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1. 发明申请

US20120253453A1 DURABLE HIGH STRENGTH POLYMER COMPOSITE SUITABLE FOR IMPLANT AND ARTICLES PRODUCED THEREFROM 有权
标题翻译：耐久高强度聚合物复合材料适用于生产的植入物及其制品
公开(公告)号：US20120253453A1
公开(公告)日：2012-10-04
申请号：US13078774
申请日：2011-04-01
申请人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh , Charles F. White
发明人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh , Charles F. White
IPC分类号： A61F2/82
CPC分类号： A61F2/24 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2472 , A61F2/2475 , A61F2210/0076 , A61F2220/005 , A61F2230/00 , A61F2230/0006 , A61F2230/0013 , A61F2230/0054 , A61L27/025 , A61L27/40 , A61L27/48 , A61L27/507 , A61L2430/20 , C08L27/00
摘要： A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. In one aspect, the composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes a porous expanded fluoropolymer membrane and an elastomer, wherein the elastomer fills substantially all of the pores of the porous expanded fluoropolymer, and the composite material comprising less than about 80% fluoropolymer by weight.
摘要翻译：公开了一种适用于各种植入构型的薄的，生物相容的，高强度的复合材料。在一个方面，复合材料在高周期弯曲应用中保持灵活性，使其特别适用于诸如心脏起搏引线或心脏瓣膜小叶的高柔性植入物。复合材料包括多孔膨胀氟聚合物膜和弹性体，其中弹性体基本上填充多孔膨胀氟聚合物的所有孔，并且复合材料包含按重量计小于约80％的含氟聚合物。

2. 发明授权

US08961599B2 Durable high strength polymer composite suitable for implant and articles produced therefrom 有权
标题翻译：耐用的高强度聚合物复合材料适用于植入物和由其制造的制品
公开(公告)号：US08961599B2
公开(公告)日：2015-02-24
申请号：US13078774
申请日：2011-04-01
申请人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh , Charles F. White
发明人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh , Charles F. White
IPC分类号： A61L27/40 , A61F2/24 , A61L27/48 , A61L27/50 , A61L27/02
CPC分类号： A61F2/24 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2472 , A61F2/2475 , A61F2210/0076 , A61F2220/005 , A61F2230/00 , A61F2230/0006 , A61F2230/0013 , A61F2230/0054 , A61L27/025 , A61L27/40 , A61L27/48 , A61L27/507 , A61L2430/20 , C08L27/00
摘要： A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. In one aspect, the composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes a porous expanded fluoropolymer membrane and an elastomer, wherein the elastomer fills substantially all of the pores of the porous expanded fluoropolymer, and the composite material comprising less than about 80% fluoropolymer by weight.
摘要翻译：公开了一种适用于各种植入构型的薄的，生物相容的，高强度的复合材料。在一个方面，复合材料在高周期弯曲应用中保持灵活性，使其特别适用于诸如心脏起搏引线或心脏瓣膜小叶的高柔性植入物。复合材料包括多孔膨胀氟聚合物膜和弹性体，其中弹性体基本上填充多孔膨胀氟聚合物的所有孔，并且复合材料包含按重量计小于约80％的含氟聚合物。

3. 发明授权

US08945212B2 Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom 有权
标题翻译：耐用的多层高强度聚合物复合材料，适用于植入物和由其制造的制品
公开(公告)号：US08945212B2
公开(公告)日：2015-02-03
申请号：US13485823
申请日：2012-05-31
申请人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh
发明人： William C. Bruchman , Paul D. Gassler , Cody L. Hartman , Peter J. Walsh
IPC分类号： A61F2/24 , A61L27/48 , A61L27/56 , A61L27/34 , A61L27/50
CPC分类号： A61F2/2403 , A61F2/24 , A61F2/2415 , A61F2210/0076 , A61F2230/00 , A61F2240/001 , A61F2240/005 , A61L27/34 , A61L27/48 , A61L27/507 , A61L27/56 , A61L2420/04 , A61L2420/08 , A61L2430/20 , Y10T29/49412 , C08L27/18
摘要： A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes at least one porous expanded fluoropolymer layer and an elastomer substantially filling substantially all of the pores of the porous expanded fluoropolymer.
摘要翻译：公开了一种适用于各种植入构型的薄的，生物相容的，高强度的复合材料。复合材料在高周期弯曲应用中保持灵活性，使其特别适用于高柔性植入物，如心脏起搏引线或心脏瓣膜小叶。复合材料包括至少一个多孔膨胀氟聚合物层和基本上填充多孔膨胀氟聚合物的基本上所有孔的弹性体。

4. 发明申请

US20130096606A1 EMBOLIC PROTECTION DEVICES AND RELATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20130096606A1
公开(公告)日：2013-04-18
申请号：US13448277
申请日：2012-04-16
申请人： William C. Bruchman , Edward H. Cully , Cody L. Hartman , Joshua J. Lovekamp , Benjamin M. Trapp
发明人： William C. Bruchman , Edward H. Cully , Cody L. Hartman , Joshua J. Lovekamp , Benjamin M. Trapp
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2210/0014 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2250/0023
摘要： According to one aspect of the disclosure, an embolic protection device is provided comprising an elongate element having a deflector at its distal end. The embolic protection device is generally configured to redirect and/or funnel embolic debris and permit at least a portion of the blood, no longer containing the redirected and/or funneled embolic debris, to perfuse the surrounding vasculature and/or tissue.

5. 发明申请

US20120323315A1 DURABLE MULTI-LAYER HIGH STRENGTH POLYMER COMPOSITE SUITABLE FOR IMPLANT AND ARTICLES PRODUCED THEREFROM 有权
标题翻译：耐久多层高强度聚合物复合材料适用于生产的植物和植物
公开(公告)号：US20120323315A1
公开(公告)日：2012-12-20
申请号：US13485823
申请日：2012-05-31
申请人： William C. Bruchman , Cody L. Hartman
发明人： William C. Bruchman , Cody L. Hartman
IPC分类号： A61F2/24 , C08L27/18 , B05D3/00 , B32B37/26 , B05D7/24
CPC分类号： A61F2/2403 , A61F2/24 , A61F2/2415 , A61F2210/0076 , A61F2230/00 , A61F2240/001 , A61F2240/005 , A61L27/34 , A61L27/48 , A61L27/507 , A61L27/56 , A61L2420/04 , A61L2420/08 , A61L2430/20 , Y10T29/49412 , C08L27/18
摘要： A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes at least one porous expanded fluoropolymer layer and an elastomer substantially filling substantially all of the pores of the porous expanded fluoropolymer.
摘要翻译：公开了一种适用于各种植入构型的薄的，生物相容的，高强度的复合材料。复合材料在高周期弯曲应用中保持灵活性，使其特别适用于高柔性植入物，如心脏起搏引线或心脏瓣膜小叶。复合材料包括至少一个多孔膨胀氟聚合物层和基本上填充多孔膨胀氟聚合物的基本上所有孔的弹性体。

6. 发明授权

US10780251B2 Expandable medical devices 有权
公开(公告)号：US10780251B2
公开(公告)日：2020-09-22
申请号：US12884711
申请日：2010-09-17
申请人： Carey V. Campbell , Joel M. Greene , Cody L. Hartman
发明人： Carey V. Campbell , Joel M. Greene , Cody L. Hartman
IPC分类号： A61M25/10 , A61F2/958
摘要： A medical device with an expandable element and slidable constraint of at least two portions surrounding the expandable element which slides away from the middle region and toward the distal and proximal ends of the expandable element upon expansion of the expandable element to influence the rate, shape and/or force required to expand the expandable element and methods for use in a body lumen are provided.

7. 发明授权

US09415193B2 Eluting medical devices 有权
标题翻译：洗脱医疗器械
公开(公告)号：US09415193B2
公开(公告)日：2016-08-16
申请号：US13603296
申请日：2012-09-04
申请人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Kranzler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
发明人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Kranzler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
IPC分类号： A61M25/10 , A61L29/08 , A61L29/16
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L2300/602 , A61M2025/105 , A61M2025/1081 , F04C2270/0421
摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.
摘要翻译：本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。

8. 发明授权

US09943428B2 Stent having adjacent elements connected by flexible webs 有权
公开(公告)号：US09943428B2
公开(公告)日：2018-04-17
申请号：US13349346
申请日：2012-01-12
申请人： Dustin C. Burkart , Edward H. Cully , Jeffrey B. Duncan , Cody L. Hartman , James D. Silverman
发明人： Dustin C. Burkart , Edward H. Cully , Jeffrey B. Duncan , Cody L. Hartman , James D. Silverman
IPC分类号： A61F2/82 , A61F2/91 , A61F2/07 , A61F2/86 , A61F2/915 , A61F2/89 , A61F2/90
CPC分类号： A61F2/91 , A61F2/07 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/915 , A61F2002/075 , A61F2002/826 , A61F2002/828 , A61F2002/91558
摘要： A stent incorporating flexible, preferably polymeric, connecting elements into the stent wherein these elements connect adjacent, spaced-apart stent elements. Preferably the spaced-apart adjacent stent elements are the result of forming the stent from a helically wound serpentine wire having space provided between adjacent windings. Other stent forms such as multiple, individual spaced-apart ring-shaped or interconnected stent elements may also be used. The connecting elements are typically web-shaped and result from creating slits or apertures in a covering of graft material applied to the stent and then, for example, applying heat to cause the slits or apertures to enlarge. The remaining graft material forms the interconnecting webs between the adjacent stent elements.

9. 发明授权

US09107733B2 Removable blood conduit filter 有权
标题翻译：可拆卸血管过滤器
公开(公告)号：US09107733B2
公开(公告)日：2015-08-18
申请号：US11331754
申请日：2006-01-13
申请人： Edward H Cully , Cody L. Hartman , Craig T. Nordhausen , Eric M. Tittelbaugh , Michael J. Vonesh
发明人： Edward H Cully , Cody L. Hartman , Craig T. Nordhausen , Eric M. Tittelbaugh , Michael J. Vonesh
IPC分类号： A61M29/00 , A61F2/01 , A61B17/221 , A61B17/22 , A61F2/06
CPC分类号： A61F2/01 , A61B17/221 , A61B2017/22035 , A61B2017/2212 , A61F2002/011 , A61F2002/016 , A61F2002/068 , A61F2230/0006 , A61F2230/005 , A61F2230/0065 , A61F2230/008 , A61F2230/0093
摘要： The present invention relates to a non-evertable blood filter that divides the transverse cross sectional area of a venous vessel into three annular regions or zones. The inner zone, the region immediately surrounding the longitudinal axis of the vessel, is maintained in a relatively open state with only minimal interference from the members making up the filter device so that blood flow can be maintained at a relatively normal rate. Concentrically surrounding the inner zone is the intermediate zone, to which captured emboli are directed out of the bloodstream passing primarily through the inner zone. Finally, concentrically surrounding the intermediate zone is the outer zone adjacent to the vessel wall. This is also intended to be kept free of emboli, so that emboli in the bloodstream immediately adjacent the vessel wall are directed away from the wall by the filter design and into the intermediate zone, thereby avoiding the accumulation of emboli adjacent the vessel wall that might otherwise result in stenosis. The blood filter is intended primarily for use as an inferior vena cava filter, although it can be made in a range of sizes allowing its use in blood vessels and particularly venous vessels of differing diameters. The filter is preferably removable.
摘要翻译：本发明涉及将静脉血管的横截面积分为三个环形区域或不同区域的不可转换血液过滤器。内部区域即立即围绕容器的纵向轴线的区域被保持在相对打开的状态，其中构成过滤装置的构件只有最小的干扰，使得可以将血流维持在相对正常的速率。集中地围绕内部区域是中间区域，被捕获的栓塞被引导到主要穿过内部区域的血流中。最后，同心围绕中间区域是与血管壁相邻的外部区域。这也意在保持没有栓塞，使得紧邻血管壁的血液中的栓塞通过过滤器设计被引导离开壁并进入中间区域，从而避免邻近容器壁的栓塞积聚否则会导致狭窄。血液过滤器主要用作下腔静脉过滤器，尽管它可以制成一系列尺寸，允许其用于血管，特别是不同直径的静脉血管。过滤器优选是可移除的。

10. 发明申请

US20130253426A1 ELUTING MEDICAL DEVICES 有权
标题翻译：医用器械
公开(公告)号：US20130253426A1
公开(公告)日：2013-09-26
申请号：US13603296
申请日：2012-09-04
申请人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Krazler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
发明人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Krazler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L2300/602 , A61M2025/105 , A61M2025/1081 , F04C2270/0421
摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.
摘要翻译：本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。

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