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1. 发明授权

US5414128A Process for the preparation of N-substituted nitro-p-phenylenediamines 失效
标题翻译：制备N-取代硝基对苯二胺的方法
公开(公告)号：US5414128A
公开(公告)日：1995-05-09
申请号：US984976
申请日：1992-12-03
申请人： Willi Steckelberg , Rolf Muller , Peter Koch
发明人： Willi Steckelberg , Rolf Muller , Peter Koch
IPC分类号： C07C209/10 , C07C213/08
CPC分类号： C07C209/10 , C07C213/08
摘要： The present invention relates to a process for the preparation of compounds of the general formula I ##STR1## by reaction of compounds of the general formula II ##STR2## with amines of the general formula III ##STR3## wherein R.sup.1 and R.sup.2 independently of one another denote hydrogen, (C.sub.1 -C.sub.4)-alkyl, C.sub.1 -C.sub.4)-hydroxyalkyl or (C.sub.5 -C.sub.6)-cycloalkyl, or, together with the nitrogen atom carrying them, form (C.sub.4 -C.sub.6)-heterocyclyl and R.sup.3 and R.sup.4 independently of one another denote hydrogen, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-hydroxyalkyl, (C.sub.1 -C.sub.2)-alkylcarbonyl or tosyl.
摘要翻译：本发明涉及通式Ⅲ的化合物（II）与通式Ⅲ的化合物（III）的制备方法，其中R1和R2彼此独立地表示氢，（ C 1 -C 4） - 烷基，C 1 -C 4） - 羟烷基或（C 5 -C 6） - 环烷基，或者与携带它们的氮原子一起形成（C 4 -C 6） - 杂环基，且R 3和R 4彼此独立地表示氢，（C 1 -C 4） - 烷基，（C 1 -C 4） - 羟烷基，（C 1 -C 2） - 烷基羰基或甲苯磺酰基。

2. 发明授权

US08153783B2 Polysaccharide based network and method for the production thereof 有权
标题翻译：基于多糖的网络及其生产方法
公开(公告)号：US08153783B2
公开(公告)日：2012-04-10
申请号：US12906710
申请日：2010-10-18
申请人： Rolf Muller , Federico Innerebner , Paul Smith , Theo A. Tervoort
发明人： Rolf Muller , Federico Innerebner , Paul Smith , Theo A. Tervoort
IPC分类号： C07H1/00 , C07H3/00 , C08B37/00 , C08B31/00 , C08B33/00 , C08B35/00
CPC分类号： C08L3/02 , A61J3/077 , A61K9/4816 , A61K9/5036 , C08B31/003 , C08L2666/02
摘要： The production of polysaccharide networks, especially starch networks, having a high network density, high solidity, a low swelling degree, and exhibiting reduced water absorption and to the uses thereof, especially, in the filed of biodegradable plastics.
摘要翻译：具有高网络密度，高固体度，低溶胀度和显示减少的吸水性的多糖网络，特别是淀粉网络的生产，尤其是在可生物降解的塑料领域。

3. 发明申请

US20120052572A1 COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权
标题翻译：用于稳定血液中DNA，RNA和蛋白质的组合物和其他生物样品在环境温度下的运输和储存
公开(公告)号：US20120052572A1
公开(公告)日：2012-03-01
申请号：US13191346
申请日：2011-07-26
申请人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
发明人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
IPC分类号： C07H21/00 , C09K15/30 , C09K15/32 , C12N5/078
CPC分类号： A01N1/021 , C12Q1/6806 , C12Q2527/125
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.
摘要翻译：公开了在与本文公开的储存组合物混合之后基本上液体，凝胶，悬浮液，浆体，半固体和/或胶体储存生物样品的组合物和方法，允许在没有冷藏的情况下储存后基本恢复生物活性。在某些实施方案中，未分级血液或组织样品可以以几个月，几个月或几年的形式储存，而不会在保存期后允许回收完整的DNA，RNA或蛋白质组分。

4. 发明申请

US20070283827A1 Method for determining operating parameters of a printing press 有权
标题翻译：确定印刷机工作参数的方法
公开(公告)号：US20070283827A1
公开(公告)日：2007-12-13
申请号：US11811432
申请日：2007-06-08
申请人： Jochen Jung , Rolf Muller , Michael Rohleder , Matthias Niedernhuber
发明人： Jochen Jung , Rolf Muller , Michael Rohleder , Matthias Niedernhuber
IPC分类号： B41F35/00
CPC分类号： B41F23/00 , B41F23/0426 , B41F23/044 , F26B21/06 , F26B25/004 , F26B25/22
摘要： A printing press, in particular a sheet-fed offset printing press, includes at least one control device, a plurality of printing units, one or more varnishing units, and one or more dryers. Variables determining a dryness of the printing material are determined and used to optimize the drying process. For that purpose, the important material streams influencing the drying process are determined at least for the region of the printing press that contains the drying device(s).
摘要翻译：印刷机，特别是单张胶版印刷机包括至少一个控制装置，多个印刷单元，一个或多个上光单元和一个或多个干燥器。测定确定印刷材料干燥度的变量并用于优化干燥过程。为此，至少对于包含干燥装置的印刷机的区域来确定影响干燥过程的重要材料流。

5. 发明申请

US20060205862A1 Polyvinyl alcohol gels 失效
标题翻译：聚乙烯醇凝胶
公开(公告)号：US20060205862A1
公开(公告)日：2006-09-14
申请号：US10553518
申请日：2004-04-15
申请人： Rolf Muller , Federico Innerebner
发明人： Rolf Muller , Federico Innerebner
IPC分类号： C08L31/04
CPC分类号： C08L23/06 , C08L23/02 , C08L23/04 , C08L23/08 , C08L23/10 , C08L29/04 , C08L91/06 , C08L91/08 , C08L101/00 , C08L2205/02 , C08L2666/06 , C08L2666/04
摘要： Polyvinyl alcohol gels, particularly hydrogels, which are produced by methods and formulas and are provided with a characteristic profile that is adjustable to a large extent, e.g., outstanding mechanical properties with moduli of elasticity of 30 MPa and stiffnesses of 25 MPa at a breaking elongation of 550 percent, or full transparency in a wide range of water contents.
摘要翻译：聚乙烯醇凝胶，特别是水凝胶，其通过方法和配方生产，并且具有可在很大程度上调节的特性轮廓，例如具有30MPa弹性模量的突出的机械性能和在断裂伸长率下的25MPa的刚度百分之五十五，或透明度广泛的含水量。

6. 发明申请

US20060199252A1 Genes encoding the synthetic pathway for the production of disorazole 审中-公开
标题翻译：编码合成途径的基因用于生产二氟唑
公开(公告)号：US20060199252A1
公开(公告)日：2006-09-07
申请号：US11330623
申请日：2006-01-12
申请人： Herbert Irschik , Maren Kopp , Rolf Muller
发明人： Herbert Irschik , Maren Kopp , Rolf Muller
IPC分类号： C12P19/62 , C12P7/64 , C07H21/04 , C12N9/10 , C12N1/21
CPC分类号： C12P17/188 , C12N15/52
摘要： The present invention relates to nucleic acid sequences and proteins derivable therefrom that have been identified in Sorangium cellulosum, which proteins are catalytically active or participate in the biosynthetic pathway of disorazoles. The invention provides novel sequences which are necessary components of the disorazole biosynthetic pathway in addition to genes dszA-D.
摘要翻译：本发明涉及在其中鉴定的核酸序列和可从其中衍生的蛋白质，其在蛋白质是催化活性的或参与disorazole的生物合成途径。本发明提供除了基因dszA-D之外，二脱氮生物合成途径的必需组分的新序列。

7. 发明申请

US20060148960A1 Polymer networks 有权
标题翻译：聚合物网络
公开(公告)号：US20060148960A1
公开(公告)日：2006-07-06
申请号：US10553293
申请日：2004-04-15
申请人： Rolf Muller , Federico Innerebner
发明人： Rolf Muller , Federico Innerebner
IPC分类号： C08L91/08
CPC分类号： C08L23/06 , C08L23/02 , C08L23/04 , C08L23/08 , C08L23/10 , C08L29/04 , C08L91/06 , C08L91/08 , C08L101/00 , C08L2205/02 , C08L2666/06 , C08L2666/04
摘要： Polymer mixtures containing a first long-chain polymer and a second short-chain polymer. The structural parameters of the two polymers are coordinated in such a way that a polymeric material is obtained which is easier to process while being provided with improved mechanical properties and in part also improved thermal properties compared with the first polymer at suitable conditions for producing the polymer mixture as a result of networks being formed and heterocrystallization taking place.
摘要翻译：含有第一长链聚合物和第二短链聚合物的聚合物混合物。两种聚合物的结构参数以这样的方式进行协调，使得获得的聚合物材料在提供改善的机械性能的同时更容易加工，并且在适合的制备聚合物的条件下与第一聚合物相比具有改善的热性能混合物由于形成网络而发生异质结果。

8. 再颁专利

USRE36860E Brushless direct current motor 失效
标题翻译：无刷直流电机
公开(公告)号：USRE36860E
公开(公告)日：2000-09-12
申请号：US710734
申请日：1996-09-20
申请人： Rolf Muller
发明人： Rolf Muller
IPC分类号： H02P6/14
CPC分类号： H02P6/14
摘要： The stator winding of a brushless D.C. motor receives two current pulses per 360.degree.-el. of rotor rotation, each current pulse being furnished via a respective current path. Each current path contains at least one power transistor switch having conductive and non-conductive states. These states are determined by respective driver transistor switches; when the driver transistor switch is in a high-output-impedance state the respective power transistor switch is rendered conductive, but when in the low-output-impedance state it renders the power transistor switch non-conductive. In various ways disclosed herein measures are taken to prevent the power transistor switches of both current paths from being simultaneously conductive. This may be accomplished using inherent or discrete base-emitter capacitances so connected that a power transistor switch is switched off abruptly but switches-on only after the elapse of a predetermined delay. Alternatively, the Hall voltage produced by the motor's rotor-position-sensing Hall cell may be applied to comparators such that the power transistor switches are not even commanded to conduct except during respective periods each shorter than 180.degree.-el.
摘要翻译：无刷直流电动机的定子绕组每360°接收两个电流脉冲。的转子旋转，每个电流脉冲经由相应的电流路径提供。每个电流路径包含至少一个具有导电和非导通状态的功率晶体管开关。这些状态由相应的驱动晶体管开关决定; 当驱动晶体管开关处于高输出阻抗状态时，各个功率晶体管开关导通，但是当处于低输出阻抗状态时，使得功率晶体管开关不导通。以本文公开的各种方式，采取措施来防止两个电流路径的功率晶体管开关同时导通。这可以使用如此连接的固有或离散的基极 - 发射极电容来使功率晶体管开关突然断开，但是仅在经过预定延迟之后接通。或者，电动机的转子位置感测霍尔单元产生的霍尔电压可以被施加到比较器，使得功率晶体管开关甚至不命令进行，除了在每个短于180度的各个周期内。

9. 发明授权

US5834873A Brushless three-phase dc motor 失效
公开(公告)号：US5834873A
公开(公告)日：1998-11-10
申请号：US448006
申请日：1995-05-23
申请人： Rolf Muller
发明人： Rolf Muller
IPC分类号： H02K1/02 , H02K1/14 , H02K21/14 , H02K29/03 , H02K29/08 , H02K1/10
CPC分类号： H02K21/14 , H02K1/146 , H02K1/148 , H02K29/03 , H02K29/08 , H02K1/02
摘要： A three-phase brushless dc motor includes a permanent-magnet rotor magnet arrangement having at least four poles and a Y-connected, or star-connected, three-phase stator winding. The winding's phases are arranged non-overlapping in slots of a slotted stator, the currents flowing in the three phases being controlled via at least three semiconductor elements by at least three magnetic-field-sensitive rotor position sensors. Each sensor is associated with a respective two of the winding's three phases and triggers a commutation which switches off the current in one of the associated two phases and switches on the current in the other of the associated two phases. The sensors are located to sense the permanent-magnet flux emanating from the rotor poles themselves. The rotor position sensors are provided at special angular locations on the stator. Each sensor is provided at an angular location at which there is not to be found, neither prior to nor subsequent to the commutation associated with that sensor, any energized stator pole; this may mean that the sensor location is (i) an angular location at which no energizable stator pole whatever is present, and it may mean that the sensor location is (ii) an angular location at which an energizable stator pole is in fact present, but during motor operation this energizable stator pole is in an unenergized state prior to a commutation associated with the particular sensor in question and likewise is in unenergized state subsequent to that commutation.

10. 发明授权

US5830880A Gene therapy of tumors with an endothelial cell-specific, cell cycle-dependent active compound 失效
标题翻译：具有内皮细胞特异性，细胞周期依赖性活性化合物的肿瘤的基因治疗
公开(公告)号：US5830880A
公开(公告)日：1998-11-03
申请号：US793107
申请日：1997-04-18
申请人： Hans-Harald Sedlacek , Klaus Bosslet , Rolf Muller
发明人： Hans-Harald Sedlacek , Klaus Bosslet , Rolf Muller
IPC分类号： C12N15/09 , A61K9/127 , A61K35/76 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/44 , A61K38/46 , A61K38/55 , A61K39/395 , A61K47/48 , A61K48/00 , A61P7/02 , A61P9/08 , A61P25/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N15/00 , C12N15/85 , C12P21/02 , C12R1/91 , C12R1/92 , C07H21/04
CPC分类号： A61K48/00 , C12N15/85 , A61K38/00 , C12N2830/15 , C12N2830/30 , C12N2830/85
摘要： A DNA sequence for the gene therapy of tumors is described. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated, in a cell-specific manner, in proliferating endothelial cells or in cells which are adjacent to these endothelial cells. This activation is regulated by the promoter module in a cell cycle-specific manner. The active substance is an inhibitor of angiogenesis or a cytostatic or cytotoxic molecule. The DNA sequence is inserted into a viral or non-viral vector which is supplemented with a ligand which possesses affinity for the activated endothelial cell.
摘要翻译： PCT No.PCT / EP95 / 03370 Sec。 371日期1997年4月18日 102（e）1997年4月18日PCT PCT 1995年8月25日PCT公布。出版物WO96 / 06940 日期1996年3月7日描述了肿瘤基因治疗的DNA序列。在其基本元素中，DNA序列由活化物序列，启动子模块和活性物质的基因组成。活化剂序列以细胞特异性方式在增殖的内皮细胞或与这些内皮细胞相邻的细胞中活化。该激活由细胞周期特异性方式由启动子模块调节。活性物质是血管发生抑制剂或细胞抑制或细胞毒性分子。将DNA序列插入病毒或非病毒载体中，其补充有对活化的内皮细胞具有亲和力的配体。

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