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1. 发明授权

US06605255B2 Repinotan kit 失效
公开(公告)号：US06605255B2
公开(公告)日：2003-08-12
申请号：US09991222
申请日：2001-11-16
申请人： Werner Kroll , Ferdinand Rombout , Horst Weber , Maria-Luisa Rodriguez , Bernd Sennhenn , Rudolf Schohe-Loop
发明人： Werner Kroll , Ferdinand Rombout , Horst Weber , Maria-Luisa Rodriguez , Bernd Sennhenn , Rudolf Schohe-Loop
IPC分类号： G01N3352
CPC分类号： C07D417/12 , G01N33/94
摘要： The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration of repinotan or its metabolites in body fluids, and also new pharmaceutical compositions containing repinotan or a physiologically acceptable salt of repinotan, and processes for their preparation.

2. 发明申请

US20140227372A1 BIOMARKERS FOR LUNG CANCER 审中-公开
标题翻译：肺癌生物标志物
公开(公告)号：US20140227372A1
公开(公告)日：2014-08-14
申请号：US14119604
申请日：2012-05-24
申请人： Edoardo Missiaglia , Simona Rossi , Pratyaksha Wirapati , Werner Kroll
发明人： Edoardo Missiaglia , Simona Rossi , Pratyaksha Wirapati , Werner Kroll
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present invention relates, in part, to methods for determining a prognosis of early stage lung cancer in an individual using one or more biomarkers.
摘要翻译：本发明部分涉及使用一种或多种生物标志物确定个体中早期肺癌预后的方法。

3. 发明授权

US07541149B1 Monoclonal antibody and assay for detecting PIIINP 有权
标题翻译：单克隆抗体和检测PIIINP的检测方法
公开(公告)号：US07541149B1
公开(公告)日：2009-06-02
申请号：US09701313
申请日：1999-05-17
申请人： Elmar Reinhold Burchardt , Werner Kroll , Mathias Gehrmann , Werner Schröder
发明人： Elmar Reinhold Burchardt , Werner Kroll , Mathias Gehrmann , Werner Schröder
IPC分类号： G01N33/53 , C07K16/28
CPC分类号： C07K16/18 , C07K14/78
摘要： The present invention relates to monoclonal antibodies binding to the N-terminal procollagen (III) propeptide (PIIINP) molecule which is a proteolytic fragment emanating from the specific cleavage of procollagen (III) by N-proteinase after exocytosis and to an assay using these antibodies.
摘要翻译：本发明涉及与N-末端前胶原（III）前肽（PIIINP）分子结合的单克隆抗体，其是由胞吐后的N-蛋白酶特异性切割前胶原（III）而产生的蛋白水解片段，以及使用这些抗体。

4. 发明授权

US07141380B2 Assessment of liver fibrosis scoring with serum marker algorithms 有权
标题翻译：用血清标记算法评估肝纤维化评分
公开(公告)号：US07141380B2
公开(公告)日：2006-11-28
申请号：US10258689
申请日：2001-04-26
申请人： Michael Volker , Michael Becka , Werner Kroll , Andreas Knorr , Mathias Gehrmann , Guido Hennig , Sylvia Unger , Elmar-Reinhold Burchardt , Michael J. Arthur , Alastair D. Burt , Massimo Pinzani , Detlef Schuppan
发明人： Michael Volker , Michael Becka , Werner Kroll , Andreas Knorr , Mathias Gehrmann , Guido Hennig , Sylvia Unger , Elmar-Reinhold Burchardt , Michael J. Arthur , Alastair D. Burt , Massimo Pinzani , Detlef Schuppan
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/6887 , G01N2333/47 , G01N2333/78 , G01N2333/8146 , G01N2333/96486 , G01N2800/085
摘要： The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.
摘要翻译：本发明涉及一种用于诊断肝纤维化的方法，其中测量两个或更多个诊断标记物，并且通过数学算法将测量值相关联，其特征在于诊断标记物选自N-末端原胶原III前肽（PIIINP），胶原蛋白IV ，胶原VI，腱生蛋白，层粘连蛋白，透明质酸，MMP-2，TIMP-1和MMP-9 / TIMP-1复合物。该算法可用于预测肝活组织检查的组织学分数。

5. 发明授权

US5238737A Use of polymer blend films as supports for diagnostic test strips 失效
标题翻译：使用聚合物共混膜作为诊断试纸的支架
公开(公告)号：US5238737A
公开(公告)日：1993-08-24
申请号：US890827
申请日：1992-06-01
申请人： Claus Burkhardt , Thomas Doege , Karlheinz Hildenbrand , Werner Kroll , Alexander Riebel , Bernhard Schulte , Philip R. Strom-Jensen , Klaus Wehling
发明人： Claus Burkhardt , Thomas Doege , Karlheinz Hildenbrand , Werner Kroll , Alexander Riebel , Bernhard Schulte , Philip R. Strom-Jensen , Klaus Wehling
IPC分类号： C08L69/00 , G01N33/52
CPC分类号： G01N33/525 , C08L69/00 , Y10T428/256 , Y10T428/31507 , Y10T428/31565 , Y10T428/31609 , Y10T428/31786
摘要： The present invention is directed to the use of polymer blend films consisting of polycarbonate and polyalkylene terephthalate supports for diagnostic test strips.
摘要翻译：本发明涉及由聚碳酸酯和聚对苯二甲酸亚烷基酯载体组成的聚合物共混物膜用于诊断测试条的用途。

6. 发明授权

US07668661B2 Liver disease-related methods and systems 有权
标题翻译：肝病相关方法和系统
公开(公告)号：US07668661B2
公开(公告)日：2010-02-23
申请号：US10868437
申请日：2004-06-15
申请人： Michael Volker , Michael Becka , Werner Kroll , Andreas Knorr , Sylvia Unger , Mathias Gehrmann , Guido Hennig , Elmar-Reinhold Burchardt , Michael J. Arthur , Alastair D. Burt , Massimo Pinzani , Detlef Schuppan , Robert P. Thiel , Christoph Petry , William Rosenberg
发明人： Michael Volker , Michael Becka , Werner Kroll , Andreas Knorr , Sylvia Unger , Mathias Gehrmann , Guido Hennig , Elmar-Reinhold Burchardt , Michael J. Arthur , Alastair D. Burt , Massimo Pinzani , Detlef Schuppan , Robert P. Thiel , Christoph Petry , William Rosenberg
IPC分类号： G06F7/00
CPC分类号： C12Q1/6883 , G01N33/6893 , G01N2800/085 , G06F19/00 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： The invention provides diagnostic methods, kits, and systems, and related computer-readable media, which use multiple blood marker values, including serum and plasma marker values, to aid in the diagnosis of the status or progress of a liver disease in a patient.The invention also provides methods and systems, and related computer-readable media, that use blood marker values, including serum and plasma marker values: (1) to screen for active ingredients useful in the treatment of a liver disease; (2) to aid in the selection of treatment regimens for patients that are predisposed to, or suffer from, liver disease; and (3) to aid in the design of clinical programs useful in monitoring the status or progress of liver disease in one or more patients.
摘要翻译：本发明提供了诊断方法，试剂盒和系统以及相关的计算机可读介质，其使用多个血液标记值，包括血清和血浆标记值，以帮助诊断患者的肝脏疾病的状态或进展。本发明还提供了使用血液标记值（包括血清和血浆标记值）的方法和系统以及相关的计算机可读介质：（1）筛选可用于治疗肝脏疾病的活性成分; （2）协助选择易患或患有肝病的患者的治疗方案; （3）协助设计有用的一个或多个病人监测肝脏病状况或进展情况的临床方案。

7. 发明申请

US20080233582A1 SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH SUSCEPTIBILITY TO CARDIOVASCULAR DISEASE 审中-公开
标题翻译：单核细胞多态性与心血管疾病的相关性相关
公开(公告)号：US20080233582A1
公开(公告)日：2008-09-25
申请号：US12019651
申请日：2008-01-25
申请人： Monika Stoll , Gerd Assmann , Helmut Schulte , Werner Kroll , Stephan Schwers , Christoph Petry
发明人： Monika Stoll , Gerd Assmann , Helmut Schulte , Werner Kroll , Stephan Schwers , Christoph Petry
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides SNPs, polymorphic variants, and haplotypes associated with cardiovascular disease. The invention also provides methods for detecting the SNPs, polymorphic variants, and haplotypes. The invention also provides methods for determining an individual's genotype with respect to one or more polymorphisms and/or haplotypes associated with cardiovascular disease. The invention further provides methods of determining whether an individual has or is susceptible to development or occurrence of a cardiovascular disease or event. The methods are useful for providing diagnostic and/or prognostic information, selecting therapeutic regimens, etc. The invention further provides reagents and kits for practicing the methods.
摘要翻译：本发明提供了与心血管疾病相关的SNP，多态变体和单体型。本发明还提供了用于检测SNP，多态变体和单体型的方法。本发明还提供了关于与心血管疾病相关的一种或多种多态性和/或单倍型确定个体基因型的方法。本发明还提供了确定个体是否具有或易于发展或发生心血管疾病或事件的方法。该方法可用于提供诊断和/或预后信息，选择治疗方案等。本发明还提供用于实施该方法的试剂和试剂盒。

8. 发明申请

US20070172907A1 Liver disease-related methods and systems 有权
标题翻译：肝病相关方法和系统
公开(公告)号：US20070172907A1
公开(公告)日：2007-07-26
申请号：US10868437
申请日：2004-06-15
申请人： Michael Volker , Michael Becka , Werner Kroll , Andreas Knorr , Sylvia Unger , Mathias Gehrmann , Guido Hennig , Elmar-Reinhold Burchardt , Michael Arthur , Alastair Burt , Massimo Pinzani , Detlef Schuppan , Robert Thiel , Christoph Petry , William Rosenberg
发明人： Michael Volker , Michael Becka , Werner Kroll , Andreas Knorr , Sylvia Unger , Mathias Gehrmann , Guido Hennig , Elmar-Reinhold Burchardt , Michael Arthur , Alastair Burt , Massimo Pinzani , Detlef Schuppan , Robert Thiel , Christoph Petry , William Rosenberg
IPC分类号： C12Q1/48 , G06F19/00
CPC分类号： C12Q1/6883 , G01N33/6893 , G01N2800/085 , G06F19/00 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： The invention provides diagnostic methods, kits, and systems, and related computer-readable media, which use multiple blood marker values, including serum and plasma marker values, to aid in the diagnosis of the status or progress of a liver disease in a patient. The invention also provides methods and systems, and related computer-readable media, that use blood marker values, including serum and plasma marker values: (1) to screen for active ingredients useful in the treatment of a liver disease; (2) to aid in the selection of treatment regimens for patients that are predisposed to, or suffer from, liver disease; and (3) to aid in the design of clinical programs useful in monitoring the status or progress of liver disease in one or more patients.
摘要翻译：本发明提供了诊断方法，试剂盒和系统以及相关的计算机可读介质，其使用多个血液标记值，包括血清和血浆标记值，以帮助诊断患者的肝脏疾病的状态或进展。本发明还提供了使用血液标记值（包括血清和血浆标记值）的方法和系统以及相关的计算机可读介质：（1）筛选可用于治疗肝脏疾病的活性成分; （2）协助选择易患或患有肝病的患者的治疗方案; （3）协助设计有用的一个或多个病人监测肝脏病状况或进展情况的临床方案。

9. 发明授权

US06663833B1 Integrated assay device and methods of production and use 失效
标题翻译：综合检测装置及生产和使用方法
公开(公告)号：US06663833B1
公开(公告)日：2003-12-16
申请号：US09263183
申请日：1999-03-05
申请人： James W. Stave , George B. Teaney, III , Werner Kroll
发明人： James W. Stave , George B. Teaney, III , Werner Kroll
IPC分类号： G01N2100
CPC分类号： G01N33/54366 , G01N33/5302 , G01N33/538 , G01N33/54313 , G01N33/558 , Y10T436/255
摘要： An assay device for the detection of analyte in a sample, methods and immunoassay formats for performing an assay with or without the device, and methods for manufacturing the device are provided. The device is a continuous liquid flow channel having a proximal and a distal end, with a detection membrane in fluid communication with the distal end of the flow channel. Interspersed between the assay buffer and detection membrane, and continuous with the liquid flow channel, are a sample delivery means, one or more reservoirs containing the reagents necessary for conducting the assay, and, optionally, mixing or incubation reservoirs for combining the sample and reagents. The geometry of the liquid flow channel regulates the flow rate of the liquids through the channel, thereby controlling incubation, mixing and reaction time. The preferred detection membrane is an immunochromatographic test strip containing immobilized reagents. The detection of labeled reagent in a particular area of the detection membrane reflects the presence or relative amount of analyte in the sample. Detection may be achieved visually. One or more liquid flow channels may be contained within a single housing for simultaneous, consecutive, or comparative sample analysis.
摘要翻译：提供了用于检测样品中分析物的测定装置，用于进行具有或不具有该装置的测定的方法和免疫测定形式以及用于制造该装置的方法。该装置是具有近端和远端的连续液体流动通道，其中检测膜与流动通道的远端流体连通。分散在测定缓冲液和检测膜之间并且与液体流动通道连续的是样品递送装置，一个或多个含有进行测定所必需的试剂的储存器，以及任选地混合或孵育用于组合样品和试剂的储存器。液体流动通道的几何形状调节通过通道的液体的流速，从而控制孵育，混合和反应时间。优选的检测膜是含有固定化试剂的免疫色谱试纸。在检测膜的特定区域中的标记试剂的检测反映了样品中分析物的存在或相对量。可以在视觉上实现检测。一个或多个液体流动通道可以包含在单个壳体内用于同时，连续或对比的样品分析。

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