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1. 发明授权

US5021414A Phenol derivatives 失效
标题翻译：苯酚衍生物
公开(公告)号：US5021414A
公开(公告)日：1991-06-04
申请号：US452069
申请日：1989-12-18
申请人： William R. Pilgrim , Derek W. Young , Brian S. Tait , Graham C. Crawley , Philip N. Edwards , George B. Hill
发明人： William R. Pilgrim , Derek W. Young , Brian S. Tait , Graham C. Crawley , Philip N. Edwards , George B. Hill
IPC分类号： A61K31/165 , A61K31/10 , A61K31/135 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/27 , A61K31/38 , A61K31/381 , A61P13/02 , A61P15/00 , C07C43/225 , C07C43/23 , C07C45/30 , C07C45/44 , C07C45/46 , C07C45/51 , C07C45/60 , C07C45/68 , C07C49/755 , C07C59/64 , C07C59/72 , C07C62/34 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C233/18 , C07C235/34 , C07C279/00 , C07C301/00 , C07C303/38 , C07C311/00 , C07C311/02 , C07C311/16 , C07C311/24 , C07C311/26 , C07C313/00 , C07C315/04 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07C319/20 , C07C323/11 , C07C323/16 , C07C323/41 , C07C323/42 , C07C323/44 , C07C323/51 , C07C323/60 , C07C325/00 , C07C327/40 , C07C327/42 , C07C327/46 , C07C327/50 , C07D333/60 , C07D333/64 , C07F7/18 , C07F9/655
CPC分类号： C07F9/6552 , C07C309/00 , C07C317/00 , C07C323/00 , C07C43/225 , C07C43/23 , C07C45/305 , C07C45/44 , C07C45/46 , C07C45/513 , C07C45/60 , C07C45/68 , C07C49/755 , C07C59/64 , C07C59/72 , C07C62/34 , C07D333/60 , C07F7/1852 , C07C2102/08 , C07C2102/10
摘要： A phenol derivative of the formulaNU--A--X--R.sup.1wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus;wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages,wherein R.sup.1 is hydrogen, or alkyl, alkenyl, cycloalkyl, halogenoalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 -- or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --S--, --SO-- or --SO.sub.2 --,wherein R.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene;wherein R.sup.12 is hydrogen or alkyl, and wherein R.sup.22 is hydrogen, cyano or nitro;or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumors or of anovulatory infertility.

2. 发明授权

US4904661A Phenol derivatives 失效
标题翻译：苯酚衍生物
公开(公告)号：US4904661A
公开(公告)日：1990-02-27
申请号：US134320
申请日：1987-12-16
申请人： William R. Pilgrim , Derek W. Young , Brian S. Tait , Graham C. Crawley , Philip N. Edwards , George B. Hill
发明人： William R. Pilgrim , Derek W. Young , Brian S. Tait , Graham C. Crawley , Philip N. Edwards , George B. Hill
IPC分类号： A61K31/165 , A61K31/10 , A61K31/135 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/27 , A61K31/38 , A61K31/381 , A61P13/02 , A61P15/00 , C07C43/225 , C07C43/23 , C07C45/30 , C07C45/44 , C07C45/46 , C07C45/51 , C07C45/60 , C07C45/68 , C07C49/755 , C07C59/64 , C07C59/72 , C07C62/34 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C233/18 , C07C235/34 , C07C279/00 , C07C301/00 , C07C303/38 , C07C311/00 , C07C311/02 , C07C311/16 , C07C311/24 , C07C311/26 , C07C313/00 , C07C315/04 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07C319/20 , C07C323/11 , C07C323/16 , C07C323/41 , C07C323/42 , C07C323/44 , C07C323/51 , C07C323/60 , C07C325/00 , C07C327/40 , C07C327/42 , C07C327/46 , C07C327/50 , C07D333/60 , C07D333/64 , C07F7/18 , C07F9/655
CPC分类号： C07F9/6552 , C07C309/00 , C07C317/00 , C07C323/00 , C07C43/225 , C07C43/23 , C07C45/305 , C07C45/44 , C07C45/46 , C07C45/513 , C07C45/60 , C07C45/68 , C07C49/755 , C07C59/64 , C07C59/72 , C07C62/34 , C07D333/60 , C07F7/1852 , C07C2102/08 , C07C2102/10
摘要： A phenol derivative of the formulaNU--A--X--R.sup.1wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus;wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages,wherein R.sup.1 is hydrogen, or alkyl, alkenyl, cycloalkyl, halogenoalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 -- or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --S--, --SO-- or --SO.sub.2 --, wherein R.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene;wherein R.sup.12 is hydrogen or alkyl, and wherein R.sup.22 is hydrogen, cyano or nitro;or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumors or of anovulatory infertility.

3. 发明授权

US4732912A Phenol derivatives 失效
标题翻译：苯酚衍生物
公开(公告)号：US4732912A
公开(公告)日：1988-03-22
申请号：US604964
申请日：1984-04-27
申请人： William R. Pilgrim , Derek W. Young , Brian S. Tait , Graham C. Crawley , Philip N. Edwards , George B. Hill
发明人： William R. Pilgrim , Derek W. Young , Brian S. Tait , Graham C. Crawley , Philip N. Edwards , George B. Hill
IPC分类号： A61K31/165 , A61K31/10 , A61K31/135 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/27 , A61K31/38 , A61K31/381 , A61P13/02 , A61P15/00 , C07C43/225 , C07C43/23 , C07C45/30 , C07C45/44 , C07C45/46 , C07C45/51 , C07C45/60 , C07C45/68 , C07C49/755 , C07C59/64 , C07C59/72 , C07C62/34 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C233/18 , C07C235/34 , C07C279/00 , C07C301/00 , C07C303/38 , C07C311/00 , C07C311/02 , C07C311/16 , C07C311/24 , C07C311/26 , C07C313/00 , C07C315/04 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07C319/20 , C07C323/11 , C07C323/16 , C07C323/41 , C07C323/42 , C07C323/44 , C07C323/51 , C07C323/60 , C07C325/00 , C07C327/40 , C07C327/42 , C07C327/46 , C07C327/50 , C07D333/60 , C07D333/64 , C07F7/18 , C07F9/655 , A61K31/275 , C07C147/10
CPC分类号： C07F9/6552 , C07C309/00 , C07C317/00 , C07C323/00 , C07C43/225 , C07C43/23 , C07C45/305 , C07C45/44 , C07C45/46 , C07C45/513 , C07C45/60 , C07C45/68 , C07C49/755 , C07C59/64 , C07C59/72 , C07C62/34 , C07D333/60 , C07F7/1852 , C07C2102/08 , C07C2102/10
摘要： A phenol derivative of the formulaNU--A--X--R.sup.1wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages,wherein R.sup.1 is hydrogen, or alkyl, alkenyl, cycloalkyl, halogenoalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 -- or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --S--, --SO-- or --SO.sub.2 --,wherein R.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene;wherein R.sup.12 is hydrogen or alkyl, and wherein R.sup.22 is hydrogen, cyano or nitro;or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumours or of anovulatory infertility.
摘要翻译：式NU-A-X-R1的酚衍生物，其中NU是包含羟基苯基 - 羟基萘基的定义的双酚核; 羟基苯基 - 羟基茚满基，羟基苯基 - 羟基苯并噻吩基或二羟基苯基 - 乙烯或亚乙烯基核; 其中A是可以被亚苯基或其它键连接的亚烷基，亚烯基或亚炔基，其中R 1是氢或烷基，烯基，环烷基，卤代烷基，芳基或芳基烷基，或R 1与R 2连接，并且其中X是-CONR2- ，-CONR 2 - ， - NR 12 CO - ， - NR 12 CS - ， - NR 12 CONR 2 - ， - SO 2 NR 2 - 或-CO-，或者当R 1不是氢时，是-NR 12 COO - ， - S-，-SO-或 - SO 2 - ，其中R 2是氢或烷基，或者R 1和R 2一起形成亚烷基; 其中R 12是氢或烷基，并且其中R 22是氢，氰基或硝基; 或其盐。该化合物具有抗雌激素活性，可用于治疗激素依赖性乳腺肿瘤或无排卵不育症。

4. 发明授权

US4061087A Plate locking structure for press cylinders 失效
标题翻译：压力缸板锁定结构
公开(公告)号：US4061087A
公开(公告)日：1977-12-06
申请号：US751276
申请日：1976-12-17
申请人： George B. Hill
发明人： George B. Hill
IPC分类号： B41F27/12 , B41F27/06
CPC分类号： B41F27/1231
摘要： Apparatus for printing press cylinders for releasably retaining printing plates. A printing plate locking bar is utilized in conjunction with a base member, the base member being fixed to a press cylinder construction and a locking bar being slidably secured thereto, thus adapted for sliding in a direction transverse to the longitudinal axis of the locking bar. Latching means is provided for releasably latching the locking bar in a particular position for printing plate removal and replacement. Spring means are supplied to spring-tension the printing plate so mounted, once the latching means is unlatched. Additional latching means may be provided for enabling the positive securement of the locking bar relative to such base member, through additional latch structure, where the plate is to be positively locked in its intended taut condition.
摘要翻译：用于印刷压力缸的装置，用于可释放地保持印刷版。印版锁定杆与底座构件结合使用，底座构件固定在压缸结构上，锁定杆可滑动地固定在其上，因此适于在横向于锁定杆的纵向轴线的方向上滑动。提供了锁定装置，用于将锁定杆可释放地锁定在用于印刷板移除和更换的特定位置。一旦锁定装置解锁，弹簧装置被提供给弹簧张紧印制板。可以提供附加的锁定装置，用于通过附加的闩锁结构使得锁定杆相对于这种基座构件的正确固定，其中板将被锁定在其预定的拉紧状态。

5. 发明授权

US3994224A Mounting structure for printing plates 失效
标题翻译：印版安装结构
公开(公告)号：US3994224A
公开(公告)日：1976-11-30
申请号：US585127
申请日：1975-06-09
申请人： George B. Hill
发明人： George B. Hill
IPC分类号： B41F27/14 , B41F27/06
CPC分类号： B41F27/14
摘要： Press cylinder structure for securing a printing plate over the cylinder's saddle. This saddle includes a first longitudinal edge permissably provided with a printing plate retainer bar, and the opposite edge of the saddle being spaced from an independent, movable, tensioned, printing-plate locking bar. Such locking bar is spring-loaded relative to the saddle, and is provided with registry orientation means. The locking bar is movable inwardly toward the saddle so as to facilitate printing plate, edge mounting onto the locking bar. Thereafter, the locking bar is urgeable outwardly with respect to the saddle so that tension may be applied to the plate. In the inward progress of the locking bar relative to the saddle, means are provided for releasably fixing the disposition of the locking bar relative to the press cylinder so that a printing plate disposed on the saddle and engagement thereof by the locking bar can be released.
摘要翻译：压缸结构，用于将印版固定在气缸的鞍座上。该鞍座包括允许设置有印版保持杆的第一纵向边缘，并且鞍座的相对边缘与独立的，可移动的，张紧的印刷板锁定杆间隔开。这种锁定杆相对于鞍座是弹簧加载的，并且设置有注册表定位装置。锁定杆可朝向鞍座向内移动，以便于印版，边缘安装到锁定杆上。此后，锁定杆可相对于鞍座向外推动，使得张力可以施加到板上。在锁定杆相对于鞍座的向内进展中，设置有用于可释放地固定锁定杆相对于压力缸的布置的装置，使得可以释放设置在鞍座上的印刷板和通过锁定杆的接合。

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