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1. 发明申请

US20070043068A1 Pyrrolo-pyridine kinase modulators 失效
标题翻译：吡咯 - 吡啶激酶调节剂
公开(公告)号：US20070043068A1
公开(公告)日：2007-02-22
申请号：US11364872
申请日：2006-02-27
申请人： William Arnold , Pierre Bounaud , Andreas Gosberg , Zhe Li , Ian McDonald , Ruo Steensma , Mark Wilson
发明人： William Arnold , Pierre Bounaud , Andreas Gosberg , Zhe Li , Ian McDonald , Ruo Steensma , Mark Wilson
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
摘要翻译：本发明提供新颖的吡咯并 - 吡啶激酶调节剂和使用新型吡咯并 - 吡啶激酶调节剂治疗由激酶活性介导的疾病的方法。

2. 发明申请

US20070287711A1 FUSED RING HETEROCYCLE KINASE MODULATORS 失效
标题翻译：融合环杂交激素调节剂
公开(公告)号：US20070287711A1
公开(公告)日：2007-12-13
申请号：US11733753
申请日：2007-04-10
申请人： William Arnold , Pierre Bounaud , Chixu Chen , Brian Eastman , Andreas Gosberg , Stefan Gradl , Stephanie Hopkins , Zhe Li , Ian McDonald , Paul Sprengeler , Ruo Steensma , Mark Wilson
发明人： William Arnold , Pierre Bounaud , Chixu Chen , Brian Eastman , Andreas Gosberg , Stefan Gradl , Stephanie Hopkins , Zhe Li , Ian McDonald , Paul Sprengeler , Ruo Steensma , Mark Wilson
IPC分类号： A61K31/495 , A61K31/4375 , C07D471/00 , C07D471/02
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
摘要翻译：本发明提供新颖的稠环杂环激酶调节剂和使用新的稠环杂环激酶调节剂来治疗由激酶活性介导的疾病的方法。

3. 发明申请

US20060030583A1 Pyrrolo-pyridine kinase modulators 失效
公开(公告)号：US20060030583A1
公开(公告)日：2006-02-09
申请号：US11192341
申请日：2005-07-27
申请人： William Arnold , Pierre Bounaud , Andreas Gosberg , Zhe Li , Ian McDonald , Ruo Steensma , Mark Wilson
发明人： William Arnold , Pierre Bounaud , Andreas Gosberg , Zhe Li , Ian McDonald , Ruo Steensma , Mark Wilson
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.

4. 发明申请

US20060035898A1 Fused ring heterocycle kinase modulators 失效
公开(公告)号：US20060035898A1
公开(公告)日：2006-02-16
申请号：US11192318
申请日：2005-07-27
申请人： William Arnold , Andreas Gosberg , Zhe Li , Ruo Steensma , Mark Wilson
发明人： William Arnold , Andreas Gosberg , Zhe Li , Ruo Steensma , Mark Wilson
IPC分类号： A61K31/498 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.

5. 发明申请

US20070117800A1 PYRIMIDINYL-THIOPHENE KINASE MODULATORS 失效
标题翻译：嘌呤霉素 - 兴奋酶激酶调节剂
公开(公告)号：US20070117800A1
公开(公告)日：2007-05-24
申请号：US11556033
申请日：2006-11-02
申请人： William Arnold , Chixu Chen , Stefan Gradl , Stephanie Hopkins , Ruo Steensma , Masaki Tomimoto , Mark Wilson
发明人： William Arnold , Chixu Chen , Stefan Gradl , Stephanie Hopkins , Ruo Steensma , Masaki Tomimoto , Mark Wilson
IPC分类号： A61K31/5377 , A61K31/506 , C07D409/14
CPC分类号： C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
摘要翻译：本发明提供新的嘧啶基 - 噻吩激酶调节剂和使用新的嘧啶基 - 噻吩激酶调节剂治疗由激酶活性介导的疾病的方法。

6. 发明授权

US09943431B2 Orthopedic device 有权
公开(公告)号：US09943431B2
公开(公告)日：2018-04-17
申请号：US13090383
申请日：2011-04-20
申请人： Julia Chang , William Arnold
发明人： Julia Chang , William Arnold
IPC分类号： A61F5/00 , A61F5/01
CPC分类号： A61F5/0111
摘要： An orthopedic device as in a dorsal splint for treating plantar fasciitis includes a substantially rigid splint member having an overmolded flexible edge and living hinges, or substantially rigid component pieces received in a flexible member, to provide improved and more comfortable fitting to a user and reduced storage requirements. The splint member is shaped and configured to engage the dorsal aspects of a user's lower leg, ankle, and foot. A soft-good strap system is provided to maintain the dorsal splint in position and has suitable padding to treat various foot conditions.

7. 发明授权

US08454546B2 Orthopedic device having a patient compliance system 有权
标题翻译：具有患者依从性的矫形装置
公开(公告)号：US08454546B2
公开(公告)日：2013-06-04
申请号：US13271629
申请日：2011-10-12
申请人： Michael Campos , Chad Leeder , William Arnold
发明人： Michael Campos , Chad Leeder , William Arnold
IPC分类号： A61F5/00 , A43B23/20
CPC分类号： A61F5/0127
摘要： An orthopedic device includes a strut assembly having a resilient shell defining opposed first and second sides, and a patient compliance system. The patient compliance includes a tightening strap connecting the first and second sides of the shell. The tightening strap has first and second end portions arranged for incremental uni-directional adjustment relative to at least one of the first and second sides of the strut assembly. The tightening strap is arranged to bend the shell and draw the first and second sides thereof toward one another.
摘要翻译：矫形装置包括具有限定相对的第一和第二侧的弹性外壳的支柱组件和患者顺应性系统。患者依从性包括连接壳体的第一和第二侧面的紧固带。紧固带具有第一和第二端部，其布置成相对于支柱组件的第一和第二侧中的至少一个进行增量的单向调节。紧固带布置成弯曲壳体并将其第一和第二侧向彼此拉出。

8. 发明授权

US07727174B2 Orthopedic device 有权
标题翻译：矫形装置
公开(公告)号：US07727174B2
公开(公告)日：2010-06-01
申请号：US12153389
申请日：2008-05-19
申请人： Julia Chang , William Arnold
发明人： Julia Chang , William Arnold
IPC分类号： A61F5/00 , A61F5/37
CPC分类号： A61F5/0111
摘要： An orthopedic device as in a dorsal splint for treating plantar fasciitis includes a substantially rigid splint member having an overmolded flexible edge and living hinges, or substantially rigid component pieces received in a flexible member, to provide improved and more comfortable fitting to a user and reduced storage requirements. The substantially rigid splint member is shaped and configured to the dorsal aspects of a user's lower leg, ankle, and foot. Straps are provided to maintain the dorsal splint in position.
摘要翻译：用于治疗足底筋膜炎的背部夹板中的矫形装置包括具有包覆成型的柔性边缘和活动铰链的基本上刚性的夹板构件或容纳在柔性构件中的基本刚性的构件，以向使用者提供改进的和更舒适的配件，并且减少存储要求。基本上刚性的夹板构件成形和构造成接合使用者的小腿，脚踝和脚的背部方面。提供带子以将背夹板保持在适当的位置。

9. 发明申请

US20080269656A1 Orthopedic device providing access to wound site 有权
标题翻译：矫形装置提供伤口部位的通路
公开(公告)号：US20080269656A1
公开(公告)日：2008-10-30
申请号：US12149047
申请日：2008-04-25
申请人： William Arnold , Michael Campos , Chad Leeder , David Armstrong
发明人： William Arnold , Michael Campos , Chad Leeder , David Armstrong
IPC分类号： A61F5/00
CPC分类号： A43B7/00 , A43B7/14 , A43B7/147 , A43B7/22 , A43B11/00 , A43B13/145 , A61F5/0102 , A61F5/0127 , A61F5/0195
摘要： Orthopedic device for treating neuropathic ulcers and other injuries while allowing easy access to the wound site on the plantar surface of a patient's foot includes a base portion and a sole that is either movably connected or removably connected to either the base or to a strut member. The base or strut is maintained in position on the lower leg while the sole may be rotated, slid, or completely removed for allowing inspection and access to the plantar surface of the patient's foot.
摘要翻译：用于治疗神经性溃疡和其他损伤的矫形装置同时允许容易地进入患者足底的足底表面上的伤口部位包括可移动地连接或可移除地连接到基部或支柱构件的底部和底部。基部或支柱保持在小腿上的适当位置，而鞋底可以旋转，滑动或完全移除，以允许检查和进入患者脚的脚底表面。

10. 发明申请

US20080035520A1 Multi-layer Medication Carrier 有权
标题翻译：多层药物载体
公开(公告)号：US20080035520A1
公开(公告)日：2008-02-14
申请号：US11779831
申请日：2007-07-18
申请人： Cathy Caracciolo , William Arnold , Christopher Bossi
发明人： Cathy Caracciolo , William Arnold , Christopher Bossi
IPC分类号： B65D83/04
CPC分类号： G07F17/0092 , A61J7/0084 , A61J7/04 , A61J2200/30 , A61J2205/60 , A61J2205/70 , G06F19/00 , G06F19/3462 , Y02A90/26
摘要： A multi-layer medication carrier or blister card may comprise a plurality of layers. A support layer is provided with one or more openings to receive corresponding blisters formed in a blister layer. A backing layer is provided over the blister layer to form one or more enclosures capable of holding unit doses of a medication. Perforations provided in at least the blister layer define unit dose packages. Dimples may be provided in the blister layer within a boundary defined by the perforations, which dimples may be used to ensure subsequent ejection of each unit dose package. An adhesive-free region in the backing layer may be provided in alignment with the perforations defining each unit dose package to further ensure proper ejection. Additionally, a partial-depth cut in the backing layer may be provided in substantial alignment with each blister, thereby facilitating removal of the unit dose of medication.
摘要翻译：多层药物载体或泡罩卡可以包括多个层。支撑层设置有一个或多个开口以接收形成在泡罩层中的相应的泡罩。背衬层设置在泡罩层上方以形成能够保持单位剂量的药物的一个或多个外壳。至少在泡罩层中提供的穿孔定义了单位剂量包装。可以在由穿孔限定的边界内的泡罩层中提供凹坑，该凹坑可用于确保每个单位剂量包装的随后喷射。背衬层中的无粘合剂区域可以设置成与限定每个单位剂量包装的穿孔对齐，以进一步确保适当的排出。此外，背衬层中的部分深度切割可以与每个泡罩基本对准地提供，从而有助于去除单位剂量的药物。

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