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1. 发明授权

US07348184B2 Protein interaction difference mapping 有权
标题翻译：蛋白质相互作用差异作图
公开(公告)号：US07348184B2
公开(公告)日：2008-03-25
申请号：US10626493
申请日：2003-07-23
申请人： William E. Rich , Egisto Boschetti , Lee O. Lomas , Tai-Tung Yip
发明人： William E. Rich , Egisto Boschetti , Lee O. Lomas , Tai-Tung Yip
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , G01N33/54306 , G01N33/6803
摘要： This invention provides methods and materials for mapping interaction characteristics between components of a multicomponent biological complex. The methods involve capturing a multicomponent complex on a solid support and washing the support with a series of elution washes forming a gradient of solute concentrations, and determining whether a particular elution wash eluted a particular component.
摘要翻译：本发明提供了用于映射多组分生物复合物的组分之间的相互作用特征的方法和材料。该方法包括在固体支持物上捕获多组分复合物，并用洗脱洗涤洗涤洗脱洗涤洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱特定组分。

2. 发明申请

US20070059776A1 Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry 审中-公开
标题翻译：使用表面增强激光解吸/电离质谱监测多肽生产和纯化的方法
公开(公告)号：US20070059776A1
公开(公告)日：2007-03-15
申请号：US11499898
申请日：2006-08-03
申请人： Egisto Boschetti , Lisa Bradbury , Huw Davies , Lee Lomas , Thang Pham , Vanitha Thulasiraman , Tai-Tung Yip
发明人： Egisto Boschetti , Lisa Bradbury , Huw Davies , Lee Lomas , Thang Pham , Vanitha Thulasiraman , Tai-Tung Yip
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/6842 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , G01N33/6803 , G01N2030/8411 , H01J49/00 , H01J49/0418 , G01N30/7233
摘要： The invention provides methods of monitoring the production of a target polypeptide by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken from multiple cell culture batches or of samples taken at different times from a given batch. The invention additionally provides methods for monitoring the purification of a target polypeptide from a mixture by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken at various times during a purification process. In addition, the invention relates to methods of identifying conditions that can be used in increasing the scale of a given purification process.
摘要翻译：本发明提供了通过产生从多个细胞培养物批次或从给定批次的不同时间采集的样品获取的样品的表面增强的激光解吸/电离质谱图来监测目标多肽的产生的方法。本发明另外提供了通过产生在纯化过程中的不同时间采集的样品的表面增强的激光解吸/电离质谱图来监测来自混合物的目标多肽的纯化的方法。此外，本发明涉及鉴定可用于增加给定纯化方法的规模的条件的方法。

3. 发明申请

US20060110819A1 Apparatus and method for expression and capture of biomolecules and complexes on adsorbent surfaces 审中-公开
标题翻译：用于在吸附剂表面上表达和捕获生物分子和复合物的装置和方法
公开(公告)号：US20060110819A1
公开(公告)日：2006-05-25
申请号：US10528820
申请日：2003-09-29
申请人： Lee Lomas , Egisto Boschetti , Tai-Tung Yip
发明人： Lee Lomas , Egisto Boschetti , Tai-Tung Yip
IPC分类号： C12M1/34
CPC分类号： G01N33/54366 , B01J2219/00283 , B01J2219/00317 , B01J2219/00423 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00695 , B01J2219/007 , B01J2219/00725 , G01N33/54353
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes apparatus and methods for the detection and isolation of binding partners and activity modulators for biomolecules. The apparatus described allows for expression, capture and analysis of one or more biomolecules in a single step.
摘要翻译：本发明涉及分子生物学，组合化学和生物化学领域。特别地，本发明描述了用于检测和分离用于生物分子的结合配偶体和活性调节剂的装置和方法。所描述的装置允许在单个步骤中表达，捕获和分析一种或多种生物分子。

4. 发明授权

US08173433B2 Platelet biomarkers for cancer 失效
标题翻译：癌症血小板生物标志物
公开(公告)号：US08173433B2
公开(公告)日：2012-05-08
申请号：US11658377
申请日：2005-04-22
申请人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
发明人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
IPC分类号： G01N33/48 , A61K35/14
CPC分类号： G01N33/6872 , G01N33/57484 , G01N2333/49 , G01N2333/503 , G01N2333/515 , G01N2800/24 , G01N2800/368
摘要： The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.
摘要翻译：本发明涉及免疫学和生物化学领域。特别地，本发明描述了用于早期检测具有全身血管生成活性相关变化，特别是癌症，炎性病症，感染以及与怀孕和流产有关的事件的临床病症的方法，装置和试剂盒。

5. 发明申请

US20090042229A1 PLATELET BIOMARKERS FOR CANCER 失效
标题翻译：癌症生物标志物
公开(公告)号：US20090042229A1
公开(公告)日：2009-02-12
申请号：US11658377
申请日：2005-04-22
申请人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
发明人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
IPC分类号： C12Q1/37 , G01N33/00 , G01N31/22 , G01N33/566
CPC分类号： G01N33/6872 , G01N33/57484 , G01N2333/49 , G01N2333/503 , G01N2333/515 , G01N2800/24 , G01N2800/368
摘要： The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.
摘要翻译：本发明涉及免疫学和生物化学领域。特别地，本发明描述了用于早期检测具有全身血管生成活性相关变化，特别是癌症，炎性病症，感染以及与怀孕和流产有关的事件的临床病症的方法，装置和试剂盒。

6. 发明授权

US07205156B2 Probes for a gas phase ion spectrometer 有权
标题翻译：气相离子光谱仪探头
公开(公告)号：US07205156B2
公开(公告)日：2007-04-17
申请号：US10960222
申请日：2004-10-06
申请人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： G01N24/00
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译：本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团可由气相离子光谱仪检测。本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合用于与气相离子光谱仪可检测的分析物结合的功能。此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将包含分析物的样品的结合官能团暴露，并通过气体从探针解吸分析物相离子光谱法。

7. 发明授权

US07479631B2 Probes for a gas phase ion spectrometer 有权
标题翻译：气相离子光谱仪探头
公开(公告)号：US07479631B2
公开(公告)日：2009-01-20
申请号：US11681377
申请日：2007-03-02
申请人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： H01J49/00 , B01D59/44 , G01N24/00
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译：本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团可由气相离子光谱仪检测。本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合用于与气相离子光谱仪可检测的分析物结合的功能。此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将结合功能暴露于含有分析物的样品，并通过气体从探针解吸分析物相离子光谱法。

8. 发明授权

US06897072B1 Probes for a gas phase ion spectrometer 有权
标题翻译：气相离子光谱仪探头
公开(公告)号：US06897072B1
公开(公告)日：2005-05-24
申请号：US09560715
申请日：2000-04-27
申请人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： H01J49/16 , C08F20/10 , C08F20/56 , G01N1/28 , G01N27/62 , G01N27/64 , H01J49/04 , H01J49/12 , G01N24/00
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译：本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团可由气相离子光谱仪检测。本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合用于与气相离子光谱仪可检测的分析物结合的功能。此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将包含分析物的样品的结合官能团暴露，并通过气体从探针解吸分析物相离子光谱法。

9. 发明申请

US20120220491A1 RETENTATE CHROMATOGRAPHY AND PROTEIN CHIP ARRAYS WITH APPLICATIONS IN BIOLOGY AND MEDICINE 有权
标题翻译：再生色素和蛋白质芯片阵列与生物医学应用
公开(公告)号：US20120220491A1
公开(公告)日：2012-08-30
申请号：US13211522
申请日：2011-08-17
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： C40B30/10
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： Analytes in a sample are resolved by retentate chromatography in a procedure involving adsorbing the analytes on a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：样品中的分析物通过在多个不同选择性条件下将底物上分析物吸附的方法中的滞留层析法解析，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

10. 发明授权

US08014952B2 Serum biomarkers in lung cancer 失效
公开(公告)号：US08014952B2
公开(公告)日：2011-09-06
申请号：US10539291
申请日：2003-12-16
申请人： Timothy Tak Chun Yip , Chi Shing Cho , Siu Kie Au , Tai-Tung Yip , Christine Yip , Victor Yip
发明人： Timothy Tak Chun Yip , Chi Shing Cho , Siu Kie Au , Tai-Tung Yip , Christine Yip , Victor Yip
IPC分类号： G01N33/48
CPC分类号： G01N33/6851 , G01N33/57423 , G06F19/18
摘要： Certain biomarkers and biomarker combinations are useful in a qualifying lung cancer status in a subject. A diagnostic methodology employing these biomarkers and combinations can detect whether a subject has lung cancer. MARKER IDMWFRACTION IM-12011A IM-22030A IM-32069A IM-42128A IM-52146A IM-62186A IM-72232A IM-82277A IM-92295A IM-102318A IM-112411A IM-122434A IM-132467A IM-142482A IM-152498A IM-162565A IM-172574A IM-182586A IM-192605A IM-202722A IM-212746A IM-222788A IM-232855A IM-242871A IM-252984A IM-263030A IM-273144A IM-283243A IM-293273A IM-303290A IM-313369A IM-323445A IM-333483A IM-343676A IM-353779A IM-363793A IM-373893A IM-383960A IM-393972A IM-403984A IM-414068A IM-424178A IM-434287A IM-444297A IM-454309A IM-464484A IM-474649A IM-484798A IM-495104A IM-505918A IM-516122A IM-526192A IM-536452A IM-546660A IM-557768A IM-568145A IM-578954A IM-589312A IM-599449A IM-6010272A IM-6111683A IM-6213376A IM-6314698A IM-6415190A IM-6466758A IM-6515951A IM-6615172A IM-6715925A IM-6823436A IM-6939794A IM-7044166A IM-7148890A IM-7254028A IM-7360170A IM-7574372A IM-7675545A IM-7777543A IM-7879507A IM-7988854A IM-80101831A IM-81104301A IM-82125160A IM-83132978A IM-84149099A IM-852016B IM-862029B IM-872144B IM-882130B IM-892168B IM-902164B IM-912200B IM-922284B IM-932299B IM-942314B IM-952414B IM-962428B IM-972451B IM-982468B IM-992483B IM-1002565B IM-1012583B IM-1022597B IM-1032697B IM-1042715B IM-1052740B IM-1062752B IM-1072767B IM-1082885B IM-1092882B IM-1102967B IM-1112977B IM-1122994B IM-1133031B IM-1143048B IM-1153148B IM-1163166B IM-1173283B IM-1183308B IM-1193332B IM-1203432B IM-1213450B IM-1223561B IM-1233615B IM-1243714B IM-1253730B IM-1263834B IM-1273899B IM-1283969B IM-1293986B IM-1303997B IM-1314013B IM-1324181B IM-1334297B IM-1344311B IM-1354465B IM-1364484B IM-1374579B IM-1384608B IM-1394669B IM-1404747B IM-1414862B IM-1424891B IM-1435033B IM-1445077B

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