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    • 2. 发明申请
    • METHOD AND APPARATUS FOR CLEANING A FLUID
    • 清洗流体的方法和装置
    • US20100219135A1
    • 2010-09-02
    • US12676502
    • 2008-09-04
    • William Lawrence PriestSatish KumarGregory Allen Slawson
    • William Lawrence PriestSatish KumarGregory Allen Slawson
    • B01D35/157
    • B01D3/42B01D1/0082B01D35/143B01D35/185G01N25/14
    • A method and apparatus for cleaning a fluid comprising a fluid supply port for receiving a contaminated fluid; a fluid return port for providing a cleaned fluid; an evaporator for evaporating liquid contaminants from the fluid; a fluid line connecting the evaporator between the fluid supply port and the fluid return port; a sensor connected to at least one of the fluid filter, the evaporator, and the fluid line; a controller connected to an output of the sensor, wherein the controller includes: a processor; and a memory device including computer readable instructions which, when executed by the processor cause the processor to perform the steps of: receiving data from the sensor; comparing the data from the sensor to reference data; sending a control signal to at least one of the fluid filter and the evaporator based on comparing the data from the sensor to the reference data.
    • 一种用于清洁流体的方法和装置,包括用于接收污染流体的流体供应口; 用于提供清洁的流体的流体返回端​​口; 用于从流体中蒸发液体污染物的蒸发器; 在所述流体供给口和所述流体返回口之间连接所述蒸发器的流体管线; 连接到流体过滤器,蒸发器和流体管线中的至少一个的传感器; 连接到所述传感器的输出的控制器,其中所述控制器包括:处理器; 以及包括计算机可读指令的存储设备,所述计算机可读指令在由所述处理器执行时使所述处理器执行以下步骤:从所述传感器接收数据; 将传感器的数据与参考数据进行比较; 基于将来自传感器的数据与参考数据进行比较,向至少一个流体过滤器和蒸发器发送控制信号。
    • 5. 发明授权
    • WDR13 as a novel biomarker useful for treating diabetes and cancer
    • WDR13作为可用于治疗糖尿病和癌症的新型生物标志物
    • US09198986B2
    • 2015-12-01
    • US14116539
    • 2012-04-27
    • Satish KumarVijay Pratap Singh
    • Satish KumarVijay Pratap Singh
    • C12N15/00A61K49/00A01K67/027C07K14/47
    • A61K49/0008A01K67/0276A01K2217/072A01K2227/105A01K2267/0331A01K2267/0362C07K14/47C07K2319/41C07K2319/43C12N2710/10043
    • WD-repeat proteins are very diverse, yet these are structurally related proteins that participate in a wide range of cellular functions. WDR13, a member of this family, is conserved from fishes to humans and localizes into the nucleus. To understand the in vivo function(s) of Wdr13 gene, we have created and characterized a mutant mouse strain lacking this gene. The mutant mice had higher serum insulin levels and increased pancreatic islet mass as a result of the enhanced beta cell proliferation. While a known cell cycle inhibitor, p21, was down regulated in the mutant islets overexpression of WDR13 in the pancreatic MIN6 cell line resulted in upregulation of p21, accompanied by retardation of cell proliferation. We suggest that WDR13 is a novel negative regulator of the pancreatic beta cell proliferation. Co-immunoprecipitation experiments showed that this protein interacts with estrogen receptors and various HDACs. We provide evidence to show that WDR13 can regulate estrogen receptors-mediated transcription both in HDAC-dependent and HDAC-independent manner. Given the higher insulin levels, better glucose clearance and the lack of insulin resistance in WDR13 deficient mice, we propose that this protein may be a potential candidate drug target for ameliorating impaired glucose metabolism in diabetes.
    • WD重复蛋白是非常多样化的,但这些是参与广泛细胞功能的结构相关蛋白。 WDR13,这个家庭的成员,从鱼类保存到人类,并定位到核心。 为了了解Wdr​​13基因的体内功能,我们创建并表征了缺乏该基因的突变小鼠株。 由于增强的β细胞增殖,突变小鼠具有较高的血清胰岛素水平和胰岛素的增加。 虽然已知的细胞周期抑制剂p21在胰岛MIN6细胞系中突变型胰岛过表达WDR13中下调,导致p21上调,伴随着细胞增殖的延迟。 我们建议WDR13是胰腺β细胞增殖的新型负调节因子。 共免疫沉淀实验显示,该蛋白质与雌激素受体和各种HDAC相互作用。 我们提供证据表明,WDR13可以调节雌激素受体介导的转录,无论是HDAC依赖型还是HDAC独立型。 鉴于WDR13缺陷小鼠胰岛素水平升高,葡萄糖清除率更高,胰岛素抵抗不足,我们建议该蛋白可能是改善糖尿病中糖代谢紊乱的潜在候选药物靶点。