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    • 1. 发明申请
    • SYSTEM FOR PROVIDING A SERVICE TO VENUES WHERE PEOPLE AGGREGATE
    • 向人们聚集的场所提供服务的系统
    • US20070179792A1
    • 2007-08-02
    • US11307262
    • 2006-01-30
    • James Kramer
    • James Kramer
    • G06Q99/00
    • G06Q30/02G06Q30/0261G06Q50/01
    • A system and method for providing a service to promoters, including venues and advertising sponsors, who wish to provide promotions. The service includes making promoter promotions accessible by the mobile phones of members associated with an organization. Typically a promotion and member are matched based on the member's geographical position, as determined automatically by a position sensor in their mobile phone, and by the member's traits and behaviors. By accepting a promotion, a member receives reward points which can be used to obtain goods and services. In addition to accessing promotions, members have mobile access to real-time information about the venues, such as the demographics of venue attendees and media posted by attendees concerning venue characteristics. Using the system, members can determine before going to a venue, such as a nightclub or bar, which venue has their preferred attendee demographic, atmosphere, music, cover charge, drink specials, friends, etc.
    • 为希望提供促销活动的发起人,包括场地和广告赞助者提供服务的系统和方法。 该服务包括通过与组织相关联的成员的移动电话访问促销者促销。 通常,促销和会员根据会员的地理位置(由手机中的位置传感器自动确定)以及会员的特征和行为进行匹配。 通过接受促销,会员可以获得可用于获得商品和服务的奖励积分。 除了访问促销活动之外,会员可以通过手机访问有关场地的实时信息,例如场地参加者的人口统计数据和与会者发布的有关场地特征的媒体。 使用该系统,会员可以在去某个地点(例如夜总会或酒吧)之前确定哪个场所有首选的人群,气氛,音乐,封面费,饮料特价,朋友等等。
    • 5. 发明申请
    • Interface for controlling a graphical image
    • 用于控制图形图像的界面
    • US20060132433A1
    • 2006-06-22
    • US11195367
    • 2005-08-01
    • James KramerFelix MaierLawrence Kuo
    • James KramerFelix MaierLawrence Kuo
    • G09G5/00
    • G06F3/016G06F3/03543
    • An interface device for interfacing a user with a computer, the computer running an application program and generating a graphical image and a graphical object, comprises a user manipuatable object in, communication with the computer, a sensor to detect a manipulation of the object, the sensor providing a signal to the computer to control the graphical image, and an actuator adapted to provide a haptic sensation to the palm of the user in relation to an interaction between the graphical image, and the graphical object, the actuator comprising a member that is deformable to provide the haptic sensation. In another version, a mouse for interfacing a user with a computer generating a graphical environment comprising a graphical hand comprises a housing, a position detector to detect a position of the mouse, the position detector capable of providing a first position signal to the computer to control the position of the graphical hand in the graphical environment, and a finger position detector to detect a position of a finger of the user, the finger position detector capable of providing a second position signal to the computer to control a graphical finger on the graphical hand in relation to the position of the finger of the user.
    • 用于将用户与计算机接口的接口设备,运行应用程序并生成图形图像和图形对象的计算机,包括与计算机通信的用户可操纵对象,用于检测对象的操纵的传感器, 传感器向计算机提供信号以控制图形图像,以及致动器,其适于相对于图形图像和图形对象之间的交互提供对用户手掌的触觉感觉,致动器包括构件 可变形以提供触觉感觉。 在另一版本中,用于将用户与生成包括图形手的图形环境的计算机接口的鼠标包括壳体,用于检测鼠标的位置的位置检测器,能够向计算机提供第一位置信号的位置检测器, 在图形环境中控制图形手的位置,以及手指位置检测器,用于检测用户手指的位置,手指位置检测器能够向计算机提供第二位置信号,以控制图形上的图形手指 相对于用户的手指的位置。
    • 9. 发明申请
    • PTERIDINONES AS KINASE INHIBITORS
    • 西替尼嗪作为激酶抑制剂
    • US20070049600A1
    • 2007-03-01
    • US11553935
    • 2006-10-27
    • William DennyGordon RewcastleEllen DobrusinJames KramerDennis McNamaraHoward Daniel ShowalterPeter Toogood
    • William DennyGordon RewcastleEllen DobrusinJames KramerDennis McNamaraHoward Daniel ShowalterPeter Toogood
    • C07D475/02A61K31/525
    • C07D475/00
    • Disclosed are compounds of the formula wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. The present invention also provides a method of treating cell proliferative disorders. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
    • 公开了下式的化合物其中:W是NH,S,SO或SO 2; R 2是(未)取代的芳基,(未)取代的杂芳基或(取代的)取代的碳环或杂环; Q是氢或低级烷基; R 4和R 6相同或不同,表示氢,卤素,低级烷基,低级烷氧基,(未)取代的芳基,(未)取代的杂芳基,(un )取代的芳基烷基或(未)取代的杂芳基烷基; 和R 8是氢,低级烷基或含有3-7个成员的(未)取代的碳环,其中至多两个成员任选是选自氧和氮的杂原子; 或(R 8)是(un)取代的芳基,(未)取代的杂芳基,(未)取代的芳基烷基或(未)取代的杂芳基烷基。 这些化合物可用于治疗细胞增殖性疾病,如癌症和再狭窄。 这些化合物是细胞周期蛋白依赖性激酶(cdks)和生长因子介导的激酶的有效抑制剂。 本发明还提供了治疗细胞增殖性疾病的方法。 本发明还提供了含有式I化合物的药学上可接受的组合物。