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1. 发明授权

US4722902A Apparatus and method for culturing cells, removing waste and concentrating product 失效
标题翻译：培养细胞的装置和方法，去除废物和浓缩产品
公开(公告)号：US4722902A
公开(公告)日：1988-02-02
申请号：US794627
申请日：1985-11-04
申请人： William H. Harm , Mark D. Hirschel , Michael L. Gruenberg
发明人： William H. Harm , Mark D. Hirschel , Michael L. Gruenberg
IPC分类号： C12M1/12 , C12M3/00 , C12M3/06 , C12N5/00
CPC分类号： C12M23/42 , C12M29/04
摘要： An apparatus and method for culturing cells includes a waste removal and product concentrating loop in which waste is removed from the medium and product produced by the cells is concentrated for harvesting. The apparatus includes a reservoir for retaining a supply of medium. The reservoir is in fluid communication with a cell culturing loop wherein medium flows from the reservoir to the cells and back to the reservoir. The medium waste removal and concentrating loop removes waste components produced by the cells and is in fluid communication with the reservoir such that medium is transferred from the reservoir to the waste removal and concentrating loop and back to the reservoir. The waste removal and concentrating loop includes a device having a semipermeable membrane. The medium flows along one side of the membrane for selective transfer of the waste components through the membrane. A mechanism for selectively producing a back pressure in the medium is included downstream of the membrane and aids in transfer of waste components through the membrane to remove the waste components from the medium.
摘要翻译：用于培养细胞的装置和方法包括废物去除和产物浓缩环，其中废物从培养基中除去，并且由细胞产生的产物被浓缩用于收获。该装置包括用于保持介质供应的储存器。储存器与细胞培养环流体连通，其中介质从储存器流动到细胞并返回储存器。中等废物去除和浓缩循环去除了由细胞产生的废物组分，并且与储存器流体连通，使得介质从储存器转移到废物移除和浓缩环并返回储存器。废物去除和浓缩回路包括具有半透膜的装置。介质沿膜的一侧流动，以便通过膜选择性地转移废物组分。用于选择性地产生介质中的背压的机构包括在膜的下游，并且有助于废物组分通过膜的转移以从介质中除去废组分。

2. 发明授权

US08383397B2 Method and system for the production of cells and cell products and applications thereof 有权
标题翻译：用于生产细胞和细胞产品的方法和系统及其应用
公开(公告)号：US08383397B2
公开(公告)日：2013-02-26
申请号：US12274993
申请日：2008-11-20
申请人： Robert J. Wojciechowski , Darrell P. Page , Karl P. Bongers , Scott T. Waniger , Beverly Norris , Mark D. Hirschel , Thiem Chan Duong Wong , Martin P. Crep , Michael J. Gramer , Grant Adams
发明人： Robert J. Wojciechowski , Darrell P. Page , Karl P. Bongers , Scott T. Waniger , Beverly Norris , Mark D. Hirschel , Thiem Chan Duong Wong , Martin P. Crep , Michael J. Gramer , Grant Adams
IPC分类号： C12M1/00
CPC分类号： C12M41/40 , A61K35/12 , C12M23/26 , C12M23/28 , C12M23/34 , C12M23/44 , C12M23/58 , C12M25/10 , C12M27/00 , C12M29/00 , C12M29/10 , C12M29/18 , C12M33/14 , C12M41/20 , C12M41/26 , C12M41/34 , C12M41/38 , C12M41/48 , C12M47/04 , C12M47/10 , C12M47/12 , C12M47/20 , C12Q3/00 , F04B43/0072 , F04B43/09 , F04B43/12 , F04B43/1292
摘要： A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.
摘要翻译：用于生产细胞和细胞衍生产品的细胞培养系统包括可复用的仪器仪表底座装置，其包含用于支持细胞培养生长的硬件。包括细胞生长室的一次性培养器具模块可拆卸地附接到仪器基座装置。基底装置包括微处理器控制和用于循环细胞培养基通过细胞生长室的泵。文化模块可拆卸地连接到仪表底座装置。将细胞引入细胞生长室，并将培养基的源流体地附着到培养器皿模块。操作参数被编程到微处理器控制中。操作泵使介质循环通过细胞生长室以在其中生长细胞或细胞产物。从细胞生长室收获生长的细胞或细胞产物，然后布置培养器官模块。

3. 发明申请

US20090269841A1 METHOD AND SYSTEM FOR THE PRODUCTION OF CELLS AND CELL PRODUCTS AND APPLICATIONS THEREOF 有权
标题翻译：用于生产细胞和细胞产物的方法和系统及其应用
公开(公告)号：US20090269841A1
公开(公告)日：2009-10-29
申请号：US12274993
申请日：2008-11-20
申请人： Robert J. Wojciechowski , Darrell Paul Page , Karl Patrick Bongers , Scott Thomas Waniger , Beverly Norris , Mark D. Hirschel , Thiem Chan Duong Wong , Martin Peder Crep , Michael J. Gramer , Grant Adams
发明人： Robert J. Wojciechowski , Darrell Paul Page , Karl Patrick Bongers , Scott Thomas Waniger , Beverly Norris , Mark D. Hirschel , Thiem Chan Duong Wong , Martin Peder Crep , Michael J. Gramer , Grant Adams
IPC分类号： C12N5/06 , C12M3/00 , C12M1/00
CPC分类号： C12M41/40 , A61K35/12 , C12M23/26 , C12M23/28 , C12M23/34 , C12M23/44 , C12M23/58 , C12M25/10 , C12M27/00 , C12M29/00 , C12M29/10 , C12M29/18 , C12M33/14 , C12M41/20 , C12M41/26 , C12M41/34 , C12M41/38 , C12M41/48 , C12M47/04 , C12M47/10 , C12M47/12 , C12M47/20 , C12Q3/00 , F04B43/0072 , F04B43/09 , F04B43/12 , F04B43/1292
摘要： A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.
摘要翻译：用于生产细胞和细胞衍生产品的细胞培养系统包括可复用的仪器仪表底座装置，其包含用于支持细胞培养生长的硬件。包括细胞生长室的一次性培养器具模块可拆卸地附接到仪器基座装置。基底装置包括微处理器控制和用于循环细胞培养基通过细胞生长室的泵。文化模块可拆卸地连接到仪表底座装置。将细胞引入细胞生长室，并将培养基的源流体地附着到培养器皿模块。操作参数被编程到微处理器控制中。操作泵使介质循环通过细胞生长室以在其中生长细胞或细胞产物。从细胞生长室收获生长的细胞或细胞产物，然后布置培养器官模块。

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