protein and fusion protein thereof.
摘要翻译：本发明一般涉及从流感嗜血杆菌b型（Hib-P2）表达外膜蛋白P2及其融合蛋白的方法。特别地，本发明涉及从流感嗜血杆菌b型或其融合蛋白的大肠杆菌中表达外膜蛋白P2的方法，其中Hib-P2蛋白或融合蛋白包含超过总蛋白的2％大肠杆菌本发明还涉及Hib-P2蛋白及其融合蛋白的纯化和重折叠方法。

6. 发明授权

US5747287A Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis 失效
公开(公告)号：US5747287A
公开(公告)日：1998-05-05
申请号：US877109
申请日：1997-06-17
申请人： Milan S. Blake , Joseph Y. Tai , Huilin L. Qi , Shu-Mei Liang , Lucjan J. J. Hronowski , Jeffrey K. Pullen
发明人： Milan S. Blake , Joseph Y. Tai , Huilin L. Qi , Shu-Mei Liang , Lucjan J. J. Hronowski , Jeffrey K. Pullen
IPC分类号： A61K39/00 , C07K14/01 , C07K14/22 , C07K1/00 , A61K39/05 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , C07K14/22 , A61K39/00 , C07K2319/00 , C12N2795/10022
摘要： The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins and fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.

7. 发明授权

US6013267A Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis 失效
标题翻译：脑膜炎奈瑟氏球菌外膜组B孔蛋白的高水平表达，纯化和重折叠的方法
公开(公告)号：US6013267A
公开(公告)日：2000-01-11
申请号：US798760
申请日：1997-02-11
申请人： Milan S. Blake , Joseph Y. Tai , Huilin L. Qi , Shu-Mei Liang , Lucjan J.J. Hronowski , Jeffrey K. Pullen
发明人： Milan S. Blake , Joseph Y. Tai , Huilin L. Qi , Shu-Mei Liang , Lucjan J.J. Hronowski , Jeffrey K. Pullen
IPC分类号： C12N15/09 , A61K39/00 , A61K39/095 , A61P31/04 , C07K1/18 , C07K14/01 , C07K14/22 , C12N1/21 , C12N15/31 , C12N15/70 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/36
CPC分类号： C07K14/005 , C07K14/22 , C12N15/70 , A61K39/00 , C07K2319/00 , C12N2795/10022 , Y10S435/849
摘要： The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins and fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.
摘要翻译：本发明一般涉及外膜蛋白脑膜炎球菌B族孔蛋白及其融合蛋白的高水平表达的方法。特别地，本发明涉及一种在大肠杆菌中表达外膜蛋白质脑膜炎球菌B蛋白孔蛋白的方法，其中脑膜炎球菌B族孔蛋白及其融合蛋白包含大肠杆菌中表达的总蛋白的2％以上。本发明还涉及脑膜炎球菌B族孔蛋白及其融合蛋白的纯化和重折叠方法及其在疫苗中的应用。

8. 发明授权

US5439808A Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis 失效
标题翻译：脑膜炎奈瑟氏球菌外膜组B孔蛋白的高水平表达，纯化和重折叠的方法
公开(公告)号：US5439808A
公开(公告)日：1995-08-08
申请号：US96182
申请日：1993-07-23
申请人： Milan S. Blake , Joseph Y. Tai , Huilin L. Qi , Shu-Mei Liang , Lucjan J. J. Hronowski , Jeffrey K. Pullen
发明人： Milan S. Blake , Joseph Y. Tai , Huilin L. Qi , Shu-Mei Liang , Lucjan J. J. Hronowski , Jeffrey K. Pullen
IPC分类号： C12N15/09 , A61K39/00 , A61K39/095 , A61P31/04 , C07K1/18 , C07K14/01 , C07K14/22 , C12N1/21 , C12N15/31 , C12N15/70 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/36 , C12N15/62 , C12N15/67
CPC分类号： C07K14/005 , C07K14/22 , C12N15/70 , A61K39/00 , C07K2319/00 , C12N2795/10022 , Y10S435/849
摘要： The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins yard fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.
摘要翻译：本发明一般涉及外膜蛋白脑膜炎球菌B族孔蛋白及其融合蛋白的高水平表达的方法。特别地，本发明涉及在大肠杆菌中表达外膜蛋白质脑膜炎双球菌B蛋白质的蛋白质的方法，其中脑膜炎球菌B蛋白质组蛋白质的蛋白质融合蛋白质包含在大肠杆菌中表达的总蛋白的2％以上。本发明还涉及脑膜炎球菌B族孔蛋白及其融合蛋白的纯化和重折叠方法及其在疫苗中的应用。

9. 发明授权

US06602508B2 Method of immunization using a Group B Streptococcus type II and type III polysaccharide conjugate vaccine 失效
标题翻译：使用B组链球菌II型和III型多糖结合疫苗进行免疫的方法
公开(公告)号：US06602508B2
公开(公告)日：2003-08-05
申请号：US09861131
申请日：2001-05-18
申请人： Francis Michon , Catherine Uitz , Joseph Y. Tai
发明人： Francis Michon , Catherine Uitz , Joseph Y. Tai
IPC分类号： A61K3909
CPC分类号： A61K39/092 , A61K39/08 , A61K47/646 , C08B37/006 , Y10S424/831
摘要： The process for depolymerizing Group B Types II and III streptococcal polysaccharide is disclosed which results in polysaccharide fragments having a reducing end suitable for conjugating to protein. Conjugate molecules, vaccines and their use to immunize mammals including humans are also disclosed.
摘要翻译：公开了解组B型II型和III型链球菌多糖的方法，其导致具有适于与蛋白质缀合的还原末端的多糖片段。还公开了缀合物分子，疫苗及其用于免疫包括人在内的哺乳动物的用途。

10. 发明授权

US06284884B1 Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof 失效
标题翻译：具有2,5-脱水-D-甘露糖末端结构的抗原B组链球菌II型和III型多糖片段及其结合疫苗
公开(公告)号：US06284884B1
公开(公告)日：2001-09-04
申请号：US08481883
申请日：1995-06-07
申请人： Francis Michon , Catherine Dong , Joseph Y. Tai
发明人： Francis Michon , Catherine Dong , Joseph Y. Tai
IPC分类号： C07H100
CPC分类号： A61K39/092 , A61K39/08 , A61K47/646 , C08B37/006 , Y10S424/831
摘要： The process for depolymerizing Group B Types II and III Streptococcus is disclosed which results in polysaccharide fragments having a reducing end suitable for conjugating to protein. Conjugate molecules, vaccines and their use to immunize mammals including humans are also disclosed.
摘要翻译：公开了B型II型和III型链球菌解聚的方法，其导致具有适合于与蛋白质缀合的还原末端的多糖片段。还公开了缀合物分子，疫苗及其用于免疫包括人在内的哺乳动物的用途。

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