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1. 发明授权

US09557328B2 Magnetic sensor device, method of operating such a device and sample 有权
标题翻译：磁传感器装置，操作这种装置和样品的方法
公开(公告)号：US09557328B2
公开(公告)日：2017-01-31
申请号：US13381115
申请日：2010-06-24
申请人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
发明人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
IPC分类号： G01N33/543 , G01N27/74 , G01N21/552
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.
摘要翻译：公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生来自所述第一检测信号在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。

2. 发明申请

US20120107961A1 MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE 有权
标题翻译：磁传感器装置，操作这种装置和样品的方法
公开(公告)号：US20120107961A1
公开(公告)日：2012-05-03
申请号：US13381115
申请日：2010-06-24
申请人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
发明人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
IPC分类号： G01N33/566 , G01N30/00
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.
摘要翻译：公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生来自所述第一检测信号在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。

3. 发明申请

US20100289483A1 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：US20100289483A1
公开(公告)日：2010-11-18
申请号：US12669218
申请日：2008-07-16
申请人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
发明人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/74
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，并且第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

4. 发明授权

US09841421B2 Sensor device for magnetically actuated particles 有权
公开(公告)号：US09841421B2
公开(公告)日：2017-12-12
申请号：US13988833
申请日：2011-11-28
申请人： Wendy Uyen Dittmer , Mikhail Mikhaylovich Ovsyanko , Toon Hendrik Evers , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus Dionisius Van Zon
发明人： Wendy Uyen Dittmer , Mikhail Mikhaylovich Ovsyanko , Toon Hendrik Evers , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus Dionisius Van Zon
IPC分类号： G01N33/543 , G01N27/82 , G01N27/72 , G01N27/74 , G01N35/00 , G01N21/27 , G01N21/552
CPC分类号： G01N33/54373 , G01N21/274 , G01N21/552 , G01N27/72 , G01N27/745 , G01N27/825 , G01N33/54326 , G01N35/0098
摘要： The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR). The evaluation results can be used to validate and/or correct the measurements obtained in the target region (TR).

5. 发明授权

US08217647B2 Measuring agglutination parameters 有权
标题翻译：测量凝集参数
公开(公告)号：US08217647B2
公开(公告)日：2012-07-10
申请号：US12518895
申请日：2007-12-18
申请人： Wendy Uyen Dittmer , Peggy De Kievit , Jeroen Hans Nieuwenhuis , Menno Willem Jose Prins , Leonardus Josephus Van Ijzendoorn , Xander Jozef Antoine Janssen
发明人： Wendy Uyen Dittmer , Peggy De Kievit , Jeroen Hans Nieuwenhuis , Menno Willem Jose Prins , Leonardus Josephus Van Ijzendoorn , Xander Jozef Antoine Janssen
IPC分类号： G01R33/00 , G01N33/553
CPC分类号： G01N15/0266 , B82Y25/00 , G01N27/745 , G01N33/54333 , G01N2015/0092 , G01R33/093 , G01R33/1269 , Y10S436/806
摘要： A method and system for measuring agglutination in a target-induced agglutination assay with one or more magnetic particles is performed in a reaction chamber. After the magnetic particles, which are capable of binding to a target are provided in the assay, an agglutination process is performed resulting in agglutinated particles. Further an alternating current magnetic field (HAC) is applied to the assay. The method further includes measuring an effect of the HAC on the one or more magnetic particles unattached to any surface. The measured effect is indicative of one or more agglutination parameters.
摘要翻译：在反应室中进行用于测定靶诱导的凝集测定中的一种或多种磁性颗粒的凝集的方法和系统。在测定中提供能够结合到靶的磁性颗粒之后，进行凝集过程，导致凝集的颗粒。此外，将交流磁场（HAC）应用于测定。该方法还包括测量HAC对未附着到任何表面的一个或多个磁性颗粒的影响。测量的效果表示一个或多个凝集参数。

6. 发明申请

US20140057366A1 SENSOR DEVICE FOR MAGNETICALLY ACTUATED PARTICLES 有权
标题翻译：用于磁力驱动颗粒的传感器装置
公开(公告)号：US20140057366A1
公开(公告)日：2014-02-27
申请号：US13988833
申请日：2011-11-28
申请人： Wendy Uyen Dittmer , Mikhail Mikhaylovich Ovsyanko , Toon Hendrik Evers , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus dionisius Van Zon
发明人： Wendy Uyen Dittmer , Mikhail Mikhaylovich Ovsyanko , Toon Hendrik Evers , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus dionisius Van Zon
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , G01N21/274 , G01N21/552 , G01N27/72 , G01N27/745 , G01N27/825 , G01N33/54326 , G01N35/0098
摘要： The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR). The evaluation results can be used to validate and/or correct the measurements obtained in the target region (TR).
摘要翻译：本发明涉及一种传感器装置（100）和用于在具有接触表面（11））的样品室（2）中检测磁性颗粒（1）的方法。传感器装置（100）包括用于检测目标区域（TR）中和/或接触表面上的至少一个参考区域中的磁性颗粒（1）的传感器单元（120,130）。此外，它包括用于产生磁场的磁场发生器（140），该磁场将磁性颗粒引导到接触表面。在这些组件的帮助下，确定与磁性颗粒（1）和/或它们的运动相关的“辅助参数”，但是与磁性颗粒和接触表面之间的目标区域中发生的结合过程无关。辅助参数可以例如与在磁场和目标区域（TR）的影响下由磁性颗粒（1）达到的位置之间的失配程度相关。评估结果可用于验证和/或校正在目标区域（TR）中获得的测量结果。

7. 发明授权

US08520211B2 Carrier for optical detection in small sample volumes 有权
标题翻译：小样本量的光学检测载体
公开(公告)号：US08520211B2
公开(公告)日：2013-08-27
申请号：US12935947
申请日：2009-04-07
申请人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
发明人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： A carrier and an apparatus for optical detection of a sample in a sample chamber includes en optical structure for refracting an input light beam into the adjacent sample chamber and for collecting an output light beam from light that originates in the sample chamber from the input light beam. The optical structure includes grooves in the surface of the carrier in which the Input light beam is transmitted Over a short distance through a sample. The optical structure can also be used for a wetting detection.
摘要翻译：用于样品室中的样品的光学检测的载体和设备包括用于将输入光束折射到相邻样品室中的光学结构，并且用于从输入光束收集来自样品室的光的输出光束。光学结构包括在载体的表面中的凹槽，其中输入光束在短距离内透射通过样品。光学结构也可用于润湿检测。

8. 发明申请

US20110026030A1 CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 有权
标题翻译：用于小样品中光学检测的载体
公开(公告)号：US20110026030A1
公开(公告)日：2011-02-03
申请号：US12935947
申请日：2009-04-07
申请人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
发明人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (L1) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.
摘要翻译：本发明涉及一种用于在样品室（2）中的样品（1）中进行光学检测的载体（11）和装置（100）。载体（11）包括用于将输入光束（L1）折射到相邻的样品室（2）中并用于从源于样品室（2）的光收集输出光束（L2）的光学结构（50）从输入光束。优选地，光学结构（50）包括在载体（11）的表面（12）中的凹槽，其中输入光束通过样品在短距离上传播。光学结构（50）也可用于润湿检测。

9. 发明申请

US20100194386A1 MAGNETIC SENSOR DEVICE 审中-公开
标题翻译：磁传感器装置
公开(公告)号：US20100194386A1
公开(公告)日：2010-08-05
申请号：US12669211
申请日：2008-07-14
申请人： Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
发明人： Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
IPC分类号： G01R33/12
CPC分类号： G01N33/54333 , G01N27/745
摘要： The present invention provides a sensor device (20) and a method for determining the presence and/or amount of target moieties (22) in a sample fluid (27), the target moieties (22) being labeled with magnetic or magnetizable objects (23). The sensor device (20) comprises a magnetic field generating means adapted for applying a retention field for retaining the labeled target moieties (22, 23) to the sensor surface (24) during fluid manipulations. Through this the binding between the labeled target moieties (22, 23) and the sensor surface (24) and/or the magnetic particles (23) and the target moieties (22) is substantially not disturbed during these fluid manipulations. This leads to a reliable and accurate sensor device (20).
摘要翻译：本发明提供一种传感器装置（20）和用于确定样品流体（27）中目标部分（22）的存在和/或数量的方法，目标部分（22）用磁性或可磁化物体（23）标记）。传感器装置（20）包括磁场产生装置，其适于在流体操纵期间施加用于将标记的目标部分（22,23）保持到传感器表面（24）的保持场。通过这一点，标记的目标部分（22,23）和传感器表面（24）和/或磁性颗粒（23）和目标部分（22）之间的结合在这些流体操纵过程中基本上不受干扰。这导致可靠且准确的传感器装置（20）。

10. 发明申请

US20100108578A1 MEANS FOR THE SEPARATION OF MAGNETIC PARTICLES 审中-公开
标题翻译：手段分离磁性颗粒
公开(公告)号：US20100108578A1
公开(公告)日：2010-05-06
申请号：US12525833
申请日：2008-01-31
申请人： Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis , Peggy De Kievit , Kim Van Ommering
发明人： Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis , Peggy De Kievit , Kim Van Ommering
IPC分类号： B03C1/02
CPC分类号： B03C1/288 , B03C1/32
摘要： The invention relates to an apparatus (300) and a method for the separation of magnetic particles (1, 2) according to their properties, particularly their magnetic susceptibility. The apparatus comprises a magnetic field generator (320) with which magnetic actuation forces (Fm) can be exerted on the magnetic particles (1, 2) that affect a prevailing movement of the particles (1, 2), said movement being caused by non-magnetic influences, e.g. thermal energy or viscous drag (Fh). The magnetic field generator may for example comprise: (i) a wire (321) that crosses the flow of a sample fluid with varying inclination (α); (ii) wires that generate a local minimum of a magnetic potential from which different particles escape by Brownian motion with different rates; or (iii) pairs of particle-attracting wires for which the attraction of one wire is temporarily interrupted to allow the fastest magnetic particles to escape.
摘要翻译：本发明涉及一种根据其特性，特别是它们的磁化率分离磁性颗粒（1,2）的装置（300）和方法。该装置包括磁场发生器（320），通过该磁场发生器可以对影响颗粒（1,2）主要运动的磁性颗粒（1,2）施加磁力驱动力（Fm），所述运动由非磁性元件磁影响，例如热能或粘滞阻力（Fh）。磁场发生器可以例如包括：（i）穿过具有不同倾斜度（α）的样品流体的流动的导线（321）; （ii）产生局部最小磁场的导线，不同的粒子由不同速率的布朗运动逃离; 或（iii）一对引线，其中一根导线的吸引力暂时中断，以允许最快的磁性颗粒逸出。

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