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1. 发明授权

US09198986B2 WDR13 as a novel biomarker useful for treating diabetes and cancer 有权
标题翻译： WDR13作为可用于治疗糖尿病和癌症的新型生物标志物
公开(公告)号：US09198986B2
公开(公告)日：2015-12-01
申请号：US14116539
申请日：2012-04-27
申请人： Satish Kumar , Vijay Pratap Singh
发明人： Satish Kumar , Vijay Pratap Singh
IPC分类号： C12N15/00 , A61K49/00 , A01K67/027 , C07K14/47
CPC分类号： A61K49/0008 , A01K67/0276 , A01K2217/072 , A01K2227/105 , A01K2267/0331 , A01K2267/0362 , C07K14/47 , C07K2319/41 , C07K2319/43 , C12N2710/10043
摘要： WD-repeat proteins are very diverse, yet these are structurally related proteins that participate in a wide range of cellular functions. WDR13, a member of this family, is conserved from fishes to humans and localizes into the nucleus. To understand the in vivo function(s) of Wdr13 gene, we have created and characterized a mutant mouse strain lacking this gene. The mutant mice had higher serum insulin levels and increased pancreatic islet mass as a result of the enhanced beta cell proliferation. While a known cell cycle inhibitor, p21, was down regulated in the mutant islets overexpression of WDR13 in the pancreatic MIN6 cell line resulted in upregulation of p21, accompanied by retardation of cell proliferation. We suggest that WDR13 is a novel negative regulator of the pancreatic beta cell proliferation. Co-immunoprecipitation experiments showed that this protein interacts with estrogen receptors and various HDACs. We provide evidence to show that WDR13 can regulate estrogen receptors-mediated transcription both in HDAC-dependent and HDAC-independent manner. Given the higher insulin levels, better glucose clearance and the lack of insulin resistance in WDR13 deficient mice, we propose that this protein may be a potential candidate drug target for ameliorating impaired glucose metabolism in diabetes.
摘要翻译： WD重复蛋白是非常多样化的，但这些是参与广泛细胞功能的结构相关蛋白。 WDR13，这个家庭的成员，从鱼类保存到人类，并定位到核心。为了了解Wdr13基因的体内功能，我们创建并表征了缺乏该基因的突变小鼠株。由于增强的β细胞增殖，突变小鼠具有较高的血清胰岛素水平和胰岛素的增加。虽然已知的细胞周期抑制剂p21在胰岛MIN6细胞系中突变型胰岛过表达WDR13中下调，导致p21上调，伴随着细胞增殖的延迟。我们建议WDR13是胰腺β细胞增殖的新型负调节因子。共免疫沉淀实验显示，该蛋白质与雌激素受体和各种HDAC相互作用。我们提供证据表明，WDR13可以调节雌激素受体介导的转录，无论是HDAC依赖型还是HDAC独立型。鉴于WDR13缺陷小鼠胰岛素水平升高，葡萄糖清除率更高，胰岛素抵抗不足，我们建议该蛋白可能是改善糖尿病中糖代谢紊乱的潜在候选药物靶点。

2. 发明申请

US20140157444A1 WDR13 AS A NOVEL BIOMARKER USEFUL FOR TREATING DIABETES AND CANCER 有权
标题翻译： WDR13作为治疗糖尿病和癌症的新型生物标志物
公开(公告)号：US20140157444A1
公开(公告)日：2014-06-05
申请号：US14116539
申请日：2012-04-27
申请人： Satish Kumar , Vijay Pratap Singh
发明人： Satish Kumar , Vijay Pratap Singh
IPC分类号： A61K49/00
CPC分类号： A61K49/0008 , A01K67/0276 , A01K2217/072 , A01K2227/105 , A01K2267/0331 , A01K2267/0362 , C07K14/47 , C07K2319/41 , C07K2319/43 , C12N2710/10043
摘要： WD-repeat proteins are very diverse, yet these are structurally related proteins that participate in a wide range of cellular functions. WDR13, a member of this family, is conserved from fishes to humans and localizes into the nucleus. To understand the in vivo function(s) of Wdr13 gene, we have created and characterized a mutant mouse strain lacking this gene. The mutant mice had higher serum insulin levels and increased pancreatic islet mass as a result of the enhanced beta cell proliferation. While a known cell cycle inhibitor, p21, was down regulated in the mutant islets overexpression of WDR13 in the pancreatic MIN6 cell line resulted in upregulation of p21, accompanied by retardation of cell proliferation. We suggest that WDR13 is a novel negative regulator of the pancreatic beta cell proliferation. Co-immunoprecipitation experiments showed that this protein interacts with estrogen receptors and various HDACs. We provide evidence to show that WDR13 can regulate estrogen receptors-mediated transcription both in HDAC-dependent and HDAC-independent manner. Given the higher insulin levels, better glucose clearance and the lack of insulin resistance in WDR13 deficient mice, we propose that this protein may be a potential candidate drug target for ameliorating impaired glucose metabolism in diabetes.
摘要翻译： WD重复蛋白是非常多样化的，但这些是参与广泛细胞功能的结构相关蛋白。 WDR13，这个家庭的成员，从鱼类保存到人类，并定位到核心。为了了解Wdr13基因的体内功能，我们创建并表征了缺乏该基因的突变小鼠株。由于增强的β细胞增殖，突变小鼠具有较高的血清胰岛素水平和胰岛素的增加。虽然已知的细胞周期抑制剂p21在胰岛MIN6细胞系中突变型胰岛过表达WDR13中下调，导致p21上调，伴随着细胞增殖的延迟。我们建议WDR13是胰腺β细胞增殖的新型负调节因子。共免疫沉淀实验显示，该蛋白质与雌激素受体和各种HDAC相互作用。我们提供证据表明，WDR13可以调节雌激素受体介导的转录，无论是HDAC依赖型还是HDAC独立型。鉴于WDR13缺陷小鼠胰岛素水平升高，葡萄糖清除率更高，胰岛素抵抗不足，我们建议该蛋白可能是改善糖尿病中糖代谢紊乱的潜在候选药物靶点。

3. 发明授权

US09802139B2 Method and apparatus for cleaning a fluid 有权
公开(公告)号：US09802139B2
公开(公告)日：2017-10-31
申请号：US12676502
申请日：2008-09-04
申请人： William Lawrence Priest , Satish Kumar , Gregory Allen Slawson
发明人： William Lawrence Priest , Satish Kumar , Gregory Allen Slawson
IPC分类号： B01D1/00 , B01D3/42 , G01N25/14 , B01D35/143
CPC分类号： B01D3/42 , B01D1/0082 , B01D35/143 , B01D35/185 , G01N25/14
摘要： A method and apparatus for cleaning a fluid comprising a fluid supply port for receiving a contaminated fluid; a fluid return port for providing a cleaned fluid; an evaporator for evaporating liquid contaminants from the fluid; a fluid line connecting the evaporator between the fluid supply port and the fluid return port; a sensor connected to at least one of the fluid filter, the evaporator, and the fluid line; a controller connected to an output of the sensor, wherein the controller includes: a processor; and a memory device including computer readable instructions which, when executed by the processor cause the processor to perform the steps of: receiving data from the sensor; comparing the data from the sensor to reference data; sending a control signal to at least one of the fluid filter and the evaporator based on comparing the data from the sensor to the reference data.

4. 发明申请

US20160016345A1 POLYACRYLONITRILE/CELLULOSE NANO-STRUCTURE FIBERS 有权
标题翻译：聚丙烯腈/纤维素纳米结构纤维
公开(公告)号：US20160016345A1
公开(公告)日：2016-01-21
申请号：US14509362
申请日：2014-10-08
申请人： Satish Kumar , Huibin Chang
发明人： Satish Kumar , Huibin Chang
IPC分类号： B29C47/00 , D01F9/16
CPC分类号： D01F9/225 , B29C47/0014 , B29K2001/00 , B29K2033/20 , D01D5/06 , D01F1/02 , D01F1/10 , D01F6/18 , D01F6/54 , D10B2505/20 , H05B3/14 , H05B3/347 , H05B2203/017 , H05B2214/04
摘要： In a method of making a carbon fiber, polyacrylonitrile is dissolved into a first solvent, thereby generating a first solution. A plurality of cellulose nano-structures is dispersed in a second solvent, thereby generating a first suspension. The first suspension is mixed with the first solution, thereby generating a first mixture. The first mixture is spun so as to draw fibers from the first mixture. The fibers are stabilized and then the fibers are carbonized. A fiber includes an elongated carbonized polyacrylonitrile matrix. A plurality of carbonized cellulose nano-structures is in the carbonized polyacrylonitrile matrix.
摘要翻译：在制造碳纤维的方法中，将聚丙烯腈溶解在第一溶剂中，从而产生第一溶液。将多个纤维素纳米结构体分散在第二溶剂中，从而产生第一悬浮液。将第一悬浮液与第一溶液混合，从而产生第一混合物。将第一混合物纺丝以从第一混合物中拉伸纤维。纤维被稳定，然后纤维被碳化。纤维包括细长的碳化聚丙烯腈基质。多个碳化纤维素纳米结构在碳化聚丙烯腈基质中。

5. 发明授权

US08527721B2 Generating a recovery snapshot and creating a virtual view of the recovery snapshot 有权
标题翻译：生成恢复快照并创建恢复快照的虚拟视图
公开(公告)号：US08527721B2
公开(公告)日：2013-09-03
申请号：US12344364
申请日：2008-12-26
申请人： Rajeev Atluri , Sudhakar Pannerselvam , Jayesh Shah , Satish Kumar , Srin Kumar
发明人： Rajeev Atluri , Sudhakar Pannerselvam , Jayesh Shah , Satish Kumar , Srin Kumar
IPC分类号： G06F12/00
CPC分类号： G06F11/1471 , G06F11/2071 , G06F2201/84
摘要： Methods, software suites, and systems of generating a recovery snapshot and creating a virtual view of the recovery snapshot are disclosed. In an embodiment, a method includes generating a recovery snapshot at a predetermined interval to retain an ability to position forward and backward when a delayed roll back algorithm is applied and creating a virtual view of the recovery snapshot using an algorithm tied to an original data, a change log data, and a consistency data related to an event. The method may include redirecting an access request to the original data based on a meta-data information provided in the virtual view. The method may further include substantially retaining a timestamp data, a location of a change, and a time offset of the change as compared with the original data.
摘要翻译：公开了生成恢复快照和创建恢复快照的虚拟视图的方法，软件套件以及系统。在一个实施例中，一种方法包括以预定间隔生成恢复快照，以便在应用延迟回退算法时保持向前和向后定位的能力，并且使用与原始数据相关联的算法创建恢复快照的虚拟视图，更改日志数据以及与事件相关的一致性数据。该方法可以包括基于虚拟视图中提供的元数据信息将访问请求重定向到原始数据。该方法还可以包括与原始数据相比基本上保留时间戳数据，变化的位置和变化的时间偏移。

6. 发明申请

US20120039386A1 Limiting the Maximum Size of an Encoded Video Picture Using Sub-Picture Based Rate Control 有权
标题翻译：使用基于子画面的速率控制来限制编码视频图像的最大尺寸
公开(公告)号：US20120039386A1
公开(公告)日：2012-02-16
申请号：US13206718
申请日：2011-08-10
申请人： Naveen Srinivasamurthy , Girish Srinivasa Murthy , Satish Kumar , Soyeb Nagori
发明人： Naveen Srinivasamurthy , Girish Srinivasa Murthy , Satish Kumar , Soyeb Nagori
IPC分类号： H04N7/26
CPC分类号： H04N19/00096 , H04N19/115 , H04N19/126 , H04N19/15 , H04N19/176
摘要： A method for encoding a picture in a video sequence is provided that includes determining the current encoded size of the picture after coding a plurality of macroblocks in the picture, determining that encoding remaining macroblocks in the picture may cause the encoded size of the picture to exceed a maximum encoded picture size, computing a quantization scale responsive to the determining, wherein the quantization scale is computed such that the estimated encoded size of the remaining macroblocks if the remaining macroblocks are quantized with the quantization scale does not exceed the difference between the maximum encoded picture size and the current encoded picture size, and quantizing at least one of the remaining macroblocks with the new quantization scale.
摘要翻译：提供了一种用于对视频序列中的图像进行编码的方法，包括：在编码图像中的多个宏块之后确定图像的当前编码大小，确定图像中的剩余宏块编码可能导致图像的编码大小超过最大编码图像大小，响应于该确定来计算量化尺度，其中计算量化比例，使得如果剩余宏块用量化比例量化的剩余宏块的估计编码大小不超过最大编码图像大小之间的差图像尺寸和当前编码图像尺寸，并用新的量化尺度量化剩余宏块中的至少一个。

7. 发明申请

US20100272978A1 CARBON FIBERS AND FILMS AND METHODS OF MAKING SAME 审中-公开
标题翻译：碳纤维和薄膜及其制造方法
公开(公告)号：US20100272978A1
公开(公告)日：2010-10-28
申请号：US12682588
申请日：2008-10-10
申请人： Satish Kumar , Han Gi Chae , Young Ho Choi
发明人： Satish Kumar , Han Gi Chae , Young Ho Choi
IPC分类号： D01F9/10 , D01F9/22 , B29C55/00 , D01F9/12
CPC分类号： H01B1/24 , D01F1/10 , D01F8/08 , D01F9/225 , Y10T428/2918
摘要： The various embodiments of the present invention provide improved carbon fibers and films, as well as methods of making the carbon fibers and films. The carbon fibers and films disclosed herein are generally formed from an acrylonitrile-containing polymer. The carbon fibers and/or films can also be formed from a composite that includes the acrylonitrile-containing polymer as well as carbon nanotubes, graphite sheets, or both. The fibers and films described herein can be tailored to exhibit one or more of high strength, high modulus, high electrical conductivity, high thermal conductivity, or optical transparency, depending on the desired application for the fibers or films.
摘要翻译：本发明的各种实施方案提供了改进的碳纤维和薄膜，以及制备碳纤维和薄膜的方法。本文公开的碳纤维和膜通常由含丙烯腈的聚合物形成。碳纤维和/或膜也可以由包含含丙烯腈的聚合物以及碳纳米管，石墨片或两者的复合材料形成。根据所需的纤维或薄膜的应用，本文所述的纤维和薄膜可以被定制以显示高强度，高模量，高导电性，高热导率或光学透明度中的一种或多种。

8. 发明申请

US20100169592A1 GENERATING A RECOVERY SNAPSHOT AND CREATING A VIRTUAL VIEW OF THE RECOVERY SNAPSHOT 有权
标题翻译：产生恢复活动并创建恢复活动的虚拟视图
公开(公告)号：US20100169592A1
公开(公告)日：2010-07-01
申请号：US12344364
申请日：2008-12-26
申请人： Rajeev Atluri , Sudhakar Pannnerselvam , Jayesh Shah , Satish Kumar , Srin Kumar
发明人： Rajeev Atluri , Sudhakar Pannnerselvam , Jayesh Shah , Satish Kumar , Srin Kumar
IPC分类号： G06F12/16 , G06F12/00
CPC分类号： G06F11/1471 , G06F11/2071 , G06F2201/84
摘要： Methods, software suites, and systems of generating a recovery snapshot and creating a virtual view of the recovery snapshot are disclosed. In an embodiment, a method includes generating a recovery snapshot at a predetermined interval to retain an ability to position forward and backward when a delayed roll back algorithm is applied and creating a virtual view of the recovery snapshot using an algorithm tied to an original data, a change log data, and a consistency data related to an event. The method may include redirecting an access request to the original data based on a meta-data information provided in the virtual view. The method may further include substantially retaining a timestamp data, a location of a change, and a time offset of the change as compared with the original data.
摘要翻译：公开了生成恢复快照和创建恢复快照的虚拟视图的方法，软件套件以及系统。在一个实施例中，一种方法包括以预定间隔生成恢复快照，以便在应用延迟回退算法时保持向前和向后定位的能力，并且使用与原始数据相关联的算法创建恢复快照的虚拟视图，更改日志数据以及与事件相关的一致性数据。该方法可以包括基于虚拟视图中提供的元数据信息将访问请求重定向到原始数据。该方法还可以包括与原始数据相比基本上保留时间戳数据，变化的位置和变化的时间偏移。

9. 发明申请

US20060039601A1 Geometric pattern matching using dynamic feature combinations 有权
标题翻译：使用动态特征组合的几何图案匹配
公开(公告)号：US20060039601A1
公开(公告)日：2006-02-23
申请号：US11032423
申请日：2005-01-10
申请人： Dinesh Nair , Matthew Fisher , Satish Kumar , Bruce Smyth , Subramanian Ramamoorthy
发明人： Dinesh Nair , Matthew Fisher , Satish Kumar , Bruce Smyth , Subramanian Ramamoorthy
IPC分类号： G06K9/62 , G06K9/00
CPC分类号： G06K9/6292 , G06K9/6282
摘要： A geometric pattern matching method to locate instances of a template image in a target image using a plurality of models with different feature combinations. A learning phase involves learning geometric information about the template image and creating a model for each of a plurality of different respective parent features. Each model comprises a relationship tree from the respective parent feature to one or more other child features, and hence each model may have different feature combinations. In a matching phase, the method may examine a plurality of different models to determine matches in the target image being analyzed. The matching phase may select different models dynamically based on prior matching results.
摘要翻译：一种几何图案匹配方法，用于使用具有不同特征组合的多个模型来定位目标图像中的模板图像的实例。学习阶段涉及学习关于模板图像的几何信息并为多个不同的相应父特征中的每一个创建模型。每个模型包括从相应的父特征到一个或多个其他子特征的关系树，因此每个模型可以具有不同的特征组合。在匹配阶段，该方法可以检查多个不同模型以确定正在分析的目标图像中的匹配。匹配阶段可以基于先前的匹配结果动态地选择不同的模型。

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