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1. 发明申请

US20070038380A1 Crystal structure of E.coli GDP-fucose synthetase (and complexes thereof) and methods of identifying agonists and antagonists using same 审中-公开
标题翻译：大肠杆菌GDP-岩藻糖合成酶（及其复合物）的晶体结构以及使用其鉴定激动剂和拮抗剂的方法
公开(公告)号：US20070038380A1
公开(公告)日：2007-02-15
申请号：US10090879
申请日：2002-03-04
申请人： William Somers , Mark Stahl , Francis Sullivan
发明人： William Somers , Mark Stahl , Francis Sullivan
IPC分类号： C07K14/475 , G06F19/00
CPC分类号： C12N9/0006 , C12N9/90
摘要： The present invention provides for crystalline GFS. The crystal structure of GFS has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of GFS activity using such models are also disclosed.
摘要翻译：本发明提供了结晶GFS。 GFS的晶体结构也使用这种材料得到解决。还提供了基于这种晶体结构的模型。还公开了使用这些模型鉴定GFS活性抑制剂的方法。

2. 发明授权

US3959418A Carburetor 失效
标题翻译：化油器
公开(公告)号：US3959418A
公开(公告)日：1976-05-25
申请号：US575827
申请日：1975-05-08
申请人： Francis Sullivan
发明人： Francis Sullivan
IPC分类号： F02M7/08 , F02M7/22 , F02M9/06 , F02M17/02
CPC分类号： F02M7/22 , F02M7/08
摘要： A carburetor comprises a mixture outlet and a connection for attaching the mixture outlet to an intake manifold. A main air intake is spaced from the mixture outlet and has a butterfly valve adjustable to control the flow of air into the carburetor. The carburetor also has a fuel inlet. A pair of spaced apart surfaces forms a fuel path from a central portion of the spaced apart surfaces to the periphery of the surfaces. The periphery is adjacent to the carburetor passageway for enabling air from the main air inlet to mix with the fuel and pass to the intake manifold. A central fuel inlet forms a path for fuel from the carburetor fuel reservoir to the surfaces central portion. The central fuel inlet comprises an elongated axially movable tube whose outer surface is tapered. A cylindrical member has its inner surface surrounding the elongated tube outer surface. The cylindrical member and the tube when spaced apart define a main fuel path from the fuel reservoir to the central portion of the surfaces. A secondary air inlet forms an air intake passageway when the main air inlet is closed. The secondary air inlet is defined by a first bore formed in the interior of the elongated tube extending from the carburetor exterior adjacent the main air intake to the central portion of the surfaces. A secondary fuel inlet forms a fuel inlet passageway for mixing with the air in the secondary air inlet. The secondary fuel inlet comprises a second bore in the elongated tube which extends from the fuel reservoir to the central portion of the surfaces. At least one orifice communicates with the bores at the central portion surfaces. A needle is movable with respect to the elongated tube in the first bore for adjusting the flow of the air-fuel mixture through the orifice.
摘要翻译：化油器包括混合物出口和用于将混合物出口附接到进气歧管的连接。主进气口与混合物出口间隔开，并具有可调节的蝶阀，以控制进入化油器的空气流。化油器也有一个燃油进口。一对间隔开的表面形成从间隔开的表面的中心部分到表面周边的燃料路径。周边与化油器通道相邻，用于使来自主空气入口的空气与燃料混合并传递到进气歧管。中央燃料入口形成燃料从化油器燃料储存器到表面中心部分的路径。中心燃料入口包括细长的可轴向移动的管，其外表面是锥形的。圆柱形构件具有围绕细长管外表面的内表面。当间隔开时，圆柱形构件和管限定从燃料储存器到表面的中心部分的主燃料路径。当主空气入口关闭时，二次空气入口形成进气通道。二次空气入口由形成在细长管内部的第一孔限定，其从邻近主进气口的化油器延伸到表面的中心部分。二次燃料入口形成用于与二次空气入口中的空气混合的燃料入口通道。辅助燃料入口包括细长管中的第二孔，其从燃料储存器延伸到表面的中心部分。至少一个孔在中心部分表面与孔连通。针可相对于第一孔中的细长管移动，以调节空气 - 燃料混合物通过孔的流动。

3. 发明申请

US20120005328A9 COMPUTER NETWORK SOFTWARE AND HARDWARE ASSET CONFIGURATION AND DISCOVERY SYSTEM AND METHOD 失效
公开(公告)号：US20120005328A9
公开(公告)日：2012-01-05
申请号：US12117533
申请日：2008-05-08
申请人： Francis Sullivan
发明人： Francis Sullivan
IPC分类号： G06F15/173
CPC分类号： H04L41/0806 , H04L41/0213 , H04L41/082 , H04L41/0853 , H04L41/12 , H04L41/22
摘要： A method, system, and network for interfacing the work-flow monitoring and reporting of a host computer, a local network of information technology devices, a community of network users, and a global information technology community. This includes the processes and system features for initiating an inventory of a plurality of information technology devices associated with the local network of information technology devices. The present disclosure further includes determining needs of the local network of information technology and associating the needs to similar needs of the community of network users, and solution product and services of the global information technology community. The system directs the host computer to research and purchase resources similar in temperament of the needs of the local network of the information technology devices, and drive the global information technology community advertisements of the needs of the local network to the user of the host computer.

4. 发明申请

US20090148427A1 PLATELET GLYCOPROTEIN IB ALPHA FUSION POLYPEPTIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译： PLATELET GLYCOPROTEIN IB ALPHA FUSION POLYPEPTIDES及其使用方法
公开(公告)号：US20090148427A1
公开(公告)日：2009-06-11
申请号：US12254940
申请日：2008-10-21
申请人： Gray D. Shaw , Dianne S. Sako , Ravindra Kumar , Francis Sullivan , Tom McDonagh
发明人： Gray D. Shaw , Dianne S. Sako , Ravindra Kumar , Francis Sullivan , Tom McDonagh
IPC分类号： A61K38/43 , A61K38/16
CPC分类号： C07K14/705 , A61K38/1709 , C07K2319/00
摘要： The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
摘要翻译：本发明提供了用于治疗或预防血管相关疾病的组合物和方法。

5. 发明申请

US20080313325A1 COMPUTER NETWORK SOFTWARE AND HARDWARE ASSET CONFIGURATION AND DISCOVERY SYSTEM AND METHOD 失效
标题翻译：计算机网络软件和硬件资产配置与发现系统及方法
公开(公告)号：US20080313325A1
公开(公告)日：2008-12-18
申请号：US12117533
申请日：2008-05-08
申请人： Francis Sullivan
发明人： Francis Sullivan
IPC分类号： G06F15/173
CPC分类号： H04L41/0806 , H04L41/0213 , H04L41/082 , H04L41/0853 , H04L41/12 , H04L41/22
摘要： A method, system, and network for interfacing the work-flow monitoring and reporting of a host computer, a local network of information technology devices, a community of network users, and a global information technology community. This includes the processes and system features for initiating an inventory of a plurality of information technology devices associated with the local network of information technology devices. The present disclosure further includes determining needs of the local network of information technology and associating the needs to similar needs of the community of network users, and solution product and services of the global information technology community. The system directs the host computer to research and purchase resources similar in temperament of the needs of the local network of the information technology devices, and drive the global information technology community advertisements of the needs of the local network to the user of the host computer.
摘要翻译：用于连接主机，本地信息技术设备网络，网络用户社区和全球信息技术社区的工作流监控和报告的方法，系统和网络。这包括用于启动与信息技术设备的本地网络相关联的多个信息技术设备的库存的过程和系统特征。本公开还包括确定本地信息技术网络的需求并将需求与网络用户社区的类似需求以及全球信息技术社区的解决方案产品和服务相结合。该系统指导主机研究和采购类似于信息技术设备本地网络需求的资源，并将本地网络需求的全球信息技术社区广告推广给主机用户。

6. 发明申请

US20070293501A1 Thioalkeneamides as Transketolase Inhibitors 失效
标题翻译：硫代烯酰胺作为转酮醇酶抑制剂
公开(公告)号：US20070293501A1
公开(公告)日：2007-12-20
申请号：US10593911
申请日：2005-03-23
申请人： Steven Boyd , Kevin Condroski , Allen Thomas , Stephen Gonzales , Indrani Gunawardana , Yvan Huerou , Todd Romoff , Francis Sullivan
发明人： Steven Boyd , Kevin Condroski , Allen Thomas , Stephen Gonzales , Indrani Gunawardana , Yvan Huerou , Todd Romoff , Francis Sullivan
IPC分类号： A61K31/44 , A61K31/444 , A61K31/4965 , A61K31/497 , A61P35/00 , C07D213/70 , C07D401/12 , C07D403/12
CPC分类号： C07D213/73 , C07D405/12 , C07D411/12
摘要： The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.
摘要翻译：本发明提供了可用作转酮酶抑制剂的式（I）的硫代链烯酰胺：其中R 1，R 2，R 3，R 3， R 4，R 5，R 6，R 9，R 11，环A如本文所定义。本发明还提供包含式（I）化合物的药物组合物。本发明提供了抑制转酮醇酶活性，减少细胞核糖-5-磷酸水平，抑制核酸合成，抑制体外和体内细胞增殖和肿瘤细胞生长，刺激肿瘤细胞凋亡和通过给予式（I）化合物或其药物组合物。

7. 发明授权

US08214476B2 Computer network software and hardware asset configuration and discovery system and method 失效
标题翻译：计算机网络软硬件资产配置与发现系统及方法
公开(公告)号：US08214476B2
公开(公告)日：2012-07-03
申请号：US12117533
申请日：2008-05-08
申请人： Francis Sullivan
发明人： Francis Sullivan
IPC分类号： G06F15/173 , G06F15/16
CPC分类号： H04L41/0806 , H04L41/0213 , H04L41/082 , H04L41/0853 , H04L41/12 , H04L41/22
摘要： A method, system, and network for interfacing the work-flow monitoring and reporting of a host computer, a local network of information technology devices, a community of network users, and a global information technology community. This includes the processes and system features for initiating an inventory of a plurality of information technology devices associated with the local network of information technology devices. The present disclosure further includes determining needs of the local network of information technology and associating the needs to similar needs of the community of network users, and solution product and services of the global information technology community. The system directs the host computer to research and purchase resources similar in temperament of the needs of the local network of the information technology devices, and drive the global information technology community advertisements of the needs of the local network to the user of the host computer.
摘要翻译：用于连接主机，本地信息技术设备网络，网络用户社区和全球信息技术社区的工作流监控和报告的方法，系统和网络。这包括用于启动与信息技术设备的本地网络相关联的多个信息技术设备的库存的过程和系统特征。本公开还包括确定本地信息技术网络的需求并将需求与网络用户社区的类似需求以及全球信息技术社区的解决方案产品和服务相结合。该系统指导主机研究和采购类似于信息技术设备本地网络需求的资源，并将本地网络需求的全球信息技术社区广告推广给主机用户。

8. 发明授权

US08195797B2 Computer network software and hardware event monitoring and reporting system and method 失效
标题翻译：计算机网络软硬件事件监控报告系统及方法
公开(公告)号：US08195797B2
公开(公告)日：2012-06-05
申请号：US13181343
申请日：2011-07-12
申请人： Francis Sullivan
发明人： Francis Sullivan
IPC分类号： G06F13/00
CPC分类号： H04L41/06 , H04L41/20 , H04L41/22 , H04L43/0817
摘要： A method, system, and network for providing a method, system, and network, for network and device event monitoring and reporting. The disclosed subject matter associates with a host computer, a local network of information technology devices, a community of network users, and a global information technology community. The present disclosure initiates an inventory of a plurality of information technology devices associated with a local network of information technology devices. The method, system and apparatus determine change in the operational status of the plurality of the information technology devices associated with the local network. Then, the present disclosure monitors for changes in the operational status of the plurality of the information technology devices associated with the local network. The disclosed subject matter then presents to the host computer information relating changes in the operational status of the information technology devices associated with the local network. The present method and system associate changes to the operational status with a plurality of products from a set of product vendors, and those changes to the operational status with a plurality of advertisements presented in association with plurality of products.
摘要翻译：一种用于提供方法，系统和网络的方法，系统和网络，用于网络和设备事件监视和报告。所公开的主题与主计算机，信息技术设备的本地网络，网络用户社区和全球信息技术社区相关联。本公开启动与信息技术设备的本地网络相关联的多个信息技术设备的清单。方法，系统和装置确定与本地网络相关联的多个信息技术设备的操作状态的变化。然后，本公开监视与本地网络相关联的多个信息技术设备的操作状态的变化。然后，所公开的主题向主计算机呈现与本地网络相关联的信息技术设备的操作状态的变化的信息。本方法和系统将来自一组产品供应商的多个产品的操作状态改变为与多个产品相关联地呈现的多个广告的操作状态的变化。

9. 发明申请

US20120011251A1 COMPUTER NETWORK SOFTWARE AND HARDWARE EVENT MONITORING AND REPORTING SYSTEM AND METHOD 失效
标题翻译：计算机网络软件和硬件事件监控和报告系统及方法
公开(公告)号：US20120011251A1
公开(公告)日：2012-01-12
申请号：US13181343
申请日：2011-07-12
申请人： Francis Sullivan
发明人： Francis Sullivan
IPC分类号： G06F15/173
CPC分类号： H04L41/06 , H04L41/20 , H04L41/22 , H04L43/0817
摘要： A method, system, and network for providing a method, system, and network, for network and device event monitoring and reporting. The disclosed subject matter associates with a host computer, a local network of information technology devices, a community of network users, and a global information technology community. The present disclosure initiates an inventory of a plurality of information technology devices associated with a local network of information technology devices. The method, system and apparatus determine change in the operational status of the plurality of the information technology devices associated with the local network. Then, the present disclosure monitors for changes in the operational status of the plurality of the information technology devices associated with the local network. The disclosed subject matter then presents to the host computer information relating changes in the operational status of the information technology devices associated with the local network. The present method and system associate changes to the operational status with a plurality of products from a set of product vendors, and those changes to the operational status with a plurality of advertisements presented in association with plurality of products.
摘要翻译：一种用于提供方法，系统和网络的方法，系统和网络，用于网络和设备事件监视和报告。所公开的主题与主计算机，信息技术设备的本地网络，网络用户社区和全球信息技术社区相关联。本公开启动与信息技术设备的本地网络相关联的多个信息技术设备的清单。方法，系统和装置确定与本地网络相关联的多个信息技术设备的操作状态的变化。然后，本公开监视与本地网络相关联的多个信息技术设备的操作状态的变化。然后，所公开的主题向主计算机呈现与本地网络相关联的信息技术设备的操作状态的变化的信息。本方法和系统将来自一组产品供应商的多个产品的操作状态改变为与多个产品相关联地呈现的多个广告的操作状态的变化。

10. 发明授权

US5869307A Human GDP-mannose 4,6-dehydratase 失效
标题翻译：人类GDP-甘露糖4,6-脱水酶
公开(公告)号：US5869307A
公开(公告)日：1999-02-09
申请号：US984246
申请日：1997-12-03
申请人： Francis Sullivan , Ronald Kriz , Ravindra Kumar
发明人： Francis Sullivan , Ronald Kriz , Ravindra Kumar
IPC分类号： A61P29/00 , C12N1/21 , C12N9/88 , C12N15/60 , C12N9/06
CPC分类号： C12N9/88
摘要： The invention provides a novel GDP-mannose 4,6-dehydratase.
摘要翻译：本发明提供了一种新的GDP-甘露糖4,6-脱水酶。

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