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1. 发明授权

US08748193B2 Apparatus for desorption and ionization of analytes 失效
标题翻译：分析物的解吸和电离装置
公开(公告)号：US08748193B2
公开(公告)日：2014-06-10
申请号：US12372478
申请日：2009-02-17
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33/537
CPC分类号： H01J49/164 , G01N33/68 , G01N33/6851 , H01J49/0418 , Y10T436/143333 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
摘要翻译：本发明一般涉及用于解析和离子化分析物的方法和装置，用于通过诸如质谱法或生物传感器等方法的后续科学分析。更具体地，本发明涉及质谱领域，特别涉及用于分析大分子如蛋白质或生物分子的基质辅助激光解吸/电离，飞行时间质谱的类型。最具体地，本发明涉及样品探针几何形状，样品探针组合物和样品探针表面化学物质，其能够使分析物（包括完整的大分子）从探针表面直接选择性捕集和解吸到气体（蒸汽）相中而不添加化学物质矩阵。

2. 发明申请

US20110313681A1 BIOMARKERS FOR PERIPHERAL ARTERY DISEASE 审中-公开
标题翻译：外周动脉疾病的生物标志物
公开(公告)号：US20110313681A1
公开(公告)日：2011-12-22
申请号：US13218012
申请日：2011-08-25
申请人： Eric T. Fung , John P. Cooke , Xiao-Ying Meng , Tai-Tung Yip , Fujan Zhang
发明人： Eric T. Fung , John P. Cooke , Xiao-Ying Meng , Tai-Tung Yip , Fujan Zhang
IPC分类号： G06F19/00 , C07K14/435 , C07K16/18 , C07K14/76
CPC分类号： G01N33/6893 , G01N2800/32 , G01N2800/324
摘要： This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients.
摘要翻译：本发明提供了血浆中的浓度与患有血浆样品的患者中存在或不存在PAD有关的生物标志物。本发明还提供用于区分长跛行者的PAD患者和不是PAD患者的生物标志物。此外，本发明提供了用于鉴定另外的生物标志物的方法，用于检测患者中生物标志物的方法，以及用于鉴定与生物标志物相互作用并可用于预防或治疗患者中PAD的药剂（包括药剂）的方法。

3. 发明申请

US20080160540A1 Polypeptides Related to Natriuretic Peptides and Methods of Their Identification and Use 审中-公开
标题翻译：与利尿钠肽相关的多肽及其鉴定和使用方法
公开(公告)号：US20080160540A1
公开(公告)日：2008-07-03
申请号：US12013606
申请日：2008-01-14
申请人： Kenneth F. Buechler , Eric Thomas Fung , Tai-Tung Yip
发明人： Kenneth F. Buechler , Eric Thomas Fung , Tai-Tung Yip
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： G01N33/74 , G01N2500/04
摘要： The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.
摘要翻译：本发明涉及与靶向所需感兴趣的多肽的抗体结合的多肽的鉴定和使用。使用利尿钠肽及其前体，特别是BNP作为实例，本发明描述了与生物样品中产生的许多利钠肽片段，最优选血液衍生的样品，其结合针对BNP的抗体。因为这样的片段的产生是一个持续的过程，其可以是尤其是引发利钠肽释放到组织中的事件发生之间经过的时间与获得或分析样品的时间的函数; 样品采集与样品分析时间之间的经过时间; 有关组织样本的类型; 储存条件; 存在蛋白水解酶的数量; 当设计用于一种或多种利钠肽的测定法和进行这样的测定时，可以使用这样的片段，以便提供准确的预后或诊断结果。

4. 发明申请

US20070042414A1 Retentate chromatography and protein chip arrays with applications in biology and medicine 审中-公开
标题翻译：保留色谱和蛋白质芯片阵列在生物学和医学应用
公开(公告)号：US20070042414A1
公开(公告)日：2007-02-22
申请号：US11509278
申请日：2006-08-23
申请人： T. Hutchens , Tai-Tung Yip
发明人： T. Hutchens , Tai-Tung Yip
IPC分类号： C40B30/06 , C40B40/08 , C40B50/06
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。所述方法包括在多种不同的选择性条件下将分析物吸附到底物上，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

5. 发明授权

US07160734B2 Retentate chromatography and protein chip arrays with applications in biology 有权
标题翻译：保留色谱和蛋白质芯片阵列与生物学应用
公开(公告)号：US07160734B2
公开(公告)日：2007-01-09
申请号：US10150587
申请日：2002-05-17
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。所述方法包括在多种不同的选择性条件下将分析物吸附到底物上，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

6. 发明申请

US20050233306A1 Retentate chromatography and protein chip arrays with applications in biology and medicine 有权
标题翻译：保留色谱和蛋白芯片阵列在生物学和医学应用
公开(公告)号：US20050233306A1
公开(公告)日：2005-10-20
申请号：US10626302
申请日：2003-07-23
申请人： T. Hutchens , Tai-Tung Yip
发明人： T. Hutchens , Tai-Tung Yip
IPC分类号： G01N33/52 , A61K49/00 , B01D15/38 , B01J20/281 , B01J20/286 , B01J20/32 , C12M1/34 , C12M1/42 , C12N15/09 , C12Q1/00 , C12Q1/68 , C40B30/04 , C40B40/10 , G01N27/62 , G01N27/64 , G01N30/00 , G01N30/02 , G01N30/46 , G01N30/90 , G01N30/95 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/566 , G01N33/68 , G01N37/00 , G06F19/00 , H01J49/04 , H01J49/26
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。该方法包括在多种不同的选择性条件下将分析物吸附到底物上，并通过解吸光谱法检测保留在底物上的分析物。该方法可用于生物学和医学，包括临床诊断和药物发现。

7. 发明授权

US06844165B2 Retentate chromatography and protein chip arrays with applications in biology and medicine 有权
标题翻译：保留色谱和蛋白芯片阵列在生物学和医学应用
公开(公告)号：US06844165B2
公开(公告)日：2005-01-18
申请号：US09745388
申请日：2000-12-21
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33/52 , A61K49/00 , B01D15/38 , B01J20/281 , B01J20/286 , B01J20/32 , C12M1/34 , C12M1/42 , C12N15/09 , C12Q1/00 , C12Q1/68 , C40B30/04 , C40B40/10 , G01N27/62 , G01N27/64 , G01N30/00 , G01N30/02 , G01N30/46 , G01N30/90 , G01N30/95 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/566 , G01N33/68 , G01N37/00 , G06F19/00 , H01J49/04 , H01J49/26
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。所述方法包括在多种不同的选择性条件下将分析物吸附到底物上，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

8. 发明授权

US06734022B2 Method and apparatus for desorption and ionization of analytes 失效
公开(公告)号：US06734022B2
公开(公告)日：2004-05-11
申请号：US09809657
申请日：2001-03-15
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33537
CPC分类号： H01J49/0418 , G01N1/405 , G01N33/6851 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.

9. 发明授权

US06528320B2 Method and apparatus for desorption and ionization of analytes 有权
公开(公告)号：US06528320B2
公开(公告)日：2003-03-04
申请号：US09742494
申请日：2000-12-20
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33537
CPC分类号： H01J49/0418 , G01N1/405 , G01N33/6851 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： The present invention comprises a sample presentation apparatus for mass spectrometry. More particulary, a complex is immoblized on the sample presenting surface.

10. 发明授权

US6027942A Surface-enhanced affinity capture for desorption and detection or analytes 失效
标题翻译：表面增强的亲和力捕获用于解吸和检测分析物
公开(公告)号：US6027942A
公开(公告)日：2000-02-22
申请号：US785636
申请日：1997-01-17
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N27/62 , G01N1/28 , G01N27/64 , G01N30/72 , G01N33/543 , G01N33/68 , H01J49/02 , H01J49/04 , H01J49/16 , H01J49/26 , H01J49/34 , H01J49/40 , G01N33/537
CPC分类号： H01J49/0418 , G01N1/405 , G01N33/6851 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： This invention relates generally to a mass spectrometer probe and a method of using said probe for desorption and ionization of analytes. The sample probe comprises an affinity reagent on the probe surface, wherein the affinity reagent is capable of selectively binding an analyte. An analyte bound to the affinity reagent can be desorbed by a high energy source and detected in the mass spectrometer. The probe and methods are useful in detection and analysis of macromolecules such as proteins or other biomolecules.
摘要翻译：本发明一般涉及质谱仪探针和使用所述探针解析和电离分析物的方法。样品探针在探针表面上包含亲和试剂，其中亲和试剂能够选择性地结合分析物。与亲和试剂结合的分析物可以通过高能源解吸并在质谱仪中检测。探针和方法可用于检测和分析大分子如蛋白质或其他生物分子。

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