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    • 2. 发明申请
    • Dual-band detector system for x-ray imaging of biological samples
    • 用于生物样品X射线成像的双波段检测器系统
    • US20050226376A1
    • 2005-10-13
    • US10990198
    • 2004-11-16
    • Wenbing YunYuxin WangDavid Scott
    • Wenbing YunYuxin WangDavid Scott
    • G01J1/42G01N23/04G01T1/00G01T1/20G01T1/202
    • G01T1/202G01T1/2018G21K2207/005
    • A digital dual-band detector functions as an imaging platform capable of extracting hard and soft tissue images, for example. The detector has a first detector system comprising a first scintillator for converting x-rays from a sample to an first optical signal, and a first detector for detecting the first optical signal in combination with a second detector system comprising a second scintillator for converting x-rays from the sample and passing through the first scintillator to a second optical signal, and a second detector for detecting the second optical signal. The detector can facilitate the implementation and deployment of recent developments and can permit low cost practical deployment in clinical applications as well as biomedical research applications where significant improvement in spatial resolution and image contrast is required. These improvements include an increase of feature detection sensitivity by more than an order of magnitude, simultaneous imaging of soft and hard (or mineralized) tissue at extremely high time resolution that is not limited by detector readout speed, and an increase in the signal to noise ratio of images by reducing the substantial background resulting from Compton scattering.
    • 例如,数字双频带检测器用作能够提取硬和软组织图像的成像平台。 检测器具有第一检测器系统,该第一检测器系统包括用于将来自样品的x射线转换成第一光信号的第一闪烁器,以及用于与第二检测器系统一起检测第一光信号的第一检测器,该第二检测器系统包括第二闪烁器, 来自样品的光并通过第一闪烁体到第二光信号;以及第二检测器,用于检测第二光信号。 检测器可以促进近期发展的实施和部署,并且可以允许临床应用中的低成本实际部署以及需要显着改善空间分辨率和图像对比度的生物医学研究应用。 这些改进包括将特征检测灵敏度提高超过一个数量级,以非常高的时间分辨率同时成像软和硬(或矿化的)组织,其不受检测器读出速度的限制,并且信号与噪声的增加 通过减少由康普顿散射产生的实质背景,图像的比例。
    • 4. 发明授权
    • Fabrication methods for micro compounds optics
    • 微复合光学制造方法
    • US07365909B2
    • 2008-04-29
    • US10688187
    • 2003-10-17
    • Wenbing YunYuxin WangMichael FeserAlan Lyon
    • Wenbing YunYuxin WangMichael FeserAlan Lyon
    • G02B27/44
    • G02B27/4211G02B3/08G02B27/4272G03F7/0005Y10S438/975
    • Methods for fabricating refractive element(s) and aligning the elements in a compound optic, typically to a zone plate element. The techniques are used for fabricating micro refractive, such as Fresnel, optics and compound optics including two or more optical elements for short wavelength radiation. One application is the fabrication of the Achromatic Fresnel Optic (AFO). Techniques for fabricating the refractive element generally include: 1) ultra-high precision mechanical machining, e.g,. diamond turning; 2) lithographic techniques including gray-scale lithography and multi-step lithographic processes; 3) high-energy beam machining, such as electron-beam, focused ion beam, laser, and plasma-beam machining; and 4) photo-induced chemical etching techniques. Also addressed are methods of aligning the two optical elements during fabrication and methods of maintaining the alignment during subsequent operation.
    • 用于制造折射元件并将复合光学元件中的元件对准的方法,通常与区域板元件对准。 这些技术用于制造微折射,例如菲涅尔,光学和复合光学器件,包括用于短波长辐射的两个或更多个光学元件。 一种应用是制造消色差菲涅耳光(AFO)。 用于制造折射元件的技术通常包括:1)超高精度机械加工,例如 钻石车削 2)光刻技术,包括灰阶光刻和多步光刻工艺; 3)高能束加工,如电子束,聚焦离子束,激光和等离子束加工; 和4)光诱导化学蚀刻技术。 还涉及在制造期间对准两个光学元件的方法以及在随后的操作期间维持对准的方法。
    • 5. 发明授权
    • Lens bonded X-ray scintillator system and manufacturing method therefor
    • 透镜结合X射线闪烁体系及其制造方法
    • US07297959B2
    • 2007-11-20
    • US11278839
    • 2006-04-06
    • Wenbing YunYuxin WangDavid R. Trapp
    • Wenbing YunYuxin WangDavid R. Trapp
    • G01T1/20
    • G01T1/2002G01T1/20
    • A scintillated CCD detector system for imaging x rays uses x-rays having a photon energy in the range of 1 to 20 keV. The detector differs from existing systems in that it provides extremely high resolution of better than a micrometer, and high detection quantum efficiency of up to 95%. The design of this detector also allows it to function as an energy filter to remove high-energy x-rays. This detector is useful in a wide range of applications including x-ray imaging, spectroscopy, and diffraction. The scintillator optical system has scintillator material with a lens system for collecting the light that is generated in the scintillator material. A substrate is used for spacing the scintillator material from the lens system.
    • 用于对x射线进行成像的闪烁CCD检测器系统使用具有在1至20keV范围内的光子能量的X射线。 检测器与现有系统不同之处在于它提供比千分尺更高的分辨率,高达95%的高检测量子效率。 该检测器的设计也可以用作能量过滤器,以去除高能X射线。 该检测器可用于广泛的应用,包括X射线成像,光谱和衍射。 闪烁体光学系统具有闪烁体材料,其具有用于收集闪烁体材料中产生的光的透镜系统。 衬底用于将闪烁体材料与透镜系统间隔开。
    • 10. 发明授权
    • X-ray mammography
    • X线摄影
    • US07412024B1
    • 2008-08-12
    • US11244825
    • 2005-10-05
    • Wenbing YunYuxin Wang
    • Wenbing YunYuxin Wang
    • G01N23/087G01T1/20H05G1/64
    • A61B6/484A61B6/4092A61B6/502G21K2207/005
    • A digital x-ray phase contrast soft tissue imaging and mammography system offers significant cancer detection sensitivity and a significant improvement in accurate detection and interpretation of mammograms. In addition, the proposed system produces digital mammograms and thus has the advantages of digital mammography. The system overcomes the limitation of the current approaches to mammography using phase contrast effects and offers substantially higher performance than the current mammography used in hospitals and clinics. The proposed system uses the phase contrast imaging, in a breast and other soft tissue structures, instead of absorption contrast employed in the current x-ray mammography, allowing detection of smaller disease structures with substantial reduction in radiation dose.
    • 数字X射线相位对比软组织成像和乳房X射线摄影系统提供了显着的癌症检测灵敏度和乳腺X线照片的精确检测和解释的显着改进。 此外,所提出的系统产生数字乳腺X线照片,因此具有数字乳腺X线照相术的优点。 该系统克服了使用相位对比效应的乳腺X线照相术的局限性,并提供比目前在医院和诊所使用的乳房X线照相术更好的性能。 所提出的系统在乳腺和其他软组织结构中使用相位对比成像,而不是在目前的X射线乳房X线照相术中使用的吸收对比度,允许以显着降低的辐射剂量检测较小的疾病结构。