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1. 发明授权

EP1759402B1 RF SURFACES AND RF ION GUIDES 有权转让
标题翻译： RF曲面和RF离子TOURS
公开(公告)号：EP1759402B1
公开(公告)日：2015-07-08
申请号：EP05753270.7
申请日：2005-05-20
申请人： Whitehouse, Craig M. , Welkie, David G.
发明人： WHITEHOUSE, Craig, M. , WELKIE, David, G. , COUSINS, Lisa
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/42 , H01J49/062

2. 发明公开

EP1759402A2 RF SURFACES AND RF ION GUIDES 有权转让
标题翻译： RF曲面和RF离子TOURS
公开(公告)号：EP1759402A2
公开(公告)日：2007-03-07
申请号：EP05753270.7
申请日：2005-05-20
申请人： Whitehouse, Craig M. , Welkie, David G.
发明人： WHITEHOUSE, Craig, M. , WELKIE, David, G. , COUSINS, Lisa
IPC分类号： H01J49/42
CPC分类号： H01J49/42 , H01J49/062
摘要： Apparatus and methods are provided for trapping, manipulation and transferring ions along RF and DC potential surfaces and through RF ion guides. Potential wells are formed neap RF-field generating surfaces due to the overlap of the radio-frequency (RF) fields and electrostatic fields created by static potentials applied to surrounding electrodes. Ions can be constrained and accumulated overtime in such wells. During confinement, ions may be subjected to various processes, such as accumulation, fragmentation, collisional cooling, focusing, mass-to-charge filtering, spatial separation ion mobility and chemical interactions, leading to improved performance in subsequent processing and analysis steps, such as mass analysis. Alternatively, the motion of ions may be better manipulated during confinement to improve the efficiency of their transport to specific locations, such as an entrance aperture into vacuum from atmospheric pressure or into a subsequent vacuum stage.

3. 发明申请

WO2005114705A2 RF SURFACES AND RF ION GUIDES 审中-公开
标题翻译：射频表面和射频指导
公开(公告)号：WO2005114705A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017748
申请日：2005-05-20
申请人： WHITEHOUSE, Craig, M. , WELKIE, David, G. , COUSINS, Lisa
发明人： WHITEHOUSE, Craig, M. , WELKIE, David, G. , COUSINS, Lisa
IPC分类号： H01J49/42
CPC分类号： H01J49/42 , H01J49/062
摘要： Apparatus and methods are provided for trapping, manipulation and transferring ions along RF and DC potential surfaces and through RF ion guides. Potential wells are formed neap RF-field generating surfaces due to the overlap of the radio-frequency (RF) fields and electrostatic fields created by static potentials applied to surrounding electrodes. Ions can be constrained and accumulated overtime in such wells. During confinement, ions may be subjected to various processes, such as accumulation, fragmentation, collisional cooling, focusing, mass-to-charge filtering, spatial separation ion mobility and chemical interactions, leading to improved performance in subsequent processing and analysis steps, such as mass analysis. Alternatively, the motion of ions may be better manipulated during confinement to improve the efficiency of their transport to specific locations, such as an entrance aperture into vacuum from atmospheric pressure or into a subsequent vacuum stage.
摘要翻译：提供了设备和方法，用于沿着RF和DC电势表面以及通过RF离子导向器捕获，操纵和转移离子。由于射频（RF）场和施加到周围电极的静电势产生的静电场的重叠，潜在的阱形成了近场的RF场产生表面。这些井中的离子可以被限制和加班。在限制期间，离子可以经历各种过程，例如累积，碎裂，碰撞冷却，聚焦，质量 - 电荷过滤，空间分离离子迁移和化学相互作用，导致后续处理和分析步骤中的改进的性能，例如质量分析。或者，可以在限制期间更好地操作离子的运动，以提高其运送到特定位置的效率，例如从大气压进入真空的入口孔或进入随后的真空级。

4. 发明申请

WO2002061798A1 CHARGED PARTICLE TRAPPING IN NEAR SURFACE POTENTIAL WELLS 审中-公开
标题翻译：充填颗粒捕获在表面潜在的细孔附近
公开(公告)号：WO2002061798A1
公开(公告)日：2002-08-08
申请号：PCT/US2002/002534
申请日：2002-01-28
申请人： ANALYTICA OF BRANDFORD, INC. , WHITEHOUSE, Craig, M. , WELKIE, David, G.
发明人： WHITEHOUSE, Craig, M. , WELKIE, David, G.
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , B82Y30/00 , H01J49/0068
摘要： A time-Of-Flight mass spectrometer (1) is configured with an electrospray ion source (2), a pulsing region (10) and electronic controls that generate a potential well for ions in the pulsing region, due to the repelling effect of a high-frequency electric field that is created in the space immediately proximate to a surface, and an additional static electric field that accelerates ions toward the surface. Ions can be constrained and accumulated over time in the potential well prior to acceleration into the Time-Of-Flight tube for mass analysis. Ions can also be directed to collide with the surface with high energy to cause Surface Induced Dissociation (SID) fragmentation, or with low energy to effect collisional cooling, hence, better spatial focusing, prior to mass analysis. The apparatus and methods described in the invention result in refined control of ion fragmentation of ion fragmentation energy and improved Time-Of-Flight mass analysis performance.
摘要翻译：飞行时间质谱仪（1）由电喷雾离子源（2），脉冲区域（10）和电子控制器构成，该电子控制器产生脉冲区域中的离子的势阱，由于一个在紧邻表面的空间中产生的高频电场以及将离子加速到表面的附加静电场。在加速进入飞行时间管以进行质量分析之前，离子可以在潜在的时间内受到约束和积累。离子也可以被引导与高能量的表面碰撞以引起表面诱导解离（SID）碎裂，或者以低能量来实现碰撞冷却，因此在质量分析之前更好地进行空间聚焦。本发明描述的装置和方法可以精确控制离子碎裂能的离子碎片，提高飞行时间质量分析性能。

5. 发明公开

EP1766651A2 CHARGED DROPLET SPRAYERS 审中-公开
标题翻译： SPRÜHERFÜRGELADENETRÖPFCHEN
公开(公告)号：EP1766651A2
公开(公告)日：2007-03-28
申请号：EP05752304.5
申请日：2005-05-19
申请人： Whitehouse, Craig M.
发明人： WHITEHOUSE, Craig, M. , WHITE, Thomas
IPC分类号： H01J27/26 , H01J49/16
CPC分类号： H01J49/165 , B01D61/00 , B01D61/425 , B01D2313/345 , G01N30/7266 , H01J49/0018 , H01J49/167 , Y10T436/212 , Y10T436/24
摘要： Charged droplet spray is formed from a solution with all or a portion of the charged droplet spray current generated from reduction or oxidation (redox) reactions occurring on surfaces removed from the first or sample solution flow path. In one embodiment of the invention, two solution flow channels are separated by a semipermeable membrane. A first or sample solution flowing through the first solution flow channel exchanges cation or anion charged species through the semipermeable membrane with a second solution or gas flowing through the second flow channel. Charge exchange is driven by the electric field applied at the charged droplet sprayer sample solution outlet. Redox reactions occur at an electrode surface in contact with the second solution. The invention increases the control and range of the Electrospray ionization process during ES/MS operation. Alternative embodiments of the invention provide for conducting redox reactions on conductive surfaces removed from the first or sample solution flow path but not separated by semipermeable membranes.
摘要翻译：从溶液形成带电的液滴喷雾，其中从在第一或样品溶液流动路径上去除的表面上发生还原或氧化（氧化还原）反应产生的所有或一部分带电液滴喷雾电流。在本发明的一个实施方案中，两个溶液流动通道被半透膜隔开。流过第一溶液流动通道的第一或样品溶液通过半透膜与穿过第二流动通道的第二溶液或气体交换阳离子或阴离子带电物质。电荷交换由在带电液滴喷雾器样品溶液出口处施加的电场驱动。在与第二溶液接触的电极表面处发生氧化还原反应。本发明增加了ES / MS操作期间电喷雾电离过程的控制和范围。本发明的替代实施方案提供了在从第一或样品溶液流动路径移除但不被半透膜隔离的导电表面上进行氧化还原反应。

6. 发明申请

WO2005114691A2 CHARGED DROPLET SPRAYERS 审中-公开
标题翻译：充电滴灌喷雾器
公开(公告)号：WO2005114691A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017573
申请日：2005-05-19
申请人： WHITEHOUSE, Craig, M. , WHITE, Thomas
发明人： WHITEHOUSE, Craig, M. , WHITE, Thomas
IPC分类号： H01J27/26
CPC分类号： H01J49/165 , B01D61/00 , B01D61/425 , B01D2313/345 , G01N30/7266 , H01J49/0018 , H01J49/167 , Y10T436/212 , Y10T436/24
摘要： Charged droplet spray is formed from a solution with all or a portion of the charged droplet spray current generated from reduction or oxidation (redox) reactions occurring on surfaces removed from the first or sample solution flow path. In one embodiment of the invention, two solution flow channels are separated by a semipermeable membrane. A first or sample solution flowing through the first solution flow channel exchanges cation or anion charged species through the semipermeable membrane with a second solution or gas flowing through the second flow channel. Charge exchange is driven by the electric field applied at the charged droplet sprayer sample solution outlet. Redox reactions occur at an electrode surface in contact with the second solution. The invention increases the control and range of the Electrospray ionization process during ES/MS operation. Alternative embodiments of the invention provide for conducting redox reactions on conductive surfaces removed from the first or sample solution flow path but not separated by semipermeable membranes.
摘要翻译：由溶液形成带电的液滴喷雾，其中从在第一或样品溶液流动路径上去除的表面上发生的还原或氧化（氧化还原）反应产生的全部或一部分带电液滴喷雾电流。在本发明的一个实施方案中，两个溶液流动通道被半透膜隔开。流过第一溶液流动通道的第一或样品溶液通过半透膜与穿过第二流动通道的第二溶液或气体交换阳离子或阴离子带电物质。电荷交换由在带电液滴喷雾器样品溶液出口处施加的电场驱动。在与第二溶液接触的电极表面处发生氧化还原反应。本发明增加了ES / MS操作期间电喷雾电离过程的控制和范围。本发明的替代实施方案提供了在从第一或样品溶液流动路径移除但不被半透膜隔离的导电表面上进行氧化还原反应。

7. 发明申请

WO2008024500A2 SAMPLE COMPONENT TRAPPING, RELEASE, AND SEPARATION WITH MEMBRANE ASSEMBLIES INTERFACED TO ELECTROSPRAY MASS SPECTROMETRY 审中-公开
标题翻译：样品组分捕获，释放和分离与膜电泳接触电泳质谱分析
公开(公告)号：WO2008024500A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/018798
申请日：2007-08-27
申请人： ANALYTICA OF BRANFORD, INC. , WHITEHOUSE, Craig, M. , WHITE, Thomas
发明人： WHITEHOUSE, Craig, M. , WHITE, Thomas
IPC分类号： G01N21/01 , G01N27/30 , G01N30/02
CPC分类号： B01D59/44 , G01N1/4005 , G01N30/00 , G01N30/7266 , H01J49/165 , Y10T436/212 , Y10T436/24
摘要： The invention provides a method and apparatus for trapping, releasing and/or separating sample components in solution passing through a channel with or without packing material present by passing ion current through the channel driven by an electric field. A portion of the ion current comprises cation and/or anion species generated from second solution flows separated from the sample solution flow path by semipermeable membranes. Cation and/or Anion ion species generated in the second solution flow regions are transferred into the sample solution flow path through ion selective semipermeable membranes. Ion current moving along the sample solution flow path is controlled by varying the composition of the second solutions and/or changing the voltage between membrane sections for a given sample solution composition. The sample composition may also be varied separately or in parallel to enhance trapping, release and/or separation efficiency and range. The invention when interfaced to an Atmospheric Pressure Ion Source, that may include Electrospray Ionization, with mass spectrometric analysis enables independent control of the on-line sample separation process and the Atmospheric Pressure Ion Source or Electrospray ionization processes.
摘要翻译：本发明提供了一种用于通过使通过离子电流通过由电场驱动的通道而使存在的填充材料通过通道的溶液中的样品组分的捕获，释放和/或分离的方法和装置。离子电流的一部分包括由通过半透膜从样品溶液流动路径分离的第二溶液流产生的阳离子和/或阴离子物质。在第二溶液流动区域中产生的阳离子和/或阴离子物质通过离子选择性半透膜转移到样品溶液流动路径中。沿着样品溶液流动路径移动的离子电流通过改变第二溶液的组成和/或改变给定样品溶液组合物的膜部分之间的电压来控制。样品组合物也可以单独地或并行地改变以提高捕获，释放和/或分离效率和范围。当与质谱分析相结合的可能包括电喷雾离子化的大气压离子源的本发明可以独立控制在线样品分离过程和大气压离子源或电喷雾离子化过程。

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