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1. 发明授权

US4484910A Dual mode automatic injector 失效
公开(公告)号：US4484910A
公开(公告)日：1984-11-27
申请号：US563767
申请日：1983-12-21
申请人： Stanley J. Sarnoff , George B. Calkins , Claudio Lopez
发明人： Stanley J. Sarnoff , George B. Calkins , Claudio Lopez
IPC分类号： A61M5/20 , A61M5/32
CPC分类号： A61M5/2033 , A61M2005/2013 , A61M2005/206 , A61M2005/2073
摘要： A dual mode automatic injector having a dual mode safety device for preventing the release of the stressed spring assembly except when it is desired to operate the medicament injecting assembly by the stressed spring assembly. The dual mode safety device comprises a first part including a pin portion disposed in a safety position extending through a central aperture in the rear wall of the housing assembly of the injector in release preventing relation with the stressed spring assembly for removal therefrom in response to a relative rearward movement with respect to the rear wall so as to permit an actuating movement to release the stressed spring assembly. The first part includes an automatic removal portion fixed to the rearward end of the pin portion. The automatic removal portion is of a size greater than the pin portion but less than the rear wall so as to present a forwardly facing surface spaced rearwardly from the rear wall operable to be engaged by a holding member while a moving member is moved forwardly into engagement with the rear wall to provide both a relative rearward removal movement for the pin portion and an actuating movement for the stressed spring assembly. The dual mode safety device also includes a separate second part and a connection between the first and second parts for (1) enabling the second part to be connected with the first part while the pin portion of the latter is in its safety position in a manual mode position wherein the first part is in rearward motion transmitting relation to the second part and (2) enabling the second part to be removed from the manual position while the pin portion of the first part is retained in its safety position. The second part includes a cap portion of a size and shape to be conveniently manually grasped by a user and moved rearwardly with respect to the housing assembly in order to effect the removal of the pin portion from its safety position when the second part is in its manual mode position.

2. 发明授权

US4578064A Plural dosage automatic injector with improved safety 失效
标题翻译：多剂量自动注射器，安全性提高
公开(公告)号：US4578064A
公开(公告)日：1986-03-25
申请号：US563768
申请日：1983-12-21
申请人： Stanley J. Sarnoff , George B. Calkins , William R. Tarello
发明人： Stanley J. Sarnoff , George B. Calkins , William R. Tarello
IPC分类号： A61M20060101 , A61M5/19 , A61M5/20 , A61M5/00
CPC分类号： A61M5/2066 , A61M5/2033 , A61M2005/206 , A61M5/19
摘要： A plural dosage automatic injector comprising an elongated tubular housing assembly having side by side first and second medicament injecting assemblies each including a container, a hypodermic needle, a liquid medicament and a plunger within the forward end portion thereof and, first and second stressed spring assemblies in the rearward end portion thereof disposed in operative relation with said first and second medicament injecting assemblies for operating the latter. A manually operable safety device is provided which includes a first safety pin operable (1) when in a safety position with respect to the first spring stressed assembly to prevent actuation and release thereof and (2) when removed from its safety position to permit the actuation and release of the second stressed spring assembly. A mechanical motion transmitting mechanism is provided which is operable to transmit a movement occurring as a result of the actuation and release of the first stressed spring assembly into a secondary actuating movement operable to (1) effect a relative movement between the automatic safety pin and the second stressed spring assembly sufficient to remove the automatic safety pin from its safety position and (2) thereafter actuate and release second stressed spring assembly to operate the second medicament injecting assembly.
摘要翻译：一种多剂量自动注射器，包括：第一和第二药剂注射组件，其细长的管状壳体组件，每个包括容器，皮下注射针，液体药物和位于其前端部分内的柱塞;以及第一和第二应力弹簧组件在其后端部分处于与所述第一和第二药剂注射组件操作的关系中，用于操作所述药剂注射组件。提供了一种可手动操作的安全装置，其包括第一安全销，所述第一安全销在相对于所述第一弹簧应力组件处于安全位置时可操作（1），以防止其致动和释放;以及（2）当从其安全位置移除以允许致动并释放第二个应力弹簧组件。提供了一种机械运动传递机构，其可操作以将由第一应力弹簧组件的致动和释放的结果传递到辅助致动运动中，该辅助致动运动可操作以（1）实现自动安全销和第二应力弹簧组件之间的相对移动第二应力弹簧组件足以将自动安全销从其安全位置移除，（2）此后致动并释放第二应力弹簧组件以操作第二药剂注射组件。

3. 发明授权

US4031893A Hypodermic injection device having means for varying the medicament capacity thereof 失效
标题翻译：具有用于改变其药物能力的装置的皮下注射装置
公开(公告)号：US4031893A
公开(公告)日：1977-06-28
申请号：US686636
申请日：1976-05-14
申请人： Sheldon Kaplan , George B. Calkins , Stanley J. Sarnoff , N. Lawrence Dalling
发明人： Sheldon Kaplan , George B. Calkins , Stanley J. Sarnoff , N. Lawrence Dalling
IPC分类号： A61M5/20 , A61M5/32 , A61M5/00
CPC分类号： A61M5/2033 , A61M2005/206 , A61M2005/2073 , A61M5/3202
摘要： A hypodermic injection device comprising a cartridge holder having a cylindrical body open at one end and closed at the other end, the closed end being provided with an aperture, a cartridge with the holder, the cartridge including an ampoule having a cylindrical sleeve open at one end and having a necked portion at the other end to receive a hub mounting a cannula, the cannula facing the apertured end of the cylindrical body, a piston slidably carried within the sleeve adjacent the open end thereof to define a medicament chamber between the piston and cannula, fluid medicament in the medicament chamber, the piston having a concave face on the side forming one end of the medicament chamber, a spring power assembly adjacent the open end of the ampoule sleeve for moving the cartridge forward and for injecting the fluid medicament, spacer means positionable between the outer face of the piston and the adjacent spring power means to vary the position of the piston within the ampoule sleeve and thereby control the volume of the medicament chamber and the medicament carried therein, a safety assembly for controlling actuation of the spring power assembly, and a resilient sheath covering the cannula to maintain the cannula in sterile condition.
摘要翻译：一种皮下注射装置，包括一个盒保持器，该药筒保持器具有在一端开放并在另一端封闭的圆柱体，封闭端设置有孔，具有保持器的药筒，该药筒包括一个具有一个在一个开口的圆柱形套筒的安瓿并且在另一端具有颈部，以接纳安装套管的套管，所述套管面向所述圆柱体的有孔端，活塞可靠地承载在所述套筒内，邻近其开口端，以在所述活塞和插管，药物腔中的流体药物，活塞在形成药物室的一端的一侧上具有凹面;弹簧动力组件，邻近安瓿套筒的开口端，用于将药筒向前移动并用于注射流体药物; 间隔件可定位在活塞的外表面和相邻的弹簧动力装置之间，以改变活塞在安瓿套筒内的位置从而控制药物室和其中所携带的药物的体积，用于控制弹簧动力组件的致动的安全组件，以及覆盖套管以将套管保持在无菌状态的弹性护套。

4. 发明授权

US4433684A Assembly for administering respiratory medicament dosage through a gas mask 失效
标题翻译：通过防毒面具施用呼吸药剂量的装置
公开(公告)号：US4433684A
公开(公告)日：1984-02-28
申请号：US244913
申请日：1981-03-18
申请人： Stanley J. Sarnoff , Rudolph S. Malooley , George B. Calkins , William R. Tarello
发明人： Stanley J. Sarnoff , Rudolph S. Malooley , George B. Calkins , William R. Tarello
IPC分类号： A61M15/00
CPC分类号： A61M15/00 , A61M15/0018 , A61M15/0028 , A61M2202/04
摘要： An assembly for enabling a respiratory medicament to be administered to a gas mask wearer without breaking the seal between the face blank of the gas mask and the wearer's face. The assembly comprises a container, a respiratory medicament dosage releasably disposed within the container, and a shroud covering the container for (1) interiorly communicating with the exterior of a normally closed passage extending through the face blank of the gas mask to the sealed interior thereof, (2) exteriorly isolating the container and (3) enabling the respiratory medicament dosage to be released from the container while the interior communicating and exterior isolating relationships are maintained.
摘要翻译：一种用于使呼吸药物能够施用于防毒面具佩戴者而不破坏防毒面具的面罩与穿着者面部之间的密封的组件。组件包括容器，可释放地设置在容器内的呼吸药剂，以及覆盖容器的护罩，用于（1）与通过防毒面具的面罩延伸到其密封的内部的常闭通道的外部内部连通，（2）外部隔离容器，（3）使内部通信和外部隔离关系得以保持，使呼吸药剂剂量从容器中释放出来。

5. 发明授权

US4226235A Plural injecting device 失效
标题翻译：多次注射装置
公开(公告)号：US4226235A
公开(公告)日：1980-10-07
申请号：US6555
申请日：1979-01-25
申请人： Stanley J. Sarnoff , George B. Calkins , N. Lawrence Dalling
发明人： Stanley J. Sarnoff , George B. Calkins , N. Lawrence Dalling
IPC分类号： A61M5/19 , A61M5/20 , A61M5/32 , A61M5/00
CPC分类号： A61M5/2033 , A61M5/2066 , A61M2005/206 , A61M2005/2073 , A61M2005/3109 , A61M5/19 , A61M5/3298
摘要： A plural injecting device comprising an outer housing assembly, a plurality of cartridge sub-assemblies, and a corresponding plurality of releasable spring sub-assemblies for effecting a forward movement of the associated hypodermic needle into the user's muscle tissue and the associated liquid medicament dosage outwardly through the needle, the sub-assemblies being mounted within the outer housing assembly so that as a result of the actuation of one of the releasable spring sub-assemblies the other releasable spring sub-assembly will be actuated so as to insure a substantially simultaneous injection of the plural dosages contained within the device. A safety arrangement in some embodiments provides for selective individual or plural dosage injection.
摘要翻译：一种多个注射装置，包括外部壳体组件，多个药筒子组件和相应的多个可释放的弹簧子组件，用于实现相关联的皮下注射针向使用者的肌肉组织的向前运动以及向外的相关液体药物剂量通过针，子组件安装在外壳组件内，使得由于可释放的弹簧子组件中的一个的致动，另一个可释放的弹簧子组件将被致动以确保基本上同时的注射包含在装置内的多个剂量。在一些实施方案中的安全装置提供选择性单次或多次剂量注射。

6. 发明授权

US4329988A Plural injection assembly 失效
标题翻译：多次注射组件
公开(公告)号：US4329988A
公开(公告)日：1982-05-18
申请号：US219488
申请日：1980-12-23
申请人： Stanley J. Sarnoff , Claudio Lopez
发明人： Stanley J. Sarnoff , Claudio Lopez
IPC分类号： A61M5/20 , A61M5/00
CPC分类号： A61M5/2033 , A61M5/2066 , A61M5/002 , A61M5/19
摘要： A plural injection assembly comprising a plurality of separate injections capable of separate actuation and a holder for stably supporting the separate injectors together and for manually facilitating the sequential actuation thereof.
摘要翻译：多个注射组件，包括能够分离致动的多个分离的注射和用于稳定地将分离的注射器支撑在一起并用于手动促进其顺序致动的保持器。

7. 发明授权

US5102393A Autoinjector converted from intramuscular to subcutaneous mode of injection 失效
标题翻译：从INTRAMUSCULAR转换为注射模式的自动注射器
公开(公告)号：US5102393A
公开(公告)日：1992-04-07
申请号：US380451
申请日：1989-07-17
申请人： Stanley J. Sarnoff , Claudio Lopez
发明人： Stanley J. Sarnoff , Claudio Lopez
IPC分类号： A61M5/20 , A61M5/24 , A61M5/32
CPC分类号： A61M5/2033 , A61M2005/206 , A61M2005/2073 , A61M5/24
摘要： An autoinjector converted from an intramuscular to a subcutaneous mode of injection comprising a housing having a medicament cartridge assembly mounted within the housing means in a storage position for movement out of the storage position and a releasable stressed spring assembly for moving the medicament cartridge assembly means out of the storage position. The stressed spring assembly is operable in response to a manual actuating procedure which does not require compression of the subcutaneous tissue to effect an intramuscular mode of injection by moving the hypodermic needle of the cartridge assembly outwardly of the housing into the muscle tissue at the injection site of a user and a major portion of the liquid medicament of the cartridge assembly outwardly through the hypodermic needle into the muscle tissue of the user. An injection mode converting structure is secured in a subcutaneous mode position for converting the mode of injection effected by the stressed spring assembly from the intramuscular mode of injection to a subcutaneous mode of injection in which the needle cannot extend substantially beyond subcutaneous tissue at the injection site of the user and a major portion of the liquid medicament enters into the subcutaneous tissue.
摘要翻译：一种自动注射器，其从肌肉内注射到皮下注射模式，包括壳体，所述壳体具有安装在所述壳体装置内的药剂盒组件，所述药剂盒组件位于所述存储位置内的存储位置，以及用于将所述药剂盒组件装置移出的释放应力弹簧组件的仓位。应力弹簧组件可操作以响应于手动致动程序，其不需要压缩皮下组织以通过将套筒组件的皮下注射针移动到注射部位的肌肉组织内，从而实现肌内注射模式使用者和药筒组件的液体药物的主要部分通过皮下注射针向外进入使用者的肌肉组织。注射模式转换结构固定在皮下模式位置，用于将由应力弹簧组件实现的注射模式从肌内注射模式转换为皮下注射模式，其中针不能在注射部位基本上延伸超过皮下组织并且液体药物的主要部分进入皮下组织。

8. 发明授权

US5085642A Conveniently carried frequent use autoinjector 失效
标题翻译：方便携带频繁使用自动注射器
公开(公告)号：US5085642A
公开(公告)日：1992-02-04
申请号：US380459
申请日：1989-07-17
申请人： Stanley J. Sarnoff , Claudio Lopez
发明人： Stanley J. Sarnoff , Claudio Lopez
IPC分类号： A61M5/20 , A61M5/32
CPC分类号： A61M5/2033 , A61M2005/206 , A61M2005/2073
摘要： An autoinjector particularly suited to be carried on the person of a user comprising a housing defining an exterior configuration of a size and shape approximately the same as that of a conventional fountain pen including a housing body assembly of elongated generally cylindrical configuration and a separate housing cap structure of elongated generally cylindrical configuration having an elongated clip thereon. The housing cap structure is detachably secured to the housing body assembly in open ended telescopic relation with an opposite end portion thereof preferably by a childproof connection. A medicament cartridge assembly is mounted in a storage position within a forward end of an interior chamber within the housing body assembly and a releasable stressed spring assembly is carried by the housing body assembly adjacent the rearward end thereof. The housing cap structure serves the dual purposes of (1) facilitating the securement of the housing cap structure and body assembly with the user's pocket and (2) alleviating the likelihood of an unwanted release of the releasable stressed spring assembly with a resultant unwanted movement of the hypodermic needle of the cartridge assembly and an unwanted movement of the liquid medicament of the cartridge assembly outwardly of the needle.
摘要翻译：一种特别适用于携带在使用者身上的自动注射器，包括壳体，该外壳限定了与常规钢笔的尺寸和形状大致相同的外部构造，该钢笔包括细长大致圆柱形构造的壳体主体组件和单独的壳体盖细长的大致圆柱形构造的结构在其上具有细长的夹子。壳体盖结构以相对端部的开口伸缩关系可拆卸地固定到壳体主体组件，优选地通过儿童防护连接。药剂盒组件安装在壳体主体组件内的内部腔室的前端内的存储位置中，并且可释放的应力弹簧组件由壳体主体组件邻近其后端承载。外壳盖结构用于（1）促进用户口袋固定外壳盖结构和主体组件的双重目的，以及（2）减轻可释放应力弹簧组件的不期望的释放的可能性，导致不必要的运动药筒组件的皮下注射针和药筒组件的液体药物不期望地移动到针的外面。

9. 发明授权

US5085641A Conveniently carried frequent use auto-injector with improved cap structure 失效
标题翻译：方便携带使用具有改进盖结构的自动注射器
公开(公告)号：US5085641A
公开(公告)日：1992-02-04
申请号：US507795
申请日：1990-04-12
申请人： Stanley J. Sarnoff , Claudio Lopez , N. Lawrence Dalling
发明人： Stanley J. Sarnoff , Claudio Lopez , N. Lawrence Dalling
IPC分类号： A61M5/178 , A61M5/20 , A61M5/31 , A61M5/32
CPC分类号： A61M5/2033 , A61M2005/206
摘要： A stressed spring assembly for providing an operative stroke in cooperating relation with a medicament cartridge assembly of an auto-injector so as to inject a liquid medicament of the medicament cartridge assembly through a hypodermic needle of the medicament cartridge assembly into an injection site of the user. The stressed spring assembly includes a cap structure serving the plural purposes of (1) facilitating the securement of the cap structure and remainder of the auto-injection with the user's pocket, (2) alleviating the likelihood of an unwanted release of the releasable mechanism of the stressed spring assembly with a resultant unwanted movement of the hypodermic needle and an unwanted movement of the liquid medicament outwardly of the hypodermic needle by requiring two different manual movements for its removal, and (3) protecting against an unwanted contact with the hypodermic needle while in extended operative position after withdrawal from the injection site. The cap structure is formed of first and second members disposed in a fixed assembled position with respect to one another into which the first and second members are snap-fitted by a relative movement toward one another in an axial direction. Both members are of a configuration enabling them to be molded by corresponding die surfaces contained on two die members movable together and apart.

10. 发明授权

US4755169A Automatic medicament ingredient mixing and injecting apparatus 失效
标题翻译：自动药物成分混合和注射装置
公开(公告)号：US4755169A
公开(公告)日：1988-07-05
申请号：US943135
申请日：1986-12-18
申请人： Stanley J. Sarnoff , William R. Tarello , Claudio Lopez , Daniel M. Karcher
发明人： Stanley J. Sarnoff , William R. Tarello , Claudio Lopez , Daniel M. Karcher
IPC分类号： A61M5/178 , A61M20060101 , A61M5/19 , A61M5/20 , A61M5/24 , A61M5/30 , A61M5/32 , A61M5/00
CPC分类号： A61M5/2066 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2005/31598 , A61M5/19 , A61M5/2448
摘要： An automatic injector apparatus comprising an outer housing assembly, a hypodermic needle, first and second containers, a first liquid medicament ingredient in the first container and a second medicament ingredient in the second container, first and second pistons in the first and second containers respectively, a releasable stressed spring arrangement capable of being released twice, once for movement through a first piston moving stroke and second through a second piston moving stroke, a first releasing device operable in response to a first predetermined actuating procedure for accomplishing a first release of the spring arrangement so as to effect movement of the first piston through a liquid medicament ingredient moving stroke causing the liquid medicament ingredient to mix with the medicament ingredient in the second container to form liquid medicament and a second releasing device operable in response to a second actuating procedure for accomplishing a second release of the spring arrangement so as to effect movement of the second piston through an operative stroke causing the hypodermic needle to be moved into the muscle tissue of the patient and the liquid medicament to be moved through the needle into the muscle tissue of the patient.
摘要翻译：一种自动注射器装置，包括外壳体组件，皮下注射针，第一和第二容器，第一容器中的第一液体药物成分和第二容器中的第二药物成分，第一和第二容器中的第一和第二活塞，可释放的应力弹簧装置，其能够被释放两次，一次用于通过第一活塞移动行程运动，第二通过第二活塞运动行程;第一释放装置，可响应于第一预定的致动程序来完成弹簧的第一释放以便通过液体药物成分移动行程来实现第一活塞的运动，使得液体药物成分与第二容器中的药物成分混合形成液体药物，第二释放装置可响应于第二致动程序而操作，完成spri的第二次释放以便实现第二活塞通过操作行程的移动，使得皮下注射针被移动到患者的肌肉组织中，并且液体药物通过针移动到患者的肌肉组织中。

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