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1. 发明申请

US20100108578A1 MEANS FOR THE SEPARATION OF MAGNETIC PARTICLES 审中-公开
标题翻译：手段分离磁性颗粒
公开(公告)号：US20100108578A1
公开(公告)日：2010-05-06
申请号：US12525833
申请日：2008-01-31
申请人： Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis , Peggy De Kievit , Kim Van Ommering
发明人： Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis , Peggy De Kievit , Kim Van Ommering
IPC分类号： B03C1/02
CPC分类号： B03C1/288 , B03C1/32
摘要： The invention relates to an apparatus (300) and a method for the separation of magnetic particles (1, 2) according to their properties, particularly their magnetic susceptibility. The apparatus comprises a magnetic field generator (320) with which magnetic actuation forces (Fm) can be exerted on the magnetic particles (1, 2) that affect a prevailing movement of the particles (1, 2), said movement being caused by non-magnetic influences, e.g. thermal energy or viscous drag (Fh). The magnetic field generator may for example comprise: (i) a wire (321) that crosses the flow of a sample fluid with varying inclination (α); (ii) wires that generate a local minimum of a magnetic potential from which different particles escape by Brownian motion with different rates; or (iii) pairs of particle-attracting wires for which the attraction of one wire is temporarily interrupted to allow the fastest magnetic particles to escape.
摘要翻译：本发明涉及一种根据其特性，特别是它们的磁化率分离磁性颗粒（1,2）的装置（300）和方法。该装置包括磁场发生器（320），通过该磁场发生器可以对影响颗粒（1,2）主要运动的磁性颗粒（1,2）施加磁力驱动力（Fm），所述运动由非磁性元件磁影响，例如热能或粘滞阻力（Fh）。磁场发生器可以例如包括：（i）穿过具有不同倾斜度（α）的样品流体的流动的导线（321）; （ii）产生局部最小磁场的导线，不同的粒子由不同速率的布朗运动逃离; 或（iii）一对引线，其中一根导线的吸引力暂时中断，以允许最快的磁性颗粒逸出。

2. 发明授权

US08970215B2 Sensor device for and a method of sensing particles 有权
标题翻译：传感器装置和感测颗粒的方法
公开(公告)号：US08970215B2
公开(公告)日：2015-03-03
申请号：US12521905
申请日：2007-07-26
申请人： Jeroen Hans Nieuwenhuis , Godefridus Johannes Verhoeckx , Menno Willem Jose Prins , Petrus Johannes Wilhelmus Van Lankvelt , Kim Van Ommering
发明人： Jeroen Hans Nieuwenhuis , Godefridus Johannes Verhoeckx , Menno Willem Jose Prins , Petrus Johannes Wilhelmus Van Lankvelt , Kim Van Ommering
IPC分类号： G01N33/558 , G01R33/12 , B82Y25/00 , G01R33/09 , G01N15/06 , G01N11/00 , G01N15/00
CPC分类号： G01R33/12 , B82Y25/00 , G01N15/0656 , G01N2011/008 , G01N2015/0053 , G01R33/093 , G01R33/1284
摘要： A sensor device for sensing particles of a sample, the sensor device including a sensing unit adapted for sensing a detection signal indicative of the presence of the particles, a viscosity measurement unit adapted for measuring the viscosity of the sample, and a correction unit adapted for correcting the detection signal based on the measured viscosity.
摘要翻译：一种用于感测样品颗粒的传感器装置，所述传感器装置包括适于感测指示颗粒存在的检测信号的感测单元，适于测量样品粘度的粘度测量单元，以及适用于基于测量的粘度校正检测信号。

3. 发明申请

US20120184048A1 METHOD FOR CHARACTERIZATION OF BIOLOGICAL BONDS 审中-公开
标题翻译：生物学特征表征方法
公开(公告)号：US20120184048A1
公开(公告)日：2012-07-19
申请号：US13498635
申请日：2010-09-07
申请人： Kim Van Ommering , Johannes Joseph Hubertina Barbara Schleipen , Jeroen Hans Nieuwenhuis
发明人： Kim Van Ommering , Johannes Joseph Hubertina Barbara Schleipen , Jeroen Hans Nieuwenhuis
IPC分类号： G01N21/49
CPC分类号： G01N33/54373 , G01N21/552 , G01N33/54313
摘要： The invention relates to the field of intensity measurements of a light scattering label bound to a surface of a support using an optical evanescent field. According to the invention, the method comprises the steps: a) Providing an assay comprising at least one light scattering label bound to a surface of a support by at least one bond; b) Measuring the fluctuations in the intensity of scattered light of the label in an optical evanescent field over time while the label is bound to the surface. The method according to the invention allows to identify different bonds and/or to distinguish between different bonds.
摘要翻译：本发明涉及使用光学渐逝场结合到支撑体表面的光散射标签的强度测量领域。根据本发明，该方法包括以下步骤：a）提供包含至少一个光散射标记的测定结合至少一个键的支持物表面; b）当标签与表面结合时，测量随着时间的推移，光学衰减场中标签的散射光强度的波动。根据本发明的方法允许识别不同的键和/或区分不同的键。

4. 发明申请

US20100109653A1 SENSOR DEVICE FOR AND A METHOD OF SENSING PARTICLES 有权
标题翻译：用于传感颗粒的传感器装置和方法
公开(公告)号：US20100109653A1
公开(公告)日：2010-05-06
申请号：US12521905
申请日：2007-07-26
申请人： Jeroen Hans Nieuwenhuis , Godefridus Johannes Verhoeckx , Menno Willem Jose Prins , Petrus Johannes Wilhelmus Van Lankvelt , Kim Van Ommering
发明人： Jeroen Hans Nieuwenhuis , Godefridus Johannes Verhoeckx , Menno Willem Jose Prins , Petrus Johannes Wilhelmus Van Lankvelt , Kim Van Ommering
IPC分类号： G01N27/74
CPC分类号： G01R33/12 , B82Y25/00 , G01N15/0656 , G01N2011/008 , G01N2015/0053 , G01R33/093 , G01R33/1284
摘要： A sensor device (50) for sensing particles (15) of a sample, the sensor device (50) comprising a sensing unit (11, 20) adapted for sensing a detection signal indicative of the presence of the particles (15), a viscosity measurement unit (11, 17, 20) adapted for measuring the viscosity of the sample, and a correction unit (20, 30) adapted for correcting the detection signal based on the measured viscosity.
摘要翻译：一种用于感测样品的颗粒（15）的传感器装置（50），所述传感器装置（50）包括适于感测指示所述颗粒（15）的存在的检测信号的感测单元（11,20），粘度适于测量样品粘度的测量单元（11,17,20）以及适于基于所测量的粘度校正检测信号的校正单元（20,30）。

5. 发明授权

US09772272B2 Substance determining apparatus 有权
公开(公告)号：US09772272B2
公开(公告)日：2017-09-26
申请号：US13498615
申请日：2010-09-24
申请人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
发明人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
IPC分类号： G01N15/06 , G01N15/14 , G01N21/47 , G01N21/552 , G01N21/64 , G01N27/74 , G01N33/543 , G01N15/02 , G01N35/00
CPC分类号： G01N15/0612 , G01N15/1434 , G01N21/47 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01N2015/025 , G01N2201/0627
摘要： A substance determining apparatus determines a substance within a fluid where particles, which have attached the substance, are bound to a binding surface. A sensing unit is configured to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface and the binding surface, and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit is configured to discriminate between different kinds of binding of the particles bound on the binding surface depending on the generated sensing signal. The binding discrimination unit may be a unit for determining the part of the sensing signal being caused by specifically bound particles and for determining the substance based on this determined part of the sensing signal.

6. 发明申请

US20120202194A1 SUBSTANCE DETERMINING APPARATUS 有权
标题翻译：物质确定装置
公开(公告)号：US20120202194A1
公开(公告)日：2012-08-09
申请号：US13498615
申请日：2010-09-24
申请人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
发明人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
IPC分类号： G01N21/63 , C12M1/34 , C12Q1/02 , C12Q1/70 , G01N33/53 , G01N21/64
CPC分类号： G01N15/0612 , G01N15/1434 , G01N21/47 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01N2015/025 , G01N2201/0627
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles, which have attached the substance, are bound to a binding surface (30). A sensing unit (33) is adapted to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface (30) and the binding surface (30) and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit (34) is adapted to discriminate between different kinds of binding of the particles bound on the binding surface (30) depending on the generated sensing signal. The binding discrimination unit (34) is preferentially a unit for determining the part of the sensing signal being caused by specifically bound particles and to determine the substance based on this determined part of the sensing signal.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。具有附着物质的颗粒结合至结合表面（30）。感测单元（33）适于产生感测信号，该感测信号指示i）结合在装订表面（30）和装订表面（30）上的颗粒之间的距离和ii）平面内位置的结合表面上的颗粒。绑定识别单元（34）适于根据产生的感测信号来区分绑定在绑定表面（30）上的粒子的不同种类的绑定。装订识别单元（34）优选地是用于确定由特定结合的粒子引起的感测信号的部分的单元，并且基于该确定的感测信号的部分来确定物质。

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