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1. 发明申请

US20070049600A1 PTERIDINONES AS KINASE INHIBITORS 审中-公开
标题翻译：西替尼嗪作为激酶抑制剂
公开(公告)号：US20070049600A1
公开(公告)日：2007-03-01
申请号：US11553935
申请日：2006-10-27
申请人： William Denny , Gordon Rewcastle , Ellen Dobrusin , James Kramer , Dennis McNamara , Howard Daniel Showalter , Peter Toogood
发明人： William Denny , Gordon Rewcastle , Ellen Dobrusin , James Kramer , Dennis McNamara , Howard Daniel Showalter , Peter Toogood
IPC分类号： C07D475/02 , A61K31/525
CPC分类号： C07D475/00
摘要： Disclosed are compounds of the formula wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. The present invention also provides a method of treating cell proliferative disorders. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
摘要翻译：公开了下式的化合物其中：W是NH，S，SO或SO 2; R 2是（未）取代的芳基，（未）取代的杂芳基或（取代的）取代的碳环或杂环; Q是氢或低级烷基; R 4和R 6相同或不同，表示氢，卤素，低级烷基，低级烷氧基，（未）取代的芳基，（未）取代的杂芳基，（un ）取代的芳基烷基或（未）取代的杂芳基烷基; 和R 8是氢，低级烷基或含有3-7个成员的（未）取代的碳环，其中至多两个成员任选是选自氧和氮的杂原子; 或（R 8）是（un）取代的芳基，（未）取代的杂芳基，（未）取代的芳基烷基或（未）取代的杂芳基烷基。这些化合物可用于治疗细胞增殖性疾病，如癌症和再狭窄。这些化合物是细胞周期蛋白依赖性激酶（cdks）和生长因子介导的激酶的有效抑制剂。本发明还提供了治疗细胞增殖性疾病的方法。本发明还提供了含有式I化合物的药学上可接受的组合物。

2. 发明申请

US20050137263A1 N-(4 substituted phenyl)-anthranilic acid hydroxamate esters 失效
标题翻译： N-（4取代苯基） - 邻氨基苯甲酸异羟肟酸酯
公开(公告)号：US20050137263A1
公开(公告)日：2005-06-23
申请号：US11051142
申请日：2005-02-04
申请人： Gordon Rewcastle , Julie Spicer , Stephen Barrett , Michael Kaufman , Jared Milbank , Haile Tecle
发明人： Gordon Rewcastle , Julie Spicer , Stephen Barrett , Michael Kaufman , Jared Milbank , Haile Tecle
IPC分类号： A61P9/04 , A61K31/165 , A61K31/166 , A61K31/18 , A61K31/21 , A61K31/27 , A61K31/66 , A61P9/10 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C229/58 , C07C233/65 , C07C237/28 , C07C259/10 , C07C311/45 , C07C317/36 , C07C323/36 , C07C323/39
CPC分类号： C07C317/36 , C07C259/10 , C07C323/36 , Y10S514/825
摘要： The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译：本发明涉及4-取代苯基氨基苯并肟酸衍生物的氧化酯，药物组合物及其使用方法。

3. 发明申请

US20050049276A1 Imidazopyridines and triazolopyridines 审中-公开
标题翻译：咪唑并吡啶和三唑并吡啶类
公开(公告)号：US20050049276A1
公开(公告)日：2005-03-03
申请号：US10896180
申请日：2004-07-20
申请人： Michael Kaufman , Mark Plummer , Gordon Rewcastle
发明人： Michael Kaufman , Mark Plummer , Gordon Rewcastle
IPC分类号： C07D471/04 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention relates to imidazopyridine and triazolopyridine derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译：本发明涉及咪唑并吡啶和三唑并吡啶衍生物，药物组合物及其使用方法。

4. 发明申请

US20050026964A1 5-Substituted-4-[(substituted phenyl) amino]-2-pyridone derivatives 有权
标题翻译： 5-取代的-4 - [（取代的苯基）氨基] -2-吡啶酮衍生物
公开(公告)号：US20050026964A1
公开(公告)日：2005-02-03
申请号：US10876100
申请日：2004-06-24
申请人： Shannon Black , Michael Kaufman , Daniel Ortwine , Mark Plummer , John Quin , Gordon Rewcastle , Aurash Shahripour , Julie Spicer , Christopher Whitehead
发明人： Shannon Black , Michael Kaufman , Daniel Ortwine , Mark Plummer , John Quin , Gordon Rewcastle , Aurash Shahripour , Julie Spicer , Christopher Whitehead
IPC分类号： A61P35/00 , C07D213/78 , C07D213/80 , C07D213/82 , C07D213/87 , C07D401/12 , C07D413/04 , A61K31/4439 , A61K31/44 , C07D213/72
CPC分类号： C07D213/78 , C07D213/80 , C07D213/82 , C07D213/87 , C07D401/12 , C07D413/04
摘要： The present invention relates to 5-substituted-4-(substituted)phenylamino-2-pyridone derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译：本发明涉及5-取代-4-（取代的）苯基氨基-2-吡啶酮衍生物，药物组合物及其使用方法。

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