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    • 1. 发明授权
    • Dental cartridge assembly auto-injector with protective needle cover
    • 牙套装配自动注射器带保护针盖
    • US5658259A
    • 1997-08-19
    • US545149
    • 1995-10-19
    • William R. PearsonDavid Edward SpadyClaudio LopezHyung J. LeeJohn G. WilmotN. Lawrence Dalling
    • William R. PearsonDavid Edward SpadyClaudio LopezHyung J. LeeJohn G. WilmotN. Lawrence Dalling
    • A61M5/20A61M5/24A61M5/315A61M5/32A61M5/00
    • A61M5/24A61M5/2033A61M5/326A61M2005/206A61M2005/2073A61M2005/247A61M2005/31516A61M2005/3247A61M2005/3267A61M5/3202
    • An injection device includes a generally tubular outer body and a medicament cartridge assembly carried within the outer body. The cartridge assembly includes a glass container, a charge of medicament disposed within the glass container, iii) a plunger member rearwardly confining the medicament, and iv) a seal for sealing the forward portion of the glass container. A needle has a rearward end disposed proximate the seal, with the seal and needle being movable with respect to one another. A rigid needle cover member is normally maintained in an inoperative position and is movable relative to said body to a protective position wherein the needle cover member extends forwardly to cover the forward end of the needle. A releasable spring is releasable in response to a predetermined actuating procedure to drive a collet member forwardly within the outer body and thereby enable i) the cartridge assembly to move relative to the needle so that the rearward end of the needle pierces the seal to establish communication with the medicament, ii) the needle to move with respect to the body so that the needle projects outwardly from the forward end of the body, and iii) the needle cover to move relative to the body from the inoperative position to the protective position so that the needle cover member extends beyond the forward end of the needle.
    • 注射装置包括大致管状的外部主体和在外部本体内承载的药物盒组件。 盒组件包括玻璃容器,设置在玻璃容器内的药物装料,iii)向后限制药物的柱塞件,以及iv)用于密封玻璃容器前部的密封件。 针具有靠近密封件设置的后端,密封件和针可相对于彼此移动。 刚性针盖构件通常保持在不工作位置并且可相对于所述主体移动到保护位置,其中针盖构件向前延伸以覆盖针的前端。 可释放的弹簧响应于预定的致动过程而可释放,以在筒体内向前驱动夹头构件,从而能够使盒组件相对于针移动,使得针的后端刺穿密封件以建立通信 与药物相连,ii)针相对于身体移动,使得针从身体的前端向外突出,以及iii)针罩相对于身体从不工作位置移动到保护位置,因此 针盖构件延伸超过针的前端。
    • 4. 发明授权
    • Autoinjector converted from intramuscular to subcutaneous mode of
injection
    • 从INTRAMUSCULAR转换为注射模式的自动注射器
    • US5102393A
    • 1992-04-07
    • US380451
    • 1989-07-17
    • Stanley J. SarnoffClaudio Lopez
    • Stanley J. SarnoffClaudio Lopez
    • A61M5/20A61M5/24A61M5/32
    • A61M5/2033A61M2005/206A61M2005/2073A61M5/24
    • An autoinjector converted from an intramuscular to a subcutaneous mode of injection comprising a housing having a medicament cartridge assembly mounted within the housing means in a storage position for movement out of the storage position and a releasable stressed spring assembly for moving the medicament cartridge assembly means out of the storage position. The stressed spring assembly is operable in response to a manual actuating procedure which does not require compression of the subcutaneous tissue to effect an intramuscular mode of injection by moving the hypodermic needle of the cartridge assembly outwardly of the housing into the muscle tissue at the injection site of a user and a major portion of the liquid medicament of the cartridge assembly outwardly through the hypodermic needle into the muscle tissue of the user. An injection mode converting structure is secured in a subcutaneous mode position for converting the mode of injection effected by the stressed spring assembly from the intramuscular mode of injection to a subcutaneous mode of injection in which the needle cannot extend substantially beyond subcutaneous tissue at the injection site of the user and a major portion of the liquid medicament enters into the subcutaneous tissue.
    • 一种自动注射器,其从肌肉内注射到皮下注射模式,包括壳体,所述壳体具有安装在所述壳体装置内的药剂盒组件,所述药剂盒组件位于所述存储位置内的存储位置,以及用于将所述药剂盒组件装置移出的释放应力弹簧组件 的仓位。 应力弹簧组件可操作以响应于手动致动程序,其不需要压缩皮下组织以通过将套筒组件的皮下注射针移动到注射部位的肌肉组织内,从而实现肌内注射模式 使用者和药筒组件的液体药物的主要部分通过皮下注射针向外进入使用者的肌肉组织。 注射模式转换结构固定在皮下模式位置,用于将由应力弹簧组件实现的注射模式从肌内注射模式转换为皮下注射模式,其中针不能在注射部位基本上延伸超过皮下组织 并且液体药物的主要部分进入皮​​下组织。
    • 5. 发明授权
    • Disposable hypodermic syringe with plastic snap-on needle hub and heat
shrink seal therefor
    • 一次性皮下注射器,带塑料扣式针座和热收缩密封
    • US4747839A
    • 1988-05-31
    • US942727
    • 1986-12-17
    • William R. TarelloClaudio Lopez
    • William R. TarelloClaudio Lopez
    • A61M5/28A61M5/32
    • A61M5/3202A61M5/286Y10S128/18
    • A disposable hypodermic syringe having a cylindrical barrel open at both its forward and rearward ends, with the forward tooled end having a necked down portion terminating in an annular flange having an outer diameter greater than that of the necked down portion and less than that of the cylindrical barrel, a stopper positioned in the necked down portion of the cylindrical barrel to seal off the tooled end of the barrel, a resilient plastic needle hub assembly fitted on the forward end of the cylindrical barrel. The hub assembly including a cylindrical body having both a forward and a rearward end, a nose portion extending forwardly from the forward end of the cylindrical body, a needle affixed to the nose portion away from the forward end of the cylindrical body, the cylindrical body being sized whereby it will resiliently fit over and engage the annular flange of the necked down portion of the cylindrical barrel to operatively retain the needle hub assembly on the cylindrical barrel with a sleeve of heat shrinkable plastic fitted over a portion of the hub assembly and contiguous cylindrical barrel whereby when heat is applied the sleeve will shrink to firmly engage the aforedescribed syringe portions and thereby provide an air tight seal between the hub body and the cylindrical barrel and in addition whereby the shrink tension will cause the hub body to more firmly engage the annular flange.
    • 一次性皮下注射器,其具有在其前端和后端两端都开口的圆柱形筒,其前向工具端具有终止于外径大于颈缩部的外径的颈缩部,并且小于 圆柱形筒,位于圆柱形筒的颈缩部分中的塞子,用于密封筒的工具端部,弹性塑料针座组件,其装配在圆柱形筒的前端上。 所述轮毂组件包括具有前端和后端的圆柱体,从所述圆柱体的前端向前延伸的鼻部,与所述圆柱体的前端相对地延伸到所述鼻部的针,所述圆柱体 其尺寸使得其将弹性地配合在圆柱形筒的颈缩部分的环形凸缘上并且接合圆柱形筒的颈缩部分的环形凸缘,以将针座组件可操作地保持在圆柱形筒上,该套筒具有装配在轮毂组件的一部分上的热收缩塑料套筒, 圆柱形筒,由此当施加热量时,套筒将收缩以牢固地接合上述注射器部分,从而在轮毂本体和圆柱形筒之间提供气密密封,此外,收缩张力将使轮毂体更牢固地接合 环形法兰
    • 6. 发明授权
    • Multiple medicament cartridge clip and medicament discharging device
therefor
    • 多个药剂盒夹和药物放电装置
    • US4518384A
    • 1985-05-21
    • US505323
    • 1983-06-17
    • William R. TarelloClaudio LopezLinda A. GordonThomas D. WhalenWilliam B. Harvey
    • William R. TarelloClaudio LopezLinda A. GordonThomas D. WhalenWilliam B. Harvey
    • A61M5/20A61M5/24A61M5/28F41A9/84A61M5/18
    • F41A9/84A61M5/20A61M5/24F41B11/85A61M2005/005A61M2005/206A61M2005/2414A61M2205/0266A61M5/2053A61M5/2425
    • A medicament discharging device and an expendable clip thereon containing a plurality of medicament cartridges. Each of the cartridges comprises a container, a dosage of medicament in the container, a hypodermic needle sealingly contained in a sterile condition in cooperating relation with the container and a movable wall means at one end of the container operable when moved through a discharging stroke to cause the sharpened end of the needle to move outwardly out of sealingly contained relation and into the muscle tissue of a patient and the medicament dosage to move outwardly of the container into the opposite end of the needle and out of the sharpened end thereof into the muscle tissue of the patient. The medicament discharging device comprises a portable manually engageable housing structure defining a medicament cartridge receiving station, a plunger mounted in the housing structure for movement through the medicament cartridge receiving station in repetitive operative cycles each of which includes a discharging stroke in one direction and a return stroke in the opposite direction, a manually actuatable mechanism for effecting movement of the plunger through an operative cycle, and a releasable connection between the housing structure and the clip for securing the same in operative relation so that successive cartridges in the clip will be presented in the medicament cartridge receiving station of the housing structure for injection in response to an operative cycle.
    • 一种药物排出装置和一个包含多个药剂盒的消耗性夹子。 每个药筒包括容器,容器中药物的剂量,密封地容纳在与容器配合关系的无菌状态下的皮下注射针,以及在容器的一端可移动的壁装置,其在移动通过排出冲程时可操作 导致针尖的尖端从密封容纳的关系向外移动到患者的肌肉组织中,并且药物剂量从容器的外部移动到针的相对端并从其尖锐的末端进入肌肉 病人的组织。 药物排放装置包括限定药剂盒接收站的便携式手动接合壳体结构,安装在壳体结构中的柱塞,用于以重复的操作循环移动通过药剂盒接收站,每个循环包括在一个方向上的排出冲程和返回 相反方向的行程,用于实现柱塞通过操作循环的运动的手动致动机构,以及壳体结构和夹子之间的可释放连接,用于将其固定在可操作的关系中,使得夹具中的连续的盒将呈现在 用于响应于操作循环的用于注射的壳体结构的药物盒接收台。
    • 7. 发明授权
    • Conveniently carried frequent use autoinjector
    • 方便携带频繁使用自动注射器
    • US5085642A
    • 1992-02-04
    • US380459
    • 1989-07-17
    • Stanley J. SarnoffClaudio Lopez
    • Stanley J. SarnoffClaudio Lopez
    • A61M5/20A61M5/32
    • A61M5/2033A61M2005/206A61M2005/2073
    • An autoinjector particularly suited to be carried on the person of a user comprising a housing defining an exterior configuration of a size and shape approximately the same as that of a conventional fountain pen including a housing body assembly of elongated generally cylindrical configuration and a separate housing cap structure of elongated generally cylindrical configuration having an elongated clip thereon. The housing cap structure is detachably secured to the housing body assembly in open ended telescopic relation with an opposite end portion thereof preferably by a childproof connection. A medicament cartridge assembly is mounted in a storage position within a forward end of an interior chamber within the housing body assembly and a releasable stressed spring assembly is carried by the housing body assembly adjacent the rearward end thereof. The housing cap structure serves the dual purposes of (1) facilitating the securement of the housing cap structure and body assembly with the user's pocket and (2) alleviating the likelihood of an unwanted release of the releasable stressed spring assembly with a resultant unwanted movement of the hypodermic needle of the cartridge assembly and an unwanted movement of the liquid medicament of the cartridge assembly outwardly of the needle.
    • 一种特别适用于携带在使用者身上的自动注射器,包括壳体,该外壳限定了与常规钢笔的尺寸和形状大致相同的外部构造,该钢笔包括细长大致圆柱形构造的壳体主体组件和单独的壳体盖 细长的大致圆柱形构造的结构在其上具有细长的夹子。 壳体盖结构以相对端部的开口伸缩关系可拆卸地固定到壳体主体组件,优选地通过儿童防护连接。 药剂盒组件安装在壳体主体组件内的内部腔室的前端内的存储位置中,并且可释放的应力弹簧组件由壳体主体组件邻近其后端承载。 外壳盖结构用于(1)促进用户口袋固定外壳盖结构和主体组件的双重目的,以及(2)减轻可释放应力弹簧组件的不期望的释放的可能性,导致不必要的运动 药筒组件的皮下注射针和药筒组件的液体药物不期望地移动到针的外面。
    • 8. 发明授权
    • Split hub assembly for a necked down cartridge tube
    • 用于颈缩筒管的分体式轮毂组件
    • US4624393A
    • 1986-11-25
    • US279956
    • 1981-07-02
    • Claudio Lopez
    • Claudio Lopez
    • A61J1/00A61J1/06A61J1/20B67D5/08
    • A61J1/2096A61J1/06A61J1/201B05B11/3049
    • A split hub assembly for use in conjunction with a cartridge assembly including a cylindrical cartridge tube having a necked down end terminating in an annular flange, the split hub assembly including a needle holder having a forward and a rearward end with a passage connecting the ends. A cylindrical body extends from the rearward end of the needle holder and surrounds a hollow spike extending from the rearward end of the needle holder in communication with the passage in the holder. A pluarlity of flexible segments extend rearwardly from the rearward end of the cylindrical body, each segment having a locking lip extending inwardly from the free end of the segment. The cylindrical body has a first locking portion adjacent the forward end portion of the body and a second locking portion adjacent the forward end portion of the body and a second locking portion adjacent the rearward end of the body. A locking portion comprising a cylindrical sleeve has an inturned locking member on its forward end which is sized to engage the first and then the second locking portion, whereby, with the locking member engaging the first locking portion on the cylindrical body and the flexible segments positioned over and around the annular flange on the necked end of the cartridge tube, rearward movement of the locking portion causes the cylindrical sleeve to engage the flexible segments and force them inwardly whereby the locking lips fit in against the rearward portion of the annular flange to secure the split hub assembly to the cartridge tube while the locking member engages the second locking portion to retain the locking means in position.
    • 一种用于与盒组件一起使用的分离式轮毂组件,其包括圆柱形筒管,该圆柱形筒管具有终止于环形凸缘的颈缩下端,所述分离轮毂组件包括具有前端和后端以及连接所述端部的通道的针保持器。 圆柱体从针保持器的后端延伸并且包围从针保持器的后端延伸的中空尖端,与保持器中的通道连通。 柔性节段的多个节点从圆柱体的后端向后延伸,每个节段具有从节段的自由端向内延伸的锁定唇缘。 圆柱体具有邻近主体的前端部分的第一锁定部分和与主体的前端部分相邻的第二锁定部分和邻近主体后端的第二锁定部分。 包括圆柱形套筒的锁定部分在其前端具有内接的锁定构件,其大小适于接合第一和第二锁定部分,由此,锁定构件接合圆柱形主体上的第一锁定部分并且将柔性段定位 在筒管的颈缩端部上的环形凸缘周围和周围,锁定部分的向后运动导致圆柱形套筒接合柔性部分并将其向内推动,由此锁定唇缘配合抵靠环形凸缘的后部,以固定 当锁定构件接合第二锁定部分以将锁定装置保持在适当位置时,分离轮毂组件到筒管。
    • 9. 发明授权
    • Dual mode automatic injector
    • US4484910A
    • 1984-11-27
    • US563767
    • 1983-12-21
    • Stanley J. SarnoffGeorge B. CalkinsClaudio Lopez
    • Stanley J. SarnoffGeorge B. CalkinsClaudio Lopez
    • A61M5/20A61M5/32
    • A61M5/2033A61M2005/2013A61M2005/206A61M2005/2073
    • A dual mode automatic injector having a dual mode safety device for preventing the release of the stressed spring assembly except when it is desired to operate the medicament injecting assembly by the stressed spring assembly. The dual mode safety device comprises a first part including a pin portion disposed in a safety position extending through a central aperture in the rear wall of the housing assembly of the injector in release preventing relation with the stressed spring assembly for removal therefrom in response to a relative rearward movement with respect to the rear wall so as to permit an actuating movement to release the stressed spring assembly. The first part includes an automatic removal portion fixed to the rearward end of the pin portion. The automatic removal portion is of a size greater than the pin portion but less than the rear wall so as to present a forwardly facing surface spaced rearwardly from the rear wall operable to be engaged by a holding member while a moving member is moved forwardly into engagement with the rear wall to provide both a relative rearward removal movement for the pin portion and an actuating movement for the stressed spring assembly. The dual mode safety device also includes a separate second part and a connection between the first and second parts for (1) enabling the second part to be connected with the first part while the pin portion of the latter is in its safety position in a manual mode position wherein the first part is in rearward motion transmitting relation to the second part and (2) enabling the second part to be removed from the manual position while the pin portion of the first part is retained in its safety position. The second part includes a cap portion of a size and shape to be conveniently manually grasped by a user and moved rearwardly with respect to the housing assembly in order to effect the removal of the pin portion from its safety position when the second part is in its manual mode position.
    • 10. 发明授权
    • Automatic medicament ingredient mixing and injecting apparatus
    • 自动药物成分混合和注射装置
    • US4755169A
    • 1988-07-05
    • US943135
    • 1986-12-18
    • Stanley J. SarnoffWilliam R. TarelloClaudio LopezDaniel M. Karcher
    • Stanley J. SarnoffWilliam R. TarelloClaudio LopezDaniel M. Karcher
    • A61M5/178A61M20060101A61M5/19A61M5/20A61M5/24A61M5/30A61M5/32A61M5/00
    • A61M5/2066A61M2005/2013A61M2005/206A61M2005/2073A61M2005/31598A61M5/19A61M5/2448
    • An automatic injector apparatus comprising an outer housing assembly, a hypodermic needle, first and second containers, a first liquid medicament ingredient in the first container and a second medicament ingredient in the second container, first and second pistons in the first and second containers respectively, a releasable stressed spring arrangement capable of being released twice, once for movement through a first piston moving stroke and second through a second piston moving stroke, a first releasing device operable in response to a first predetermined actuating procedure for accomplishing a first release of the spring arrangement so as to effect movement of the first piston through a liquid medicament ingredient moving stroke causing the liquid medicament ingredient to mix with the medicament ingredient in the second container to form liquid medicament and a second releasing device operable in response to a second actuating procedure for accomplishing a second release of the spring arrangement so as to effect movement of the second piston through an operative stroke causing the hypodermic needle to be moved into the muscle tissue of the patient and the liquid medicament to be moved through the needle into the muscle tissue of the patient.
    • 一种自动注射器装置,包括外壳体组件,皮下注射针,第一和第二容器,第一容器中的第一液体药物成分和第二容器中的第二药物成分,第一和第二容器中的第一和第二活塞, 可释放的应力弹簧装置,其能够被释放两次,一次用于通过第一活塞移动行程运动,第二通过第二活塞运动行程;第一释放装置,可响应于第一预定的致动程序来完成弹簧的第一释放 以便通过液体药物成分移动行程来实现第一活塞的运动,使得液体药物成分与第二容器中的药物成分混合形成液体药物,第二释放装置可响应于第二致动程序而操作, 完成spri的第二次释放 以便实现第二活塞通过操作行程的移动,使得皮下注射针被移动到患者的肌肉组织中,并且液体药物通过针移动到患者的肌肉组织中。