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1. 发明授权

US07955389B2 Artificial sphincter system 有权
标题翻译：人造括约肌系统
公开(公告)号：US07955389B2
公开(公告)日：2011-06-07
申请号：US12140943
申请日：2008-06-17
申请人： Wen-Shiang Chen , Hao-Li Liu , Yen-Tung Huang , Chien-Ching Ma , Wei-Bor Tsai , Wen-Pin Shih , Chi-An Dai
发明人： Wen-Shiang Chen , Hao-Li Liu , Yen-Tung Huang , Chien-Ching Ma , Wei-Bor Tsai , Wen-Pin Shih , Chi-An Dai
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/14 , A61F2210/0014 , A61F2210/0057
摘要： An artificial sphincter system having: (1) a hollow object, which has the ability of contraction and expansion; (2) a shape memory alloy (SMA), which is connected with the hollow object, changes its shape to imitate the motion of human muscle by applying different electric current; (3) an electric power to provide different amounts of electric current to the shape memory alloy and let it contract or expand to control the motion of the hollow object to imitate the motion of human muscle; and (4) a photo resistor added between the electric power and the shape memory alloy, which senses the brightness of surrounding light and controls A/D (analog-to-digital) values of the electric power to cause different conditions of contraction and expansion of each part of the shape memory alloy.
摘要翻译：一种人造括约肌系统，具有：（1）具有收缩膨胀能力的中空物体; （2）与中空物体连接的形状记忆合金（SMA），通过施加不同的电流来改变其形状以模仿人体的运动; （3）向形状记忆合金提供不同量的电流并使其收缩或膨胀以控制中空物体的运动以模仿人肌肉的运动的电力; 和（4）在电力和形状记忆合金之间添加的光电阻，其感测周围光的亮度并控制电力的A / D（模数）值，以引起不同的收缩和膨胀条件形状记忆合金的每一部分。

2. 发明申请

US20090248151A1 ARTIFICIAL SPHINCTER SYSTEM 有权
标题翻译：人造喷雾系统
公开(公告)号：US20090248151A1
公开(公告)日：2009-10-01
申请号：US12140943
申请日：2008-06-17
申请人： Wen-Shiang Chen , Hao-Li Liu , Yen-Tung Huang , Chien-Ching Ma , Wei-Bor Tsai , Wen-Pin Shih , Chi-An Dai
发明人： Wen-Shiang Chen , Hao-Li Liu , Yen-Tung Huang , Chien-Ching Ma , Wei-Bor Tsai , Wen-Pin Shih , Chi-An Dai
IPC分类号： A61F2/14
CPC分类号： A61F2/08 , A61F2/14 , A61F2210/0014 , A61F2210/0057
摘要： The present invention relates to a kind of artificial sphincter system, which takes shape memory alloy (SMA) as its motion device, and then cooperates with controlled circuit to imitate the motion of human sphincter, especially in imitating iris. The present invention can be used in a human body, a robot or a machine.
摘要翻译：本发明涉及一种人造括约肌系统，其以形状记忆合金（SMA）作为其运动装置，然后与受控电路配合以模拟人括约肌的运动，特别是模仿虹膜。本发明可以用于人体，机器人或机器。

3. 发明授权

US08046994B2 Precision method and apparatus for controlling the shape memory alloy 有权
标题翻译：用于控制形状记忆合金的精密方法和装置
公开(公告)号：US08046994B2
公开(公告)日：2011-11-01
申请号：US12289419
申请日：2008-10-28
申请人： Hao-Li Liu , Wen-Shiang Chen , Chen-Kai Jan
发明人： Hao-Li Liu , Wen-Shiang Chen , Chen-Kai Jan
IPC分类号： F01B29/10 , H02N10/00
CPC分类号： F03G7/065
摘要： The invention discloses a method and apparatus to control the shaping change of Shape-Memory-Alloy (SMA). The piece-wised current drain control device is designed to independently deliver current to stimulate sectional SMA but not the entire one. The invention is also successfully implemented on an automatic light sensitive aperture control device to simulate the light response of a pupil. The control technique can extend the application potential of SMA toward precise actuation, aeronautical applications, surgical tools, or biomedical applications such as artificial organ or muscles.
摘要翻译：本发明公开了一种控制形状记忆合金（SMA）成型变化的方法和装置。分流电流漏极控制装置被设计成独立地传递电流以刺激SMA部分而不是整个SMA。本发明也成功地实现在自动光敏光圈控制装置上以模拟光瞳的光响应。控制技术可以将SMA的应用潜力扩大到精确致动，航空应用，外科手术工具或生物医学应用，如人造器官或肌肉。

4. 发明申请

US20100005795A1 Precision method and apparatus for controlling the shape memory alloy 有权
标题翻译：用于控制形状记忆合金的精密方法和装置
公开(公告)号：US20100005795A1
公开(公告)日：2010-01-14
申请号：US12289419
申请日：2008-10-28
申请人： Hao-Li Liu , Wen-Shiang Chen , Chen-Kai Jan
发明人： Hao-Li Liu , Wen-Shiang Chen , Chen-Kai Jan
IPC分类号： F03G7/06
CPC分类号： F03G7/065
摘要： The invention discloses a method and apparatus to control the shaping change of Shape-Memory-Alloy (SMA). The piece-wised current drain control device is designed to independently deliver current to stimulate sectional SMA but not the entire one. The invention is also successfully implemented on an automatic light sensitive aperture control device to simulate the light response of a pupil. The control technique can extend the application potential of SMA toward precise actuation, aeronautical applications, surgical tools, or biomedical applications such as artificial organ or muscles.
摘要翻译：本发明公开了一种控制形状记忆合金（SMA）成型变化的方法和装置。分流电流漏极控制装置被设计成独立地传递电流以刺激SMA部分而不是整个SMA。本发明也成功地实现在自动光敏光圈控制装置上以模拟光瞳的光响应。控制技术可以将SMA的应用潜力扩大到精确致动，航空应用，外科手术工具或生物医学应用，如人造器官或肌肉。

5. 发明申请

US20120123302A1 Multiple-Frequency Ultrasonic Phased Array Driving System 有权
标题翻译：多频超声相控阵驱动系统
公开(公告)号：US20120123302A1
公开(公告)日：2012-05-17
申请号：US12946256
申请日：2010-11-15
申请人： Hao-Li Liu , Hsu Chang , Sheng-Fu Chen
发明人： Hao-Li Liu , Hsu Chang , Sheng-Fu Chen
IPC分类号： A61N7/00 , G01N29/00
CPC分类号： A61N7/00 , A61N2007/0073 , A61N2007/0078 , B06B1/0284 , B06B1/0622
摘要： An apparatus for sonicating a patient includes an ultrasound array having a plurality of transducers; a driving module for driving said transducers; and a control kernel for causing said driving module to drive said transducers concurrently at two different frequencies.
摘要翻译：用于超声处理患者的装置包括具有多个换能器的超声阵列; 用于驱动所述换能器的驱动模块; 以及用于使所述驱动模块以两个不同频率同时驱动所述换能器的控制内核。

6. 发明申请

US20110306881A1 High-intensity focused ultrasound thermal ablation apparatus having integrated temperature estimation and elastography for thermal lesion determination and the method thereof 有权
标题翻译：具有集成的温度估计和弹性成像用于热病变测定的高强度聚焦超声热消融装置及其方法
公开(公告)号：US20110306881A1
公开(公告)日：2011-12-15
申请号：US12926326
申请日：2010-11-10
申请人： Hao-Li Liu , Ming-Shi Lin
发明人： Hao-Li Liu , Ming-Shi Lin
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/02 , A61B8/485 , A61B8/5223 , A61B8/54 , A61B8/587 , A61B2017/00084 , A61B2090/378
摘要： The invention disclosed a high-intensity focused ultrasound thermal ablation apparatus having integrated temperature estimation and elastography for thermal lesion determination and the method thereof, using the different power to burn by the same focused ultrasound transducer, and then using the apparatus to measure the temperature and elasticity estimating by the relevant analysis method.
摘要翻译：本发明公开了一种具有用于热病变确定的综合温度估计和弹性成像的高强度聚焦超声热消融装置及其方法，使用不同功率通过相同的聚焦超声换能器燃烧，然后使用该装置测量温度和通过相关分析方法估计弹性。

7. 发明授权

US07530272B2 Multiple frequency ultrasound apparatus 有权
公开(公告)号：US07530272B2
公开(公告)日：2009-05-12
申请号：US11889682
申请日：2007-08-15
申请人： Hao-Li Liu , Chao-Ming Hsieh
发明人： Hao-Li Liu , Chao-Ming Hsieh
IPC分类号： G01H13/00 , H01L41/00
CPC分类号： B06B1/0276
摘要： The invention disclosed that the multiple frequency ultrasound apparatus using unique transducer will contain many actuations module, a coupled circuit and a transducer. Each actuation module can separately output the signal of the different frequency, the coupled circuit connecting the actuation module for coupling with the signal of the different frequency. The transducer can receive the signal of the multiple frequencies, then for outputting the multiple ultrasound frequency by the way of transferring from the electrical energy to the mechanical energy.

8. 发明授权

US08226559B2 Method and apparatus for real-time temperature measuring for high-intensity focused ultrasound(HIFU) therapy system 有权
标题翻译：用于高强度聚焦超声（HIFU）治疗系统的实时温度测量方法和装置
公开(公告)号：US08226559B2
公开(公告)日：2012-07-24
申请号：US12155689
申请日：2008-06-09
申请人： Hao-Li Liu , I-Yeh Lu , Sheng-Min Huang
发明人： Hao-Li Liu , I-Yeh Lu , Sheng-Min Huang
IPC分类号： A61B8/00 , G01N29/00
CPC分类号： A61N7/02 , A61B5/01 , A61B34/25 , A61B2017/00084 , A61B2017/00106
摘要： The invention is disclosed to design a real-time pulse/echo system to perform 1-D real-time temperature measurement and integrate in the high-intensity focused ultrasound system. In the invention, a modified echo-time shifting algorithm is developed to calculate the corresponding phase shift from echo signal, which correlates with the instantaneous temperature change during heating process.
摘要翻译：公开了本发明，以设计实时脉冲/回波系统来执行1-D实时温度测量并集成在高强度聚焦超声系统中。在本发明中，开发了一种改进的回波 - 时移算法，用于计算回波信号的相应相移，这与加热过程中的瞬时温度变化相关。

9. 发明申请

US20120095325A1 TREATMENT OF BRAIN DISEASES VIA ULTRASOUND/MAGNETIC TARGETING DELIVERY AND TRACING OF THERAPEUTIC AGENTS 审中-公开
标题翻译：通过超声波/磁性定向递送和治疗药物的治疗来治疗脑疾病
公开(公告)号：US20120095325A1
公开(公告)日：2012-04-19
申请号：US13273368
申请日：2011-10-14
申请人： Kuo-Chen Wei , Hao-Li Liu , Mu-Yi Hua
发明人： Kuo-Chen Wei , Hao-Li Liu , Mu-Yi Hua
IPC分类号： A61B5/055 , A61N7/00 , B82Y5/00
CPC分类号： A61B5/0515 , A61B5/0042 , A61M37/0092 , A61M2210/0693 , B82Y5/00
摘要： Disclosed herein is a method for treating a brain disease in which focused ultrasound and magnetic targeting are applied to a subject in need of such treatment, so that therapeutic agent-magnetic nanoparticle composites are directed across the blood-brain barrier to a designated locus inside the brain of the subject. Each of the composites includes a magnetic nanoparticle that is formed of an iron-based core and a shell encapsulating the iron-based core, and a therapeutic agent that is bound to the shell of the magnetic nanoparticle. The magnetic nanoparticle has a size ranging from 5 to 200 nm. The iron-based core has a crystalline structure that imparts the composites with a sufficiently high magnetization, thereby enhancing magnetic targeting of the composites to the designated locus inside the brain of the subject. The magnetic targeting treatment is conducted via a magnet providing a magnetic flux density not less than 0.18 T.
摘要翻译：本文公开了一种治疗脑疾病的方法，其中将聚焦超声和磁性靶向应用于需要这种治疗的受试者，使得治疗剂 - 磁性纳米颗粒复合物穿过血脑屏障被引导到内部的指定位点主题的大脑。每种复合材料包括由铁基核心和包封铁基核心的壳形成的磁性纳米颗粒，以及结合到磁性纳米颗粒的壳的治疗剂。磁性纳米粒子的尺寸范围为5〜200nm。铁基芯具有赋予复合材料足够高的磁化强度的晶体结构，从而增强复合材料对受试者脑内指定位点的磁性靶向。磁性靶向处理通过提供磁通密度不小于0.18T的磁体进行。

10. 发明申请

US20110306880A1 METHOD FOR DYNAMICALLY ANALYZING DISTRIBUTION VARIATION OF SCATTERERS AND APPLICATION USING THE SAME 有权
标题翻译：用于动态分析散射体分布变化的方法及其应用
公开(公告)号：US20110306880A1
公开(公告)日：2011-12-15
申请号：US12913481
申请日：2010-10-27
申请人： Meng-Lin LI , Hao-Li Liu , Da-Wei Li
发明人： Meng-Lin LI , Hao-Li Liu , Da-Wei Li
IPC分类号： A61B8/14 , A61B18/12
CPC分类号： A61B8/08 , A61B2090/378 , A61N7/02
摘要： A method for dynamically analyzing distribution variation of scatterers is provided and used for dynamically analyzing changes in two or three dimensional scatterer distribution and concentration of ultrasound data by using probability density function along with a moving window technique. The present invention has advantages in low computation load and may be used for real-time analysis. A method for dynamically detecting thermal ablation area and thermal ablation level and a method for dynamically controlling thermal ablation intensity are also provided for non-invasive detection and thermal ablation.
摘要翻译：提供动态分析散射体分布变化的方法，用于动态分析二维或三维散射体分布的变化和超声数据的浓度，并利用概率密度函数和移动窗口技术。本发明具有计算负荷低的优点，可用于实时分析。还提供了用于动态检测热消融区域和热消融水平的方法以及用于动态控制热消融强度的方法用于非侵入式检测和热消融。

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