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1. 发明授权

US06592887B2 Water soluble film for oral administration with instant wettability 有权
公开(公告)号：US06592887B2
公开(公告)日：2003-07-15
申请号：US10161670
申请日：2002-06-05
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61F702
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.

2. 发明授权

US06284264B1 Water soluble film for oral administration with instant wettability 有权
标题翻译：用于口服的具有即时润湿性的水溶性薄膜
公开(公告)号：US06284264B1
公开(公告)日：2001-09-04
申请号：US09630562
申请日：2000-08-02
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61F702
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
摘要翻译：公开了含有用于口腔的治疗剂和/或呼吸清新剂的组合物。载体包含与某些成分组合的水溶性聚合物并提供治疗和/或美容效果。使用现有的涂覆技术将薄膜进行涂布和干燥，并显示即时润湿性，随后在口腔给药时快速溶解/崩解。

3. 发明授权

US5244677A Application system for drug containing microemulsions 失效
标题翻译：含微量药物的药物应用系统
公开(公告)号：US5244677A
公开(公告)日：1993-09-14
申请号：US979446
申请日：1992-11-20
申请人： Karl W. Kreckel , Horst-Georg Zerbe
发明人： Karl W. Kreckel , Horst-Georg Zerbe
IPC分类号： A61K9/70 , A61L15/00
CPC分类号： A61K9/703 , A61K9/7084 , Y10T428/14 , Y10T428/1476 , Y10T428/249953 , Y10T428/249982 , Y10T428/28
摘要： The invention deals with devices, in particular with bandage strips, for a transdermal delivery of drugs to patients, whereby the drug formulations include highly viscous preparations, topical solutions of a low viscosity and micro-emulsions of a low viscosity containing the drugs. Depending on the consistency of the medium containing the drug, the drug formulation is stored in a reservoir, consisting, e.g., of a punched out cavity or of an absorbent piece of material, which is encased or supported by a carrier element (a foamed material piece or a non-woven fleece tape) adhering to the skin by means of a skin-compatible adhesive, whereby specially formed protective films are applied at the filling and delivery side during the storage of the device to prevent a lateral migration, and whereby during its use, the device can be refilled with dosed amounts by the patient without requiring a removal of the device from the skin surface to be treated (FIG. 2).
摘要翻译：本发明涉及用于药物经皮递送给患者的装置，特别是用于绷带的装置，其中药物制剂包括高粘度制剂，低粘度的局部溶液和含有药物的低粘度微乳液。取决于含有药物的培养基的一致性，药物制剂储存在由例如冲压出的空腔或吸收材料片组成的容器中，该容器被载体元件（泡沫材料）包裹或支撑片或非织造羊毛带）通过皮肤相容的粘合剂粘附到皮肤上，由此在装置的储存期间在填充和输送侧施加特殊形成的保护膜以防止横向移动，并且由此在在使用时，可以不需要从待治疗的皮肤表面去除装置，患者可以以患者的剂量重新装满装置（图2）。

4. 发明授权

US06709671B2 Water soluble film for oral administration with instant wettability 有权
标题翻译：用于口服的具有即时润湿性的水溶性薄膜
公开(公告)号：US06709671B2
公开(公告)日：2004-03-23
申请号：US10143962
申请日：2002-05-14
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61K1300
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
摘要翻译：公开了含有用于口腔的治疗剂和/或呼吸清新剂的组合物。载体包含与某些成分组合的水溶性聚合物并提供治疗和/或美容效果。使用现有的涂覆技术将薄膜进行涂布和干燥，并显示即时润湿性，随后在口腔给药时快速溶解/崩解。

5. 发明授权

US5948430A Water soluble film for oral administration with instant wettability 失效
公开(公告)号：US5948430A
公开(公告)日：1999-09-07
申请号：US904607
申请日：1997-08-01
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61K9/70 , A61K8/00 , A61K8/34 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/49 , A61K8/64 , A61K8/73 , A61K8/81 , A61K8/86 , A61K8/90 , A61K8/92 , A61K8/97 , A61K9/00 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61P1/02 , A61P11/00 , A61Q11/00 , A61F7/02 , A61L15/16 , A61K13/00
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.

6. 发明申请

US20120114705A1 WATER SOLUBLE FILM FOR ORAL ADMINISTRATION WITH INSTANT WETTABILITY 审中-公开
标题翻译：水溶性薄膜用于口腔管理，具有固定的湿度
公开(公告)号：US20120114705A1
公开(公告)日：2012-05-10
申请号：US13292590
申请日：2011-11-09
申请人： Horst Georg ZERBE , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg ZERBE , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61K9/00 , A61K47/44 , A61K47/32 , A61K47/38 , A61P29/00 , A61K47/10 , A61K47/12
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
摘要翻译：公开了含有用于口腔的治疗剂和/或呼吸清新剂的组合物。载体包含与某些成分组合的水溶性聚合物并提供治疗和/或美容效果。使用现有的涂覆技术将薄膜进行涂布和干燥，并显示即时润湿性，随后在口腔给药时快速溶解/崩解。

7. 发明授权

US5223261A Transdermal estradiol delivery system 失效
标题翻译：经皮雌二醇递送系统
公开(公告)号：US5223261A
公开(公告)日：1993-06-29
申请号：US815908
申请日：1991-12-31
申请人： Gregory R. Nelson , Horst-Georg Zerbe , Cheryl L. Moore , Steven M. Wick
发明人： Gregory R. Nelson , Horst-Georg Zerbe , Cheryl L. Moore , Steven M. Wick
IPC分类号： A61K9/70 , A61K31/565
CPC分类号： A61K9/7053 , A61K31/565 , A61K9/7061
摘要： A pressure-sensitive adhesive sheet material for delivering estradiol to skin, the sheet material comprising a backing with a layer of a pressure-sensitive adhesive adjacent thereto, said pressure-sensitive adhesive layer comprising a pressure-sensitive adhesive polymer, two or more skin penetration-enhancing ingredients and estradiol. The sheet material is useful for systemic treatment of conditions associated with estradiol deficiency. Methods of using such adhesive sheet material are also described.
摘要翻译：一种用于将雌二醇递送到皮肤的压敏粘合片材料，所述片材包含背衬与邻近的粘合剂层的所述压敏粘合剂层，所述压敏粘合剂层包含压敏粘合剂聚合物，两次或更多次皮肤渗透 - 增强成分和雌二醇。片材可用于全身治疗与雌二醇缺乏相关的病症。还描述了使用这种粘合片材的方法。

8. 发明授权

US08865202B2 Water soluble film for oral administration with instant wettability 有权
标题翻译：用于口服的具有即时润湿性的水溶性薄膜
公开(公告)号：US08865202B2
公开(公告)日：2014-10-21
申请号：US10771388
申请日：2004-02-05
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61K8/73 , A61K8/72 , A61K47/00 , A61K47/38 , A61Q11/00 , A61K31/44 , A61K8/02 , A61K9/00 , A61K8/39 , A61K8/81 , A61K8/92 , A61K8/90 , A61K8/49
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
摘要翻译：公开了含有用于口腔的治疗剂和/或呼吸清新剂的组合物。载体包含与某些成分组合的水溶性聚合物并提供治疗和/或美容效果。使用现有的涂覆技术将薄膜进行涂布和干燥，并显示即时润湿性，随后在口腔给药时快速溶解/崩解。

9. 发明授权

US06177096B1 Water soluble film for oral administration with instant wettability 有权
公开(公告)号：US06177096B1
公开(公告)日：2001-01-23
申请号：US09287181
申请日：1999-04-06
申请人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
发明人： Horst Georg Zerbe , Jian-Hwa Guo , Anthony Serino
IPC分类号： A61F702
CPC分类号： A61K8/0208 , A61K8/39 , A61K8/4926 , A61K8/731 , A61K8/8176 , A61K8/90 , A61K8/922 , A61K9/006 , A61Q11/00
摘要： A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.

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