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1. 发明授权

US4734198A Dialysis solution mixing system 失效
标题翻译：透析液混合系统
公开(公告)号：US4734198A
公开(公告)日：1988-03-29
申请号：US577387
申请日：1984-02-06
申请人： William H. Harm , Larry E. Fuller , Earnest R. Caine , Raymond F. Cracauer , Louis C. Cosentino , F. Jesus Martinez
发明人： William H. Harm , Larry E. Fuller , Earnest R. Caine , Raymond F. Cracauer , Louis C. Cosentino , F. Jesus Martinez
IPC分类号： A61M1/16 , B01F1/00 , B01F5/10 , B01D13/00
CPC分类号： B01F15/0254 , A61M1/1656 , A61M1/1666 , B01F1/0022 , B01F1/0038 , B01F5/106
摘要： A system and process for preparation of dialysis solution from dry chemicals and water on a large scale batch basis. The required amount of water is metered into a dialysis solution tank. Water from the tank is pumped into a spray head which is positioned above a shipping drum containing predetermined amounts of chemicals. Water rains down on the chemicals dissolving and/or entraining the same and the resulting slurry is returned to the dialysate tank as a slurry by means of a pickup wand and suction source. The liquid and chemicals in the dialysis solution tank are continually cycled until all the chemicals in the drum have been removed. Typically, an additional drum containing other kinds of chemicals is then added to the dialysis solution tank in the same manner. Circulation of the solution is continued within the tank until a fully uniform solution results. Dialysis solution in the tank is then filtered and checked for conductivity prior to its direct use in hemodialysis or dilution in a conventional proportioning system.
摘要翻译：一种大规模批量制备干粉和水的透析液系统和方法。将所需量的水计量到透析溶液罐中。来自罐的水被泵送到喷雾头中，该喷头位于包含预定量化学品的运输滚筒上方。在溶解和/或夹带的化学物质上下沉下来，所得到的浆液通过拾取杆和抽吸源作为浆料返回到透析液罐中。透析溶液罐中的液体和化学物质不断循环，直到滚筒中的所有化学物质被去除。通常，以相同的方式将含有其它种类化学物质的另外的鼓加入到透析溶液罐中。溶液的循环在罐内继续进行，直到得到完全均匀的溶液。然后将透析溶液过滤并检查其电导率，然后直接用于血液透析或常规配比系统中的稀释。

2. 发明授权

US4517081A Dialyzer reuse machine 失效
标题翻译：透析机回用机
公开(公告)号：US4517081A
公开(公告)日：1985-05-14
申请号：US472075
申请日：1983-03-04
申请人： Bruce P. Amiot , Larry E. Fuller , Felix J. Martinez , Louis C. Cosentino , William H. Harm , Wayne I. Nelson
发明人： Bruce P. Amiot , Larry E. Fuller , Felix J. Martinez , Louis C. Cosentino , William H. Harm , Wayne I. Nelson
IPC分类号： A61M1/16 , A61M1/36 , B01D65/02 , B01D65/10 , B01D31/00
CPC分类号： B01D65/102 , A61M1/168 , A61M1/3643 , B01D65/02 , B01D65/022 , A61M2205/705 , A61M2209/082 , B01D2321/168
摘要： A dialyzer reuse machine comprising means for passing a series of liquid and gaseous fluids through the dialysate and blood compartments of the dialyzer at different flow rates according to a predetermined sequence for cleaning and disinfecting the dialyzer and means for accurately measuring the volume of the blood compartment upon completion of the dialyzer cleaning steps. Capacitive probe and load cell embodiments of the volume measuring means are disclosed. A specially designed jet pump permits a pressure leak test and dilution of stock chemicals to be performed using only tap water pressure as a source of motive force.
摘要翻译：一种透析器再利用机器，其包括用于根据用于清洁和消毒透析器的预定顺序使一系列液体和气体流体通过透析器的透析液和血液隔室的不同流量的装置和用于精确测量血液室的体积的装置完成透析器清洁步骤后。公开了体积测量装置的电容式探头和称重传感器实施例。专门设计的喷射泵允许使用自来水压力作为动力来源进行压力泄漏测试和稀释化学药品。

3. 外观设计

USD297620S Multi-port cap fitting for a flask 失效
公开(公告)号：USD297620S
公开(公告)日：1988-09-13
申请号：US658690
申请日：1984-10-09
申请人： Ray F. Cracauer , William R. Martin , William H. Harm
设计人： Ray F. Cracauer , William R. Martin , William H. Harm

4. 发明授权

US4722902A Apparatus and method for culturing cells, removing waste and concentrating product 失效
标题翻译：培养细胞的装置和方法，去除废物和浓缩产品
公开(公告)号：US4722902A
公开(公告)日：1988-02-02
申请号：US794627
申请日：1985-11-04
申请人： William H. Harm , Mark D. Hirschel , Michael L. Gruenberg
发明人： William H. Harm , Mark D. Hirschel , Michael L. Gruenberg
IPC分类号： C12M1/12 , C12M3/00 , C12M3/06 , C12N5/00
CPC分类号： C12M23/42 , C12M29/04
摘要： An apparatus and method for culturing cells includes a waste removal and product concentrating loop in which waste is removed from the medium and product produced by the cells is concentrated for harvesting. The apparatus includes a reservoir for retaining a supply of medium. The reservoir is in fluid communication with a cell culturing loop wherein medium flows from the reservoir to the cells and back to the reservoir. The medium waste removal and concentrating loop removes waste components produced by the cells and is in fluid communication with the reservoir such that medium is transferred from the reservoir to the waste removal and concentrating loop and back to the reservoir. The waste removal and concentrating loop includes a device having a semipermeable membrane. The medium flows along one side of the membrane for selective transfer of the waste components through the membrane. A mechanism for selectively producing a back pressure in the medium is included downstream of the membrane and aids in transfer of waste components through the membrane to remove the waste components from the medium.
摘要翻译：用于培养细胞的装置和方法包括废物去除和产物浓缩环，其中废物从培养基中除去，并且由细胞产生的产物被浓缩用于收获。该装置包括用于保持介质供应的储存器。储存器与细胞培养环流体连通，其中介质从储存器流动到细胞并返回储存器。中等废物去除和浓缩循环去除了由细胞产生的废物组分，并且与储存器流体连通，使得介质从储存器转移到废物移除和浓缩环并返回储存器。废物去除和浓缩回路包括具有半透膜的装置。介质沿膜的一侧流动，以便通过膜选择性地转移废物组分。用于选择性地产生介质中的背压的机构包括在膜的下游，并且有助于废物组分通过膜的转移以从介质中除去废组分。

5. 发明授权

US07905859B2 Pump with venting 有权
标题翻译：泵排气
公开(公告)号：US07905859B2
公开(公告)日：2011-03-15
申请号：US11680871
申请日：2007-03-01
申请人： Gail Beth Bynum , Mark Henry Faust , Jay Gregory Johnson , Clinton S. Vilks , William H. Harm
发明人： Gail Beth Bynum , Mark Henry Faust , Jay Gregory Johnson , Clinton S. Vilks , William H. Harm
IPC分类号： A61M37/00
CPC分类号： A61M5/14244 , A61M5/14566 , A61M5/16859 , A61M2005/14264 , A61M2205/583 , A61M2205/75 , A61M2205/82 , A61M2207/00
摘要： A medication pump includes a housing including an external wall and a plurality of internal adjoining housings, including a first housing enclosing a cartridge. The pump includes a primary vent for venting the medication pump to atmosphere, the primary vent including a primary liquid barrier allowing passage of gas therethrough while preventing passage of liquid therethrough. The pump includes a secondary vent on the first housing, the secondary vent including a secondary liquid barrier allowing passage of gas therethrough to an interior of the housing while preventing passage of liquid therethrough.
摘要翻译：药物泵包括壳体，其包括外壁和多个内部相邻的壳体，包括围绕盒的第一壳体。泵包括用于将药泵排放到大气中的主通气口，主通气口包括允许气体通过的主液体屏障，同时防止液体通过其中。所述泵包括在所述第一壳体上的次级通风口，所述次级通风口包括允许气体通过其进入所述壳体内部的次级液体屏障，同时防止液体通过其中。

6. 发明授权

US4973558A Method of culturing cells using highly gas saturated media 失效
标题翻译：使用高度气体饱和介质培养细胞的方法
公开(公告)号：US4973558A
公开(公告)日：1990-11-27
申请号：US187355
申请日：1988-04-28
申请人： John R. Wilson , William A. Gaines, Jr. , Darrell P. Page , William H. Harm
发明人： John R. Wilson , William A. Gaines, Jr. , Darrell P. Page , William H. Harm
IPC分类号： C12M1/04 , C12M3/06 , C12N5/02
CPC分类号： C12M29/16 , C12M29/12 , Y10S435/818
摘要： A method of culturing cells by providing a highly gassed media on a continuous basis to cells grown in a hollow fiber cartridge includes entraining the media with gas above the gas solubility level of the media. The media is then permitted to rest in a substantially quiescent state so that non-solubilized gas leaves the media. The media is then pressurized prior to delivery to the hollow fibers sufficiently so that the pressure drop and/or flow disturbance in the cell culturing device does not decrease the gas solubility level of the media below the media's gas saturation point.

7. 发明授权

US4650766A Culturing apparatus 失效
标题翻译：培养装置
公开(公告)号：US4650766A
公开(公告)日：1987-03-17
申请号：US658548
申请日：1984-10-09
申请人： William H. Harm , John J. Peluso
发明人： William H. Harm , John J. Peluso
IPC分类号： C12M1/04 , C12M3/00
CPC分类号： C12M29/04 , C12M23/24 , C12M41/12
摘要： An apparatus for growing and maintaining microorganisms or cells within a culturing chamber simultaneously heats and gasses a nutrient solution being delivered through the culturing chamber. The apparatus includes a pump for pumping the nutrient solution from a nutrient source through gas-diffusable tubing to a heating and gassing block. From the heating and gassing block, the nutrient solution is transported through the tubing to the culturing chamber. A heating source preferably delivers water at a predetermined temperature to fluid passages of a retention well in which the culturing chamber is maintained, and through the heating and gassing block such that the retention well and the heating and gassing block are kept essentially at the same temperature. Gas from a gas source is presented to the tubing through the heating and gassing block for diffusion through the tubing into the nutrient solution.
摘要翻译：用于培养和保持培养室内的微生物或细胞的装置同时加热和吸收通过培养室输送的营养液。该装置包括用于将营养液从营养源通过气体扩散管道泵送到加热和放气块的泵。从加热和放气块，营养液通过管道输送到培养室。加热源优选将预定温度的水输送到保持培养室的保留孔的流体通道，并且通过加热和放气块，使得保留阱和加热和放气块基本上保持在相同的温度。来自气源的气体通过加热和放气块提供给管道，用于通过管道扩散到营养液中。

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