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1. 发明授权

US06762267B2 Controlled release polyacrylic acid granules and a process for preparing the same 有权
标题翻译：控释聚丙烯酸颗粒及其制备方法
公开(公告)号：US06762267B2
公开(公告)日：2004-07-13
申请号：US10403721
申请日：2003-03-31
申请人： Daniel James Adams , David William Weaver , William R. Wilber , Jian-Hwa Guo , Edward S. Greenberg
发明人： Daniel James Adams , David William Weaver , William R. Wilber , Jian-Hwa Guo , Edward S. Greenberg
IPC分类号： C08F22046
CPC分类号： C08J3/12 , A61K9/2027 , B29B9/00 , B29K2033/00 , C08J3/16 , C08J2333/02
摘要： The present invention pertains to a method for forming polyacrylic acid granules and granules formed therefrom wherein the granules are flowable, have an increased bulk density relative to the as polymerized polyacrylic acids, and a low amount of dust which is generally characterized herein as particles which pass through a 325 mesh screen. The granules formed by the method of the present invention can be used to prepare controlled release tablets, especially controlled release pharmaceutical tablets. The controlled release properties of the tablets formed from granules prepared according to the present invention are unexpectedly better than tablets prepared from granules formed by other known granulation methods.
摘要翻译：本发明涉及形成由其形成的聚丙烯酸颗粒和颗粒的方法，其中颗粒是可流动的，相对于作为聚合的聚丙烯酸而言具有增加的堆积密度，并且少量的粉尘通常在本文中被表征为通过通过325目筛网。通过本发明的方法形成的颗粒可用于制备控释片剂，特别是控释片剂。由根据本发明制备的颗粒形成的片剂的控制释放性能出乎意料地优于由通过其它已知的造粒方法形成的颗粒制备的片剂。

2. 发明授权

US06623756B1 Directly compressed solid dosage articles 失效
标题翻译：直接压缩固体剂量物品
公开(公告)号：US06623756B1
公开(公告)日：2003-09-23
申请号：US09559687
申请日：2000-04-27
申请人： William R. Wilber , Jian-Hwa Guo , Edward S. Greenberg
发明人： William R. Wilber , Jian-Hwa Guo , Edward S. Greenberg
IPC分类号： A61K920
CPC分类号： A61K9/2095 , A61K9/2027
摘要： Solid dosage articles such as pharmaceutical tablets for the controlled release of a desired compound such as an active ingredient are directly compressed from a flowable, compressible mixture of the active ingredient, a slightly cross-linked rheology modifying polymer or copolymer, and one or more excipients. The rheology modifying polymer or copolymer is a granulated powder of suitable particle size and is generally made from one or more unsaturated (di)carboxylic acids, half ester thereof, and other optional monomers.
摘要翻译：用于控制释放所需化合物如活性成分的固体剂量制品直接从活性成分，轻微交联的流变改性聚合物或共聚物和一种或多种赋形剂的可流动的可压缩混合物中压制。流变改性聚合物或共聚物是合适粒度的造粒粉末，通常由一种或多种不饱和（二）羧酸，其半酯和其它任选的单体制成。

3. 发明授权

US08865202B2 Water soluble film for oral administration with instant wettability 有权
标题翻译：用于口服的具有即时润湿性的水溶性薄膜
公开(公告)号：US08865202B2
公开(公告)日：2014-10-21
申请号：US10771388
申请日：2004-02-05
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61K8/73 , A61K8/72 , A61K47/00 , A61K47/38 , A61Q11/00 , A61K31/44 , A61K8/02 , A61K9/00 , A61K8/39 , A61K8/81 , A61K8/92 , A61K8/90 , A61K8/49
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
摘要翻译：公开了含有用于口腔的治疗剂和/或呼吸清新剂的组合物。载体包含与某些成分组合的水溶性聚合物并提供治疗和/或美容效果。使用现有的涂覆技术将薄膜进行涂布和干燥，并显示即时润湿性，随后在口腔给药时快速溶解/崩解。

4. 发明授权

US06177096B1 Water soluble film for oral administration with instant wettability 有权
公开(公告)号：US06177096B1
公开(公告)日：2001-01-23
申请号：US09287181
申请日：1999-04-06
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61F702
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.

5. 发明申请

US20120114705A1 WATER SOLUBLE FILM FOR ORAL ADMINISTRATION WITH INSTANT WETTABILITY 审中-公开
标题翻译：水溶性薄膜用于口腔管理，具有固定的湿度
公开(公告)号：US20120114705A1
公开(公告)日：2012-05-10
申请号：US13292590
申请日：2011-11-09
申请人： Horst Georg ZERBE , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg ZERBE , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61K9/00 , A61K47/44 , A61K47/32 , A61K47/38 , A61P29/00 , A61K47/10 , A61K47/12
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
摘要翻译：公开了含有用于口腔的治疗剂和/或呼吸清新剂的组合物。载体包含与某些成分组合的水溶性聚合物并提供治疗和/或美容效果。使用现有的涂覆技术将薄膜进行涂布和干燥，并显示即时润湿性，随后在口腔给药时快速溶解/崩解。

6. 发明授权

US06572889B1 Controlled release solid dosage carbamazepine formulations 失效
标题翻译：可控释放固体剂量卡马西平配方
公开(公告)号：US06572889B1
公开(公告)日：2003-06-03
申请号：US10092826
申请日：2002-03-07
申请人： Jian-Hwa Guo
发明人： Jian-Hwa Guo
IPC分类号： A61K922
CPC分类号： A61K9/2077 , A61K9/1635 , A61K9/2027 , A61K31/55
摘要： A polymer or copolymer composition derived from one or more unsaturated carboxylic acids that is cross-linked and carbamazepine in conjunction with conventional materials such as fillers, excipients, and surface active agents is disclosed. Solid dosage forms of immediate and sustained release tablets containing the polymer or copolymer composition can be formed by wet granulation or wet granulation followed by blending with direct compression ingredients. The polymer or copolymer, as a controlled release agent, can enhance controlled-release properties while meeting acceptable release rates as specified by the USP.
摘要翻译：公开了一种聚合物或共聚物组合物，其衍生自一种或多种与交联的不饱和羧酸和卡马西平结合常规材料如填料，赋形剂和表面活性剂。含有聚合物或共聚物组合物的立即和缓释片剂的固体剂型可以通过湿法制粒或湿法制粒形成，然后与直接压片成分共混。作为控释剂的聚合物或共聚物可以在满足USP规定的可接受释放速率的同时增强控释特性。

7. 发明授权

US06709671B2 Water soluble film for oral administration with instant wettability 有权
标题翻译：用于口服的具有即时润湿性的水溶性薄膜
公开(公告)号：US06709671B2
公开(公告)日：2004-03-23
申请号：US10143962
申请日：2002-05-14
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61K1300
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
摘要翻译：公开了含有用于口腔的治疗剂和/或呼吸清新剂的组合物。载体包含与某些成分组合的水溶性聚合物并提供治疗和/或美容效果。使用现有的涂覆技术将薄膜进行涂布和干燥，并显示即时润湿性，随后在口腔给药时快速溶解/崩解。

8. 发明授权

US5948430A Water soluble film for oral administration with instant wettability 失效
公开(公告)号：US5948430A
公开(公告)日：1999-09-07
申请号：US904607
申请日：1997-08-01
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61K9/70 , A61K8/00 , A61K8/34 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/49 , A61K8/64 , A61K8/73 , A61K8/81 , A61K8/86 , A61K8/90 , A61K8/92 , A61K8/97 , A61K9/00 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61P1/02 , A61P11/00 , A61Q11/00 , A61F7/02 , A61L15/16 , A61K13/00
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.

9. 发明授权

US06723781B1 Hydrogels containing substances 失效
标题翻译：含有物质的水凝胶
公开(公告)号：US06723781B1
公开(公告)日：2004-04-20
申请号：US09650926
申请日：2000-08-29
申请人： Dean M. Frate , Jian-Hwa Guo
发明人： Dean M. Frate , Jian-Hwa Guo
IPC分类号： C08L3302
CPC分类号： A61K9/7023 , Y10S524/916
摘要： A blend of one or more crosslinked polymers or copolymers prepared from an olefinically unsaturated polymerizable carboxylic or anhydride monomer and at least one high molecular weight essentially linear polymer prepared from an olefinically unsaturated polymerizable carboxylic acid monomer. The blend is neutralized to typically a low pH, and generally contains a noncovalent, e.g. ionic, crosslinking agent, and a cure rate modifier. The hydrogel blend is capable of containing a large amount of water, has good tack, good adhesion, and can be utilized as an application vehicle having a backing thereon as well as containing various substances such as personal care compounds, pharmaceuticals, active ingredients, and the like. Conversely, the hydrogel blend can be dried and subsequently wetted without substantial loss of properties.
摘要翻译：由烯属不饱和可聚合的羧酸或酸酐单体制备的一种或多种交联聚合物或共聚物的共混物和由烯属不饱和可聚合羧酸单体制备的至少一种高分子量基本上线性的聚合物。共混物被中和至通常的低pH值，并且通常含有非共价键。离子交联剂和固化速率改性剂。水凝胶共混物能够含有大量的水，具有良好的粘着性，良好的粘合性，并且可以用作其上具有背衬的应用载体，并且可以含有各种物质，例如个人护理化合物，药物，活性成分和类似。相反地，水凝胶共混物可以被干燥并随后润湿而没有显着的性能损失。

10. 发明授权

US06623754B2 Dosage form of N-acetyl cysteine 失效
标题翻译： N-乙酰半胱氨酸的剂型
公开(公告)号：US06623754B2
公开(公告)日：2003-09-23
申请号：US09681689
申请日：2001-05-21
申请人： Jian-Hwa Guo , William Robert Wilber
发明人： Jian-Hwa Guo , William Robert Wilber
IPC分类号： A61K920
CPC分类号： A61K9/2054 , A61K9/2027
摘要： A directly-compressed, controlled release tablet contains N-acetyl cysteine as the active ingredient.
摘要翻译：直接压片的控释片含有N-乙酰半胱氨酸作为活性成分。

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